WO2009064994A1 - Mitral spacer - Google Patents
Mitral spacer Download PDFInfo
- Publication number
- WO2009064994A1 WO2009064994A1 PCT/US2008/083570 US2008083570W WO2009064994A1 WO 2009064994 A1 WO2009064994 A1 WO 2009064994A1 US 2008083570 W US2008083570 W US 2008083570W WO 2009064994 A1 WO2009064994 A1 WO 2009064994A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- segment
- heart valve
- valve implant
- shaft
- spacer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/246—Devices for obstructing a leak through a native valve in a closed condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/044—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors with a threaded shaft, e.g. screws
- A61B2017/0441—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors with a threaded shaft, e.g. screws the shaft being a rigid coil or spiral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
- A61B2017/048—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery for reducing heart wall tension, e.g. sutures with a pad on each extremity
Definitions
- the present disclosure relates to the repair and/or correction of dysfunctional heart valves, and more particularly pertains to heart valve implants and systems and methods for delivery and implementation of the same.
- a human heart has four chambers, the left and right atrium and the left and right ventricles.
- the chambers of the heart alternately expand and contract to pump blood through the vessels of the body.
- the cycle of the heart includes the simultaneous contraction of the left and right atria, passing blood from the atria to the left and right ventricles.
- the left and right ventricles then simultaneously contract forcing blood from the heart and through the vessels of the body.
- the heart also includes a check valve at the upstream end of each chamber to ensure that blood flows in the correct direction through the body as the heart chambers expand and contract. These valves may become damaged or otherwise fail to function properly, resulting in their inability to properly close when the downstream chamber contracts.
- Mitral regurgitation is a common variety of heart valve dysfunction or insufficiency. Mitral regurgitation occurs when the mitral valve separating the left coronary atrium and the left ventricle fails to properly close. As a result, upon contraction of the left ventricle blood may leak or flow from the left ventricle back into the left atrium, rather than being forced through the aorta. Any disorder that weakens or damages the mitral valve can prevent it from closing properly, thereby causing leakage or regurgitation. Mitral regurgitation is considered to be chronic when the condition persists rather than occurring for only a short period of time.
- mitral regurgitation may result in a decrease in blood flow through the body (cardiac output).
- Correction of mitral regurgitation typically requires surgical intervention. Surgical valve repair or replacement is carried out as an open heart procedure. The repair or replacement surgery may last in the range of about three to five hours, and is carried out with the patient under general anesthesia. The nature of the surgical procedure requires the patient to be placed on a heart-lung machine. Because of the severity/complexity/danger associated with open heart surgical procedures, corrective surgery for mitral regurgitation is typically not recommended until the patient's ejection fraction drops below 60% and/or the left ventricle is larger than 45 mm at rest.
- FIG. 1 is a perspective view of an embodiment of a mitral valve implant consistent with the present disclosure
- FIG. 2 depicts an embodiment mitral valve implant consistent with the present disclosure implanted within a heart in an open position
- FIG. 3 depicts an embodiment mitral valve implant consistent with the present disclosure implanted within a heart in a closed position
- FIG. 4 is a perspective view of the mitral valve implant shown in FIG. 1 in an unassembled state consistent with the present disclosure
- FIG. 5 is a cross-sectional view of another embodiment of the spacer segment consistent with the mitral valve implant according to the present disclosure
- FIG. 6 is a perspective view of another embodiment of the spacer segment and shaft consistent with the mitral valve implant according to the present disclosure
- FIG. 7 is a perspective view of another embodiment of the spacer consistent with the mitral valve implant according to the present disclosure.
- FIG. 8 is a perspective view of one embodiment of a collapsed spacer segment partially disposed within a lumen of an implant delivery system
- FIG. 9 is an end view of the collapsed spacer segment within the lumen consistent with FIG. 8; and FIG. 10 depicts one embodiment of a mitral valve implant including a plurality of individual segments disposed within an implant delivery system consistent with the present disclosure.
- FIG. 1 a perspective view of one embodiment of a mitral valve implant
- mitral valve implant 10 may generally include a spacer or valve body portion 12 which may be coupled to a shaft 14.
- the shaft 14 may be coupled to at least one anchor portion 16 configured to couple, attach, and/or otherwise secure the mitral valve implant 10 to native coronary tissue.
- at least a portion of the spacer 12 may be configured to be disposed proximate a mitral valve 18 as generally shown in FIGS. 2 and 3 such that the mitral valve implant 10 may interact and/or cooperate with at least a portion of the native mitral valve 18 to reduce and/or eliminate excessive regurgitation through the mitral valve 18.
- the spacer 12 of the mitral valve implant 10 shown in FIG. 1 may comprise at least two individual segments or components 20a-20n.
- the plurality of segments 20a-20n may be configured to be individually delivered and assembled proximate an implant site of the mitral valve implant 10 to form a spacer 12 having an overall size and shape configured to accommodate, at least in part, a patient's anatomy, etiology of valve regurgitation, and/or the limitations of the implant delivery system.
- the plurality of segments 20a-20n may be configured to form a mitral valve implant 10 having a spacer 12 with at least one cross-sectional dimension that is larger than the internal cross-sectional dimensions of the implant delivery system used to deliver the mitral valve implant 10.
- the plurality of segments 20a-20n may also allow a mitral valve implant 10 to be constructed including a spacer 12 having an external size, contour, and shape based on, at least in part, the patient's anatomy and etiology of the regurgitate valve.
- the mitral valve implant 10 may provide an enhanced sealing surface for the leaflets 19 of the mitral valve 18 for reducing and/or eliminating excessive regurgitation.
- the spacer 12 may be comprised of at least two segments 20a-20n that may be coupled to each other and, ultimately, to the shaft 14. Consequently, a mitral valve implant 10 according to one embodiment of the present disclosure may be built-up or constructed from multiple segments 20a-20n such that the resulting, constructed spacer 12 may have various cross-sectional shapes, sizes, configurations, or contours based on, at least in part, the patient's anatomy and etiology of the regurgitant valve. The cross-sectional shapes, sizes, configurations, or contours of the resulting spacer 12 may be varied by design and by quantity of the plurality of segments 20a-20n.
- a mitral valve implant 10 may be constructed including a spacer 12 having at least one external cross- sectional dimension that may be larger than the internal cross-sectional dimensions of the implant delivery system.
- a spacer 12 having at least one external cross- sectional dimension that may be larger than the internal cross-sectional dimensions of the implant delivery system.
- FIG. 4 one embodiment of an exploded, unassembled mitral valve implant 10 and spacer 12 is shown in FIG. 4.
- the plurality of segments 20a-20n are shown having a generally tubular or cylindrical shape.
- one or more of the segments 20a-20n may include other shapes and/or configurations.
- one or more of the segments 20a-20n of the spacer 12 may include a symmetrical or non- symmetrical geometry. At least one segment 20a-20n may also have a tapered and/or a bell-like shape. In another aspect, one or more of the segments 20a-20n may be configured to be disposed substantially concentric with an adjacent segment 20 and/or the shaft 14. Alternatively, one or more of the segments 20a-20n may be configured to be non- concentric with an adjacent segment 20 and/or the shaft 14.
- one or more of the segments 20a-20n may be configured to be disposed substantially coextensively with one or more adjacent segments 20.
- at least one of the segments 20a-20n may be configured to be non-coextensive with one or more adjacent segments 20.
- at least one segment 20 may be configured to be disposed about only a portion of an adjacent segment 20.
- one or more of the segments 20a-20n may be configured such that a single surface of a segment 20 is in substantially direct contact with at least a portion of the surfaces of two or more adjacent segments 20. For example, a first segment 20a, FIG.
- first segment 20a may include an outer or exterior surface 28 that substantially directly contacts two adjacent segments 20b and 20c.
- surface 28 may also include an inner or interior surface of the first segment 20a.
- At least one of the plurality of segments 20a-20n, FIG. 4, may be coupled, mounted, or otherwise secured to at least a portion of the shaft 14 using any known technique and/or device.
- a first segment 20a may be coupled to a distal end 13 of the shaft 14 generally opposite the anchor portion 16.
- the shaft 14 may extend longitudinally beyond the spacer 12 in both directions as generally shown in FIG. 1.
- one or more segments 20a-20n may be disposed proximate a central region of the shaft 14.
- two or more segments 20a-20n may be coupled, mounted, or otherwise secured to at least a portion of the shaft 14.
- One or more segments 20a-20n may be coupled to at least a portion of the shaft 14 by way of an adhesive or cement (for example, but not limited to, a biologically acceptable adhesive or cement), bonding/molding (for example, but not limited to, overmolding and the like), or welding (for example, but not limited to, ultrasonic welding or the like).
- the segments 20a-20n may also be coupled to at least a portion of the shaft 14 using a fastening mechanism.
- the fastening mechanism may substantially fix the position of one or more of the segments 20a-20n and the spacer 12 with respect to the mitral valve implant 10 (and specifically with respect to the shaft 14).
- a fastening mechanism may include one or more detents or protrusions 19 as shown in FIG. 6.
- the detents 19 may be provided as a spring-biased detent, a resilient/elastically deformable detent, or a substantially solid detent.
- the shaft 14 may be provided with one or more detents 19 extending generally outwardly from the shaft 14.
- one or more of the segments 20a-20n may be provided with detents 19 for coupling with the shaft 14.
- One or more of the detents 19 may be integrally formed with the shaft 14 and/or segment 20.
- one or more of the detents 19 may be provided as a separate feature coupled to and/or formed on the shaft 14 and/or segment 20.
- the segment 20a may be slidably coupled to the shaft 14 by pressing the segment 20a over at least one of the detents 19, which may at least partially retract or deform to permit passage of at least one of the detents 19 through an opening 21 and into a cavity 23 of the segment 20a.
- the spring- biased or resilient/elastically deformable detent 19 may at least partially expand and/or recover, thereby resisting passage of the one or more spring-biased detents 19 back through the opening 21.
- the shaft 14 and/or the cavity 23 may be provided with a recessed region (not shown) configured to at least partially receive and engage the detent 19.
- the size and shape of the detent 19, the opening 21, cavity 23, and/or recessed region as well as the force provided by the spring-biased or resilient detent may be configured to engage each other such that the segment 20a may either permit movement of the segment 20a or substantially prevent movement of the segment 20a.
- the segment 20a may be slidably coupled to the shaft 14 by pressing the segment 20a over at least one of the detents 19.
- the opening 21 of the segment 20a may at least partially elastically deform to permit passage of at least one of the detents 19 into the cavity 23. Once the detent 19 has been pressed through the opening 21, the opening 21 may at least partially elastically recover, thereby resisting passage of the detent 19 back through the opening 21.
- the size and shape of the detent 19, the opening 21, and/or cavity 23, as well as the elastic properties may be configured to engage each other such that the segment 20a may either permit movement of the segment 20a or substantially prevent movement of the segment 20a.
- Various other arrangements may be employed for providing detents on the shaft 14 and/or the segments 20a-20n for coupling, controlling and/or limiting translation of the spacer 12 along the shaft 14.
- the segments 20a-20n may be selectively removable from the shaft 14 by applying a force along the longitudinal axis L sufficient to overcome the holding force of the detents 19.
- At least one segment 20b-20n may be configured to be at least partially disposed about and coupled to the first segment 20a as generally depicted in FIGS. 1 and 5. Additional segments 20n may also be configured to be at least partially disposed about and coupled to an inner, adjacent segment (for example, segment 20b).
- the number and configuration of segments 20a-20n may be based on, at least in part, the patient's anatomy and etiology of the regurgitant valve, as well as the physical limitations of the implant delivery system (such as, but not limited to, the internal cross-sectional dimensions of the implant delivery system).
- the additional segments 20b-20n may include an internal cavity 40, for example, as seen in FIG. 4, which may be configured to at least partially receive at least a portion of an inner, adjacent segment 20.
- the term “inner, adjacent segment” or the like is intended to refer to a segment 20 which is at least partially disposed radially inwardly, e.g., generally towards the shaft 14.
- the term “additional segments” and the like is intended to refer to segments which are at least partially coupled to at least one inner, adjacent segment.
- a second segment 20b may include a cavity 40' configured to at least partially receive the first segment 20a.
- a third segment 20n may include a cavity 40" configured to at least partially receive the second segment 20b. While three segments 20 are shown, the spacer 12 may include a greater or less number of segments 20.
- One or more of the cavities 40 may have an internal contour configured to substantially correspond to the outer surface 42 of one or more of the inner, adjacent segments 20 to be received therein.
- the cavity 40 may include an inner surface 44 that is substantially coextensive with the outer surface 42 of one or more of the inner, adjacent segments 20 to be received therein.
- One or more of the cavities 40 and outer surfaces 44 may be configured to provide an interference and/or friction fit.
- one or more of the cavities 40 may be deformable such that the cavity 40 stretches (either permanently or resiliently deformable) to receive at least a portion of the inner, adjacent segments 20 to be received therein.
- One or more of the cavities 40 and/or segments 20a-20n may be configured to reduce or substantially eliminate the rotation of one segment 20 relative to an adjacent segment 20.
- a cavity 40 and an inner, adjacent segment 20 may be provided with a non- cylindrical shape such that the inner, adjacent segment 20 may be received in the cavity 40 in substantially only a single orientation.
- Other configurations for reducing and/or eliminating the rotational movement of adjacent segments 20 are also possible.
- cavities 40 are shown having a configuration which may substantially entirely circumscribe at least a portion of the outer surface 42 of an inner, adjacent segment 20 to be received therein, one or more of the cavities 42 may be configured to be disposed only about a portion of the outer surface 42 of the inner, adjacent segment 20 to be received therein.
- one or more of the cavities 40 may be configured to be radially disposed about less than 360 degrees of the outer surface 42 of the inner, adjacent segment 20 to be received therein as shown in FIG. 7.
