WO2009070592A3 - Differentiation of human embryonic stem cells - Google Patents

Differentiation of human embryonic stem cells Download PDF

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Publication number
WO2009070592A3
WO2009070592A3 PCT/US2008/084705 US2008084705W WO2009070592A3 WO 2009070592 A3 WO2009070592 A3 WO 2009070592A3 US 2008084705 W US2008084705 W US 2008084705W WO 2009070592 A3 WO2009070592 A3 WO 2009070592A3
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WO
WIPO (PCT)
Prior art keywords
stem cells
differentiation
present
methods
pluripotent stem
Prior art date
Application number
PCT/US2008/084705
Other languages
French (fr)
Other versions
WO2009070592A2 (en
Inventor
Alireza Rezania
Original Assignee
Lifescan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2706560A priority Critical patent/CA2706560C/en
Priority to BRPI0819609-5A2A priority patent/BRPI0819609A2/en
Priority to CN200880117963.2A priority patent/CN101878298B/en
Priority to AT08855258T priority patent/ATE523585T1/en
Priority to MX2010005805A priority patent/MX2010005805A/en
Priority to KR1020157019763A priority patent/KR101706928B1/en
Application filed by Lifescan, Inc. filed Critical Lifescan, Inc.
Priority to RU2010126217/10A priority patent/RU2473684C2/en
Priority to EP08855258A priority patent/EP2229434B1/en
Priority to JP2010536133A priority patent/JP5710264B2/en
Publication of WO2009070592A2 publication Critical patent/WO2009070592A2/en
Publication of WO2009070592A3 publication Critical patent/WO2009070592A3/en
Priority to HK11101688.2A priority patent/HK1147521A1/en

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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Abstract

The present invention provides methods to promote the differentiation of pluripotent stem cells and the products related to or resulting from such methods. In particular, the present invention provides an improved method for the formation of pancreatic hormone expressing cells and pancreatic hormone secreting cells. In addition, the present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer and the products related to or resulting from such methods. The present invention also provides methods to promote glucose-stimulated insulin secretion in insulin-producing cells derived from pluripotent stem cells.
PCT/US2008/084705 2007-11-27 2008-11-25 Differentiation of human embryonic stem cells WO2009070592A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BRPI0819609-5A2A BRPI0819609A2 (en) 2007-11-27 2008-11-25 DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
CN200880117963.2A CN101878298B (en) 2007-11-27 2008-11-25 The differentiation of human embryo stem cell
AT08855258T ATE523585T1 (en) 2007-11-27 2008-11-25 DIFFERENTIATION OF HUMAN EMBRYONAL STEM CELLS
MX2010005805A MX2010005805A (en) 2007-11-27 2008-11-25 Differentiation of human embryonic stem cells.
KR1020157019763A KR101706928B1 (en) 2007-11-27 2008-11-25 Differentiation of human embryonic stem cells
CA2706560A CA2706560C (en) 2007-11-27 2008-11-25 Differentiation of human embryonic stem cells to pancreatic cells
RU2010126217/10A RU2473684C2 (en) 2007-11-27 2008-11-25 Differentiation of human embryo stem cells
EP08855258A EP2229434B1 (en) 2007-11-27 2008-11-25 Differentiation of human embryonic stem cells
JP2010536133A JP5710264B2 (en) 2007-11-27 2008-11-25 Differentiation of human embryonic stem cells
HK11101688.2A HK1147521A1 (en) 2007-11-27 2011-02-21 Differentiation of human embryonic stem cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99052907P 2007-11-27 2007-11-27
US60/990,529 2007-11-27

Publications (2)

Publication Number Publication Date
WO2009070592A2 WO2009070592A2 (en) 2009-06-04
WO2009070592A3 true WO2009070592A3 (en) 2009-10-15

Family

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Family Applications (1)

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PCT/US2008/084705 WO2009070592A2 (en) 2007-11-27 2008-11-25 Differentiation of human embryonic stem cells

Country Status (13)

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US (5) US9062290B2 (en)
EP (1) EP2229434B1 (en)
JP (2) JP5710264B2 (en)
KR (2) KR101592182B1 (en)
CN (2) CN107574142B (en)
AT (1) ATE523585T1 (en)
BR (1) BRPI0819609A2 (en)
CA (3) CA2706560C (en)
ES (1) ES2372463T3 (en)
HK (1) HK1147521A1 (en)
MX (1) MX2010005805A (en)
RU (1) RU2473684C2 (en)
WO (1) WO2009070592A2 (en)

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