WO2009051837A3 - Vaccine nanotechnology - Google Patents

Vaccine nanotechnology Download PDF

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Publication number
WO2009051837A3
WO2009051837A3 PCT/US2008/011932 US2008011932W WO2009051837A3 WO 2009051837 A3 WO2009051837 A3 WO 2009051837A3 US 2008011932 W US2008011932 W US 2008011932W WO 2009051837 A3 WO2009051837 A3 WO 2009051837A3
Authority
WO
WIPO (PCT)
Prior art keywords
provides
cells
nanocarriers
inventive vaccine
optionally
Prior art date
Application number
PCT/US2008/011932
Other languages
French (fr)
Other versions
WO2009051837A2 (en
Inventor
Andrian Ulrich H Von
Omid C Farokhzad
Robert S Langer
Tobias Junt
Ashley Moseman
Liangfang Zhang
Pamela Basto
Matteo Iannacone
Frank Alexis
Original Assignee
Massachusetts Inst Technology
Andrian Ulrich H Von
Omid C Farokhzad
Robert S Langer
Tobias Junt
Ashley Moseman
Liangfang Zhang
Pamela Basto
Matteo Iannacone
Frank Alexis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Andrian Ulrich H Von, Omid C Farokhzad, Robert S Langer, Tobias Junt, Ashley Moseman, Liangfang Zhang, Pamela Basto, Matteo Iannacone, Frank Alexis filed Critical Massachusetts Inst Technology
Priority to US12/681,814 priority Critical patent/US10736848B2/en
Priority to JP2010528911A priority patent/JP2011500569A/en
Priority to CA2702083A priority patent/CA2702083C/en
Priority to AU2008314647A priority patent/AU2008314647B2/en
Priority to CN200880116677A priority patent/CN101861165A/en
Priority to ES08839738.5T priority patent/ES2627292T3/en
Priority to MX2013008271A priority patent/MX350501B/en
Priority to EP08839738.5A priority patent/EP2217269B1/en
Priority to MX2010003642A priority patent/MX2010003642A/en
Priority to BRPI0817664 priority patent/BRPI0817664A2/en
Priority to EP18183983.8A priority patent/EP3424525A1/en
Priority to US12/428,395 priority patent/US8343498B2/en
Priority to US12/428,388 priority patent/US8591905B2/en
Priority to US12/428,408 priority patent/US8277812B2/en
Priority to US12/428,381 priority patent/US8343497B2/en
Publication of WO2009051837A2 publication Critical patent/WO2009051837A2/en
Publication of WO2009051837A3 publication Critical patent/WO2009051837A3/en
Priority to EP09740582.3A priority patent/EP2344187B1/en
Priority to AU2009303338A priority patent/AU2009303338B2/en
Priority to EP09740580.7A priority patent/EP2344186B1/en
Priority to KR1020117010817A priority patent/KR101756995B1/en
Priority to EP09740581.5A priority patent/EP2346528B1/en
Priority to US13/123,884 priority patent/US8562998B2/en
Priority to PCT/US2009/060233 priority patent/WO2010042863A1/en
Priority to CA2740248A priority patent/CA2740248C/en
Priority to CN200980150137.2A priority patent/CN102245201B/en
Priority to US13/123,886 priority patent/US8932595B2/en
Priority to CN200980149914.1A priority patent/CN102245199B/en
Priority to PCT/US2009/060242 priority patent/WO2010042870A1/en
Priority to JP2011531225A priority patent/JP6133539B2/en
Priority to AU2009303344A priority patent/AU2009303344B8/en
Priority to RU2011118880/15A priority patent/RU2487712C2/en
Priority to KR1020117010819A priority patent/KR20110074903A/en
Priority to MX2011003843A priority patent/MX2011003843A/en
Priority to KR1020117010818A priority patent/KR101732744B1/en
Priority to JP2011531219A priority patent/JP5905259B2/en
Priority to CA2740162A priority patent/CA2740162C/en
Priority to BRPI0920282A priority patent/BRPI0920282A2/en
Priority to BRPI0920284A priority patent/BRPI0920284A2/en
Priority to PCT/US2009/060250 priority patent/WO2010042876A1/en
Priority to CN2009801499156A priority patent/CN102245200A/en
Priority to US13/123,888 priority patent/US8637028B2/en
Priority to JP2011531223A priority patent/JP5937354B2/en
Priority to AU2009303334A priority patent/AU2009303334B2/en
Priority to MX2011003846A priority patent/MX336721B/en
Priority to RU2011118878/15A priority patent/RU2497542C2/en
Priority to CA2740155A priority patent/CA2740155C/en
Priority to BRPI0920283A priority patent/BRPI0920283A2/en
Priority to PCT/US2009/060236 priority patent/WO2010042866A1/en
Priority to US13/123,887 priority patent/US8906381B2/en
Priority to EP09741522A priority patent/EP2344185A1/en
Priority to RU2011118879/15A priority patent/RU2496517C2/en
Priority to MX2011003842A priority patent/MX2011003842A/en
Priority to JP2011531220A priority patent/JP5854837B2/en
Priority to IL205010A priority patent/IL205010A/en
Priority to IL212244A priority patent/IL212244A/en
Priority to IL212245A priority patent/IL212245B/en
Priority to IL212240A priority patent/IL212240A0/en
Priority to US13/651,124 priority patent/US9233072B2/en
Priority to US13/844,258 priority patent/US9526702B2/en
Priority to US13/844,100 priority patent/US9474717B2/en
Priority to US13/844,382 priority patent/US9539210B2/en
Priority to US14/046,827 priority patent/US9308280B2/en
Priority to US14/084,424 priority patent/US9439859B2/en
Priority to JP2014173556A priority patent/JP2014221838A/en
Priority to JP2014223983A priority patent/JP6140127B2/en
Priority to IL240444A priority patent/IL240444B/en
Priority to JP2017030031A priority patent/JP6250851B2/en
Priority to IL256268A priority patent/IL256268B/en
Priority to US16/544,464 priority patent/US11547667B2/en
Priority to IL269427A priority patent/IL269427B/en