- the additional segments 20b-20n may be coupled to an inner, adjacent segment 20 using any known technique and/or device.
- the additional segments 20b-20n may be coupled to an inner, adjacent segment 20 using an interference fit between the cavity 40 and the outer surface 42 of the inner, adjacent segment 20 as discussed above.
- one or more of the additional segments 20b-20n may be coupled to an inner, adjacent segment 20 using an adhesive or cement (for example, but not limited to, a biologically acceptable adhesive or cement), bonding/molding (for example, but not limited to, overmolding and the like), or welding (for example, but not limited to, ultrasonic welding or the like).
- an adhesive or cement for example, but not limited to, a biologically acceptable adhesive or cement
- bonding/molding for example, but not limited to, overmolding and the like
- welding for example, but not limited to, ultrasonic welding or the like.
- the additional segments 20b-20n may also be coupled to at least a portion of an inner, adjacent segment 20 using a fastening mechanism.
- the fastening mechanism may substantially fix the position of one or more of the segments 20a-20n with respect to the mitral valve implant 10.
- the fastening mechanism may allow one or more of the segments 20a-20n and the spacer 12 to move relative to the shaft 14.
- the fastening mechanism may allow the one or more of the segments 20a-20n and spacer 12 to move generally along the longitudinal axis L and/or radially with respect to the shaft 14.
- One example of a fastening mechanism may include one or more detents or protrusions 19 as shown in FIG. 4.
- the detents 19 may be disposed out the outer surface 42 of one or more of the segments 20a-20n and/or may be disposed at least partially within the cavity 40 of one or more of the segments 20a-20n.
- the detents 19 may include any of the various detent configurations discussed above such as, but not limited to, spring-biased detents, resilient/elastically deformable detents, or substantially solid detents.
- At least a portion of the body 24 of one or more of the plurality of segments 20a-20n may be expandable, retractable, collapsible and/or reducible in volume to facilitate percutaneous and/or transluminal delivery of the mitral valve implant 10.
- one or more of the segments 20a-20n of the mitral valve implant 10 may include a collapsible member, which may be reduced in volume and/or reduced in maximum cross-section during delivery to the heart and/or during placement and/or attachment of the anchor 16 to native coronary tissue.
- the segments 20a-20n may be expanded, inflated, and/or otherwise increased in volume or size. Accordingly, the mitral valve implant 10 may be delivered to an implantation site via a smaller diameter catheter, and/or via smaller vessels, than would otherwise be required.
- the deformable segments 20a-20n may be collapsed to a reduced size, which may, for example, facilitate loading the mitral valve implant 10 into a lumen 51 of a catheter delivery system 53 as generally shown in FIGS. 8 and 9.
- a catheter delivery system 53 may be suitable for transluminal delivery of a mitral valve implant 10, including the segments 20a- 20n, to the heart as will be explained further below.
- the segments 20a-20n may be deformed to facilitate loading into a catheter delivery system 53.
- the segments 20a-20n may be collapsed and may be rolled and/or folded to a generally cylindrical shape, allowing the segments 20a-20n to be loaded in a catheter having a generally circular lumen 51 as generally depicted in FIGS. 8 and 9.
- a collapsed and/or rolled or folded segments 20a-20n may be inflated, restoring the segments 20a-20n to expanded configuration.
- a collapsed and/or rolled or folded segments 20a-20n may be inflated and restored to an expanded configuration once the mitral valve implant 10 has been delivered to the heart and deployed from a catheter delivery system 53.
- Inflating the segments 20a-20n may be carried out by introducing a fluid, such as saline, into the at least one cavity of the segments 20a-20n.
- a fluid such as saline
- the segments 20a-20n may be inflated with a setting or curable fluid.
- the setting or curable fluid may set and/or be cured to a solid and/or semi-solid state within the cavity of the segments 20a-20n.
- a material may be a thermoset polymer resin, a gel material, such as silicone gel, etc.
- At least a portion of the segments 20a-20n may also be constructed from a shape- memory material.
- at least a portion of the segments 20a-20n may include a shape-memory alloy such as, but not limited to, copper-zinc-aluminum, copper-aluminum- nickel, and nickel-titanium (NiTi) alloys.
- the shape-memory alloy may include either oneway or two-way shape memory and may be introduced in to the delivery catheter lumen 51 having a shape which does not exceed the interior dimensions of the delivery catheter lumen 51.
- the segments 20a-20n may have a generally elongated or generally helical shape. Upon delivery to proximate the mitral valve 18, the shape-memory segments 20a-20n may be heated to cause the segments 20a-20n to deform into the desired shape for installation.
- one or more of the plurality of segments 20a-20n may have generally solid geometry.
- the phrases "generally solid geometry,” “substantially solid geometry,” or the like are intended to mean a geometry having an outer surface that defines a substantially fixed or constant volume. That is, a volume of the segments 20a-20n does not substantially change before and after implantation of the mitral valve implant 10.
- a "generally solid geometry” may include, without limitation, a solid, semi-solid, or porous (e.g., micro- or nano-scale pores) material. The use a plurality of segments 20a-20n having a generally solid geometry may reduce the complexity and/or cost associated with the fabrication and/or implantation of the mitral valve implant 10.
- a segment 20 having a generally solid geometry may be provided having an outer cross-section which is no larger than the inner cross-section of the delivery lumen 51.
- the first segment 20a may be provided having a generally solid geometry while additional segments 20n may be provided having a deformable geometry.
- One or more of the segments 20a-20n may also be coupled to the shaft 14 prior to delivery of the mitral valve implant 10 to the heart.
- the segments 20a-20n coupled to the shaft 14 may be provided having external cross-sectional dimensions (when either expanded or collapsed) that are no larger than the internal cross-sectional dimensions of the implant delivery system.
- At least a portion of the plurality of segments 20a-20n may be constructed from a synthetic and/or biological material depending on the application and the patient condition.
- the segments 20a-20n may include a plurality of layers.
- the segments 20a-20n may include an open or closed cell foam substrate (for example, but not limited to, Invalon polyvinyl) and an outer layer of a material that is biologically acceptable.
- the outer layer may also include a material that is soft and/or deformable (either permanently or resiliently deformable) that may reduce and/or eliminate further scarring and/or damage to the leaflets 19 of the mitral valve 18.
- the substrate of the segments 20a-20n may be coated with or formed substantially from a silicone urethane composite such as, but not limited to, Elasteon or the like.
- the plurality of segments 20a-20n when assembled as generally depicted in FIG. 1, may form a mitral valve implant 10 including a spacer 12 having an outer surface 27 that may be configured to interact and/or cooperate with at least a portion of the native mitral valve 18 (e.g., the leaflets 19) to reduce and/or eliminate excessive regurgitation as illustrated in FIGS. 2 and 3.
- the mitral valve implant 10 (and in particular, the plurality of segments 20a-20n forming the spacer 12) may be selected from a range or set of sizes and shapes.
- a "standard set” may be utilized where a set of “consensus” sizes and shapes of segments 20a-20n are pre-manufactured and provided to health care providers as a kit.
- This particular aspect has the advantage of being the most uniform and therefore the least expensive for the patient.
- a "custom design” may be fabricated where the exact size and shape of one or more of the segments 20a-20n is determined only after precise and/or detailed measurements of the dimensions of a patient's mitral valve 18 are obtained.
- the overall size and/or shape of the spacer 10 may be contoured to a specific patient if necessary.
- the plurality of segments 20a-20n may be aligned serially along at least a portion of the shaft 14 (i.e., one segment 20a after another segment 20b) and inserted into the implant delivery system 53, a portion of which is generally depicted in FIG. 10.
- the implant delivery system 53 may include a catheter 55 having a generally circular inner lumen 51.
- the catheter 55 may include any catheter known to those skilled in art. While only a single lumen 51 is shown for clarity, the catheter 55 may include a plurality of lumens 51.
- one or more of the segments 20a-20n may have an outer cross-section that is larger than the internal cross-section of the lumen 51.
- the plurality of segments 20a- 20n may be deformed or otherwise reduced in cross-section and/or volume such that each of the segments 20a-20n may fit within the lumen 51.
- the mitral valve implant 10 may be moved or delivered proximate the implant site using any device know to those skilled in the art. While moving the mitral valve implant 10 through the delivery catheter system 53, the plurality of segments 20a-20n may be individually rotated to facilitate movement of the plurality of segments 20a-20n. This may be particularly useful to facilitate navigating the plurality of segments 20a-20n about curves, bends or the like in the catheter 55.
- the shaft 14 may include a generally rigid shaft and/or a generally flexible shaft.
- shaft 14 and the plurality of segments 20a-20n may be separately loaded into the catheter delivery system 53 and delivered to the implant site.
- the shaft 14 (which may optionally include the anchor portion 16) may be first loaded into the catheter delivery system 53 and the plurality of segments 20a-20n may be subsequently serially loaded into the catheter delivery system 53.
- the order of loading and/or delivering the shaft 14 and/or plurality of segments 20a-20 to the implant site may be changed.
- the plurality of segments 20a-20n may be disposed or arranged about the shaft 14 and inner, adjacent segments 20b-20n to construct a spacer 12 having a desired size and shape.
- spacer 12 is illustrated having a generally cylindrical outer surface, the size and shape of the spacer 12 and each of the plurality of segments 20a-20n may be varied by design and by quantity to accommodate the patient anatomy, etiology, and limitations of the delivery system 100 (e.g., the internal dimensions of the catheter lumen).
- a first segment 20a of the spacer 12, FIG. 1, may be slidably coupled to the shaft 14.
- the segment 20a may include an opening 46 extending from a first end 44 of the spacer 12, through the spacer 12, and to a second end 40.
- the opening 46 may extend generally axially through the spacer 12 and may be sized to slidably receive at least a portion of the shaft 14 therethrough.
- the shaft 14 may include one or more stops 48, 50.
- the stops 48, 50 may be sized and/or shaped to control and/or restrict translation of the spacer 12 along the shaft 14 beyond the respective stops 48, 50. In this manner, in the illustrated embodiment, translation of the spacer 12 along the shaft 14 may be restricted to the expanse of the shaft 14 between the stops 48, 50.
- One or more of the stops 48, 50 may be integrally formed with the shaft 14. Furthermore, one or more of the stops 48, 50 (such as, but not limited to, stop 50) may be provided as a separate member coupled to and/or formed on the shaft 14. In an embodiment in which one or more of the stops 48, 50 are integrally formed with the shaft 14, the spacer 12 may be slidably coupled to the shaft 14 by pressing the spacer 12 over at least one of the stops 48, 50, which may at least partially elastically deform the opening 46 to permit passage of at least one of the stops 48, 50. Once the one or more of the stops 48, 50 have been pressed through the opening 46, the opening 46 may at least partially elastically recover, thereby resisting passage of the one or more stops 48, 50 back through the opening 46. Various other arrangements may be employed for providing stops on the shaft 14 and/or for controlling and/or limiting translation of the spacer 12 along the shaft 14.
- the anchor portion 16 may include a helical member 52 coupled to the shaft 14. As shown, the helical member 52 may be loosely wound such that adjacent turns of the helical member 52 do not contact one another, for example resembling a corkscrew-type configuration.
- the anchor portion 16 may be engaged with tissue by rotating the anchor portion 16 about the axis of the helical member 52, thereby advancing the anchor portion 16 into tissue. Consistent with such an embodiment, the anchor portion 16 may resist pulling out from the tissue.
- the anchor portion 16 may be provided as an extension of the shaft 14 wound in a helical configuration. Consistent with related embodiments, the anchor portion 16 may be formed as a separate feature and may be coupled to the shaft 14, e.g., using mechanical fasteners, welding, adhesive, etc.
- the anchor portion 16 may include various configurations capable of being coupled to and/or otherwise attached to native coronary tissue.
- the anchor portion 16 may include one or more prongs adapted to pierce coronary tissue and to alone, or in conjunction with other features, resist removal of the anchor portion 16 from tissue.
- the anchor portion 16 may include a plurality of prongs which may engage native coronary tissue.
- the anchor portion 16 may include features that may facilitate attachment by suturing. Exemplary features to facilitate suturing may include rings or openings, suture penetrable tabs, etc.
- Various other anchor portions 16 that may allow attachment or coupling to native coronary tissue may also suitably be employed in connection with the present disclosure.
- the mitral valve implant 10 is shown implanted within a heart 102.
- the mitral valve implant 10 may be disposed at least partially within the left ventricle 64 of the heart 102.
- the anchor portion 16 may be engaged with native coronary tissue within and/or adjacent to the left ventricle 64.
- the shaft 14, coupled to the anchor portion 16, may extend into the left ventricle 64.
- the shaft 14 may further extend at least partially within the mitral valve 18, i.e., the shaft 14 may extend at least partially between the cusps or leaflets 19 of the mitral valve 18, and may also extend at least partially into the left atrium 62.
- the spacer 12 of the mitral valve implant 10 may be positioned at least partially within the left ventricle 64 with the bottom portion 44 within the left ventricle 64 and with the upper portion 40 positioned at least partially within and/or pointed towards the left atrium 62.
- FIG. 2 depicts the heart 102 in a condition in which the pressure of blood within the left atrium 62 is at equal to, or higher than, the pressure of blood within the left ventricle 64, e.g., during contraction of the left atrium 62.
- the pressure of blood within the left atrium 62 is greater than or equal to the pressure of blood within the left ventricle 64, blood may flow from the left atrium 62 into the left ventricle 64.
- the pressure differential and/or the flow of blood from the left atrium 62 to the left ventricle 64 may slidably translate the spacer 12 along the shaft 14 toward the left ventricle 64, in the direction of blood flow between the chambers.
