WO2009026178A3 - High concentration local anesthetic formulations - Google Patents
High concentration local anesthetic formulations Download PDFInfo
- Publication number
- WO2009026178A3 WO2009026178A3 PCT/US2008/073381 US2008073381W WO2009026178A3 WO 2009026178 A3 WO2009026178 A3 WO 2009026178A3 US 2008073381 W US2008073381 W US 2008073381W WO 2009026178 A3 WO2009026178 A3 WO 2009026178A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- local anesthetic
- high concentration
- anesthetic
- ameliorate
- anesthetic formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2008289109A AU2008289109B2 (en) | 2007-08-17 | 2008-08-15 | High concentration local anesthetic formulations |
JP2010521214A JP5358574B2 (en) | 2007-08-17 | 2008-08-15 | High concentration local anesthetic formulation |
CA2696632A CA2696632C (en) | 2007-08-17 | 2008-08-15 | High concentration local anesthetic formulations |
EP08798025A EP2187969A2 (en) | 2007-08-17 | 2008-08-15 | High concentration local anesthetic formulations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95645807P | 2007-08-17 | 2007-08-17 | |
US60/956,458 | 2007-08-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009026178A2 WO2009026178A2 (en) | 2009-02-26 |
WO2009026178A3 true WO2009026178A3 (en) | 2009-10-08 |
Family
ID=40193778
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/073381 WO2009026178A2 (en) | 2007-08-17 | 2008-08-15 | High concentration local anesthetic formulations |
Country Status (6)
Country | Link |
---|---|
US (3) | US20090048296A1 (en) |
EP (1) | EP2187969A2 (en) |
JP (1) | JP5358574B2 (en) |
AU (1) | AU2008289109B2 (en) |
CA (1) | CA2696632C (en) |
WO (1) | WO2009026178A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9283177B2 (en) | 2007-01-16 | 2016-03-15 | Juventio, Llc | Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic |
WO2008089242A1 (en) | 2007-01-16 | 2008-07-24 | Dermworx, Incorporated | Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic |
US8652443B2 (en) * | 2008-02-14 | 2014-02-18 | Precision Dermatology, Inc. | Foamable microemulsion compositions for topical administration |
CA2730787A1 (en) | 2008-07-16 | 2010-01-21 | David M. Cohen | Topical drug delivery system |
WO2010019953A1 (en) | 2008-08-15 | 2010-02-18 | Arcion Therapeutics, Inc. | High concentration local anesthetic formulations for treating non-neuropathic pain |
WO2010033726A2 (en) | 2008-09-17 | 2010-03-25 | The Brigham And Women's Hospital, Inc. | Drug delivery composition comprising a self-assembled gelator |
RU2497679C2 (en) | 2008-10-02 | 2013-11-10 | Милан Инк. | Method of making multilayer adhesive laminated material |
EP2470172A1 (en) * | 2009-08-26 | 2012-07-04 | Nuvo Research Inc. | Pharmaceutical formulations and methods of use |
EP3412279B1 (en) | 2010-09-24 | 2021-02-17 | The Brigham and Women's Hospital, Inc. | Nanostructured gels capable of controlled release of encapsulated agents |
US9271945B2 (en) * | 2014-02-04 | 2016-03-01 | Maureen Ann HURLEY | Dermal pain relief delivery system |
DK3097907T3 (en) * | 2015-05-28 | 2018-12-10 | Abdi Ibrahim Ilac Sanayi Ve Ticaret A S | A GEL formulation comprising anesthetic and anesthetic agents |
US10039830B2 (en) | 2016-03-04 | 2018-08-07 | Cetylite Industries, Inc. | Topical anesthetic composition |
DE202016105646U1 (en) | 2016-06-10 | 2017-09-13 | Farco-Pharma Gmbh | Medical composition, in particular in the form of a medicinal gel |
WO2018144991A1 (en) | 2017-02-03 | 2018-08-09 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
