WO2009017716A3 - Pulsatile gastric retentive dosage forms - Google Patents

Pulsatile gastric retentive dosage forms Download PDF

Info

Publication number
WO2009017716A3
WO2009017716A3 PCT/US2008/009139 US2008009139W WO2009017716A3 WO 2009017716 A3 WO2009017716 A3 WO 2009017716A3 US 2008009139 W US2008009139 W US 2008009139W WO 2009017716 A3 WO2009017716 A3 WO 2009017716A3
Authority
WO
WIPO (PCT)
Prior art keywords
dosage forms
gastric retentive
stomach
administration
acid
Prior art date
Application number
PCT/US2008/009139
Other languages
French (fr)
Other versions
WO2009017716A2 (en
Inventor
Verne Earle Cowles
Sui Yuen Eddie Hou
Bret Berner
Chien-Hsuan Han
Ryan Douglas Fell
Chunhong Gu
Original Assignee
Depomed Inc
Verne Earle Cowles
Sui Yuen Eddie Hou
Bret Berner
Chien-Hsuan Han
Ryan Douglas Fell
Chunhong Gu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depomed Inc, Verne Earle Cowles, Sui Yuen Eddie Hou, Bret Berner, Chien-Hsuan Han, Ryan Douglas Fell, Chunhong Gu filed Critical Depomed Inc
Priority to CN2008801008164A priority Critical patent/CN101888828A/en
Priority to CA2694602A priority patent/CA2694602A1/en
Priority to EP08794829A priority patent/EP2192892A2/en
Priority to MX2010001071A priority patent/MX2010001071A/en
Priority to AU2008282900A priority patent/AU2008282900B2/en
Priority to JP2010519222A priority patent/JP2010534721A/en
Publication of WO2009017716A2 publication Critical patent/WO2009017716A2/en
Publication of WO2009017716A3 publication Critical patent/WO2009017716A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/282Organic compounds, e.g. fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/2853Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

Dosage forms for delayed and pulsed release of therapeutic agents into the stomach are described. The dosage forms are gastric retentive dosage forms that achieve release of the therapeutic agent into the stomach and upper gastrointestinal tract subsequent to administration of the dosage form. The dosage forms find particular use in administration of acid-labile active agents such as proton pump inhibitors, and in treating gastric acid secretion such as gastroesophageal reflux disease (GERD) and nocturnal acid breakthrough (NAB).
PCT/US2008/009139 2007-07-27 2008-07-25 Pulsatile gastric retentive dosage forms WO2009017716A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN2008801008164A CN101888828A (en) 2007-07-27 2008-07-25 Pulsatile gastric retentive dosage forms
CA2694602A CA2694602A1 (en) 2007-07-27 2008-07-25 Pulsatile gastric retentive dosage forms
EP08794829A EP2192892A2 (en) 2007-07-27 2008-07-25 Pulsatile gastric retentive dosage forms
MX2010001071A MX2010001071A (en) 2007-07-27 2008-07-25 Pulsatile gastric retentive dosage forms.
AU2008282900A AU2008282900B2 (en) 2007-07-27 2008-07-25 Pulsatile gastric retentive dosage forms
JP2010519222A JP2010534721A (en) 2007-07-27 2008-07-25 Pulse type gastric retentive preparation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95250107P 2007-07-27 2007-07-27
US60/952,501 2007-07-27
US96771707P 2007-09-05 2007-09-05
US60/967,717 2007-09-05

Publications (2)

Publication Number Publication Date
WO2009017716A2 WO2009017716A2 (en) 2009-02-05
WO2009017716A3 true WO2009017716A3 (en) 2009-07-30

Family

ID=40219415

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/009139 WO2009017716A2 (en) 2007-07-27 2008-07-25 Pulsatile gastric retentive dosage forms

Country Status (8)

