WO2009049914A3 - Novel patient subgroups for thrombolysis - Google Patents
Novel patient subgroups for thrombolysis Download PDFInfo
- Publication number
- WO2009049914A3 WO2009049914A3 PCT/EP2008/008871 EP2008008871W WO2009049914A3 WO 2009049914 A3 WO2009049914 A3 WO 2009049914A3 EP 2008008871 W EP2008008871 W EP 2008008871W WO 2009049914 A3 WO2009049914 A3 WO 2009049914A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thrombolysis
- patient subgroups
- novel patient
- patient
- novel
- Prior art date
Links
- 230000002537 thrombolytic effect Effects 0.000 title abstract 2
- 206010008089 Cerebral artery occlusion Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES08838897.0T ES2611155T3 (en) | 2007-10-18 | 2008-10-20 | Novel subgroups of patients for thrombolysis |
EP08838897.0A EP2211898B1 (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis |
SI200831750A SI2211898T1 (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis |
UAA201005957A UA100994C2 (en) | 2007-10-18 | 2008-10-20 | Use of desmoteplase for the treatment of stroke |
AU2008314048A AU2008314048B2 (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis |
JP2010529300A JP5509085B2 (en) | 2007-10-18 | 2008-10-20 | A novel patient subgroup for thrombolysis |
EA201070485A EA020776B1 (en) | 2007-10-18 | 2008-10-20 | Method for treating stroke |
CA2702378A CA2702378A1 (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis |
MX2010004157A MX2010004157A (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis. |
LTEP08838897.0T LT2211898T (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis |
BRPI0817785-6A BRPI0817785A2 (en) | 2007-10-18 | 2008-10-20 | Subgroups of thrombolysis patients |
DK08838897.0T DK2211898T3 (en) | 2007-10-18 | 2008-10-20 | New patient subgroup for thrombolysis |
NZ584640A NZ584640A (en) | 2007-10-18 | 2008-10-20 | Use of a plasminogen activator (desmoteplase) in the treatment of stroke |
CN200880112073.2A CN101903039B (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis |
US12/682,779 US20100272704A1 (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis |
RS20170031A RS55590B1 (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis |
ZA2010/02548A ZA201002548B (en) | 2007-10-18 | 2010-04-12 | Novel patient subgroups for thrombolysis |
IL205175A IL205175A0 (en) | 2007-10-18 | 2010-04-18 | Medicaments comprising a plasminogen acitvator for use in treating stroke in a patient subgroup |
HK11105336.9A HK1151233A1 (en) | 2007-10-18 | 2011-05-30 | Novel patient subgroups for thrombolysis |
US14/181,153 US20140314736A1 (en) | 2007-10-18 | 2014-02-14 | Novel patient subgroups for thrombolysis |
HRP20170001TT HRP20170001T1 (en) | 2007-10-18 | 2017-01-03 | Novel patient subgroups for thrombolysis |
CY20171100041T CY1118417T1 (en) | 2007-10-18 | 2017-01-11 | Novel Subpopulations of Patients Benefiting from Thrombolysis |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07020401.1 | 2007-10-18 | ||
EP07020401A EP2050462A1 (en) | 2007-10-18 | 2007-10-18 | Improved treatment of stroke patients |
EP07022867 | 2007-11-26 | ||
EP07022867.1 | 2007-11-26 | ||
EP08017954.2 | 2008-10-15 | ||
EP08017954 | 2008-10-15 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/682,779 A-371-Of-International US20100272704A1 (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis |
US14/181,153 Continuation US20140314736A1 (en) | 2007-10-18 | 2014-02-14 | Novel patient subgroups for thrombolysis |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009049914A2 WO2009049914A2 (en) | 2009-04-23 |
WO2009049914A3 true WO2009049914A3 (en) | 2009-08-06 |
Family
ID=40567844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/008871 WO2009049914A2 (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis |
Country Status (29)
Country | Link |
---|---|
US (2) | US20100272704A1 (en) |