AU2018266131B2 (en) | 2017-05-08 | 2021-07-29 | Alivio Therapeutics, Inc. | Formulation of nanostructured gels for increased agent loading and adhesion |
CN113825495A (en) | 2018-10-11 | 2021-12-21 | 阿利维奥治疗学股份有限公司 | Non-injectable hydrogel formulations for smart release |
CN111803632B (en) * | 2019-04-09 | 2022-04-29 | 北京五和博澳药业股份有限公司 | Flavone polyphenol medicine self-emulsifying composition, preparation method thereof, medicine composition and application |
Family Cites Families (41)
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CA1165240A (en) * | 1980-07-09 | 1984-04-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
JPS6185315A (en) * | 1984-10-04 | 1986-04-30 | Teikoku Seiyaku Kk | Sheet-like preparation |
US4863721A (en) * | 1987-05-22 | 1989-09-05 | The Procter & Gamble Company | Reduced stinging antiperspirant compositions |
US4752466A (en) * | 1987-08-31 | 1988-06-21 | Johnson & Johnson Products, Inc. | Thrombin aerosol |
US5380754A (en) * | 1988-02-29 | 1995-01-10 | Virotex Corporation | Topical composition enhancing healing of viral lesions |
US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5300291A (en) * | 1988-03-04 | 1994-04-05 | Noven Pharmaceuticals, Inc. | Method and device for the release of drugs to the skin |
US4994267A (en) * | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US4814168A (en) * | 1988-03-04 | 1989-03-21 | Noven Pharmaceuticals, Inc. | Transdermal multipolymer drug delivery system |
CA1338779C (en) * | 1989-03-17 | 1996-12-10 | Harry Hind | Method for treating pain associated with herpes-zoster and post-herpetic neuralgia by topical application of local anesthetics |
US5411738A (en) * | 1989-03-17 | 1995-05-02 | Hind Health Care, Inc. | Method for treating nerve injury pain associated with shingles (herpes-zoster and post-herpetic neuralgia) by topical application of lidocaine |
JP3115625B2 (en) * | 1991-03-30 | 2000-12-11 | 帝國製薬株式会社 | Topical patch containing lidocaine |
DK82892D0 (en) * | 1992-06-24 | 1992-06-24 | Michael Hansen | APPLICATION OF BRAIN ADDITION FROM BEES AND WHEPS FOR THE PREPARATION OF MEDICINAL PRODUCTS TO TREAT INFECTIONS |
DE4309830C1 (en) * | 1993-03-26 | 1994-05-05 | Lohmann Therapie Syst Lts | Transdermal patches for oestradiol admin. - contg. isopropylidene mono- or di-glycerol as penetration enhancer |
US5415866A (en) * | 1993-07-12 | 1995-05-16 | Zook; Gerald P. | Topical drug delivery system |
US5807568A (en) * | 1994-12-27 | 1998-09-15 | Mcneil-Ppc, Inc. | Enhanced delivery of topical compositions containing flurbiprofen |
DE19526864A1 (en) * | 1995-07-22 | 1997-01-23 | Labtec Gmbh | Hormone patches |
US5667799A (en) * | 1995-10-30 | 1997-09-16 | Caldwell; Larry J. | Method for treating headache pain with topical local anesthetic compositions |
JPH09268123A (en) * | 1996-03-30 | 1997-10-14 | Nichiban Co Ltd | Cataplasm for local anesthesia |
US5814659A (en) * | 1996-04-23 | 1998-09-29 | Dtr Dermal Therapy (Barbados) Inc. | Topical analgesic composition |
FR2748207B1 (en) * | 1996-05-06 | 1998-06-12 | Cird Galderma | COMPOSITION BASED ON A COMPOUND MODULATING THE REACTIVITY OF NERVOUS FIBERS |
US5955097A (en) * | 1996-10-18 | 1999-09-21 | Virotex Corporation | Pharmaceutical preparation applicable to mucosal surfaces and body tissues |
US5948433A (en) * | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
US6103266A (en) * | 1998-04-22 | 2000-08-15 | Tapolsky; Gilles H. | Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues |
