WO2009085356A8 - Methods of using and constructing nanosensor platforms - Google Patents

Methods of using and constructing nanosensor platforms Download PDF

Info

Publication number
WO2009085356A8
WO2009085356A8 PCT/US2008/078502 US2008078502W WO2009085356A8 WO 2009085356 A8 WO2009085356 A8 WO 2009085356A8 US 2008078502 W US2008078502 W US 2008078502W WO 2009085356 A8 WO2009085356 A8 WO 2009085356A8
Authority
WO
WIPO (PCT)
Prior art keywords
constructing
nanosensor
methods
platforms
present
Prior art date
Application number
PCT/US2008/078502
Other languages
French (fr)
Other versions
WO2009085356A2 (en
WO2009085356A3 (en
Inventor
Chongwu Zhou
Mark E. Thompson
Richard James Cote
Fumiaki Ishikawa
Marco Curreli
Hsiao-Kang Chang
Original Assignee
University Of Southern California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Southern California filed Critical University Of Southern California
Priority to EP08867520A priority Critical patent/EP2210093A4/en
Priority to CA2701447A priority patent/CA2701447A1/en
Priority to JP2010528111A priority patent/JP2011518311A/en
Priority to CN2008801175504A priority patent/CN102016570A/en
Priority to US12/680,833 priority patent/US20100260745A1/en
Publication of WO2009085356A2 publication Critical patent/WO2009085356A2/en
Publication of WO2009085356A3 publication Critical patent/WO2009085356A3/en
Publication of WO2009085356A8 publication Critical patent/WO2009085356A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Electrochemistry (AREA)
  • Composite Materials (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The present invention relates to the use of nanowires, nanotubes and nanosensor platforms. In one embodiment, the present invention provides a method of constructing a nanosensor platform. In another embodiment, the present invention provides a method of analyzing multiple biomarker signals on a nanosensor platform for the detection of a disease.
PCT/US2008/078502 2007-10-01 2008-10-01 Methods of using and constructing nanosensor platforms WO2009085356A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08867520A EP2210093A4 (en) 2007-10-01 2008-10-01 Methods of using and constructing nanosensor platforms
CA2701447A CA2701447A1 (en) 2007-10-01 2008-10-01 Methods of using and constructing nanosensor platforms
JP2010528111A JP2011518311A (en) 2007-10-01 2008-10-01 How to use and build a nanosensor platform
CN2008801175504A CN102016570A (en) 2007-10-01 2008-10-01 Methods of using and constructing nanosensor platforms
US12/680,833 US20100260745A1 (en) 2007-10-01 2008-10-01 Methods of using and constructing nanosensor platforms

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US97678007P 2007-10-01 2007-10-01
US97677407P 2007-10-01 2007-10-01
US60/976,774 2007-10-01
US60/976,780 2007-10-01

Publications (3)

Publication Number Publication Date
WO2009085356A2 WO2009085356A2 (en) 2009-07-09
WO2009085356A3 WO2009085356A3 (en) 2009-10-15
WO2009085356A8 true WO2009085356A8 (en) 2010-04-29

Family

ID=40526648

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2008/078452 WO2009046110A1 (en) 2007-10-01 2008-10-01 Detection of mthylated dna and dna mutations
PCT/US2008/078502 WO2009085356A2 (en) 2007-10-01 2008-10-01 Methods of using and constructing nanosensor platforms
PCT/US2008/078491 WO2009046136A2 (en) 2007-10-01 2008-10-01 Microfluidic integration with nanosensor platform

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2008/078452 WO2009046110A1 (en) 2007-10-01 2008-10-01 Detection of mthylated dna and dna mutations

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2008/078491 WO2009046136A2 (en) 2007-10-01 2008-10-01 Microfluidic integration with nanosensor platform

Country Status (6)