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Abstract

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
PCT/US2008/011932 2007-10-12 2008-10-12 Vaccine nanotechnology WO2009051837A2 (en)

Priority Applications (69)

Application Number Priority Date Filing Date Title
US12/681,814 US10736848B2 (en) 2007-10-12 2008-10-12 Vaccine nanotechnology
JP2010528911A JP2011500569A (en) 2007-10-12 2008-10-12 Vaccine nanotechnology
CA2702083A CA2702083C (en) 2007-10-12 2008-10-12 Vaccine nanotechnology
AU2008314647A AU2008314647B2 (en) 2007-10-12 2008-10-12 Vaccine nanotechnology
CN200880116677A CN101861165A (en) 2007-10-12 2008-10-12 Vaccine nanotechnology
ES08839738.5T ES2627292T3 (en) 2007-10-12 2008-10-12 Vaccine Nanotechnology
MX2013008271A MX350501B (en) 2007-10-12 2008-10-12 Vaccine nanotechnology.
EP08839738.5A EP2217269B1 (en) 2007-10-12 2008-10-12 Vaccine nanotechnology
MX2010003642A MX2010003642A (en) 2007-10-12 2008-10-12 Vaccine nanotechnology.
BRPI0817664 BRPI0817664A2 (en) 2007-10-12 2008-10-12 Nanoparticles, method for preparing nanoparticles and method for therapeutically or prophylactically treating an individual
EP18183983.8A EP3424525A1 (en) 2007-10-12 2008-10-12 Vaccine nanotechnology
US12/428,395 US8343498B2 (en) 2008-10-12 2009-04-22 Adjuvant incorporation in immunonanotherapeutics
US12/428,388 US8591905B2 (en) 2008-10-12 2009-04-22 Nicotine immunonanotherapeutics
US12/428,408 US8277812B2 (en) 2008-10-12 2009-04-22 Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US12/428,381 US8343497B2 (en) 2008-10-12 2009-04-22 Targeting of antigen presenting cells with immunonanotherapeutics
EP09740582.3A EP2344187B1 (en) 2008-10-12 2009-10-09 Targeting of antigen presenting cells with immunonanotherapeutics
AU2009303338A AU2009303338B2 (en) 2008-10-12 2009-10-09 Adjuvant incorporation in immunonanotherapeutics
EP09740580.7A EP2344186B1 (en) 2008-10-12 2009-10-09 Immunonanotherapeutics
KR1020117010817A KR101756995B1 (en) 2008-10-12 2009-10-09 Adjuvant incorporation in immononanotherapeutics
EP09740581.5A EP2346528B1 (en) 2008-10-12 2009-10-09 Nicotine immunonanotherapeutics
US13/123,884 US8562998B2 (en) 2008-10-12 2009-10-09 Targeting of antigen presenting cells with immunonanotherapeutics
PCT/US2009/060233 WO2010042863A1 (en) 2008-10-12 2009-10-09 IMMUNONANOTHERAPEUTICS THAT PROVIDE IgG HUMORAL RESPONSE WITHOUT T-CELL ANTIGEN
CA2740248A CA2740248C (en) 2008-10-12 2009-10-09 Nicotine immunonanotherapeutics
CN200980150137.2A CN102245201B (en) 2008-10-12 2009-10-09 Adjuvant in immunonanotherapeutics is integrated
US13/123,886 US8932595B2 (en) 2008-10-12 2009-10-09 Nicotine immunonanotherapeutics
CN200980149914.1A CN102245199B (en) 2008-10-12 2009-10-09 Pass through immunonanotherapeutics target antigen presenting cells
PCT/US2009/060242 WO2010042870A1 (en) 2008-10-12 2009-10-09 Adjuvant incorporation in immunonanotherapeutics
JP2011531225A JP6133539B2 (en) 2008-10-12 2009-10-09 Targeting antigen-presenting cells with immuno-nanotherapy agents
AU2009303344A AU2009303344B8 (en) 2008-10-12 2009-10-09 Targeting of antigen presenting cells with immunonanotherapeutics
RU2011118880/15A RU2487712C2 (en) 2008-10-12 2009-10-09 Nicotinic ummunonanotherapeutic drugs
KR1020117010819A KR20110074903A (en) 2008-10-12 2009-10-09 Nicotine immononanotherapeutics
MX2011003843A MX2011003843A (en) 2008-10-12 2009-10-09 Adjuvant incorporation in immunonanotherapeutics.
KR1020117010818A KR101732744B1 (en) 2008-10-12 2009-10-09 Targeting of antigen presenting cells with immononanotherapeutics