Country Link
US (2) US20090028941A1 (en)
EP (1) EP2192892A2 (en)
JP (1) JP2010534721A (en)
CN (1) CN101888828A (en)
AU (1) AU2008282900B2 (en)
CA (1) CA2694602A1 (en)
MX (1) MX2010001071A (en)
WO (1) WO2009017716A2 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITFI20070253A1 (en) * 2007-11-09 2009-05-10 Valpharma Internat S P A PHARMACEUTICAL FORMULATIONS FOR THE ADMINISTRATION OF IPP.
US8372432B2 (en) 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
CA2720108C (en) 2008-03-11 2016-06-07 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
CN102046154A (en) * 2008-06-03 2011-05-04 诺瓦提斯公司 Pulsatile release of valsartan
WO2010018593A2 (en) * 2008-07-03 2010-02-18 Torrent Pharmaceuticals Ltd. Gastric acid resistant benzimidazole multiple unit tablet composition
WO2010019915A1 (en) 2008-08-15 2010-02-18 Depomed Inc. Gastric retentive pharmaceutical compositions for treatment and prevention of cns disorders
FR2949061B1 (en) * 2009-08-12 2013-04-19 Debregeas Et Associes Pharma FLOATING MICROGRANULES
WO2011025673A1 (en) * 2009-08-26 2011-03-03 Aptapharma, Inc. Multilayer minitablets
US20110052685A1 (en) * 2009-08-31 2011-03-03 Depomed, Inc. Gastric retentive pharmaceutical compositions for immediate and extended release of acetaminophen
US20110104272A1 (en) * 2009-11-05 2011-05-05 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of acetaminophen and phenylephrine
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
US9205577B2 (en) * 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
US11202853B2 (en) * 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
US20110287096A1 (en) * 2010-05-18 2011-11-24 Abon Pharmaceuticals, Llc Modified gastroretentive drug delivery system for amine drugs
CA2808546C (en) 2010-08-18 2018-02-20 Evonik Roehm Gmbh Gastric resistant pharmaceutical or nutraceutical formulation comprising one or more salts of alginic acid
CA2850468C (en) 2010-09-28 2019-08-13 Depomed, Inc. Gastric retentive dosage forms for extended release of acamprosate into the upper gastrointestinal tract
WO2012092486A2 (en) * 2010-12-29 2012-07-05 Dr. Reddy's Laboratories Ltd. Modified release benzimidazole formulations
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
US9050335B1 (en) 2011-05-17 2015-06-09 Mallinckrodt Llc Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia
US9439860B2 (en) 2012-06-25 2016-09-13 Mylan, Inc. Fenofibrate formulation
US8722083B2 (en) * 2012-06-25 2014-05-13 Mylan, Inc. Fenofibrate formulation
KR102062357B1 (en) 2013-02-13 2020-01-03 레드힐 바이오파마 엘티디 Pharmaceutical compositions for the treatment of helicobacter pylori
CN107530289A (en) * 2015-02-27 2018-01-02 扣带回治疗学有限公司 Three pulse release excitement agent formulations
CA2977168C (en) * 2015-03-31 2020-01-28 Laboratorios Bago S.A. Enteric-coated pellets containing a proton pump inhibitor
CN106236715B (en) * 2015-06-03 2021-05-07 南京三迭纪医药科技有限公司 Pharmaceutical dosage forms and uses thereof
JP6657974B2 (en) * 2016-01-12 2020-03-04 トヨタ紡織株式会社 Metal-resin integrated molded product and method of manufacturing the same
KR101884230B1 (en) * 2016-02-29 2018-08-01 주식회사 유영제약 Formulation containing esomeprazole
US10327994B2 (en) * 2016-05-02 2019-06-25 Dose Pack Llc System and methods for customized medicine dosages in a capsule
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
JP7071748B2 (en) * 2016-12-02 2022-05-19 クレキシオ バイオサイエンシーズ エルティーディー. Gastric retention system
CN108956912A (en) * 2017-05-17 2018-12-07 亚宝药业集团股份有限公司 A kind of measuring method of Nifedipine sustained release tablets dissolution curve
US10987311B2 (en) 2017-06-16 2021-04-27 Kashiv Specialty Pharmaceuticals, Llc Extended release compositions comprising pyridostigmine
US10588863B2 (en) 2017-06-16 2020-03-17 Kashiv Biosciences, Llc Extended release compositions comprising pyridostigmine
CA3031412C (en) 2017-06-16 2020-08-11 Kashiv Pharma Llc Gastroretentive dosage forms for sustained drug delivery
US20210145777A1 (en) * 2017-06-16 2021-05-20 Altibio, Inc. Modified-release tiopronin compositions, kits and methods for treating cystinuria and related disorders
US11229606B2 (en) 2018-06-18 2022-01-25 Amneal Complex Products Research Llc Extended release compositions comprising pyridostigmine
US20230041197A1 (en) * 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
US20210196627A1 (en) * 2018-08-15 2021-07-01 Lyndra, Inc. Systems for enteric delivery of therapeutic agents
CN111141854A (en) * 2018-11-06 2020-05-12 中国科学院大连化学物理研究所 Method for simultaneously extracting polar and low-polar metabolites from biological sample
CN110372869B (en) * 2019-08-24 2021-08-27 思必康(厦门)新材料有限公司 Polyvinyl alcohol-heparin polymer and preparation method and application thereof
US11878011B2 (en) 2020-05-07 2024-01-23 Redhill Biopharma Ltd. Method for eradicating Helicobacter pylori infection in patients regardless of body mass index