Country Link
US (3) US20110275544A1 (en)
EP (2) EP2205714A4 (en)
JP (2) JP2011518311A (en)
CN (1) CN102016570A (en)
CA (3) CA2701380C (en)
WO (3) WO2009046110A1 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5211790B2 (en) * 2007-03-26 2013-06-12 住友化学株式会社 DNA methylation measurement method
CA2701380C (en) * 2007-10-01 2014-03-11 University Of Southern California Detection of methylated dna and dna mutations
WO2013154750A1 (en) 2012-04-10 2013-10-17 The Trustees Of Columbia Unversity In The City Of New York Systems and methods for biological ion channel interfaces
US20100204062A1 (en) * 2008-11-07 2010-08-12 University Of Southern California Calibration methods for multiplexed sensor arrays
WO2010115143A1 (en) * 2009-04-03 2010-10-07 University Of Southern California Surface modification of nanosensor platforms to increase sensitivity and reproducibility
WO2011017077A2 (en) * 2009-07-27 2011-02-10 Trustees Of Boston University Nanochannel-based sensor system with controlled sensitivity
GB201004147D0 (en) * 2010-03-12 2010-04-28 Dna Electronics Ltd Method and apparatus for sensing methylation
DE102010046047A1 (en) * 2010-09-22 2012-03-22 Actc-Anti Crime Technology Corporation Gmbh Substance for use in court
CN102033089A (en) * 2010-10-27 2011-04-27 清华大学 Biosensor and packaging structure thereof and detection system
US8450131B2 (en) * 2011-01-11 2013-05-28 Nanohmics, Inc. Imprinted semiconductor multiplex detection array
EP2663862A4 (en) * 2011-01-11 2015-01-21 Univ Columbia Systems and methods for single-molecule detection using nanotubes
WO2012116161A1 (en) 2011-02-23 2012-08-30 The Trustees Of Columbia University In The City Of New York Systems and methods for single-molecule detection using nanopores
US9599614B2 (en) 2011-03-14 2017-03-21 Yale University Calibration of nanostructure sensors
US20130201316A1 (en) 2012-01-09 2013-08-08 May Patents Ltd. System and method for server based control
WO2013158280A1 (en) 2012-04-20 2013-10-24 The Trustees Of Columbia University In The City Of New York Systems and methods for single-molecule nucleic-acid assay platforms
US10088477B2 (en) 2012-07-30 2018-10-02 The Regents Of The University Of California Biomolecular detection test strip design
EP2885424B1 (en) * 2012-08-17 2016-10-05 The United States of America, as Represented by The Secretary, Department of Health and Human Services Cyclopentane-peptide nucleic acids for qualitative and quantitative detection of nucleic acids
EP2885431A4 (en) * 2012-08-17 2016-07-13 Bio Nems Corp Nucleic acid classification
EP2735868B1 (en) * 2012-11-26 2015-11-25 University College Cork Nanowire electrode sensor
US9316612B2 (en) 2013-01-04 2016-04-19 Yale University Regenerative nanosensor devices
KR102056928B1 (en) * 2013-01-16 2019-12-18 삼성디스플레이 주식회사 Touch screen panel and method for manufacturing the same
US9435896B2 (en) * 2013-07-31 2016-09-06 Globalfoundries Inc. Radiation detector based on charged self-assembled monolayers on nanowire devices
JP6651184B2 (en) * 2014-08-08 2020-02-19 日本化薬株式会社 Field effect transistor and sensor using the same
CA2967022A1 (en) * 2014-11-07 2016-05-12 Proteosense Devices, systems, and methods for the detection of analytes
DE102014016712B4 (en) * 2014-11-13 2022-12-01 Dräger Safety AG & Co. KGaA Transportable chip measurement system and method for operating a transportable chip measurement system
US20180031483A1 (en) * 2014-11-26 2018-02-01 Washington University In St. Louis Bioplasmonic detection of biomarkers in body fluids using peptide recognition elements
EP3230722A4 (en) 2015-01-30 2018-09-19 Hewlett-Packard Development Company, L.P. Signal transmission bandwidth allocation on a microfluidic chip
KR102338748B1 (en) * 2015-04-21 2021-12-15 삼성디스플레이 주식회사 Touch screen panel and fabrication method of the same
US20170016894A1 (en) * 2015-07-15 2017-01-19 Orizhan Bioscience Limited Detection Comprising Signal Amplifier
WO2017058827A1 (en) * 2015-09-29 2017-04-06 Essenlix Corp. Method of detecting an analyte in a sample
US10502725B2 (en) * 2015-10-13 2019-12-10 University Of Utah Research Foundation Ultra-low power digital chemical analyzers
US10502724B2 (en) 2015-10-13 2019-12-10 University Of Utah Research Foundation Ultra-low power digital chemical analyzers
KR20240045375A (en) 2016-06-30 2024-04-05 그래프웨어 테크놀로지스 인크. Polar fluid gated field effect devices
CN106483191B (en) * 2016-10-27 2019-03-08 吉林大学 A method of Mass Spectrometer Method repeatability is improved by eliminating dessert effect
CN111149141A (en) 2017-09-04 2020-05-12 Nng软件开发和商业有限责任公司 Method and apparatus for collecting and using sensor data from a vehicle
CN109470679B (en) * 2017-09-08 2021-04-23 清华大学 Molecular carrier for molecular detection
US20210038653A1 (en) * 2018-02-02 2021-02-11 Fred Hutchinson Cancer Research Center Methods for treating facioscapulohumeral muscular dystrophy
WO2020035852A2 (en) 2018-08-14 2020-02-20 Neurotrigger Ltd. Method and apparatus for transcutaneous facial nerve stimulation and applications thereof
US11143584B2 (en) 2018-10-02 2021-10-12 International Business Machines Corporation Selective functionalization of sensing surface
US10968098B2 (en) * 2018-10-02 2021-04-06 International Business Machines Corporation Selective functionalization of sensing surface with nanoscale spatial resolution
WO2020170237A1 (en) 2019-02-19 2020-08-27 Edgy Bees Ltd. Estimating real-time delay of a video data stream
US11054384B1 (en) 2019-12-23 2021-07-06 Nanodx, Inc. Sensor system and methods of making
CN111551607B (en) * 2020-05-21 2023-05-16 福建医锦智能科技有限公司 Biological array for detection and detection method thereof
WO2023283031A2 (en) * 2021-06-15 2023-01-12 Richard Postrel Handheld device for early detection of disease, biological, chemical, and pathogenic agents