- Sliding translation of the spacer 12 along the shaft 14 may at least partially withdraw the spacer 12 from the mitral valve 18 to an open position, as shown.
- a passage may be opened between the spacer 12 and the mitral valve 18, allowing blood to flow from the left atrium 62 to the left ventricle 64.
- Translation of the spacer 12 away from the mitral valve 18 may be controlled and/or limited by the stop 48.
- the stop 48 In the open position, the stop 48 may maintain the spacer 12 in general proximity to the mitral valve 18 while still permitting sufficient clearance between the mitral valve 18 and the spacer 12 to permit adequate blood flow from the left atrium 62 to the left ventricle 64.
- the flow of blood from left atrium 62 to the left ventricle 64 may cause the mitral valve 18 to flare and/or expand outwardly away from the mitral valve implant 10, permitting blood flow between the implant 10 and the cusps 19 of the mitral valve 19.
- the pressure of blood in the left ventricle 64 may increase such that the blood pressure in the left ventricle 64 is greater than the blood pressure in the left atrium 62. Additionally, as the pressure of the blood in the left ventricle 64 initially increases above the pressure of the blood in the left atrium 62, blood may begin to flow towards and/or back into the left atrium 62. The pressure differential and/or initial flow of blood from the left ventricle 64 into the left atrium 62 may act against the spacer 12 and may translate the spacer 12 toward the left atrium 104. For example, pressurized blood within the left ventricle 64 may act against the bottom of the spacer 12 inducing sliding translation of the spacer 12 along the shaft 14 toward the left atrium 62.
- the spacer 12 may be translated toward and/or at least partially into the left atrium 62. At least a portion of the spacer 12 may interact with, engage, and/or be positioned adjacent to at least a portion of the mitral valve 18. For example, at least a portion of at least one cusp 19 of the mitral valve 18 may contact at least a portion of the spacer 12. Engagement between the spacer 12 and the mitral valve 18 may restrict and/or prevent the flow of blood from the left ventricle 64 back into the left atrium 62.
- the mitral valve 18 may also at least partially close around the spacer 12, thereby also restricting and/or preventing the flow of blood from the left ventricle 64 to the left atrium 62.
- at least a portion of one or both of the cusps 19 of the mitral valve 18 may contact at least a portion of the spacer 12.
- the pressure against the bottom 44 of the spacer 12 may increase.
- the increase in pressure against the bottom 44 of the spacer 12 may, in turn, increase the engagement between the spacer 12 and the mitral valve 18.
- Sliding translation of the spacer 12 toward the left atrium 62 may at least partially be controlled and/or limited by the stop 50 coupled to the shaft 14. Additionally, translation of the spacer 12 toward the left atrium 62 may be at least partially limited and/or controlled by engagement between the spacer 12 and the mitral valve 18. One or both of these restrictions on the translation of the spacer 12 may, in some embodiments, prevent the spacer 12 from passing fully into the left atrium 62. Furthermore, the diameter and/or shape of the spacer 12 may limit and/or restrict the movement of the spacer 12 into the left atrium 62.
- the preceding embodiment may, therefore, provide a mitral valve implant that is slidably translatable relative to the mitral valve to reduce and/or eliminate regurgitation. Additional embodiments of a mitral valve implant are described in co-pending U.S. Patent Application Serial No. 11/258,828, entitled “Heart Valve Implant” filed on October 26, 2005, U.S. Patent Application Serial No. 11/748,147, entitled “Safety for Mitral Valve Plug” filed on May 14, 2007, U.S. Patent Application Serial No. 11/748,138, entitled “Solid Construct Mitral Spacer” filed on May 14, 2007, and U.S. Patent Application Serial No. 11/748,121, entitled “Ballon Mitral Spacer” filed on May 14, 2007, all of which are hereby incorporated by reference.
- the mitral valve implant may include a generally stationary spacer and may include more than one anchoring portions.
- the implant herein has been disclosed above in the context of a mitral valve implant.
- An implant consistent with the present disclosure may also suitably be employed in other applications, e.g., as an implant associated with one of the other valves of the heart, etc.
- the present invention should not, therefore, be construed as being limited to use for reducing and/or preventing regurgitation of the mitral valve.
- the present disclosure features a heart valve implant.
- the heart valve implant may include a shaft extending generally along a longitudinal axis of the heart valve implant.
- a spacer may comprise a plurality of individual segments including at least a first segment configured to be coupled to the shaft and at least a second segment configured to be coupled to a least a portion of an outer surface of the first segment.
- the plurality of individual segments may define an outer surface of the spacer configured to interact with at least a portion of at least one cusp of a heart valve to at least partially restrict a flow of blood through the heart valve in a closed position.
- the heart valve implant may also include at least one anchor configured to be coupled to a first end region of the shaft.
- the present disclosure features a method of introducing a heart valve implant with respect to a heart valve.
- the method may include providing a heart valve implant comprising a shaft, at least one anchor configured to be coupled to the shaft, and a spacer including a plurality of individual segments including a first and at least a second segment.
- the plurality of individual segments may define an outer surface of the spacer configured to interact with at least a portion of at least one cusp of a heart valve to at least partially restrict a flow of blood through the heart valve in a closed position.
- the plurality of individual segments may be serially aligned.
- the shaft and the first and the plurality of segments may be percutaneously delivered proximate the heart and the first segment may be coupled to the shaft.
- the second segment may be coupled to at least a portion of an outer surface of the first segment to define the spacer and the heart valve implant may be secured within the heart.
- the present disclosure features a heart valve implant system.
- the heart valve implant system may comprise a catheter including a lumen and a heart valve implant.
- the heart valve implant may comprise a shaft extending generally along a longitudinal axis of the heart valve implant.
- a spacer may comprise a plurality of individual segments including at least a first segment configured to be coupled to the shaft and at least a second segment configured to be coupled to a least a portion of an outer surface of the first segment.
- the second segment may include at least one cross-sectional dimension that is larger than an internal cross-section of the lumen.
- the plurality of individual segments may define an outer surface of the spacer configured to interact with at least a portion of at least one cusp of a heart valve to at least partially restrict a flow of blood through the heart valve in a closed position.
- At least one anchor may be configured to be coupled to a first end region of the shaft.
- the present disclosure is not intended to be limited to a system or method which must satisfy one or more of any stated or implied object or feature of the present disclosure and should not be limited to the preferred, exemplary, or primary embodiment(s) described herein.
- the foregoing description of a preferred embodiment of the present disclosure has been presented for purposes of illustration and description. It is not intended to be exhaustive or to limit the present disclosure to the precise form disclosed. Obvious modifications or variations are possible in light of the above teachings. The embodiment was chosen and described to provide the best illustration of the principles of the present disclosure and its practical application to thereby enable one of ordinary skill in the art to utilize the present disclosure in various embodiments and with various modifications as is suited to the particular use contemplated. All such modifications and variations are within the scope of the present disclosure as determined by the claims when interpreted in accordance with breadth to which they are fairly, legally and equitably entitled.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2008322556A AU2008322556A1 (en) | 2007-11-15 | 2008-11-14 | Mitral spacer |
EP08849442A EP2211787A4 (en) | 2007-11-15 | 2008-11-14 | Mitral spacer |
CA2705938A CA2705938A1 (en) | 2007-11-15 | 2008-11-14 | Mitral spacer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/940,674 US7785366B2 (en) | 2005-10-26 | 2007-11-15 | Mitral spacer |
US11/940,674 | 2007-11-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009064994A1 true WO2009064994A1 (en) | 2009-05-22 |
Family
ID=40639152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/083570 WO2009064994A1 (en) | 2007-11-15 | 2008-11-14 | Mitral spacer |
Country Status (5)
Country | Link |
---|---|
US (3) | US7785366B2 (en) |
EP (1) | EP2211787A4 (en) |
AU (1) | AU2008322556A1 (en) |
CA (1) | CA2705938A1 (en) |
WO (1) | WO2009064994A1 (en) |
Families Citing this family (279)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0850607A1 (en) | 1996-12-31 | 1998-07-01 | Cordis Corporation | Valve prosthesis for implantation in body channels |
US6454799B1 (en) | 2000-04-06 | 2002-09-24 | Edwards Lifesciences Corporation | Minimally-invasive heart valves and methods of use |
US6733525B2 (en) | 2001-03-23 | 2004-05-11 | Edwards Lifesciences Corporation | Rolled minimally-invasive heart valves and methods of use |
US6893460B2 (en) | 2001-10-11 | 2005-05-17 | Percutaneous Valve Technologies Inc. | Implantable prosthetic valve |
US20050075725A1 (en) | 2003-10-02 | 2005-04-07 | Rowe Stanton J. | Implantable prosthetic valve with non-laminar flow |
US8012201B2 (en) * | 2004-05-05 | 2011-09-06 | Direct Flow Medical, Inc. | Translumenally implantable heart valve with multiple chamber formed in place support |
CA2583591C (en) | 2004-10-02 | 2018-10-30 | Christoph Hans Huber | Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support |
WO2006086434A1 (en) | 2005-02-07 | 2006-08-17 | Evalve, Inc. | Methods, systems and devices for cardiac valve repair |
WO2011034628A1 (en) * | 2005-02-07 | 2011-03-24 | Evalve, Inc. | Methods, systems and devices for cardiac valve repair |
US20100298929A1 (en) * | 2005-02-07 | 2010-11-25 | Thornton Troy L | Methods, systems and devices for cardiac valve repair |
US8568477B2 (en) * | 2005-06-07 | 2013-10-29 | Direct Flow Medical, Inc. | Stentless aortic valve replacement with high radial strength |
US7780723B2 (en) | 2005-06-13 | 2010-08-24 | Edwards Lifesciences Corporation | Heart valve delivery system |
US8167932B2 (en) | 2005-10-18 | 2012-05-01 | Edwards Lifesciences Corporation | Heart valve delivery system with valve catheter |
US9259317B2 (en) | 2008-06-13 | 2016-02-16 | Cardiosolutions, Inc. | System and method for implanting a heart implant |
US7785366B2 (en) * | 2005-10-26 | 2010-08-31 | Maurer Christopher W | Mitral spacer |
US8778017B2 (en) | 2005-10-26 | 2014-07-15 | Cardiosolutions, Inc. | Safety for mitral valve implant |
US8092525B2 (en) * | 2005-10-26 | 2012-01-10 | Cardiosolutions, Inc. | Heart valve implant |
US8449606B2 (en) | 2005-10-26 | 2013-05-28 | Cardiosolutions, Inc. | Balloon mitral spacer |
US8216302B2 (en) | 2005-10-26 | 2012-07-10 | Cardiosolutions, Inc. | Implant delivery and deployment system and method |
US8852270B2 (en) | 2007-11-15 | 2014-10-07 | Cardiosolutions, Inc. | Implant delivery system and method |