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487327A (en) * 1982-12-21 1984-12-11 Grayson Robert E Locking capsule
WO1988001160A1 (en) * 1986-08-19 1988-02-25 Hughes Raymond J Tamper evident capsule and insert device
US4764380A (en) * 1982-03-22 1988-08-16 Alza Corporation Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
EP0669129A2 (en) * 1994-02-28 1995-08-30 Bayer Ag Expandable release controlled medicaments
WO1998011879A1 (en) * 1996-09-19 1998-03-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
WO1999007342A1 (en) * 1997-08-11 1999-02-18 Alza Corporation Prolonged release active agent dosage form adapted for gastric retention
WO1999033446A1 (en) * 1997-12-29 1999-07-08 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
WO2003035041A1 (en) * 2001-10-25 2003-05-01 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
WO2005079384A2 (en) * 2004-02-13 2005-09-01 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Expandable gastric retention device
WO2007083309A2 (en) * 2006-01-18 2007-07-26 Intec Pharma Ltd. Method and apparatus for forming delivery devices for oral intake of an agent

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
AT397345B (en) * 1990-04-04 1994-03-25 Chemiefaser Lenzing Ag PHARMACEUTICAL PREPARATION WITH DELAYED ACTIVE SUBSTANCE RELEASE BASED ON HEMICELLULOSES
US5443459A (en) * 1991-01-30 1995-08-22 Alza Corporation Osmotic device for delayed delivery of agent
US5582837A (en) * 1992-03-25 1996-12-10 Depomed, Inc. Alkyl-substituted cellulose-based sustained-release oral drug dosage forms
US5877192A (en) * 1993-05-28 1999-03-02 Astra Aktiebolag Method for the treatment of gastric acid-related diseases and production of medication using (-) enantiomer of omeprazole
US5783212A (en) * 1996-02-02 1998-07-21 Temple University--of the Commonwealth System of Higher Education Controlled release drug delivery system
US20050244497A1 (en) * 1997-11-05 2005-11-03 Wockhardt Limited Delayed delivery system for acid-sensitive drugs
SE9704870D0 (en) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
US6372254B1 (en) * 1998-04-02 2002-04-16 Impax Pharmaceuticals Inc. Press coated, pulsatile drug delivery system suitable for oral administration
US6602521B1 (en) * 1998-09-29 2003-08-05 Impax Pharmaceuticals, Inc. Multiplex drug delivery system suitable for oral administration
US6098629A (en) * 1999-04-07 2000-08-08 Endonetics, Inc. Submucosal esophageal bulking device
MXPA02007254A (en) * 2000-02-04 2002-12-09 Depomed Inc Shell and core dosage form approaching zero order drug release.
US6627223B2 (en) * 2000-02-11 2003-09-30 Eurand Pharmaceuticals Ltd. Timed pulsatile drug delivery systems
AU6872201A (en) * 2000-06-23 2002-01-08 Teva Pharma Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
US6500457B1 (en) * 2000-08-14 2002-12-31 Peirce Management, Llc Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent
EP1738751B1 (en) * 2001-01-12 2011-05-11 Sun Pharma Advanced Research Company Ltd Spaced drug delivery system
CA2449009A1 (en) * 2001-05-29 2002-12-05 Depomed Development, Ltd Method of treating gastroesophageal reflux disease and nocturnal acid breakthrough