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA739100B (en) * 1972-12-15 1974-10-30 Ici Ltd Pesticidal composition's and process
US5637716A (en) * 1993-07-30 1997-06-10 Eisai Co., Ltd. Processes for the preparation of hydroquinone and benzoquinone derivatives
US6036774A (en) * 1996-02-26 2000-03-14 President And Fellows Of Harvard College Method of producing metal oxide nanorods
US5897945A (en) * 1996-02-26 1999-04-27 President And Fellows Of Harvard College Metal oxide nanorods
WO1999004626A1 (en) * 1997-07-28 1999-02-04 Fox Chase Cancer Center Novel gene encoding a dna repair endonuclease and methods of use thereof
US6346189B1 (en) * 1998-08-14 2002-02-12 The Board Of Trustees Of The Leland Stanford Junior University Carbon nanotube structures made using catalyst islands
WO2001063284A2 (en) * 2000-02-25 2001-08-30 Luminex Corporation Internal standards and controls for multiplexed assay
AU2001252973A1 (en) * 2000-04-17 2001-10-30 Purdue Research Foundation Biosensor and related method
US9709559B2 (en) * 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US6709566B2 (en) * 2000-07-25 2004-03-23 The Regents Of The University Of California Method for shaping a nanotube and a nanotube shaped thereby
US7301199B2 (en) * 2000-08-22 2007-11-27 President And Fellows Of Harvard College Nanoscale wires and related devices
KR100991573B1 (en) * 2000-12-11 2010-11-04 프레지던트 앤드 펠로우즈 오브 하버드 칼리지 Nanosensors
US20070128744A1 (en) * 2005-07-27 2007-06-07 Tour James M Self-assembly of molecules and nanotubes and/or nanowires in nanocell computing devices, and methods for programming same
US6723299B1 (en) * 2001-05-17 2004-04-20 Zyvex Corporation System and method for manipulating nanotubes
US6706402B2 (en) * 2001-07-25 2004-03-16 Nantero, Inc. Nanotube films and articles
JP2003144172A (en) 2001-11-16 2003-05-20 Nisshinbo Ind Inc Oligonucleotide-immobilized board for detecting methylation
US20040253741A1 (en) * 2003-02-06 2004-12-16 Alexander Star Analyte detection in liquids with carbon nanotube field effect transistor devices
US20070048181A1 (en) * 2002-09-05 2007-03-01 Chang Daniel M Carbon dioxide nanosensor, and respiratory CO2 monitors
US20040026684A1 (en) * 2002-04-02 2004-02-12 Nanosys, Inc. Nanowire heterostructures for encoding information
WO2003093494A2 (en) * 2002-05-04 2003-11-13 Aviva Biosciences Corporation Apparatus including ion transport detecting structures and methods of use
JP2006511819A (en) * 2002-05-10 2006-04-06 イピトミ バイオシステムズ インコーポレイテッド Unique recognition sequences and their use in protein analysis
WO2003104789A1 (en) * 2002-06-06 2003-12-18 Rutgers, The State University Of New Jersey MULTIFUNCTIONAL BIOSENSOR BASED ON ZnO NANOSTRUCTURES
US6946851B2 (en) * 2002-07-03 2005-09-20 The Regents Of The University Of California Carbon nanotube array based sensor
WO2004020662A2 (en) * 2002-08-27 2004-03-11 Epigenomics Ag Method and nucleic acids for the analysis of breast cell proliferative disorders
AU2003251307A1 (en) * 2002-09-10 2004-04-30 The Trustees Of The University Pennsylvania Carbon nanotubes: high solids dispersions and nematic gels thereof
US7143785B2 (en) * 2002-09-25 2006-12-05 California Institute Of Technology Microfluidic large scale integration
WO2004034025A2 (en) * 2002-10-10 2004-04-22 Nanosys, Inc. Nano-chem-fet based biosensors