US8932348B2 (en) | 2006-05-18 | 2015-01-13 | Edwards Lifesciences Corporation | Device and method for improving heart valve function |
CA2652471C (en) | 2006-06-01 | 2014-09-09 | Edwards Lifesciences Corporation | Prosthetic insert for improving heart valve function |
US9585743B2 (en) | 2006-07-31 | 2017-03-07 | Edwards Lifesciences Cardiaq Llc | Surgical implant devices and methods for their manufacture and use |
WO2008016578A2 (en) | 2006-07-31 | 2008-02-07 | Cartledge Richard G | Sealable endovascular implants and methods for their use |
US9408607B2 (en) | 2009-07-02 | 2016-08-09 | Edwards Lifesciences Cardiaq Llc | Surgical implant devices and methods for their manufacture and use |
DE602007007050D1 (en) | 2006-09-08 | 2010-07-22 | Edwards Lifesciences Corp | |
US7935144B2 (en) | 2006-10-19 | 2011-05-03 | Direct Flow Medical, Inc. | Profile reduction of valve implant |
US8133213B2 (en) | 2006-10-19 | 2012-03-13 | Direct Flow Medical, Inc. | Catheter guidance through a calcified aortic valve |
US8236045B2 (en) | 2006-12-22 | 2012-08-07 | Edwards Lifesciences Corporation | Implantable prosthetic valve assembly and method of making the same |
US8480730B2 (en) | 2007-05-14 | 2013-07-09 | Cardiosolutions, Inc. | Solid construct mitral spacer |
US9566178B2 (en) | 2010-06-24 | 2017-02-14 | Edwards Lifesciences Cardiaq Llc | Actively controllable stent, stent graft, heart valve and method of controlling same |
US20090088836A1 (en) | 2007-08-23 | 2009-04-02 | Direct Flow Medical, Inc. | Translumenally implantable heart valve with formed in place support |
DE102007043830A1 (en) | 2007-09-13 | 2009-04-02 | Lozonschi, Lucian, Madison | Heart valve stent |
US8597347B2 (en) | 2007-11-15 | 2013-12-03 | Cardiosolutions, Inc. | Heart regurgitation method and apparatus |
ES2887787T3 (en) | 2007-12-14 | 2021-12-27 | Edwards Lifesciences Corp | Leaflet Attachment Frame for a Prosthetic Valve |
ES2400494T3 (en) | 2008-02-29 | 2013-04-10 | Edwards Lifesciences Corporation | Expandable element to deploy a prosthetic device |
US9061119B2 (en) | 2008-05-09 | 2015-06-23 | Edwards Lifesciences Corporation | Low profile delivery system for transcatheter heart valve |
PT3263070T (en) | 2008-06-06 | 2020-01-07 | Edwards Lifesciences Corp | Low profile transcatheter heart valve |
US8591460B2 (en) * | 2008-06-13 | 2013-11-26 | Cardiosolutions, Inc. | Steerable catheter and dilator and system and method for implanting a heart implant |
US8323335B2 (en) | 2008-06-20 | 2012-12-04 | Edwards Lifesciences Corporation | Retaining mechanisms for prosthetic valves and methods for using |
US8652202B2 (en) | 2008-08-22 | 2014-02-18 | Edwards Lifesciences Corporation | Prosthetic heart valve and delivery apparatus |
US8790387B2 (en) | 2008-10-10 | 2014-07-29 | Edwards Lifesciences Corporation | Expandable sheath for introducing an endovascular delivery device into a body |
US8439970B2 (en) | 2009-07-14 | 2013-05-14 | Edwards Lifesciences Corporation | Transapical delivery system for heart valves |
EP2477555B1 (en) | 2009-09-15 | 2013-12-25 | Evalve, Inc. | Device for cardiac valve repair |
DK2483289T3 (en) | 2009-10-02 | 2019-06-11 | Biogen Ma Inc | PROCEDURES FOR PREVENTION AND REMOVAL OF TRISULATION CONNECTIONS |
EP2509538B1 (en) | 2009-12-08 | 2017-09-20 | Avalon Medical Ltd. | Device and system for transcatheter mitral valve replacement |
US8475525B2 (en) | 2010-01-22 | 2013-07-02 | 4Tech Inc. | Tricuspid valve repair using tension |
US8961596B2 (en) * | 2010-01-22 | 2015-02-24 | 4Tech Inc. | Method and apparatus for tricuspid valve repair using tension |
US10058323B2 (en) | 2010-01-22 | 2018-08-28 | 4 Tech Inc. | Tricuspid valve repair using tension |
US9307980B2 (en) | 2010-01-22 | 2016-04-12 | 4Tech Inc. | Tricuspid valve repair using tension |
PT3335670T (en) | 2010-03-05 | 2022-07-27 | Edwards Lifesciences Corp | Retaining mechanisms for prosthetic valves |
US8795354B2 (en) | 2010-03-05 | 2014-08-05 | Edwards Lifesciences Corporation | Low-profile heart valve and delivery system |
CA2793839C (en) * | 2010-03-23 | 2018-05-22 | Boston Scientific Scimed, Inc. | Annuloplasty device |
US8974475B2 (en) | 2010-04-30 | 2015-03-10 | Medtronic, Inc. | Methods and devices for cardiac valve repair or replacement |
US9603708B2 (en) | 2010-05-19 | 2017-03-28 | Dfm, Llc | Low crossing profile delivery catheter for cardiovascular prosthetic implant |
US9526483B2 (en) | 2010-07-15 | 2016-12-27 | Medtronic Vascular Galway | Apical closure system |
US8657872B2 (en) | 2010-07-19 | 2014-02-25 | Jacques Seguin | Cardiac valve repair system and methods of use |
EP2595569A4 (en) | 2010-07-23 | 2016-02-24 | Edwards Lifesciences Corp | Retaining mechanisms for prosthetic valves |
PT3626208T (en) | 2010-10-05 | 2021-04-22 | Edwards Lifesciences Corp | Prosthetic heart valve |
CA2822381C (en) | 2010-12-23 | 2019-04-02 | Foundry Newco Xii, Inc. | System for mitral valve repair and replacement |
US8888843B2 (en) | 2011-01-28 | 2014-11-18 | Middle Peak Medical, Inc. | Device, system, and method for transcatheter treatment of valve regurgitation |
US8845717B2 (en) | 2011-01-28 | 2014-09-30 | Middle Park Medical, Inc. | Coaptation enhancement implant, system, and method |
US9155619B2 (en) | 2011-02-25 | 2015-10-13 | Edwards Lifesciences Corporation | Prosthetic heart valve delivery apparatus |
US9289282B2 (en) | 2011-05-31 | 2016-03-22 | Edwards Lifesciences Corporation | System and method for treating valve insufficiency or vessel dilatation |
WO2012177942A2 (en) | 2011-06-21 | 2012-12-27 | Hanson Gifford, Iii | Prosthetic heart valve devices and associated systems and methods |
WO2013011502A2 (en) | 2011-07-21 | 2013-01-24 | 4Tech Inc. | Method and apparatus for tricuspid valve repair using tension |
US9119716B2 (en) | 2011-07-27 | 2015-09-01 | Edwards Lifesciences Corporation | Delivery systems for prosthetic heart valve |
US9161837B2 (en) | 2011-07-27 | 2015-10-20 | The Cleveland Clinic Foundation | Apparatus, system, and method for treating a regurgitant heart valve |
US10799360B2 (en) | 2011-07-27 | 2020-10-13 | The Cleveland Clinic Foundation | Systems and methods for treating a regurgitant heart valve |
CA2957442C (en) | 2011-08-11 | 2019-06-04 | Tendyne Holdings, Inc. | Improvements for prosthetic valves and related inventions |
US9364637B2 (en) | 2011-09-06 | 2016-06-14 | Medtronic, Inc. | Transcatheter balloon-assisted mitral valve navigation device and method |
US9510948B2 (en) | 2011-09-09 | 2016-12-06 | Emory University | Systems, devices and methods for repair of heart valve lesions |
EP2750630B1 (en) | 2011-10-19 | 2021-06-30 | Twelve, Inc. | Device for heart valve replacement |
US11202704B2 (en) | 2011-10-19 | 2021-12-21 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
JP6133309B2 (en) | 2011-10-19 | 2017-05-24 | トゥエルヴ, インコーポレイテッド | Prosthetic heart valve device |
US9655722B2 (en) | 2011-10-19 | 2017-05-23 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9763780B2 (en) | 2011-10-19 | 2017-09-19 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
US9039757B2 (en) | 2011-10-19 | 2015-05-26 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9827093B2 (en) | 2011-10-21 | 2017-11-28 | Edwards Lifesciences Cardiaq Llc | Actively controllable stent, stent graft, heart valve and method of controlling same |
EP4049626A1 (en) | 2011-12-09 | 2022-08-31 | Edwards Lifesciences Corporation | Prosthetic heart valve having improved commissure supports |
US8652145B2 (en) | 2011-12-14 | 2014-02-18 | Edwards Lifesciences Corporation | System and method for crimping a prosthetic valve |
US9827092B2 (en) | 2011-12-16 | 2017-11-28 | Tendyne Holdings, Inc. | Tethers for prosthetic mitral valve |
US9078747B2 (en) | 2011-12-21 | 2015-07-14 | Edwards Lifesciences Corporation | Anchoring device for replacing or repairing a heart valve |
ES2785667T3 (en) | 2012-01-31 | 2020-10-07 | Mitral Valve Tech Sarl | Mitral valve restraint devices and systems |
EP3424469A1 (en) | 2012-02-22 | 2019-01-09 | Syntheon TAVR, LLC | Actively controllable stent, stent graft and heart valve |
US9579198B2 (en) | 2012-03-01 | 2017-02-28 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
US9414823B2 (en) | 2012-04-25 | 2016-08-16 | Medtronic Ventor Technologies Ltd. | Hole-closure device |
US9445897B2 (en) | 2012-05-01 | 2016-09-20 | Direct Flow Medical, Inc. | Prosthetic implant delivery device with introducer catheter |
EP2849680B1 (en) | 2012-05-16 | 2019-01-09 | Edwards Lifesciences Corporation | Coaptation element for reducing cardiac valve regurgitation |
US9474605B2 (en) | 2012-05-16 | 2016-10-25 | Edwards Lifesciences Corporation | Devices and methods for reducing cardiac valve regurgitation |
US8961594B2 (en) | 2012-05-31 | 2015-02-24 | 4Tech Inc. | Heart valve repair system |
DE102012010798A1 (en) | 2012-06-01 | 2013-12-05 | Universität Duisburg-Essen | Implantable device for improving or eliminating heart valve insufficiency |
WO2014022124A1 (en) | 2012-07-28 | 2014-02-06 | Tendyne Holdings, Inc. | Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly |
WO2014021905A1 (en) * | 2012-07-30 | 2014-02-06 | Tendyne Holdings, Inc. | Improved delivery systems and methods for transcatheter prosthetic valves |
WO2014081796A1 (en) | 2012-11-21 | 2014-05-30 | Edwards Lifesciences Corporation | Retaining mechanisms for prosthetic heart valves |
US9788948B2 (en) | 2013-01-09 | 2017-10-17 | 4 Tech Inc. | Soft tissue anchors and implantation techniques |
US9168129B2 (en) | 2013-02-12 | 2015-10-27 | Edwards Lifesciences Corporation | Artificial heart valve with scalloped frame design |
US9907681B2 (en) | 2013-03-14 | 2018-03-06 | 4Tech Inc. | Stent with tether interface |
US9232998B2 (en) | 2013-03-15 | 2016-01-12 | Cardiosolutions Inc. | Trans-apical implant systems, implants and methods |
US9289297B2 (en) | 2013-03-15 | 2016-03-22 | Cardiosolutions, Inc. | Mitral valve spacer and system and method for implanting the same |
US11224510B2 (en) | 2013-04-02 | 2022-01-18 | Tendyne Holdings, Inc. | Prosthetic heart valve and systems and methods for delivering the same |
US10463489B2 (en) | 2013-04-02 | 2019-11-05 | Tendyne Holdings, Inc. | Prosthetic heart valve and systems and methods for delivering the same |
US10478293B2 (en) | 2013-04-04 | 2019-11-19 | Tendyne Holdings, Inc. | Retrieval and repositioning system for prosthetic heart valve |
TR201816620T4 (en) | 2013-05-20 | 2018-11-21 | Edwards Lifesciences Corp | Heart valve prosthesis delivery device. |
AU2014268631B2 (en) | 2013-05-20 | 2019-08-01 | Twelve, Inc. | Implantable heart valve devices, mitral valve repair devices and associated systems and methods |
US9610159B2 (en) | 2013-05-30 | 2017-04-04 | Tendyne Holdings, Inc. | Structural members for prosthetic mitral valves |
CN105473107B (en) | 2013-06-14 | 2018-05-11 | 心脏解决方案有限公司 | Bicuspid valve spacer and its implant system and method |
CN108814772B (en) | 2013-06-25 | 2020-09-08 | 坦迪尼控股股份有限公司 | Thrombus management and structural compliance features for prosthetic heart valves |
AU2014296087B2 (en) | 2013-08-01 | 2019-08-01 | Tendyne Holdings, Inc. | Epicardial anchor devices and methods |
WO2015023579A1 (en) | 2013-08-12 | 2015-02-19 | Mitral Valve Technologies Sa | Apparatus and methods for implanting a replacement heart valve |
LT3545906T (en) | 2013-08-14 | 2021-03-10 | Mitral Valve Technologies Sarl | Replacement heart valve apparatus |
US10195028B2 (en) | 2013-09-10 | 2019-02-05 | Edwards Lifesciences Corporation | Magnetic retaining mechanisms for prosthetic valves |
WO2015058039A1 (en) | 2013-10-17 | 2015-04-23 | Robert Vidlund | Apparatus and methods for alignment and deployment of intracardiac devices |
US10166098B2 (en) | 2013-10-25 | 2019-01-01 | Middle Peak Medical, Inc. | Systems and methods for transcatheter treatment of valve regurgitation |
EP3656353A1 (en) | 2013-10-28 | 2020-05-27 | Tendyne Holdings, Inc. | Prosthetic heart valve and systems for delivering the same |
US9526611B2 (en) | 2013-10-29 | 2016-12-27 | Tendyne Holdings, Inc. | Apparatus and methods for delivery of transcatheter prosthetic valves |