NO312443B1 (en) * | 1998-08-26 | 2002-05-13 | Odd A Olsen | Spray nozzle device |
US6953590B1 (en) * | 1998-10-05 | 2005-10-11 | Yutoku Pharmaceutical Ind. Co., Ltd. | Tape material for transcutaneous absorption |
US6299902B1 (en) * | 1999-05-19 | 2001-10-09 | The University Of Georgia Research Foundation, Inc. | Enhanced transdermal anesthesia of local anesthetic agents |
US6962691B1 (en) * | 1999-05-20 | 2005-11-08 | U & I Pharmaceuticals Ltd. | Topical spray compositions |
US7018647B1 (en) * | 1999-12-27 | 2006-03-28 | Teikoku Seiyaku Co., Ltd | Patches for external use |
US20020006435A1 (en) * | 2000-01-27 | 2002-01-17 | Samuels Paul J. | Transdermal anesthetic and vasodilator composition and methods for topical administration |
US20030027833A1 (en) * | 2001-05-07 | 2003-02-06 | Cleary Gary W. | Compositions and delivery systems for administration of a local anesthetic agent |
US6894078B2 (en) * | 2001-09-17 | 2005-05-17 | James G. Castillo | Alcohol based topical anesthetic formulation and method |
US6676961B1 (en) * | 2002-03-06 | 2004-01-13 | Automated Carrier Technologies, Inc. | Transdermal patch assembly |
US20040214215A1 (en) * | 2003-03-07 | 2004-10-28 | Yu Ruey J. | Bioavailability and improved delivery of alkaline pharmaceutical drugs |
KR101113003B1 (en) * | 2003-03-20 | 2012-02-24 | 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 | Formulation for a metered dose inhaler using hydro-fluoro-alkanes as propellants |
ES2535045T3 (en) * | 2003-04-10 | 2015-05-04 | Vanderbilt Royalty Sub L.P. | Uses and compositions for capsaicin administration |
US20050014823A1 (en) * | 2003-07-17 | 2005-01-20 | Soderlund Patrick L. | Topical anesthetic composition and method of administration |
JP2006298934A (en) * | 2006-06-26 | 2006-11-02 | Larry J Caldwell | Method for treating pain of headache by using topical local anesthetic composition |
WO2010019953A1 (en) * | 2008-08-15 | 2010-02-18 | Arcion Therapeutics, Inc. | High concentration local anesthetic formulations for treating non-neuropathic pain |
-
2008
- 2008-08-15 EP EP08798025A patent/EP2187969A2/en not_active Withdrawn
- 2008-08-15 CA CA2696632A patent/CA2696632C/en not_active Expired - Fee Related
- 2008-08-15 WO PCT/US2008/073381 patent/WO2009026178A2/en active Application Filing
- 2008-08-15 JP JP2010521214A patent/JP5358574B2/en not_active Expired - Fee Related
- 2008-08-15 US US12/192,871 patent/US20090048296A1/en not_active Abandoned
- 2008-08-15 AU AU2008289109A patent/AU2008289109B2/en not_active Ceased
-
2014
- 2014-09-11 US US14/483,839 patent/US20150018387A1/en not_active Abandoned
-
2020
- 2020-01-28 US US16/774,490 patent/US20200338064A1/en not_active Abandoned
Non-Patent Citations (2)
Title |
---|
MARRA, D.E. ET AL.: "Systemic toxicity from topically applied Lidocaine in conjunction with fractional photothermolysis", ARCH. DERMATOL., vol. 142, 2006, pages 1024 - 1026, XP002509848 * |
See also references of EP2187969A2 * |
Also Published As
Publication number | Publication date |
---|---|
JP2010536793A (en) | 2010-12-02 |
JP5358574B2 (en) | 2013-12-04 |
AU2008289109B2 (en) | 2012-02-02 |
EP2187969A2 (en) | 2010-05-26 |
US20150018387A1 (en) | 2015-01-15 |
AU2008289109A1 (en) | 2009-02-26 |
WO2009026178A2 (en) | 2009-02-26 |
CA2696632C (en) | 2014-05-27 |
US20090048296A1 (en) | 2009-02-19 |
US20200338064A1 (en) | 2020-10-29 |
CA2696632A1 (en) | 2009-02-26 |
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