CN1520286B (en) * 2001-07-04 2010-12-01 太阳医药工业有限公司 Gastric retention controlled drug delivery system
US6723340B2 (en) * 2001-10-25 2004-04-20 Depomed, Inc. Optimal polymer mixtures for gastric retentive tablets
ITMI20012481A1 (en) * 2001-11-23 2003-05-23 Univ Parma MODULAR SYSTEMS FOR THE CONTROLLED RELEASE OF SUBSTANCE WITH SPATIAL AND TEMPORAL CONTROL
US6682759B2 (en) * 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
WO2003090723A1 (en) * 2002-04-23 2003-11-06 Bristol-Myers Squibb Company Modified-release vasopeptidase inhibitor formulation, combinations and method
US20060135406A1 (en) * 2002-10-14 2006-06-22 Sabina Glozman Compositions and methods for treating pathologies that necessitate suppression of gastric acid secretion
US7314640B2 (en) * 2003-07-11 2008-01-01 Mongkol Sriwongjanya Formulation and process for drug loaded cores
US20050013863A1 (en) * 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
KR20060083198A (en) * 2003-08-27 2006-07-20 벡타 리미티드 Compositions for treating pathologies that necessitate suppression of gastric acid secretion
US20050249806A1 (en) * 2004-02-10 2005-11-10 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory drug
EP1750717B1 (en) * 2004-02-11 2017-07-19 Rubicon Research Private Limited Controlled release pharmaceutical compositions with improved bioavailability
TW200533391A (en) * 2004-03-25 2005-10-16 Sun Pharmaceutical Ind Ltd Gastric retention drug delivery system
AR052225A1 (en) * 2004-11-04 2007-03-07 Astrazeneca Ab FORMULATIONS OF MODIFIED RELEASE TABLETS FOR INHIBITORS OF THE PUMP OF PROTONS
US20080166407A1 (en) * 2005-07-29 2008-07-10 Shalaby Shalaby W Solid oral formulations for combination therapy
RU2467740C2 (en) * 2005-12-28 2012-11-27 Такеда Фармасьютикал Компани Лимитед Controlled release solid drug
EP1973530A2 (en) * 2005-12-30 2008-10-01 Advancis Pharmaceutical Corporation Gastric release pulse system for drug delivery

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4764380A (en) * 1982-03-22 1988-08-16 Alza Corporation Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
US4487327A (en) * 1982-12-21 1984-12-11 Grayson Robert E Locking capsule
WO1988001160A1 (en) * 1986-08-19 1988-02-25 Hughes Raymond J Tamper evident capsule and insert device
EP0669129A2 (en) * 1994-02-28 1995-08-30 Bayer Ag Expandable release controlled medicaments
WO1998011879A1 (en) * 1996-09-19 1998-03-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
WO1999007342A1 (en) * 1997-08-11 1999-02-18 Alza Corporation Prolonged release active agent dosage form adapted for gastric retention
WO1999033446A1 (en) * 1997-12-29 1999-07-08 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
WO2003035041A1 (en) * 2001-10-25 2003-05-01 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
WO2005079384A2 (en) * 2004-02-13 2005-09-01 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Expandable gastric retention device
WO2007083309A2 (en) * 2006-01-18 2007-07-26 Intec Pharma Ltd. Method and apparatus for forming delivery devices for oral intake of an agent