WO2004044586A1 (en) 2002-11-08 2004-05-27 Nanomix, Inc. Nanotube-based electronic detection of biological molecules
EP1583957B1 (en) * 2002-11-14 2009-02-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Ion-sensitive field effect transistor and method for producing an ion-sensitive field effect transistor
US20040200734A1 (en) * 2002-12-19 2004-10-14 Co Man Sung Nanotube-based sensors for biomolecules
CN1517707A (en) * 2003-01-16 2004-08-04 中国科学院电子学研究所 Method of preparing capillary channel and its sampling method
US6855606B2 (en) * 2003-02-20 2005-02-15 Taiwan Semiconductor Manufacturing Company, Ltd. Semiconductor nano-rod devices
JP3657591B2 (en) * 2003-03-25 2005-06-08 独立行政法人科学技術振興機構 P-channel field effect transistor and sensor using the same
TWI346202B (en) * 2003-05-14 2011-08-01 Nantero Inc Sensor platform using a non-horizontally oriented nanotube element and methods of making sensor,capacitive structure and resistive structure
WO2005019793A2 (en) * 2003-05-14 2005-03-03 Nantero, Inc. Sensor platform using a horizontally oriented nanotube element
US7910064B2 (en) * 2003-06-03 2011-03-22 Nanosys, Inc. Nanowire-based sensor configurations
US7670831B2 (en) * 2003-06-13 2010-03-02 Korea Advanced Institute Of Science And Technology Conductive carbon nanotubes dotted with metal and method for fabricating a biosensor using the same
US7416911B2 (en) * 2003-06-24 2008-08-26 California Institute Of Technology Electrochemical method for attaching molecular and biomolecular structures to semiconductor microstructures and nanostructures
CN1852863A (en) * 2003-07-29 2006-10-25 威廉马歇莱思大学 Selective functionalization of carbon nanotubes
US8346482B2 (en) * 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
TWI253502B (en) * 2003-08-26 2006-04-21 Ind Tech Res Inst A structure and manufacturing process of a nano device transistor for a biosensor
US7632234B2 (en) * 2003-08-29 2009-12-15 Medtronic, Inc. Implantable biosensor devices for monitoring cardiac marker molecules
US8105780B2 (en) * 2003-09-22 2012-01-31 Agency For Science, Technology And Research Device and method of detecting mutations and polymorphisms in DNA
US20050253137A1 (en) * 2003-11-20 2005-11-17 President And Fellows Of Harvard College Nanoscale arrays, robust nanostructures, and related devices
US7394118B2 (en) * 2004-03-09 2008-07-01 University Of Southern California Chemical sensor using semiconducting metal oxide nanowires
WO2006071247A2 (en) * 2004-03-30 2006-07-06 California Institute Of Technology Diagnostic assays including multiplexed lateral flow immunoassays with quantum dots
CN101010780B (en) * 2004-04-30 2012-07-25 纳米系统公司 Systems and methods for nanowire growth and harvesting
US7785922B2 (en) * 2004-04-30 2010-08-31 Nanosys, Inc. Methods for oriented growth of nanowires on patterned substrates
EP1766400B1 (en) * 2004-06-03 2009-04-15 Meso Scale Technologies, LLC Methods for conducting whole blood assays
US20070264623A1 (en) * 2004-06-15 2007-11-15 President And Fellows Of Harvard College Nanosensors
WO2006024023A2 (en) * 2004-08-24 2006-03-02 Nanomix, Inc. Nanotube sensor devices for dna detection
US7635423B2 (en) * 2004-09-30 2009-12-22 E. I. Du Pont De Nemours And Company Redox potential mediated, heterogeneous, carbon nanotube biosensing
US7473943B2 (en) * 2004-10-15 2009-01-06 Nanosys, Inc. Gate configuration for nanowire electronic devices