JP2011531219A JP5905259B2 (en) 2008-10-12 2009-10-09 Immuno-nanotherapeutic agent that provides an IgG humoral response without T cell antigen
CA2740162A CA2740162C (en) 2008-10-12 2009-10-09 Targeting of antigen presenting cells with immunonanotherapeutics
BRPI0920282A BRPI0920282A2 (en) 2008-10-12 2009-10-09 composition and method for inducing humoral immune response
BRPI0920284A BRPI0920284A2 (en) 2008-10-12 2009-10-09 composition and method
PCT/US2009/060250 WO2010042876A1 (en) 2008-10-12 2009-10-09 Targeting of antigen presenting cells with immunonanotherapeutics
CN2009801499156A CN102245200A (en) 2008-10-12 2009-10-09 Nicotine immunonanotherapeutics
US13/123,888 US8637028B2 (en) 2008-10-12 2009-10-09 Adjuvant incorporation in immunonanotherapeutics
JP2011531223A JP5937354B2 (en) 2008-10-12 2009-10-09 Incorporation of adjuvants into immuno-nanotherapy agents
AU2009303334A AU2009303334B2 (en) 2008-10-12 2009-10-09 Nicotine immunonanotherapeutics
MX2011003846A MX336721B (en) 2008-10-12 2009-10-09 Nicotine immunonanotherapeutics.
RU2011118878/15A RU2497542C2 (en) 2008-10-12 2009-10-09 Targeting of antigen-presenting cells of immunonanotherapy drugs
CA2740155A CA2740155C (en) 2008-10-12 2009-10-09 Adjuvant incorporation in immunonanotherapeutics
BRPI0920283A BRPI0920283A2 (en) 2008-10-12 2009-10-09 composition and method for inducing humoral immune response
PCT/US2009/060236 WO2010042866A1 (en) 2008-10-12 2009-10-09 Nicotine immunonanotherapeutics
US13/123,887 US8906381B2 (en) 2008-10-12 2009-10-09 Immunonanotherapeutics that provide IGG humoral response without T-cell antigen
EP09741522A EP2344185A1 (en) 2008-10-12 2009-10-09 Adjuvant incorporation in immunonanotherapeutics
RU2011118879/15A RU2496517C2 (en) 2008-10-12 2009-10-09 Adjuvant addition to immunonanotherapeutic agents
MX2011003842A MX2011003842A (en) 2008-10-12 2009-10-09 Targeting of antigen presenting cells with immunonanotherapeutics .
JP2011531220A JP5854837B2 (en) 2008-10-12 2009-10-09 Nicotine immune nanotherapeutic
IL205010A IL205010A (en) 2007-10-12 2010-04-11 Polymer based nanoparticles comprising t- cell and b-cell antigens
IL212244A IL212244A (en) 2008-10-12 2011-04-10 Nicotine immunonanotherapeutic
IL212245A IL212245B (en) 2008-10-12 2011-04-10 Targeting of antigen presenting cells with immunonanotherapeutics
IL212240A IL212240A0 (en) 2008-10-12 2011-04-10 Adjuvant incorporation in immunonanotherapeutics
US13/651,124 US9233072B2 (en) 2008-10-12 2012-10-12 Adjuvant incorporation in immunonanotherapeutics
US13/844,258 US9526702B2 (en) 2007-10-12 2013-03-15 Vaccine nanotechnology
US13/844,100 US9474717B2 (en) 2007-10-12 2013-03-15 Vaccine nanotechnology
US13/844,382 US9539210B2 (en) 2007-10-12 2013-03-15 Vaccine nanotechnology
US14/046,827 US9308280B2 (en) 2008-10-12 2013-10-04 Targeting of antigen presenting cells with immunonanotherapeutics
US14/084,424 US9439859B2 (en) 2008-10-12 2013-11-19 Adjuvant incorporation in immunoanotherapeutics
JP2014173556A JP2014221838A (en) 2008-10-12 2014-08-28 Adjuvant incorporation in immunonanotherapeutics
JP2014223983A JP6140127B2 (en) 2008-10-12 2014-11-04 Immuno-nanotherapeutic agent that provides an IgG humoral response without T cell antigen
IL240444A IL240444B (en) 2007-10-12 2015-08-09 Vaccine nanotechnology
JP2017030031A JP6250851B2 (en) 2008-10-12 2017-02-21 Targeting antigen-presenting cells with immuno-nanotherapy agents
IL256268A IL256268B (en) 2007-10-12 2017-12-12 Vaccine nanotechnology
US16/544,464 US11547667B2 (en) 2007-10-12 2019-08-19 Vaccine nanotechnology
IL269427A IL269427B (en) 2007-10-12 2019-09-18 Vaccine nanotechnology