EP3062709A2 (en) | 2013-10-30 | 2016-09-07 | 4Tech Inc. | Multiple anchoring-point tension system |
US10022114B2 (en) | 2013-10-30 | 2018-07-17 | 4Tech Inc. | Percutaneous tether locking |
US10052095B2 (en) | 2013-10-30 | 2018-08-21 | 4Tech Inc. | Multiple anchoring-point tension system |
CA2934975A1 (en) | 2013-11-11 | 2015-05-14 | Edwards Lifesciences Cardiaq Llc | Systems and methods for manufacturing a stent frame |
US9622863B2 (en) | 2013-11-22 | 2017-04-18 | Edwards Lifesciences Corporation | Aortic insufficiency repair device and method |
DE102013017993A1 (en) | 2013-11-29 | 2015-06-03 | Universität Duisburg-Essen | Implantable device for improving or eliminating heart valve insufficiency |
US10098734B2 (en) | 2013-12-05 | 2018-10-16 | Edwards Lifesciences Corporation | Prosthetic heart valve and delivery apparatus |
US9901444B2 (en) | 2013-12-17 | 2018-02-27 | Edwards Lifesciences Corporation | Inverted valve structure |
WO2015120122A2 (en) | 2014-02-05 | 2015-08-13 | Robert Vidlund | Apparatus and methods for transfemoral delivery of prosthetic mitral valve |
US9986993B2 (en) | 2014-02-11 | 2018-06-05 | Tendyne Holdings, Inc. | Adjustable tether and epicardial pad system for prosthetic heart valve |
EP3107500B1 (en) | 2014-02-18 | 2021-11-24 | Edwards Lifesciences Corporation | Flexible commissure frame |
JP2017506118A (en) | 2014-02-20 | 2017-03-02 | マイトラル・ヴァルヴ・テクノロジーズ・エス・アー・エール・エル | Coiled anchor, prosthetic heart valve, and deployment device for supporting a prosthetic heart valve |
EP3107498B1 (en) | 2014-02-21 | 2020-09-30 | Mitral Valve Technologies Sàrl | Prosthetic mitral valve with anchoring device |
CN106068109B (en) | 2014-03-10 | 2019-07-23 | 坦迪尼控股股份有限公司 | Device and method for positioning and monitoring the tether load of prosthetic mitral valve |
US10154904B2 (en) | 2014-04-28 | 2018-12-18 | Edwards Lifesciences Corporation | Intravascular introducer devices |
US10195025B2 (en) | 2014-05-12 | 2019-02-05 | Edwards Lifesciences Corporation | Prosthetic heart valve |
CA2958061A1 (en) | 2014-06-18 | 2015-12-23 | Middle Peak Medical, Inc. | Mitral valve implants for the treatment of valvular regurgitation |
EP3157607B1 (en) | 2014-06-19 | 2019-08-07 | 4Tech Inc. | Cardiac tissue cinching |
JP6740140B2 (en) | 2014-06-24 | 2020-08-12 | ポラレス・メディカル・インコーポレイテッド | System and method for securing an implant |
US10016272B2 (en) | 2014-09-12 | 2018-07-10 | Mitral Valve Technologies Sarl | Mitral repair and replacement devices and methods |
EP3200726B1 (en) | 2014-09-29 | 2023-07-05 | The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin | A heart valve treatment device |
US20160144156A1 (en) | 2014-11-20 | 2016-05-26 | Edwards Lifesciences Corporation | Inflatable device with etched modifications |
EP3284412A1 (en) | 2014-12-02 | 2018-02-21 | 4Tech Inc. | Off-center tissue anchors |
CR20170245A (en) | 2014-12-05 | 2017-09-14 | Edwards Lifesciences Corp | DIRIGIBLE CATETER WITH TRACTION CABLE |
JP6826035B2 (en) | 2015-01-07 | 2021-02-03 | テンダイン ホールディングス,インコーポレイテッド | Artificial mitral valve, and devices and methods for its delivery |
CN107896484B (en) | 2015-02-05 | 2020-09-08 | 坦迪尼控股股份有限公司 | Expandable epicardial pad and delivery devices and methods therefor |
US10231834B2 (en) | 2015-02-09 | 2019-03-19 | Edwards Lifesciences Corporation | Low profile transseptal catheter and implant system for minimally invasive valve procedure |
US10105226B2 (en) | 2015-02-10 | 2018-10-23 | Edwards Lifesciences Corporation | Offset cardiac leaflet coaptation element |
US10039637B2 (en) | 2015-02-11 | 2018-08-07 | Edwards Lifesciences Corporation | Heart valve docking devices and implanting methods |
US10327896B2 (en) | 2015-04-10 | 2019-06-25 | Edwards Lifesciences Corporation | Expandable sheath with elastomeric cross sectional portions |
US10792471B2 (en) | 2015-04-10 | 2020-10-06 | Edwards Lifesciences Corporation | Expandable sheath |
JP6694948B2 (en) | 2015-04-16 | 2020-05-20 | テンダイン ホールディングス,インコーポレイテッド | Device and method for delivery, repositioning and retrieval of a transcatheter prosthetic valve |
US10232564B2 (en) | 2015-04-29 | 2019-03-19 | Edwards Lifesciences Corporation | Laminated sealing member for prosthetic heart valve |
US9974650B2 (en) | 2015-07-14 | 2018-05-22 | Edwards Lifesciences Corporation | Prosthetic heart valve |
US10179046B2 (en) | 2015-08-14 | 2019-01-15 | Edwards Lifesciences Corporation | Gripping and pushing device for medical instrument |
US11026788B2 (en) | 2015-08-20 | 2021-06-08 | Edwards Lifesciences Corporation | Loader and retriever for transcatheter heart valve, and methods of crimping transcatheter heart valve |
JP7111610B2 (en) | 2015-08-21 | 2022-08-02 | トゥエルヴ, インコーポレイテッド | Implantable Heart Valve Devices, Mitral Valve Repair Devices, and Related Systems and Methods |
US10588744B2 (en) | 2015-09-04 | 2020-03-17 | Edwards Lifesciences Corporation | Delivery system for prosthetic heart valve |
US10327894B2 (en) | 2015-09-18 | 2019-06-25 | Tendyne Holdings, Inc. | Methods for delivery of prosthetic mitral valves |
US10314703B2 (en) | 2015-09-21 | 2019-06-11 | Edwards Lifesciences Corporation | Cylindrical implant and balloon |
US10350067B2 (en) | 2015-10-26 | 2019-07-16 | Edwards Lifesciences Corporation | Implant delivery capsule |
US11259920B2 (en) | 2015-11-03 | 2022-03-01 | Edwards Lifesciences Corporation | Adapter for prosthesis delivery device and methods of use |
US9592121B1 (en) | 2015-11-06 | 2017-03-14 | Middle Peak Medical, Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
US10321996B2 (en) | 2015-11-11 | 2019-06-18 | Edwards Lifesciences Corporation | Prosthetic valve delivery apparatus having clutch mechanism |
US10265169B2 (en) | 2015-11-23 | 2019-04-23 | Edwards Lifesciences Corporation | Apparatus for controlled heart valve delivery |
US11033387B2 (en) | 2015-11-23 | 2021-06-15 | Edwards Lifesciences Corporation | Methods for controlled heart valve delivery |
US10583007B2 (en) | 2015-12-02 | 2020-03-10 | Edwards Lifesciences Corporation | Suture deployment of prosthetic heart valve |
CN108430391B (en) | 2015-12-03 | 2020-09-08 | 坦迪尼控股股份有限公司 | Frame features for prosthetic mitral valves |
US10357351B2 (en) | 2015-12-04 | 2019-07-23 | Edwards Lifesciences Corporation | Storage assembly for prosthetic valve |
US11008676B2 (en) | 2015-12-16 | 2021-05-18 | Edwards Lifesciences Corporation | Textured woven fabric for use in implantable bioprostheses |
CN108366859B (en) | 2015-12-28 | 2021-02-05 | 坦迪尼控股股份有限公司 | Atrial capsular bag closure for prosthetic heart valves |
US10363130B2 (en) | 2016-02-05 | 2019-07-30 | Edwards Lifesciences Corporation | Devices and systems for docking a heart valve |
US10179043B2 (en) | 2016-02-12 | 2019-01-15 | Edwards Lifesciences Corporation | Prosthetic heart valve having multi-level sealing member |
US10779941B2 (en) | 2016-03-08 | 2020-09-22 | Edwards Lifesciences Corporation | Delivery cylinder for prosthetic implant |
US11219746B2 (en) | 2016-03-21 | 2022-01-11 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799677B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799676B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
WO2017165842A1 (en) | 2016-03-24 | 2017-09-28 | Edwards Lifesciences Corporation | Delivery system for prosthetic heart valve |
US10159569B2 (en) | 2016-04-12 | 2018-12-25 | Lars Erickson | Minimally invasive atrio-ventricular valve treatment by chordae adjustment |
US10799358B2 (en) | 2016-04-12 | 2020-10-13 | Lars Erickson | Catheter system for selectively manipulating and connecting cardiac tissues |
EP3448316B1 (en) | 2016-04-29 | 2023-03-29 | Medtronic Vascular Inc. | Prosthetic heart valve devices with tethered anchors |
US10470877B2 (en) | 2016-05-03 | 2019-11-12 | Tendyne Holdings, Inc. | Apparatus and methods for anterior valve leaflet management |
WO2017218375A1 (en) | 2016-06-13 | 2017-12-21 | Tendyne Holdings, Inc. | Sequential delivery of two-part prosthetic mitral valve |
CN109640887B (en) | 2016-06-30 | 2021-03-16 | 坦迪尼控股股份有限公司 | Prosthetic heart valve and apparatus and method for delivering same |
US10828150B2 (en) | 2016-07-08 | 2020-11-10 | Edwards Lifesciences Corporation | Docking station for heart valve prosthesis |
US10856981B2 (en) | 2016-07-08 | 2020-12-08 | Edwards Lifesciences Corporation | Expandable sheath and methods of using the same |
EP3484411A1 (en) | 2016-07-12 | 2019-05-22 | Tendyne Holdings, Inc. | Apparatus and methods for trans-septal retrieval of prosthetic heart valves |
US11096781B2 (en) | 2016-08-01 | 2021-08-24 | Edwards Lifesciences Corporation | Prosthetic heart valve |
EP3496665B1 (en) | 2016-08-15 | 2023-11-15 | The Cleveland Clinic Foundation | Apparatuses for at least partially supporting a valve leaflet of a regurgitant heart valve |
CR20190069A (en) | 2016-08-26 | 2019-05-14 | Edwards Lifesciences Corp | Heart valve docking coils and systems |
US10722359B2 (en) | 2016-08-26 | 2020-07-28 | Edwards Lifesciences Corporation | Heart valve docking devices and systems |
US10357361B2 (en) | 2016-09-15 | 2019-07-23 | Edwards Lifesciences Corporation | Heart valve pinch devices and delivery systems |
US10575944B2 (en) | 2016-09-22 | 2020-03-03 | Edwards Lifesciences Corporation | Prosthetic heart valve with reduced stitching |
US10973631B2 (en) | 2016-11-17 | 2021-04-13 | Edwards Lifesciences Corporation | Crimping accessory device for a prosthetic valve |
US10463484B2 (en) | 2016-11-17 | 2019-11-05 | Edwards Lifesciences Corporation | Prosthetic heart valve having leaflet inflow below frame |
US10603165B2 (en) | 2016-12-06 | 2020-03-31 | Edwards Lifesciences Corporation | Mechanically expanding heart valve and delivery apparatus therefor |
PT3554424T (en) | 2016-12-16 | 2023-04-03 | Edwards Lifesciences Corp | Deployment systems, tools, and methods for delivering an anchoring device for a prosthetic valve |
CR20190308A (en) | 2016-12-20 | 2020-01-24 | Edwards Lifesciences Corp | Systems and mechanisms for deploying a docking device for a replacement heart valve |
US10813749B2 (en) | 2016-12-20 | 2020-10-27 | Edwards Lifesciences Corporation | Docking device made with 3D woven fabric |
CN115137529A (en) | 2016-12-21 | 2022-10-04 | 特里弗洛心血管公司 | Heart valve support devices and methods for making and using the same |
US11654023B2 (en) | 2017-01-23 | 2023-05-23 | Edwards Lifesciences Corporation | Covered prosthetic heart valve |
US11013600B2 (en) | 2017-01-23 | 2021-05-25 | Edwards Lifesciences Corporation | Covered prosthetic heart valve |
US11185406B2 (en) | 2017-01-23 | 2021-11-30 | Edwards Lifesciences Corporation | Covered prosthetic heart valve |
USD867595S1 (en) | 2017-02-01 | 2019-11-19 | Edwards Lifesciences Corporation | Stent |
US10653524B2 (en) | 2017-03-13 | 2020-05-19 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
US10478303B2 (en) | 2017-03-13 | 2019-11-19 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
CN114587711A (en) | 2017-03-13 | 2022-06-07 | 宝来瑞斯医疗有限公司 | Devices, systems, and methods for transcatheter treatment of valve regurgitation |
DE102017002974A1 (en) | 2017-03-28 | 2018-10-04 | Immanuel Diakonie Gmbh | Heart valve implant, suitable for use in minimally invasive surgery for the repair of a heart valve and / or a heart valve beating on the beating heart |
US10575950B2 (en) | 2017-04-18 | 2020-03-03 | Twelve, Inc. | Hydraulic systems for delivering prosthetic heart valve devices and associated methods |
LT3682854T (en) | 2017-04-18 | 2022-03-10 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10433961B2 (en) | 2017-04-18 | 2019-10-08 | Twelve, Inc. | Delivery systems with tethers for prosthetic heart valve devices and associated methods |
US10702378B2 (en) | 2017-04-18 | 2020-07-07 | Twelve, Inc. | Prosthetic heart valve device and associated systems and methods |
US11224511B2 (en) | 2017-04-18 | 2022-01-18 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10973634B2 (en) | 2017-04-26 | 2021-04-13 | Edwards Lifesciences Corporation | Delivery apparatus for a prosthetic heart valve |