US7560366B1 (en) * 2004-12-02 2009-07-14 Nanosys, Inc. Nanowire horizontal growth and substrate removal
US7544978B2 (en) * 2005-01-24 2009-06-09 Lawrence Livermore National Security, Llc Lipid nanotube or nanowire sensor
JP4891550B2 (en) * 2005-02-10 2012-03-07 独立行政法人科学技術振興機構 N-type transistor, n-type transistor sensor, and n-type transistor channel manufacturing method
US20060188934A1 (en) * 2005-02-22 2006-08-24 Ying-Lan Chang System and method for implementing a high-sensitivity sensor with improved stability
EP1902143A1 (en) * 2005-03-29 2008-03-26 Applera Corporation Nanowire-based system for analysis of nucleic acids
US20100227382A1 (en) * 2005-05-25 2010-09-09 President And Fellows Of Harvard College Nanoscale sensors
KR100748408B1 (en) * 2005-06-28 2007-08-10 한국화학연구원 Carbon nanotube biosensors with aptamers as molecular recognition elements and method for sensing target material using the same
US20070001581A1 (en) * 2005-06-29 2007-01-04 Stasiak James W Nanostructure based light emitting devices and associated methods
US7410912B2 (en) * 2005-09-02 2008-08-12 The Hong Kong Polytechnic University Methods of manufacturing metal oxide nanowires
US20070092870A1 (en) * 2005-10-20 2007-04-26 Yiping Zhao Detection of biomolecules
US8043409B2 (en) * 2005-11-10 2011-10-25 Sumitomo Metal Mining Co., Ltd. Indium-based nanowire product, oxide nanowire product, and electroconductive oxide nanowire product, as well as production methods thereof
CN101310389B (en) * 2005-11-18 2010-06-23 Nxp股份有限公司 Metal-base nanowire transistor
US20070161029A1 (en) * 2005-12-05 2007-07-12 Panomics, Inc. High throughput profiling of methylation status of promoter regions of genes
EP1977444A4 (en) * 2005-12-15 2009-05-13 Univ Columbia Sensing devices from molecular electronic devices
JP2009540798A (en) 2006-03-15 2009-11-26 プレジデント アンド フェロウズ オブ ハーバード カレッジ Nano bioelectronics
US7718995B2 (en) * 2006-06-20 2010-05-18 Panasonic Corporation Nanowire, method for fabricating the same, and device having nanowires
JP2008082988A (en) * 2006-09-28 2008-04-10 Hokkaido Univ Detecting method utilizing multistage amplification
WO2008051762A2 (en) * 2006-10-26 2008-05-02 Abbott Laboratories Immunoassay of analytes in samples containing endogenous anti-analyte antibodies
WO2008127314A1 (en) * 2006-11-22 2008-10-23 President And Fellows Of Harvard College High-sensitivity nanoscale wire sensors
WO2008070058A2 (en) * 2006-12-04 2008-06-12 Purdue Research Foundation Method and apparatus for detection of molecules using sensor array
US20080200342A1 (en) * 2007-02-15 2008-08-21 Rao Rupa S Device, Array, And Methods For Disease Detection And Analysis
US8956823B2 (en) * 2007-08-20 2015-02-17 Bio-Rad Laboratories, Inc. Anti-antibody reagent
US7795677B2 (en) * 2007-09-05 2010-09-14 International Business Machines Corporation Nanowire field-effect transistors
CA2701380C (en) 2007-10-01 2014-03-11 University Of Southern California Detection of methylated dna and dna mutations
US20100204062A1 (en) * 2008-11-07 2010-08-12 University Of Southern California Calibration methods for multiplexed sensor arrays
WO2010115143A1 (en) 2009-04-03 2010-10-07 University Of Southern California Surface modification of nanosensor platforms to increase sensitivity and reproducibility
WO2011146881A1 (en) 2010-05-20 2011-11-24 University Of Southern California Pan-antibody assays - principles, methods, and devices