EP (1) | EP2211898B1 (en) |
JP (2) | JP5509085B2 (en) |
KR (1) | KR20100089077A (en) |
CN (1) | CN101903039B (en) |
AR (1) | AR068914A1 (en) |
AU (1) | AU2008314048B2 (en) |
BR (1) | BRPI0817785A2 (en) |
CA (1) | CA2702378A1 (en) |
CL (1) | CL2009000752A1 (en) |
CY (1) | CY1118417T1 (en) |
DK (1) | DK2211898T3 (en) |
EA (1) | EA020776B1 (en) |
ES (1) | ES2611155T3 (en) |
HK (1) | HK1151233A1 (en) |
HR (1) | HRP20170001T1 (en) |
HU (1) | HUE032867T2 (en) |
IL (1) | IL205175A0 (en) |
LT (1) | LT2211898T (en) |
MX (1) | MX2010004157A (en) |
MY (1) | MY159200A (en) |
NZ (1) | NZ584640A (en) |
PL (1) | PL2211898T3 (en) |
PT (1) | PT2211898T (en) |
RS (1) | RS55590B1 (en) |
SI (1) | SI2211898T1 (en) |
TW (1) | TWI482628B (en) |
WO (1) | WO2009049914A2 (en) |
ZA (1) | ZA201002548B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10153601A1 (en) * | 2001-11-02 | 2003-05-22 | Paion Gmbh | DSPA for the treatment of stroke |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005018564A2 (en) * | 2003-08-22 | 2005-03-03 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a low-molecular-weight heparin for the treatment of central nervous system damage |
US20060135425A1 (en) * | 2003-05-02 | 2006-06-22 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4766075A (en) * | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
US5244806A (en) * | 1985-08-26 | 1993-09-14 | Eli Lilly And Company | DNA encoding novel tissue plasminogen activator derivatives having kringles 1 and 2 deleted, vectors and host cells |
IL87276A (en) * | 1987-08-03 | 1995-07-31 | Fujisawa Pharmaceutical Co | Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same |
US5094953A (en) * | 1988-03-21 | 1992-03-10 | Genentech, Inc. | Human tissue plasminogen activator variants |
FI100403B (en) * | 1988-07-20 | 1997-11-28 | Schering Ag | Process for Preparation of Glycocylated or Glycocylated Pla Sminogen Activators of Vampire Bats Saliva |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
US5676947A (en) * | 1989-02-07 | 1997-10-14 | Boehringer Manneheim Gmbh | Method for treating thromboembolic conditions using thrombolytically active proteins |
DE3903581A1 (en) * | 1989-02-07 | 1990-08-16 | Boehringer Mannheim Gmbh | FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE |
US6008019A (en) * | 1989-02-13 | 1999-12-28 | Schering Aktiengesellschaft | Plasminogen activator from saliva of the vampire bat |
US5891664A (en) * | 1989-04-07 | 1999-04-06 | Cancerforskningsfondet Af 1989 | Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR) |
US5326700A (en) * | 1990-11-06 | 1994-07-05 | Eli Lilly And Company | DNA sequences encoding t-PA derivatives with cleavable sites |
DK0580685T3 (en) * | 1991-04-16 | 1996-03-04 | Boehringer Mannheim Gmbh | Pharmaceutical packaging unit containing plasminogen activators for multiple bolus administration |
US5595736A (en) * | 1991-04-22 | 1997-01-21 | Eli Lilly And Company | Compounds and methods for treatment of thromboembolic disorders |
ES2107790T3 (en) * | 1992-12-04 | 1997-12-01 | Schering Ag | THROMBIN INHIBITOR FROM SALIVA OF PROTOSTOMIES. |
US5510330A (en) * | 1994-03-25 | 1996-04-23 | Boehringer Mannheim Gmbh | Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof. |
GB9412131D0 (en) * | 1994-06-17 | 1994-08-10 | British Bio Technology | Thrombolytic composition |
US5827832A (en) * | 1995-03-06 | 1998-10-27 | Interneuron Pharmaceuticals, Inc. | Method of protecting brain tissue from cerebral infarction subsequent to ischemia |
US5786187A (en) * | 1995-09-21 | 1998-07-28 | The Research Foundation Of State University Of New York | Method for reducing neuronal degeneration associated with seizure |
US5945432A (en) * | 1995-12-22 | 1999-08-31 | The University Of Vermont And State Agricultural College | Thrombolytic agents and thienopyridine derivatives in acute stroke |