US10959846B2 (en) | 2017-05-10 | 2021-03-30 | Edwards Lifesciences Corporation | Mitral valve spacer device |
US10792151B2 (en) | 2017-05-11 | 2020-10-06 | Twelve, Inc. | Delivery systems for delivering prosthetic heart valve devices and associated methods |
US10842619B2 (en) | 2017-05-12 | 2020-11-24 | Edwards Lifesciences Corporation | Prosthetic heart valve docking assembly |
US11135056B2 (en) | 2017-05-15 | 2021-10-05 | Edwards Lifesciences Corporation | Devices and methods of commissure formation for prosthetic heart valve |
CN110650711B (en) | 2017-05-22 | 2022-04-01 | 爱德华兹生命科学公司 | Valve anchors and methods of installation |
US20210401571A9 (en) | 2017-05-31 | 2021-12-30 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
US10646338B2 (en) | 2017-06-02 | 2020-05-12 | Twelve, Inc. | Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods |
US11026785B2 (en) | 2017-06-05 | 2021-06-08 | Edwards Lifesciences Corporation | Mechanically expandable heart valve |
US10869759B2 (en) | 2017-06-05 | 2020-12-22 | Edwards Lifesciences Corporation | Mechanically expandable heart valve |
US10709591B2 (en) | 2017-06-06 | 2020-07-14 | Twelve, Inc. | Crimping device and method for loading stents and prosthetic heart valves |
US10639152B2 (en) | 2017-06-21 | 2020-05-05 | Edwards Lifesciences Corporation | Expandable sheath and methods of using the same |
JP7277389B2 (en) | 2017-06-30 | 2023-05-18 | エドワーズ ライフサイエンシーズ コーポレイション | Docking station for transcatheter valves |
SG11201913126YA (en) | 2017-06-30 | 2020-01-30 | Edwards Lifesciences Corp | Lock and release mechanisms for trans-catheter implantable devices |
US10729541B2 (en) | 2017-07-06 | 2020-08-04 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10786352B2 (en) | 2017-07-06 | 2020-09-29 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10857334B2 (en) | 2017-07-12 | 2020-12-08 | Edwards Lifesciences Corporation | Reduced operation force inflator |
US11154399B2 (en) | 2017-07-13 | 2021-10-26 | Tendyne Holdings, Inc. | Prosthetic heart valves and apparatus and methods for delivery of same |
US10918473B2 (en) | 2017-07-18 | 2021-02-16 | Edwards Lifesciences Corporation | Transcatheter heart valve storage container and crimping mechanism |
KR101965637B1 (en) | 2017-07-31 | 2019-04-03 | (주) 타우피엔유메디칼 | A device for the treatment of tricuspid regurgitation in the pulmonary artery |
KR101972991B1 (en) | 2017-07-31 | 2019-08-16 | (주) 타우피엔유메디칼 | Equipment for the treatment of tricuspid regurgitation |
IL301081A (en) | 2017-08-11 | 2023-05-01 | Edwards Lifesciences Corp | Sealing element for prosthetic heart valve |
US11083575B2 (en) | 2017-08-14 | 2021-08-10 | Edwards Lifesciences Corporation | Heart valve frame design with non-uniform struts |
US10932903B2 (en) | 2017-08-15 | 2021-03-02 | Edwards Lifesciences Corporation | Skirt assembly for implantable prosthetic valve |
US10898319B2 (en) | 2017-08-17 | 2021-01-26 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
US10973628B2 (en) | 2017-08-18 | 2021-04-13 | Edwards Lifesciences Corporation | Pericardial sealing member for prosthetic heart valve |
US10722353B2 (en) | 2017-08-21 | 2020-07-28 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
USD890333S1 (en) | 2017-08-21 | 2020-07-14 | Edwards Lifesciences Corporation | Heart valve docking coil |
US10806573B2 (en) | 2017-08-22 | 2020-10-20 | Edwards Lifesciences Corporation | Gear drive mechanism for heart valve delivery apparatus |
US11141145B2 (en) | 2017-08-25 | 2021-10-12 | Edwards Lifesciences Corporation | Devices and methods for securing a tissue anchor |
JP7291124B2 (en) | 2017-08-28 | 2023-06-14 | テンダイン ホールディングス,インコーポレイテッド | Heart valve prosthesis with tethered connections |
US11173032B2 (en) | 2017-08-28 | 2021-11-16 | Edwards Lifesciences Corporation | Transcatheter device for treating mitral regurgitation |
US11051939B2 (en) | 2017-08-31 | 2021-07-06 | Edwards Lifesciences Corporation | Active introducer sheath system |
US10973629B2 (en) | 2017-09-06 | 2021-04-13 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
US11065117B2 (en) | 2017-09-08 | 2021-07-20 | Edwards Lifesciences Corporation | Axisymmetric adjustable device for treating mitral regurgitation |
US11147667B2 (en) | 2017-09-08 | 2021-10-19 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
IL305364A (en) | 2017-10-18 | 2023-10-01 | Edwards Lifesciences Corp | Catheter assembly |
US11207499B2 (en) | 2017-10-20 | 2021-12-28 | Edwards Lifesciences Corporation | Steerable catheter |
US10799350B2 (en) | 2018-01-05 | 2020-10-13 | Edwards Lifesciences Corporation | Percutaneous implant retrieval connector and method |
WO2019144121A1 (en) | 2018-01-22 | 2019-07-25 | Edwards Lifesciences Corporation | Heart shape preserving anchor |
WO2019154927A1 (en) | 2018-02-09 | 2019-08-15 | The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | A heart valve therapeutic device |
US11026791B2 (en) | 2018-03-20 | 2021-06-08 | Medtronic Vascular, Inc. | Flexible canopy valve repair systems and methods of use |
US11285003B2 (en) | 2018-03-20 | 2022-03-29 | Medtronic Vascular, Inc. | Prolapse prevention device and methods of use thereof |
US11318011B2 (en) | 2018-04-27 | 2022-05-03 | Edwards Lifesciences Corporation | Mechanically expandable heart valve with leaflet clamps |
US11007061B2 (en) | 2018-05-24 | 2021-05-18 | Edwards Lifesciences Corporation | Adjustable percutaneous heart valve repair system |
US11844914B2 (en) | 2018-06-05 | 2023-12-19 | Edwards Lifesciences Corporation | Removable volume indicator for syringe |
KR20210082188A (en) | 2018-10-19 | 2021-07-02 | 에드워즈 라이프사이언시스 코포레이션 | Artificial heart valve with non-cylindrical frame |
US11779728B2 (en) | 2018-11-01 | 2023-10-10 | Edwards Lifesciences Corporation | Introducer sheath with expandable introducer |
KR102268984B1 (en) | 2019-01-17 | 2021-06-24 | (주) 타우피엔유메디칼 | A device for the treatment of position-adjustable tricuspid regurgitation |
CN111437065A (en) | 2019-01-17 | 2020-07-24 | TauPNU医疗有限公司 | Position-adjustable tricuspid valve backflow surgical instrument |
KR102156647B1 (en) | 2019-01-21 | 2020-09-16 | (주) 타우피엔유메디칼 | An assembled device for treatment of tricuspid regurgitation |
WO2020198273A2 (en) | 2019-03-26 | 2020-10-01 | Edwards Lifesciences Corporation | Prosthetic heart valve |
KR102268993B1 (en) | 2019-05-16 | 2021-06-24 | (주) 타우피엔유메디칼 | A device for the treatment of tricuspid regurgitation with position fixing tube |
US10842628B1 (en) | 2019-05-22 | 2020-11-24 | TriFlo Cardiovascular Inc. | Heart valve support device |
WO2021024183A1 (en) | 2019-08-05 | 2021-02-11 | Croivalve Ltd. | Apparatus and methods for treating a defective cardiac valve |
CN114901212A (en) * | 2019-08-08 | 2022-08-12 | 透壁系统有限责任公司 | Valvuloplasty and pacing procedures, related devices and methods |
EP3831343B1 (en) | 2019-12-05 | 2024-01-31 | Tendyne Holdings, Inc. | Braided anchor for mitral valve |
US11648114B2 (en) | 2019-12-20 | 2023-05-16 | Tendyne Holdings, Inc. | Distally loaded sheath and loading funnel |
US11951002B2 (en) | 2020-03-30 | 2024-04-09 | Tendyne Holdings, Inc. | Apparatus and methods for valve and tether fixation |
US11395910B2 (en) | 2020-05-20 | 2022-07-26 | Rainbow Medical Ltd. | Passive pump |
WO2021257774A1 (en) | 2020-06-18 | 2021-12-23 | Edwards Lifesciences Corporation | Crimping methods |
WO2022039853A1 (en) | 2020-08-19 | 2022-02-24 | Tendyne Holdings, Inc. | Fully-transseptal apical pad with pulley for tensioning |
AU2021330813A1 (en) | 2020-08-24 | 2023-03-02 | Edwards Lifesciences Corporation | Methods and systems for aligning a commissure of a prosthetic heart valve with a commissure of a native valve |
CA3193292A1 (en) | 2020-08-31 | 2022-03-03 | Edwards Lifesciences Corporation | Systems and methods for crimping and device preparation |
US11266502B1 (en) | 2020-12-14 | 2022-03-08 | Versa Vascular Inc. | System and method for cardiac valve repair |
US11464634B2 (en) | 2020-12-16 | 2022-10-11 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation with secondary anchors |
US11759321B2 (en) | 2021-06-25 | 2023-09-19 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
WO2023002256A1 (en) | 2021-07-22 | 2023-01-26 | Mtex Cardio Ag | Cardiac leaflet coapters |
US11357629B1 (en) | 2021-10-25 | 2022-06-14 | Rainbow Medical Ltd. | Diastolic heart failure treatment |
US11484700B1 (en) | 2021-10-25 | 2022-11-01 | Yossi Gross | Mechanical treatment of heart failure |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5582607A (en) * | 1994-09-09 | 1996-12-10 | Carbomedics, Inc. | Heart valve prosthesis rotator with bendable shaft and drive mechanism |
US6769434B2 (en) * | 2000-06-30 | 2004-08-03 | Viacor, Inc. | Method and apparatus for performing a procedure on a cardiac valve |
US20070093890A1 (en) * | 2005-10-26 | 2007-04-26 | Eliasen Kenneth A | Heart valve implant |
US20070213578A1 (en) * | 1999-08-09 | 2007-09-13 | Alexander Khairkhahan | System for improving cardiac function |
US20070255399A1 (en) * | 2005-10-26 | 2007-11-01 | Eliasen Kenneth A | Balloon Mitral Spacer |
Family Cites Families (198)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2549731A (en) * | 1944-12-18 | 1951-04-17 | Vincent E Wattley | Flexible test prod |
US2625967A (en) * | 1949-12-19 | 1953-01-20 | Illinois Tool Works | Screw-holding and screw-driving tool |
US3197788A (en) | 1962-04-23 | 1965-08-03 | Inst Of Medical Sciences | Prosthetic valve for cardiac surgery |
US3445916A (en) | 1967-04-19 | 1969-05-27 | Rudolf R Schulte | Method for making an anatomical check valve |
US3551913A (en) | 1968-04-02 | 1971-01-05 | Donald P Shiley | Heart valve prosthesis with guard structure |
GB1268484A (en) | 1968-06-28 | 1972-03-29 | Brian John Bellhouse | Improvements relating to non-return valves particularly as prosthetics |
US3589392A (en) | 1969-05-05 | 1971-06-29 | Louis C Meyer | Split leaflet check valve for cardiac surgery and the like |
US3586029A (en) | 1969-06-16 | 1971-06-22 | Aero Flow Dynamics Inc | Apparatus for automatically controlling fluid flow according to predetermined volumetric proportions |
US3671979A (en) | 1969-09-23 | 1972-06-27 | Univ Utah | Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve |
GB1264472A (en) | 1969-09-25 | 1972-02-23 | ||
US3689942A (en) * | 1969-11-28 | 1972-09-12 | Richard K Rapp | Prosthetic heart valve |
US3739402A (en) | 1970-10-15 | 1973-06-19 | Cutter Lab | Bicuspid fascia lata valve |
US3714671A (en) | 1970-11-30 | 1973-02-06 | Cutter Lab | Tissue-type heart valve with a graft support ring or stent |
US3737919A (en) | 1971-03-16 | 1973-06-12 | Univ Minnesota | Pivoted disc-type heart valve |
US4291420A (en) | 1973-11-09 | 1981-09-29 | Medac Gesellschaft Fur Klinische Spezialpraparate Mbh | Artificial heart valve |
US3983581A (en) | 1975-01-20 | 1976-10-05 | William W. Angell | Heart valve stent |
AR206762A1 (en) | 1976-01-01 | 1976-08-13 | Pisanu A | LOW PROFILE BIOPROTHESIS DERIVED FROM PORCINE HETEROLOGICAL AORTIC VALVE |
US4084268A (en) | 1976-04-22 | 1978-04-18 | Shiley Laboratories, Incorporated | Prosthetic tissue heart valve |
US4297749A (en) | 1977-04-25 | 1981-11-03 | Albany International Corp. | Heart valve prosthesis |
AR221872A1 (en) | 1979-03-16 | 1981-03-31 | Liotta Domingo S | IMPROVEMENTS IN IMPANTABLE HEART VALVES |
EP0125393B1 (en) | 1980-11-03 | 1987-12-09 | Shiley Incorporated | Prosthetic heart valve |
US4439185A (en) * | 1981-10-21 | 1984-03-27 | Advanced Cardiovascular Systems, Inc. | Inflating and deflating device for vascular dilating catheter assembly |
AU8398782A (en) | 1982-03-12 | 1983-10-24 | Webster, Wilton W. Jr. | Autoinflatable catheter |
US4597767A (en) | 1982-12-15 | 1986-07-01 | Andrew Lenkei | Split leaflet heart valve |
US4865030A (en) * | 1987-01-21 | 1989-09-12 | American Medical Systems, Inc. | Apparatus for removal of objects from body passages |
US4960424A (en) * | 1988-06-30 | 1990-10-02 | Grooters Ronald K | Method of replacing a defective atrio-ventricular valve with a total atrio-ventricular valve bioprosthesis |
