WO2009049098A3 - Materials and methods for regulating the activity of phosphatases - Google Patents

Materials and methods for regulating the activity of phosphatases Download PDF

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Publication number
WO2009049098A3
WO2009049098A3 PCT/US2008/079426 US2008079426W WO2009049098A3 WO 2009049098 A3 WO2009049098 A3 WO 2009049098A3 US 2008079426 W US2008079426 W US 2008079426W WO 2009049098 A3 WO2009049098 A3 WO 2009049098A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphatases
activity
regulating
materials
methods
Prior art date
Application number
PCT/US2008/079426
Other languages
French (fr)
Other versions
WO2009049098A2 (en
Inventor
Zhong-Yin Zhang
Yantao He
Original Assignee
Univ Indiana Res & Tech Corp
Zhong-Yin Zhang
Yantao He
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Indiana Res & Tech Corp, Zhong-Yin Zhang, Yantao He filed Critical Univ Indiana Res & Tech Corp
Publication of WO2009049098A2 publication Critical patent/WO2009049098A2/en
Publication of WO2009049098A3 publication Critical patent/WO2009049098A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Reported herein are bidentate or tridentate salicylic acid based combinatorial libraries and method of making and using the same to inhibit phosphatases. Generally, these inhibitors include elements that interact with both the active site and a nearby peripheral site of phosphates such as Lyp, SHP2 and mPTPB. These moleuces are used to study, characterize, regulate and inhibit various phosphatases. These molecules and pharmaceutically acceptable salts of them may be use to treat various diseases or conditions that involve the activity of at least one phosphatase.
PCT/US2008/079426 2007-10-09 2008-10-09 Materials and methods for regulating the activity of phosphatases WO2009049098A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97860307P 2007-10-09 2007-10-09
US60/978,603 2007-10-09

Publications (2)

Publication Number Publication Date
WO2009049098A2 WO2009049098A2 (en) 2009-04-16
WO2009049098A3 true WO2009049098A3 (en) 2009-05-28

Family

ID=40549839

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/079426 WO2009049098A2 (en) 2007-10-09 2008-10-09 Materials and methods for regulating the activity of phosphatases

Country Status (1)

Country Link
WO (1) WO2009049098A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9493436B2 (en) 2011-04-26 2016-11-15 Indiana University Research And Technology Corporation Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymes involved in the pathology of Mycobacterium tuberculosis
PL2848612T3 (en) * 2012-05-08 2017-12-29 Ishihara Sangyo Kaisha, Ltd. Method for producing a substituted benzoic acid compound
CN104311525A (en) * 2014-09-13 2015-01-28 中山大学 Use of marine fungus-derived Azaphilone compound in preparation of antituberculosis drugs
CN104311526B (en) * 2014-09-13 2016-03-23 中山大学 The dinaphthalene analog derivative in thalassiomycetes source and preparation method thereof and the application in tuberculosis
CN107109701B (en) * 2014-09-16 2020-10-09 斯坦福国际研究院 Discovery of affinity reagents and catalysts by fiber array scanning techniques
WO2018045182A1 (en) * 2016-09-01 2018-03-08 The Board Of Regents Of Hte University Of Texas System Disubstituted and trisubtituted 1,2,3-triazoles as wnt inhibitors
AU2019239658A1 (en) 2018-03-21 2020-11-12 Suzhou Puhe BioPharma Co., Ltd. SHP2 inhibitors and uses thereof
CA3130083A1 (en) 2019-03-01 2020-09-10 Revolution Medicines, Inc. Bicyclic heterocyclyl compounds and uses thereof
JP2022522777A (en) 2019-03-01 2022-04-20 レボリューション メディシンズ インコーポレイテッド Bicyclic heteroaryl compounds and their use
US11608346B2 (en) 2019-11-04 2023-03-21 Revolution Medicines, Inc. Ras inhibitors
JP2022553858A (en) 2019-11-04 2022-12-26 レボリューション メディシンズ インコーポレイテッド RAS inhibitor
CA3159559A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
JP2023500328A (en) 2019-11-08 2023-01-05 レボリューション メディシンズ インコーポレイテッド Bicyclic heteroaryl compound and use thereof
JP2023505100A (en) 2019-11-27 2023-02-08 レボリューション メディシンズ インコーポレイテッド Covalent RAS inhibitors and uses thereof
EP4267250A1 (en) 2020-12-22 2023-11-01 Qilu Regor Therapeutics Inc. Sos1 inhibitors and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119501A1 (en) * 1997-05-20 2002-08-29 Bahija Jallal Diagnosis and treatment of PTP04 related disorders
US6596772B1 (en) * 1999-08-27 2003-07-22 Sugen, Inc. Phosphate mimics and methods of treatment using phosphatase inhibitors
US7005445B2 (en) * 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119501A1 (en) * 1997-05-20 2002-08-29 Bahija Jallal Diagnosis and treatment of PTP04 related disorders
US6596772B1 (en) * 1999-08-27 2003-07-22 Sugen, Inc. Phosphate mimics and methods of treatment using phosphatase inhibitors
US7005445B2 (en) * 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YU ET AL.: "Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.", PROC. NATL. ACAD. SCI., vol. 104, no. 50, 11 December 2007 (2007-12-11), USA, pages 19767 - 19772 *

Also Published As

Publication number Publication date
WO2009049098A2 (en) 2009-04-16

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