Also Published As

Publication number Publication date
US20100260745A1 (en) 2010-10-14
CN102016570A (en) 2011-04-13
WO2009046110A1 (en) 2009-04-09
CA2701401C (en) 2013-05-14
WO2009046136A3 (en) 2009-05-22
CA2701447A1 (en) 2009-07-09
EP2210093A4 (en) 2012-12-05
WO2009046136A2 (en) 2009-04-09
WO2009085356A2 (en) 2009-07-09
JP2011518311A (en) 2011-06-23
EP2205714A4 (en) 2011-01-12
CA2701380C (en) 2014-03-11
CA2701380A1 (en) 2009-04-09
CA2701401A1 (en) 2009-04-09
US20110275544A1 (en) 2011-11-10
US20100292348A1 (en) 2010-11-18
JP2012163578A (en) 2012-08-30
EP2210093A2 (en) 2010-07-28
US8609333B2 (en) 2013-12-17
EP2205714A1 (en) 2010-07-14
WO2009085356A3 (en) 2009-10-15

Similar Documents

Publication Publication Date Title
WO2009085356A8 (en) Methods of using and constructing nanosensor platforms
WO2009069134A3 (en) Functional analysis of neurophysiological data
GB2481950B (en) Surface microstructure measurement method, surface microstructure measurement data analysis method and surface microstructure measurement system.
WO2007106244A3 (en) Method for quantifying reservoir connectivity using fluid travel times
EP2113743A4 (en) Displacement measuring method, displacement measuring instrument, displacement measuring target and structure
GB2411087B (en) Measurement and signature intelligence analysis and reduction technique
WO2009070676A3 (en) Determining postural stability
EP1887363A4 (en) Micro overall analysis system, inspection chip, and inspection method
WO2008008899A3 (en) Methods and systems for compliance confirmation and incentives
EP1959836A4 (en) Ultrasound measurement system and method
HK1119236A1 (en) System and method for coding information on a biosensor test strip
EP1941434A4 (en) System, method, and computer program product for providing travel information using information obtained from other travelers
EP1870714A4 (en) Microstructure probe card, and microstructure inspecting device, method, and computer program
EP1977205A4 (en) Method and system for combined raman and libs detection
GB2428482B (en) System, apparatus and method for conducting borehole resistivity measurements
WO2010045490A3 (en) Human biomarker hypermapping for depressive disorders
IL188242A0 (en) Method for determining traffic information, and a device arranged to perform the method
AU2007266218B2 (en) Biomarkers for diagnosing multiple sclerosis, and methods thereof
EP2021313A4 (en) Biomarkers for diagnosing multiple sclerosis, and methods thereof
EP1831661A4 (en) Apparatus for measuring force applied by the hand, analysing apparatus and system
EP1816568A4 (en) Recording apparatus, recording method, program, and computer readable recording medium
EP1927850A4 (en) Bio-sensor measuring device, bio-sensor measuring system, and bio-sensor measuring method
EP1739407A4 (en) Sensor, measuring equipment and measuring method
GB2448631A8 (en) Nanotube circuit analysis system and method
EP2069783A4 (en) Biosensor, manufacturing method thereof, and biosensing apparatus including the same

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880117550.4

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08867520

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2701447

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2010528111

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008867520

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 12680833

Country of ref document: US