US5002067A (en) * | 1989-08-23 | 1991-03-26 | Medtronic, Inc. | Medical electrical lead employing improved penetrating electrode |
US5665100A (en) * | 1989-12-05 | 1997-09-09 | Yoon; Inbae | Multifunctional instrument with interchangeable operating units for performing endoscopic procedures |
US5797958A (en) * | 1989-12-05 | 1998-08-25 | Yoon; Inbae | Endoscopic grasping instrument with scissors |
US5411552A (en) | 1990-05-18 | 1995-05-02 | Andersen; Henning R. | Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis |
DK124690D0 (en) | 1990-05-18 | 1990-05-18 | Henning Rud Andersen | FAT PROTECTION FOR IMPLEMENTATION IN THE BODY FOR REPLACEMENT OF NATURAL FLEET AND CATS FOR USE IN IMPLEMENTING A SUCH FAT PROTECTION |
GB9012716D0 (en) | 1990-06-07 | 1990-08-01 | Frater Robert W M | Mitral heart valve replacements |
US5397351A (en) | 1991-05-13 | 1995-03-14 | Pavcnik; Dusan | Prosthetic valve for percutaneous insertion |
US5217484A (en) * | 1991-06-07 | 1993-06-08 | Marks Michael P | Retractable-wire catheter device and method |
US5370685A (en) * | 1991-07-16 | 1994-12-06 | Stanford Surgical Technologies, Inc. | Endovascular aortic valve replacement |
US5261916A (en) * | 1991-12-12 | 1993-11-16 | Target Therapeutics | Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling |
KR0137691B1 (en) * | 1991-12-12 | 1998-04-27 | 티. 엔겔슨 에릭 | Detachable pusher vasoocclusive coil assembly with interlocking coupling |
US5222973A (en) * | 1992-03-09 | 1993-06-29 | Sharpe Endosurgical Corporation | Endoscopic grasping tool surgical instrument |
US5318589A (en) * | 1992-04-15 | 1994-06-07 | Microsurge, Inc. | Surgical instrument for endoscopic surgery |
US5308357A (en) * | 1992-08-21 | 1994-05-03 | Microsurge, Inc. | Handle mechanism for manual instruments |
US5350397A (en) * | 1992-11-13 | 1994-09-27 | Target Therapeutics, Inc. | Axially detachable embolic coil assembly |
US6283127B1 (en) | 1992-12-03 | 2001-09-04 | Wesley D. Sterman | Devices and methods for intracardiac procedures |
US5462527A (en) * | 1993-06-29 | 1995-10-31 | C.R. Bard, Inc. | Actuator for use with steerable catheter |
US5638827A (en) * | 1994-02-01 | 1997-06-17 | Symbiosis Corporation | Super-elastic flexible jaws assembly for an endoscopic multiple sample bioptome |
US5611800A (en) * | 1994-02-15 | 1997-03-18 | Alphatec Manufacturing, Inc. | Spinal fixation system |
US5509428A (en) | 1994-05-31 | 1996-04-23 | Dunlop; Richard W. | Method and apparatus for the creation of tricuspid regurgitation |
US5554185A (en) | 1994-07-18 | 1996-09-10 | Block; Peter C. | Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same |
US6217610B1 (en) | 1994-07-29 | 2001-04-17 | Edwards Lifesciences Corporation | Expandable annuloplasty ring |
US5814062A (en) | 1994-12-22 | 1998-09-29 | Target Therapeutics, Inc. | Implant delivery assembly with expandable coupling/decoupling mechanism |
US5634936A (en) | 1995-02-06 | 1997-06-03 | Scimed Life Systems, Inc. | Device for closing a septal defect |
US5814098A (en) | 1995-06-07 | 1998-09-29 | St. Jude Medical, Inc. | Adjustable sizing apparatus |
US5989242A (en) * | 1995-06-26 | 1999-11-23 | Trimedyne, Inc. | Therapeutic appliance releasing device |
US5653712A (en) * | 1995-10-02 | 1997-08-05 | Stern; Howard G. | Intramedullary bone groover |
US5649949A (en) * | 1996-03-14 | 1997-07-22 | Target Therapeutics, Inc. | Variable cross-section conical vasoocclusive coils |
US5993474A (en) * | 1996-06-11 | 1999-11-30 | Asahi Kogaku Kogyo Kabushiki Kaisha | Treatment accessory for endoscope |
US5792179A (en) | 1996-07-16 | 1998-08-11 | Sideris; Eleftherios B. | Retrievable cardiac balloon placement |
US5776075A (en) * | 1996-08-09 | 1998-07-07 | Symbiosis Corporation | Endoscopic bioptome jaw assembly having three or more jaws and an endoscopic instrument incorporating same |
US5895391A (en) * | 1996-09-27 | 1999-04-20 | Target Therapeutics, Inc. | Ball lock joint and introducer for vaso-occlusive member |
EP0850607A1 (en) | 1996-12-31 | 1998-07-01 | Cordis Corporation | Valve prosthesis for implantation in body channels |
US6406420B1 (en) | 1997-01-02 | 2002-06-18 | Myocor, Inc. | Methods and devices for improving cardiac function in hearts |
US5928224A (en) | 1997-01-24 | 1999-07-27 | Hearten Medical, Inc. | Device for the treatment of damaged heart valve leaflets and methods of using the device |
US6508825B1 (en) | 1997-02-28 | 2003-01-21 | Lumend, Inc. | Apparatus for treating vascular occlusions |
US6090096A (en) | 1997-04-23 | 2000-07-18 | Heartport, Inc. | Antegrade cardioplegia catheter and method |
US5957949A (en) | 1997-05-01 | 1999-09-28 | World Medical Manufacturing Corp. | Percutaneous placement valve stent |
AU9225598A (en) | 1997-09-04 | 1999-03-22 | Endocore, Inc. | Artificial chordae replacement |
US5957865A (en) | 1997-09-25 | 1999-09-28 | Merit Medical Systems, Inc. | Flexible catheter guidewire |
US6332893B1 (en) * | 1997-12-17 | 2001-12-25 | Myocor, Inc. | Valve to myocardium tension members device and method |
US6808498B2 (en) * | 1998-02-13 | 2004-10-26 | Ventrica, Inc. | Placing a guide member into a heart chamber through a coronary vessel and delivering devices for placing the coronary vessel in communication with the heart chamber |
US6945980B2 (en) * | 1998-06-03 | 2005-09-20 | Medtronic, Inc. | Multiple loop tissue connector apparatus and methods |
US6165183A (en) | 1998-07-15 | 2000-12-26 | St. Jude Medical, Inc. | Mitral and tricuspid valve repair |
US6152144A (en) | 1998-11-06 | 2000-11-28 | Appriva Medical, Inc. | Method and device for left atrial appendage occlusion |
US8118822B2 (en) * | 1999-03-01 | 2012-02-21 | Medtronic, Inc. | Bridge clip tissue connector apparatus and methods |
EP2078498B1 (en) | 1999-04-09 | 2010-12-22 | Evalve, Inc. | Apparatus for cardiac valve repair |
US8216256B2 (en) | 1999-04-09 | 2012-07-10 | Evalve, Inc. | Detachment mechanism for implantable fixation devices |
US6283995B1 (en) | 1999-04-15 | 2001-09-04 | Sulzer Carbomedics Inc. | Heart valve leaflet with scalloped free margin |
US6183512B1 (en) * | 1999-04-16 | 2001-02-06 | Edwards Lifesciences Corporation | Flexible annuloplasty system |
US6309417B1 (en) * | 1999-05-12 | 2001-10-30 | Paul A. Spence | Heart valve and apparatus for replacement thereof |
US6287339B1 (en) | 1999-05-27 | 2001-09-11 | Sulzer Carbomedics Inc. | Sutureless heart valve prosthesis |
US7192442B2 (en) * | 1999-06-30 | 2007-03-20 | Edwards Lifesciences Ag | Method and device for treatment of mitral insufficiency |
US6416549B1 (en) * | 1999-07-19 | 2002-07-09 | Sulzer Carbomedics Inc. | Antithrombogenic annuloplasty ring having a biodegradable insert |
ATE284651T1 (en) * | 1999-07-19 | 2005-01-15 | Uimberto Tramonte Silvano | ENDOSSAL DENTAL IMPLANT |
US6994092B2 (en) * | 1999-11-08 | 2006-02-07 | Ev3 Sunnyvale, Inc. | Device for containing embolic material in the LAA having a plurality of tissue retention structures |
US8579966B2 (en) | 1999-11-17 | 2013-11-12 | Medtronic Corevalve Llc | Prosthetic valve for transluminal delivery |
FR2800984B1 (en) | 1999-11-17 | 2001-12-14 | Jacques Seguin | DEVICE FOR REPLACING A HEART VALVE PERCUTANEOUSLY |
US7018406B2 (en) | 1999-11-17 | 2006-03-28 | Corevalve Sa | Prosthetic valve for transluminal delivery |
US6458153B1 (en) | 1999-12-31 | 2002-10-01 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
US6929633B2 (en) | 2000-01-25 | 2005-08-16 | Bacchus Vascular, Inc. | Apparatus and methods for clot dissolution |
MXPA02007253A (en) | 2000-01-27 | 2003-09-22 | 3F Therapeutics Inc | Prosthetic heart valve. |
US20050070999A1 (en) | 2000-02-02 | 2005-03-31 | Spence Paul A. | Heart valve repair apparatus and methods |
US6797002B2 (en) | 2000-02-02 | 2004-09-28 | Paul A. Spence | Heart valve repair apparatus and methods |
US6821297B2 (en) | 2000-02-02 | 2004-11-23 | Robert V. Snyders | Artificial heart valve, implantation instrument and method therefor |
US6478776B1 (en) | 2000-04-05 | 2002-11-12 | Biocardia, Inc. | Implant delivery catheter system and methods for its use |
US6454799B1 (en) | 2000-04-06 | 2002-09-24 | Edwards Lifesciences Corporation | Minimally-invasive heart valves and methods of use |
US7056294B2 (en) | 2000-04-13 | 2006-06-06 | Ev3 Sunnyvale, Inc | Method and apparatus for accessing the left atrial appendage |
US6419695B1 (en) | 2000-05-22 | 2002-07-16 | Shlomo Gabbay | Cardiac prosthesis for helping improve operation of a heart valve |
US6869444B2 (en) | 2000-05-22 | 2005-03-22 | Shlomo Gabbay | Low invasive implantable cardiac prosthesis and method for helping improve operation of a heart valve |
US6440132B1 (en) | 2000-05-24 | 2002-08-27 | Roger P. Jackson | Open head bone screw closure with threaded boss |
US6805711B2 (en) | 2000-06-02 | 2004-10-19 | 3F Therapeutics, Inc. | Expandable medical implant and percutaneous delivery |
US6358277B1 (en) * | 2000-06-21 | 2002-03-19 | The International Heart Institute Of Montana Foundation | Atrio-ventricular valvular device |
US6419696B1 (en) * | 2000-07-06 | 2002-07-16 | Paul A. Spence | Annuloplasty devices and related heart valve repair methods |
DE20013905U1 (en) * | 2000-08-12 | 2000-12-21 | Stryker Trauma Gmbh | Sleeve-shaped device for holding screws when screwing into an object, e.g. into a bone with the help of a screwdriver |
US7510572B2 (en) | 2000-09-12 | 2009-03-31 | Shlomo Gabbay | Implantation system for delivery of a heart valve prosthesis |
US7691144B2 (en) | 2003-10-01 | 2010-04-06 | Mvrx, Inc. | Devices, systems, and methods for reshaping a heart valve annulus |
US6461382B1 (en) | 2000-09-22 | 2002-10-08 | Edwards Lifesciences Corporation | Flexible heart valve having moveable commissures |
US7070618B2 (en) | 2000-10-25 | 2006-07-04 | Viacor, Inc. | Mitral shield |
US6482228B1 (en) | 2000-11-14 | 2002-11-19 | Troy R. Norred | Percutaneous aortic valve replacement |
US6974476B2 (en) | 2003-05-05 | 2005-12-13 | Rex Medical, L.P. | Percutaneous aortic valve |
US6746404B2 (en) | 2000-12-18 | 2004-06-08 | Biosense, Inc. | Method for anchoring a medical device between tissue |
US6454798B1 (en) | 2000-12-21 | 2002-09-24 | Sulzer Carbomedics Inc. | Polymer heart valve with helical coaption surface |
EP1367949B1 (en) | 2001-03-05 | 2008-05-14 | Tyco Healthcare Group Lp | Grasping instrument |
US7186264B2 (en) * | 2001-03-29 | 2007-03-06 | Viacor, Inc. | Method and apparatus for improving mitral valve function |
US20020188170A1 (en) | 2001-04-27 | 2002-12-12 | Santamore William P. | Prevention of myocardial infarction induced ventricular expansion and remodeling |
US6676702B2 (en) * | 2001-05-14 | 2004-01-13 | Cardiac Dimensions, Inc. | Mitral valve therapy assembly and method |
US6673100B2 (en) | 2001-05-25 | 2004-01-06 | Cordis Neurovascular, Inc. | Method and device for retrieving embolic coils |
US6675809B2 (en) * | 2001-08-27 | 2004-01-13 | Richard S. Stack | Satiation devices and methods |
CN101810521B (en) * | 2001-08-27 | 2015-05-13 | 辛尼科有限责任公司 | Satiation devices and methods |
US6592606B2 (en) | 2001-08-31 | 2003-07-15 | Advanced Cardiovascular Systems, Inc. | Hinged short cage for an embolic protection device |
GB0125925D0 (en) * | 2001-10-29 | 2001-12-19 | Univ Glasgow | Mitral valve prosthesis |
US6824562B2 (en) | 2002-05-08 | 2004-11-30 | Cardiac Dimensions, Inc. | Body lumen device anchor, device and assembly |
US6908478B2 (en) * | 2001-12-05 | 2005-06-21 | Cardiac Dimensions, Inc. | Anchor and pull mitral valve device and method |
US6793673B2 (en) * | 2002-12-26 | 2004-09-21 | Cardiac Dimensions, Inc. | System and method to effect mitral valve annulus of a heart |
US6978176B2 (en) | 2001-12-08 | 2005-12-20 | Lattouf Omar M | Treatment for patient with congestive heart failure |
US20030144573A1 (en) | 2001-12-19 | 2003-07-31 | Heilman Marlin S. | Back-flow limiting valve member |
US20030144574A1 (en) | 2001-12-19 | 2003-07-31 | Heilman Marlin S. | Method and apparatus for providing limited back-flow in a blood pump during a non-pumping state |
US6764510B2 (en) | 2002-01-09 | 2004-07-20 | Myocor, Inc. | Devices and methods for heart valve treatment |