Also Published As

Publication number Publication date
WO2009017716A2 (en) 2009-02-05
JP2010534721A (en) 2010-11-11
US20090028941A1 (en) 2009-01-29
MX2010001071A (en) 2010-03-09
CN101888828A (en) 2010-11-17
CA2694602A1 (en) 2009-02-05
EP2192892A2 (en) 2010-06-09
US20160038411A1 (en) 2016-02-11
AU2008282900B2 (en) 2014-05-22
AU2008282900A1 (en) 2009-02-05

Similar Documents

Publication Publication Date Title
WO2009017716A3 (en) Pulsatile gastric retentive dosage forms
WO2010062688A3 (en) Dosage form for insertion into the mouth
WO2010114425A3 (en) Pharmaceutical composition comprising a proton pump inhibitor and a prebiotic for the treatment of ulcerous lesions of the stomach and duodenum
HRP20151437T1 (en) Fast acting inhibitor of gastric acid secretion
IL199234A (en) Crystalline form of racemic ilaprazole, pharmaceutical compositions comprising it for inhibiting gastric acid secretion and use thereof in the preparation of medicaments for treating gastrointestinal inflammatory disorders
HRP20120754T1 (en) Dosage form containing pantoprazole as active ingredient
WO2012117257A8 (en) Diethylstilbestrol dosage form and use for the treatment of prostate or breast cancer
NZ597534A (en) Method for treating a patient in need of aspirin therapy
HRP20211046T1 (en) Uses of benzimidazole derivative for nocturnal acid breakthrough
NO20075393L (en) Acarbose-based methods and designs for the treatment of chronic constipation
CN102397277A (en) Esomeprazole-containing medicinal composition
JP2014240435A (en) Compositions and methods for inhibiting gastric acid secretion
AU2016277587B2 (en) Buffered upper GI absorption promoter
WO2010117756A3 (en) Substituted benzimidazole pharmaceutical formulations
RU2005122465A (en) (-) - TENATOPRAZOL ENANTIOMER AND ITS APPLICATION IN THERAPY
RS20050796A (en) Pharmaceutical compositions comprising a proton pump inhibitor and a prokinetic agent
CN102805737A (en) Lansoprazole enteric oral disintegrating tablet and preparation method thereof
RU2015106931A (en) MEDICINE FOR GASTROESOPHAGEAL REFLUX DISEASE
EA200701499A1 (en) DOSAGE FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS
Oh Pharmacological therapy of peptic ulcer
RU2006132127A (en) APPLICATION OF NIFUROXASIDE AS A COMPONENT OF COMBINED MEDICINE THERAPY OF DISEASES ASSOCIATED WITH HELICOBACTER PYLORI, AND A METHOD OF TREATMENT AIMED AT ERADICATION OF AN ACTIVATOR
JP2008525314A5 (en)
RU2007129408A (en) METHOD OF GROWING PIGS IN THE PERIOD OF FEEDING
RU2005101299A (en) EMERGENCY FIRST-AID KIT AND MUTUAL AID KIT FOR BLEEDING FROM THE ESOPHAGULA, STOMACH AND DUODENAL
WO2006137839A3 (en) Combination therapy for treating cyclooxygenase-2 mediated diseases or conditions in patients at risk of thrombotic cardiovascular events

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880100816.4

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08794829

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2694602

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2010519222

Country of ref document: JP

Ref document number: MX/A/2010/001071

Country of ref document: MX

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008282900

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2008794829

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2008282900

Country of ref document: AU

Date of ref document: 20080725

Kind code of ref document: A