Applications Claiming Priority (2)

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US97959607P 2007-10-12 2007-10-12
US60/979,596 2007-10-12

Related Parent Applications (2)

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US12/428,388 Continuation-In-Part US8591905B2 (en) 2008-10-12 2009-04-22 Nicotine immunonanotherapeutics
US12/428,408 Continuation-In-Part US8277812B2 (en) 2008-10-12 2009-04-22 Immunonanotherapeutics that provide IgG humoral response without T-cell antigen

Related Child Applications (13)

Application Number Title Priority Date Filing Date
US12/681,814 A-371-Of-International US10736848B2 (en) 2007-10-12 2008-10-12 Vaccine nanotechnology
US12/428,381 Continuation-In-Part US8343497B2 (en) 2008-10-12 2009-04-22 Targeting of antigen presenting cells with immunonanotherapeutics
US12/428,408 Continuation-In-Part US8277812B2 (en) 2008-10-12 2009-04-22 Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US12/428,395 Continuation-In-Part US8343498B2 (en) 2008-10-12 2009-04-22 Adjuvant incorporation in immunonanotherapeutics
US12/428,388 Continuation-In-Part US8591905B2 (en) 2008-10-12 2009-04-22 Nicotine immunonanotherapeutics
US13/123,888 Continuation-In-Part US8637028B2 (en) 2008-10-12 2009-10-09 Adjuvant incorporation in immunonanotherapeutics
US13/123,887 Continuation-In-Part US8906381B2 (en) 2008-10-12 2009-10-09 Immunonanotherapeutics that provide IGG humoral response without T-cell antigen
PCT/US2009/060242 Continuation-In-Part WO2010042870A1 (en) 2008-10-12 2009-10-09 Adjuvant incorporation in immunonanotherapeutics
US13/123,886 Continuation-In-Part US8932595B2 (en) 2008-10-12 2009-10-09 Nicotine immunonanotherapeutics
US13/844,382 Continuation US9539210B2 (en) 2007-10-12 2013-03-15 Vaccine nanotechnology
US13/844,258 Continuation US9526702B2 (en) 2007-10-12 2013-03-15 Vaccine nanotechnology
US13/844,100 Continuation US9474717B2 (en) 2007-10-12 2013-03-15 Vaccine nanotechnology
US16/544,464 Continuation US11547667B2 (en) 2007-10-12 2019-08-19 Vaccine nanotechnology

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JP (8) JP2011500569A (en)
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BR (1) BRPI0817664A2 (en)
CA (2) CA2917512A1 (en)
ES (2) ES2627292T3 (en)
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