WO2009097014A3 - Therapeutic kinase modulators - Google Patents
Therapeutic kinase modulators Download PDFInfo
- Publication number
- WO2009097014A3 WO2009097014A3 PCT/US2008/074820 US2008074820W WO2009097014A3 WO 2009097014 A3 WO2009097014 A3 WO 2009097014A3 US 2008074820 W US2008074820 W US 2008074820W WO 2009097014 A3 WO2009097014 A3 WO 2009097014A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- molecules
- kinase modulators
- therapeutic kinase
- relates
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
- G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Abstract
The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, and modulating protein kinase activity. Molecules of the invention can modulate casein kinase (CK) activity. The invention also relates in part to methods for using such molecules.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2698463A CA2698463A1 (en) | 2007-08-31 | 2008-08-29 | Therapeutic kinase modulators |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96955607P | 2007-08-31 | 2007-08-31 | |
US60/969,556 | 2007-08-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009097014A2 WO2009097014A2 (en) | 2009-08-06 |
WO2009097014A3 true WO2009097014A3 (en) | 2009-12-30 |
Family
ID=40523789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/074820 WO2009097014A2 (en) | 2007-08-31 | 2008-08-29 | Therapeutic kinase modulators |
Country Status (3)
Country | Link |
---|---|
US (1) | US7910600B2 (en) |
CA (1) | CA2698463A1 (en) |
WO (1) | WO2009097014A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010135571A1 (en) * | 2009-05-20 | 2010-11-25 | Cylene Pharmaceuticals, Inc. | Novel protein kinase modulators |
CN102703456B (en) * | 2012-05-15 | 2014-04-02 | 武汉生命之美科技有限公司 | Action target site of death-associated protein kinase (DAPK3) gene hsa-miR-20a |
EP3074391B1 (en) | 2013-11-28 | 2019-07-31 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Rna polymerase i inhibitors and uses thereof |
CN107056819B (en) * | 2017-04-17 | 2019-08-23 | 牡丹江医学院 | A kind of drug and preparation method thereof preventing and treating myocardial ischemia |
JP7277390B2 (en) * | 2017-07-31 | 2023-05-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Anti-Cancer/Anti-Fibrosis Compounds |
JP7335893B2 (en) | 2017-12-22 | 2023-08-30 | ラヴェンナ ファーマシューティカルズ,インコーポレイテッド | Chromenopyridine Derivatives as Phosphatidylinositol Phosphate Kinase Inhibitors |
US11071727B2 (en) | 2018-01-26 | 2021-07-27 | Northwestern University | Therapeutic targeting of proteolytic cleavage of the mixed lineage leukemia gene product (MLL1) by taspase1 using kinase inhibitors |
TW202112784A (en) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | Chromenopyrimidine derivatives as phosphatidylinositol phosphate kinase inhibitors |
CN114957252B (en) * | 2022-07-14 | 2023-09-05 | 苏州施安鼎泰生物医药技术有限公司 | Compound, preparation method thereof, pharmaceutical composition and application thereof in preparation of EED inhibitor |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5766863A (en) * | 1993-11-23 | 1998-06-16 | Genentech, Inc. | Kinase receptor activation assay |
US20030065180A1 (en) * | 2000-03-28 | 2003-04-03 | American Home Products Corporation | Tricyclic protein kinase inhibitors |
US20030069265A1 (en) * | 2000-12-05 | 2003-04-10 | Geeta Saxena | Therapeutics for chemokine mediated diseases |
WO2004007754A2 (en) * | 2002-07-12 | 2004-01-22 | Rigel Pharmaceuticals, Inc. | Modulators of cellular proliferation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL171985C (en) * | 1976-02-10 | 1983-06-16 | Rhone Poulenc Ind | METHOD FOR PREPARING PREPARATIONS WITH ACTION AGAINST SCHISTOSOMIASIS, THE PREPARED PREPARATIONS SO GIVEN AND METHOD FOR PREPARING 1,2-DITHIOOL COMPOUNDS. |
US5624677A (en) * | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
US6772081B1 (en) * | 2002-05-21 | 2004-08-03 | Data Recognition Corporation | Priority system and method for processing standardized tests |
US7507727B2 (en) * | 2003-04-07 | 2009-03-24 | Cylene Pharmaceuticals, Inc. | Substituted quinobenzoxazine analogs and methods of using thereof |
NZ553746A (en) * | 2004-09-17 | 2010-06-25 | Cylene Pharmaceuticals Inc | Quinolone analogs as cell proliferation inhibitors |
-
2008
- 2008-08-29 US US12/201,892 patent/US7910600B2/en active Active
- 2008-08-29 CA CA2698463A patent/CA2698463A1/en not_active Abandoned
- 2008-08-29 WO PCT/US2008/074820 patent/WO2009097014A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5766863A (en) * | 1993-11-23 | 1998-06-16 | Genentech, Inc. | Kinase receptor activation assay |
US20030065180A1 (en) * | 2000-03-28 | 2003-04-03 | American Home Products Corporation | Tricyclic protein kinase inhibitors |
US20030069265A1 (en) * | 2000-12-05 | 2003-04-10 | Geeta Saxena | Therapeutics for chemokine mediated diseases |
WO2004007754A2 (en) * | 2002-07-12 | 2004-01-22 | Rigel Pharmaceuticals, Inc. | Modulators of cellular proliferation |
Non-Patent Citations (1)
Title |
---|
REWCASTLE ET AL.: "Synthesis of 4-(Phenylamino)pyrimidine Derivatives as ATP-Competitive Protein Kinase Inhibitors with Potential for Cancer Chemotherapy.", CURRENT ORGANIC CHEMISTRY, vol. 4, 2000, pages 679 - 706 * |
Also Published As
Publication number | Publication date |
---|---|
US7910600B2 (en) | 2011-03-22 |
US20090093465A1 (en) | 2009-04-09 |
WO2009097014A2 (en) | 2009-08-06 |
CA2698463A1 (en) | 2009-08-06 |
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