DK1487357T3 (en) | 2002-03-15 | 2012-03-19 | Gore & Ass | Coupling system useful for placement of implants |
US7572276B2 (en) | 2002-05-06 | 2009-08-11 | Warsaw Orthopedic, Inc. | Minimally invasive instruments and methods for inserting implants |
AU2003247526A1 (en) * | 2002-06-12 | 2003-12-31 | Mitral Interventions, Inc. | Method and apparatus for tissue connection |
AU2003248750A1 (en) | 2002-06-27 | 2004-01-19 | J. Luis Guerrero | Ventricular remodeling for artioventricular valve regurgitation |
US8348963B2 (en) | 2002-07-03 | 2013-01-08 | Hlt, Inc. | Leaflet reinforcement for regurgitant valves |
KR100442330B1 (en) | 2002-09-03 | 2004-07-30 | 주식회사 엠아이텍 | Stent and manufacturing method the same |
AU2003277118A1 (en) | 2002-10-01 | 2004-04-23 | Ample Medical, Inc. | Devices for retaining native heart valve leaflet |
EP1560545B1 (en) | 2002-10-10 | 2008-07-30 | The Cleveland Clinic Foundation | Apparatus for replacing a mitral valve with a stentless bioprosthetic valve having chordae |
US7112219B2 (en) | 2002-11-12 | 2006-09-26 | Myocor, Inc. | Devices and methods for heart valve treatment |
US7247134B2 (en) | 2002-11-12 | 2007-07-24 | Myocor, Inc. | Devices and methods for heart valve treatment |
US7404824B1 (en) * | 2002-11-15 | 2008-07-29 | Advanced Cardiovascular Systems, Inc. | Valve aptation assist device |
US6830585B1 (en) | 2003-01-14 | 2004-12-14 | 3F Therapeutics, Inc. | Percutaneously deliverable heart valve and methods of implantation |
US7381210B2 (en) | 2003-03-14 | 2008-06-03 | Edwards Lifesciences Corporation | Mitral valve repair system and method for use |
US7473266B2 (en) | 2003-03-14 | 2009-01-06 | Nmt Medical, Inc. | Collet-based delivery system |
US7175656B2 (en) | 2003-04-18 | 2007-02-13 | Alexander Khairkhahan | Percutaneous transcatheter heart valve replacement |
EP1472996B1 (en) * | 2003-04-30 | 2009-09-30 | Medtronic Vascular, Inc. | Percutaneously delivered temporary valve |
TW590007U (en) | 2003-06-06 | 2004-06-01 | Univ Tamkang | Tri-leaflet mechanical heart valve |
US7537592B2 (en) | 2003-06-20 | 2009-05-26 | Plc Medical Systems, Inc. | Endovascular tissue removal device |
US7204255B2 (en) | 2003-07-28 | 2007-04-17 | Plc Medical Systems, Inc. | Endovascular tissue removal device |
US7160322B2 (en) | 2003-08-13 | 2007-01-09 | Shlomo Gabbay | Implantable cardiac prosthesis for mitigating prolapse of a heart valve |
US20050038509A1 (en) | 2003-08-14 | 2005-02-17 | Ashe Kassem Ali | Valve prosthesis including a prosthetic leaflet |
WO2005039392A2 (en) | 2003-10-22 | 2005-05-06 | Endius Incorporated | Method and surgical tool for inserting a longitudinal member |
US7056286B2 (en) | 2003-11-12 | 2006-06-06 | Adrian Ravenscroft | Medical device anchor and delivery system |
WO2005060882A1 (en) * | 2003-12-09 | 2005-07-07 | Gi Dynamics, Inc. | Apparatus to be anchored within the gastrointestinal tract and anchoring method |
US20050159810A1 (en) | 2004-01-15 | 2005-07-21 | Farzan Filsoufi | Devices and methods for repairing cardiac valves |
US8012201B2 (en) | 2004-05-05 | 2011-09-06 | Direct Flow Medical, Inc. | Translumenally implantable heart valve with multiple chamber formed in place support |
US7704268B2 (en) * | 2004-05-07 | 2010-04-27 | Nmt Medical, Inc. | Closure device with hinges |
JP2008513060A (en) | 2004-09-14 | 2008-05-01 | エドワーズ ライフサイエンシーズ アーゲー | Device and method for treatment of heart valve regurgitation |
US7658757B2 (en) | 2004-10-08 | 2010-02-09 | Boston Scientific Scimed, Inc. | Endoprosthesis delivery system |
US20060178700A1 (en) | 2004-12-15 | 2006-08-10 | Martin Quinn | Medical device suitable for use in treatment of a valve |
WO2009053952A2 (en) | 2007-10-26 | 2009-04-30 | Mednua Limited | A medical device for use in treatment of a valve |
WO2006086434A1 (en) | 2005-02-07 | 2006-08-17 | Evalve, Inc. | Methods, systems and devices for cardiac valve repair |
WO2006091597A1 (en) | 2005-02-22 | 2006-08-31 | Cardiofocus, Inc. | Deflectable sheath catheters |
US8083793B2 (en) | 2005-02-28 | 2011-12-27 | Medtronic, Inc. | Two piece heart valves including multiple lobe valves and methods for implanting them |
US20060199995A1 (en) | 2005-03-02 | 2006-09-07 | Venkataramana Vijay | Percutaneous cardiac ventricular geometry restoration device and treatment for heart failure |
SE531468C2 (en) | 2005-04-21 | 2009-04-14 | Edwards Lifesciences Ag | An apparatus for controlling blood flow |
US8002742B2 (en) | 2005-04-22 | 2011-08-23 | Accessclosure, Inc. | Apparatus and methods for sealing a puncture in tissue |
WO2006127509A2 (en) | 2005-05-20 | 2006-11-30 | Mayo Foundation For Medical Education And Research | Devices and methods for reducing cardiac valve regurgitation |
US20060293698A1 (en) | 2005-06-28 | 2006-12-28 | Medtronic Vascular, Inc. | Retainer device for mitral valve leaflets |
WO2007012046A2 (en) | 2005-07-19 | 2007-01-25 | Stout Medical Group, L.P. | Anatomical measurement tool |
US20070049980A1 (en) | 2005-08-30 | 2007-03-01 | Zielinski Todd M | Trans-septal pressure sensor |
US7785366B2 (en) * | 2005-10-26 | 2010-08-31 | Maurer Christopher W | Mitral spacer |
US8852270B2 (en) | 2007-11-15 | 2014-10-07 | Cardiosolutions, Inc. | Implant delivery system and method |
US8216302B2 (en) | 2005-10-26 | 2012-07-10 | Cardiosolutions, Inc. | Implant delivery and deployment system and method |
US9259317B2 (en) | 2008-06-13 | 2016-02-16 | Cardiosolutions, Inc. | System and method for implanting a heart implant |
US8778017B2 (en) | 2005-10-26 | 2014-07-15 | Cardiosolutions, Inc. | Safety for mitral valve implant |
US8052659B2 (en) | 2005-11-10 | 2011-11-08 | Phase One Medical Llc | Catheter device |
WO2007062054A2 (en) | 2005-11-21 | 2007-05-31 | The Brigham And Women's Hospital, Inc. | Percutaneous cardiac valve repair with adjustable artificial chordae |
US20080221566A1 (en) | 2005-11-29 | 2008-09-11 | Krishnan Subramaniam C | Method and apparatus for detecting and achieving closure of patent foramen ovale |
US8142470B2 (en) | 2005-12-01 | 2012-03-27 | Atritech, Inc. | Method for accessing the left atrial appendage with a balloon-tipped transeptal sheath |
US10039531B2 (en) | 2005-12-15 | 2018-08-07 | Georgia Tech Research Corporation | Systems and methods to control the dimension of a heart valve |
EP1959865B1 (en) | 2005-12-15 | 2014-12-10 | The Cleveland Clinic Foundation | Apparatus for treating a regurgitant valve |
EP1962695A1 (en) | 2005-12-22 | 2008-09-03 | NMT Medical, Inc. | Catch members for occluder devices |
US20070185571A1 (en) | 2006-02-06 | 2007-08-09 | The Cleveland Clinic Foundation | Apparatus and method for treating a regurgitant valve |
US20070198050A1 (en) | 2006-02-22 | 2007-08-23 | Phase One Medica, Llc | Medical implant device |
US7536228B2 (en) | 2006-03-24 | 2009-05-19 | Micardia Corporation | Activation device for dynamic ring manipulation |
US7867283B2 (en) * | 2006-05-30 | 2011-01-11 | Boston Scientific Scimed, Inc. | Anti-obesity diverter structure |
CA2652471C (en) | 2006-06-01 | 2014-09-09 | Edwards Lifesciences Corporation | Prosthetic insert for improving heart valve function |
WO2007144865A1 (en) | 2006-06-15 | 2007-12-21 | Mednua Limited | A medical device suitable for use in treatment of a valve |
WO2008028037A2 (en) * | 2006-08-30 | 2008-03-06 | Andrew Young | Distender device and method for treatment of obesity and metabolic and other diseases |
US7657326B2 (en) | 2006-11-08 | 2010-02-02 | Cardiac Pacemakers, Inc. | Cardiac lead with a retractable helix |
US8105392B2 (en) * | 2006-11-08 | 2012-01-31 | Boston Scientific Scimed, Inc. | Pyloric obesity valve |
US8337518B2 (en) | 2006-12-20 | 2012-12-25 | Onset Medical Corporation | Expandable trans-septal sheath |
US20080208328A1 (en) | 2007-02-23 | 2008-08-28 | Endovalve, Inc. | Systems and Methods For Placement of Valve Prosthesis System |
US20080255678A1 (en) * | 2007-04-13 | 2008-10-16 | Cully Edward H | Medical apparatus and method of making the same |
US8480730B2 (en) | 2007-05-14 | 2013-07-09 | Cardiosolutions, Inc. | Solid construct mitral spacer |
US20090105816A1 (en) | 2007-10-19 | 2009-04-23 | Olsen Daniel H | System using a helical retainer in the direct plication annuloplasty treatment of mitral valve regurgitation |
US8597347B2 (en) | 2007-11-15 | 2013-12-03 | Cardiosolutions, Inc. | Heart regurgitation method and apparatus |
US8591460B2 (en) | 2008-06-13 | 2013-11-26 | Cardiosolutions, Inc. | Steerable catheter and dilator and system and method for implanting a heart implant |
JP2012522595A (en) * | 2009-04-03 | 2012-09-27 | メタモディクス インコーポレイテッド | Modular gastrointestinal prosthesis |
US9278019B2 (en) * | 2009-04-03 | 2016-03-08 | Metamodix, Inc | Anchors and methods for intestinal bypass sleeves |
ES2593753T3 (en) * | 2010-10-19 | 2016-12-13 | Apollo Endosurgery, Inc. | Duodenal sleeve with anchor without perforation |
US9554932B2 (en) * | 2013-03-15 | 2017-01-31 | Ez-Off Weight Loss, Llc | System and method for gastric restriction and malabsorption |
-
2007
- 2007-11-15 US US11/940,674 patent/US7785366B2/en active Active
-
2008
- 2008-11-14 CA CA2705938A patent/CA2705938A1/en not_active Abandoned
- 2008-11-14 WO PCT/US2008/083570 patent/WO2009064994A1/en active Application Filing
- 2008-11-14 EP EP08849442A patent/EP2211787A4/en not_active Withdrawn
- 2008-11-14 AU AU2008322556A patent/AU2008322556A1/en not_active Abandoned
-
2010
- 2010-08-31 US US12/872,228 patent/US8486136B2/en active Active
-
2013
- 2013-07-16 US US13/943,170 patent/US9232999B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5582607A (en) * | 1994-09-09 | 1996-12-10 | Carbomedics, Inc. | Heart valve prosthesis rotator with bendable shaft and drive mechanism |
US20070213578A1 (en) * | 1999-08-09 | 2007-09-13 | Alexander Khairkhahan | System for improving cardiac function |
US6769434B2 (en) * | 2000-06-30 | 2004-08-03 | Viacor, Inc. | Method and apparatus for performing a procedure on a cardiac valve |
US20070093890A1 (en) * | 2005-10-26 | 2007-04-26 | Eliasen Kenneth A | Heart valve implant |
US20070255399A1 (en) * | 2005-10-26 | 2007-11-01 | Eliasen Kenneth A | Balloon Mitral Spacer |
Non-Patent Citations (1)
Title |
---|
See also references of EP2211787A4 * |
Also Published As
Publication number | Publication date |
---|---|
US9232999B2 (en) | 2016-01-12 |
US20090043382A1 (en) | 2009-02-12 |
AU2008322556A1 (en) | 2009-05-22 |
EP2211787A4 (en) | 2010-12-29 |
US20140200657A1 (en) | 2014-07-17 |
CA2705938A1 (en) | 2009-05-22 |
US8486136B2 (en) | 2013-07-16 |
US20100324668A1 (en) | 2010-12-23 |
US7785366B2 (en) | 2010-08-31 |
EP2211787A1 (en) | 2010-08-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9232999B2 (en) | Mitral spacer | |
US8480730B2 (en) | Solid construct mitral spacer | |
EP2150206B1 (en) | Balloon mitral spacer | |
US8778017B2 (en) | Safety for mitral valve implant | |
EP1948087B1 (en) | Heart valve implant | |
JP6605445B2 (en) | Mitral valve spacer or system and method for implanting it | |
US8597347B2 (en) | Heart regurgitation method and apparatus | |
CN109938878B (en) | Hydraulic delivery systems for prosthetic heart valve devices and related methods | |
US20170325949A1 (en) | Heart Valve Implant And Methods For Delivering And Implanting Same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08849442 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008322556 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2705938 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008849442 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2008322556 Country of ref document: AU Date of ref document: 20081114 Kind code of ref document: A |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01E Ref document number: PI0818097 Country of ref document: BR Free format text: VIDE PARECER NO E-PARECER |
|
ENPW | Started to enter national phase and was withdrawn or failed for other reasons |
Ref document number: PI0818097 Country of ref document: BR Free format text: PEDIDO RETIRADO EM RELACAO AO BRASIL POR NAO ATENDER AS DETERMINACOES REFERENTES A ENTRADA DO PEDIDO NA FASE NACIONAL E POR NAO CUMPRIMENTO DA EXIGENCIA FORMULADA NA RPI 2332 |