US20020081294A1 (en) * | 1996-01-23 | 2002-06-27 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-CD18 antibody in stroke |
US5731186A (en) * | 1996-02-05 | 1998-03-24 | Schering Aktiengesellschaft | Method for the production of rDSPA α1 |
US6354999B1 (en) * | 2000-01-14 | 2002-03-12 | Florence Medical Ltd. | System and method for detecting, localizing, and characterizing occlusions and aneurysms in a vessel |
GB0025473D0 (en) * | 2000-10-17 | 2000-11-29 | Pfizer Ltd | Pharmaceutical combinations |
DE10153601A1 (en) * | 2001-11-02 | 2003-05-22 | Paion Gmbh | DSPA for the treatment of stroke |
US20080057050A1 (en) * | 2003-05-02 | 2008-03-06 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
US20080213244A1 (en) * | 2003-05-05 | 2008-09-04 | Wolfgang Sohngen | Glutamate Receptor Antagonists as Neuroprotectives |
AU2006282856A1 (en) * | 2005-08-25 | 2007-03-01 | Biogen Idec Ma Inc. | Nogo receptor polypeptides and polypeptide fragments and uses thereof |
-
2008
- 2008-10-17 TW TW097139886A patent/TWI482628B/en not_active IP Right Cessation
- 2008-10-17 AR ARP080104540A patent/AR068914A1/en unknown
- 2008-10-20 RS RS20170031A patent/RS55590B1/en unknown
- 2008-10-20 WO PCT/EP2008/008871 patent/WO2009049914A2/en active Application Filing
- 2008-10-20 BR BRPI0817785-6A patent/BRPI0817785A2/en not_active IP Right Cessation
- 2008-10-20 MX MX2010004157A patent/MX2010004157A/en active IP Right Grant
- 2008-10-20 CN CN200880112073.2A patent/CN101903039B/en not_active Expired - Fee Related
- 2008-10-20 DK DK08838897.0T patent/DK2211898T3/en active
- 2008-10-20 PT PT88388970T patent/PT2211898T/en unknown
- 2008-10-20 EA EA201070485A patent/EA020776B1/en not_active IP Right Cessation
- 2008-10-20 JP JP2010529300A patent/JP5509085B2/en not_active Expired - Fee Related
- 2008-10-20 KR KR1020107010609A patent/KR20100089077A/en active Search and Examination
- 2008-10-20 CA CA2702378A patent/CA2702378A1/en not_active Abandoned
- 2008-10-20 HU HUE08838897A patent/HUE032867T2/en unknown
- 2008-10-20 AU AU2008314048A patent/AU2008314048B2/en not_active Ceased
- 2008-10-20 PL PL08838897T patent/PL2211898T3/en unknown
- 2008-10-20 EP EP08838897.0A patent/EP2211898B1/en active Active
- 2008-10-20 US US12/682,779 patent/US20100272704A1/en not_active Abandoned
- 2008-10-20 ES ES08838897.0T patent/ES2611155T3/en active Active
- 2008-10-20 SI SI200831750A patent/SI2211898T1/en unknown
- 2008-10-20 LT LTEP08838897.0T patent/LT2211898T/en unknown
- 2008-10-20 MY MYPI2010001704A patent/MY159200A/en unknown
- 2008-10-20 NZ NZ584640A patent/NZ584640A/en not_active IP Right Cessation
-
2009
- 2009-03-27 CL CL2009000752A patent/CL2009000752A1/en unknown
-
2010
- 2010-04-12 ZA ZA2010/02548A patent/ZA201002548B/en unknown
- 2010-04-18 IL IL205175A patent/IL205175A0/en unknown
-
2011
- 2011-05-30 HK HK11105336.9A patent/HK1151233A1/en not_active IP Right Cessation
-
2014
- 2014-01-07 JP JP2014000825A patent/JP2014065739A/en not_active Withdrawn
- 2014-02-14 US US14/181,153 patent/US20140314736A1/en not_active Abandoned
-
2017
- 2017-01-03 HR HRP20170001TT patent/HRP20170001T1/en unknown
- 2017-01-11 CY CY20171100041T patent/CY1118417T1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060135425A1 (en) * | 2003-05-02 | 2006-06-22 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
WO2005018564A2 (en) * | 2003-08-22 | 2005-03-03 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a low-molecular-weight heparin for the treatment of central nervous system damage |
Non-Patent Citations (1)
Title |
---|
MAULAZ A, PIECHOWSKI-JOWIAK B, MICHEL P, BOGOUSSLAVSKY J: "Selecting patients for early stroke treatment with penumbra images", CEREBROVASC DIS, vol. 20(suppl2), 2005, pages 19 - 24, XP009094739 * |
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