WO2009019673A3 - Multi-chamber mixing ampoule - Google Patents

Multi-chamber mixing ampoule Download PDF

Info

Publication number
WO2009019673A3
WO2009019673A3 PCT/IL2007/000987 IL2007000987W WO2009019673A3 WO 2009019673 A3 WO2009019673 A3 WO 2009019673A3 IL 2007000987 W IL2007000987 W IL 2007000987W WO 2009019673 A3 WO2009019673 A3 WO 2009019673A3
Authority
WO
WIPO (PCT)
Prior art keywords
ampoule
mixture
components
housing
proximal
Prior art date
Application number
PCT/IL2007/000987
Other languages
French (fr)
Other versions
WO2009019673A2 (en
Inventor
Shlomo Haimi
Yehezkel Menashe
Original Assignee
Shlomo Haimi
Yehezkel Menashe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shlomo Haimi, Yehezkel Menashe filed Critical Shlomo Haimi
Priority to PCT/IL2007/000987 priority Critical patent/WO2009019673A2/en
Publication of WO2009019673A2 publication Critical patent/WO2009019673A2/en
Publication of WO2009019673A3 publication Critical patent/WO2009019673A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126—Specific display means related to dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means

Abstract

The present invention provides a multi-compartment ampoule for the storage of the separated components of a multiple component mixture and then mixing them together in a single ampoule. The ampoule housing has a proximal dispensing end. The distal end of the ampoule housing is sealed by an end plug configured with an axial through bore. A portion of an axially displaceable plunger element passes thorough the axial through bore and extends into the interior volume and is fixedly attached to an axially displaceable piston element slideablely deployed within the ampoule housing so as to sealingly divide the interior volume into at least first and second storage regions that are pre-filled with the separate components that will be mixed together just prior to use. Axial displacement of the plunger element, and thereby the piston element, in a first direction discharges a first component of the mixture from the distal storage region through a one-way flow configuration into the proximal storage region. After the two components are in a single storage region, they may be thoroughly mixed together. Once the components are mixed, dispensing of the mixture may be by any number of methods. The mixture may be dispensed as if from a standard ampoule, wherein the needle of a syringe is inserted through the sealing membrane and the prescribed amount of the mixture is drawn out. Alternatively, the ampoule may be inserted into an injection device, such as an injection pen for example, in a manner similar to a standard ampoule. The additional features of a needle cannula configured for attachment directly to the proximal dispensing end of the ampoule housing and graduated markings on the shaft of the plunger that are indicative of volume dispensation combined with the basic ampoule provides an embodiment that can store the separated components of the mixture before use, provide a way of mixing the components together in the same ampoule and that can be used as the syringe to dispense the mixture directly into the patient.
PCT/IL2007/000987 2007-08-07 2007-08-07 Multi-chamber mixing ampoule WO2009019673A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IL2007/000987 WO2009019673A2 (en) 2007-08-07 2007-08-07 Multi-chamber mixing ampoule

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IL2007/000987 WO2009019673A2 (en) 2007-08-07 2007-08-07 Multi-chamber mixing ampoule

Publications (2)

Publication Number Publication Date
WO2009019673A2 WO2009019673A2 (en) 2009-02-12
WO2009019673A3 true WO2009019673A3 (en) 2016-06-09

Family

ID=40341845

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/000987 WO2009019673A2 (en) 2007-08-07 2007-08-07 Multi-chamber mixing ampoule

Country Status (1)

Country Link
WO (1) WO2009019673A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9149581B2 (en) * 2009-03-09 2015-10-06 Glucago Llc Compact device for rapidly mixing and delivering substances to a patient
FR3038518A1 (en) 2015-07-08 2017-01-13 Guerbet Sa SYRINGE AND METHOD OF ASSEMBLING

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5785683A (en) * 1995-07-17 1998-07-28 Szapiro; Jaime Luis Disposable syringe with two variable volume chambers
US6419656B1 (en) * 1999-03-19 2002-07-16 Arzneimittel Gmbh Apotheker Vetter & Ravensburg Medical syringe with braked step-advance plunger

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5785683A (en) * 1995-07-17 1998-07-28 Szapiro; Jaime Luis Disposable syringe with two variable volume chambers
US6419656B1 (en) * 1999-03-19 2002-07-16 Arzneimittel Gmbh Apotheker Vetter & Ravensburg Medical syringe with braked step-advance plunger

Also Published As

Publication number Publication date
WO2009019673A2 (en) 2009-02-12

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