WO2009152167A3 - Delivery of therapeutics - Google Patents
Delivery of therapeutics Download PDFInfo
- Publication number
- WO2009152167A3 WO2009152167A3 PCT/US2009/046773 US2009046773W WO2009152167A3 WO 2009152167 A3 WO2009152167 A3 WO 2009152167A3 US 2009046773 W US2009046773 W US 2009046773W WO 2009152167 A3 WO2009152167 A3 WO 2009152167A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- therapeutics
- delivery
- methods
- devices
- present
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5115—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
- A61L2300/222—Steroids, e.g. corticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/624—Nanocapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Abstract
The present invention provides materials and devices for the controlled release of therapeutics, and methods for uses thereof.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5997608P | 2008-06-09 | 2008-06-09 | |
US5997908P | 2008-06-09 | 2008-06-09 | |
US61/059,976 | 2008-06-09 | ||
US61/059,979 | 2008-06-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009152167A2 WO2009152167A2 (en) | 2009-12-17 |
WO2009152167A3 true WO2009152167A3 (en) | 2010-05-14 |
Family
ID=41417375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/046773 WO2009152167A2 (en) | 2008-06-09 | 2009-06-09 | Delivery of therapeutics |
Country Status (2)
Country | Link |
---|---|
US (1) | US20100040672A1 (en) |
WO (1) | WO2009152167A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10799593B2 (en) | 2008-06-09 | 2020-10-13 | Northwestern University | Nanodiamond particle complexes |
CA2766912A1 (en) * | 2009-05-28 | 2010-12-02 | Northwestern University | Nanodiamond particle complexes |
CA2879407A1 (en) * | 2012-07-18 | 2014-01-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of preparing silica-coated nanodiamonds |
US9049805B2 (en) | 2012-08-30 | 2015-06-02 | Lockheed Martin Corporation | Thermally-conductive particles in printed wiring boards |
DE102012023348B4 (en) * | 2012-11-29 | 2016-09-29 | Hochschule München | Method for testing an active substance depot by means of an imaging method |
WO2016062764A1 (en) * | 2014-10-23 | 2016-04-28 | Biotronik Se & Co. Kg | Method for treating a medical implant |
US9616022B1 (en) * | 2016-07-07 | 2017-04-11 | The Florida International University Board Of Trustees | Nanodiamond compositions and their use for drug delivery |
WO2023034056A1 (en) * | 2021-09-03 | 2023-03-09 | Bionaut Labs Ltd. | Hydrogel-matrix encapsulated oligonucleotides and methods for formulating and using encapsulated oligonucleotides |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050220829A1 (en) * | 2004-03-30 | 2005-10-06 | Chien-Min Sung | Healthcare and cosmetic compositions containing nanodiamond |
US20050281858A1 (en) * | 2004-06-18 | 2005-12-22 | Kloke Tim M | Devices, articles, coatings, and methods for controlled active agent release |
US20060051401A1 (en) * | 2004-09-07 | 2006-03-09 | Board Of Regents, The University Of Texas System | Controlled nanofiber seeding |
WO2008022258A2 (en) * | 2006-08-16 | 2008-02-21 | Surmodics, Inc. | Methods and materials for increasing the adhesion of elution control matrices to substrates |
US20090004241A1 (en) * | 2007-06-08 | 2009-01-01 | Northwestern University | Polymer nanofilm coatings |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3640741A (en) * | 1970-02-24 | 1972-02-08 | Hollister Inc | Composition containing gel |
US3865108A (en) * | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
US4002173A (en) * | 1974-07-23 | 1977-01-11 | International Paper Company | Diester crosslinked polyglucan hydrogels and reticulated sponges thereof |
DE2437629C3 (en) * | 1974-08-05 | 1978-09-21 | Basf Ag, 6700 Ludwigshafen | Process for the preparation of insoluble polymers of N-vinyllactams which are only slightly swellable in water |
US4014335A (en) * | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
US4207893A (en) * | 1977-08-29 | 1980-06-17 | Alza Corporation | Device using hydrophilic polymer for delivering drug to biological environment |
US5460830A (en) * | 1990-06-22 | 1995-10-24 | The Regents Of The University Of California | Biochemically active agents for chemical catalysis and cell receptor activation |
US6774278B1 (en) * | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
US6632457B1 (en) * | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
US6335029B1 (en) * | 1998-08-28 | 2002-01-01 | Scimed Life Systems, Inc. | Polymeric coatings for controlled delivery of active agents |
AU2001264623A1 (en) * | 2000-05-16 | 2001-11-26 | Biocure, Inc. | Membranes formed from amphiphilic copolymers |
US20060222756A1 (en) * | 2000-09-29 | 2006-10-05 | Cordis Corporation | Medical devices, drug coatings and methods of maintaining the drug coatings thereon |
DE10125599A1 (en) * | 2001-05-25 | 2002-11-28 | Stockhausen Chem Fab Gmbh | Super-absorbent polymer powder for use in e.g. diapers, packaging and soil improvers, obtained by pre-swelling polycarboxy-polysaccharide in water and then drying and surface-crosslinking resulting hydrogel |
US7828728B2 (en) * | 2003-07-25 | 2010-11-09 | Dexcom, Inc. | Analyte sensor |
KR20040097126A (en) * | 2002-02-15 | 2004-11-17 | 씨브이 쎄러퓨틱스, 인코포레이티드 | Polymer coating for medical devices |
EP1493015A4 (en) * | 2002-04-05 | 2006-01-04 | Powerzyme Inc | Analyte sensor |
US7329414B2 (en) * | 2002-05-03 | 2008-02-12 | Biopsy Sciences, Llc | Biodegradable polymer for marking tissue and sealing tracts |
EP1549689B1 (en) * | 2002-10-02 | 2010-05-26 | Coloplast A/S | A hydrogel |
US7173655B2 (en) * | 2002-10-18 | 2007-02-06 | Hewlett-Packard Development Company, L.P. | Capture of sensory data in association with digital still images |
US7459169B2 (en) * | 2002-10-21 | 2008-12-02 | Allvivo, Inc. | Surface coating comprising bioactive compound |
WO2004060967A1 (en) * | 2002-12-31 | 2004-07-22 | Nektar Therapeutics Al, Corporation | Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof |
US7820130B2 (en) * | 2003-11-26 | 2010-10-26 | William Marsh Rice University | Functionalization of nanodiamond powder through fluorination and subsequent derivatization reactions |
US7211108B2 (en) * | 2004-01-23 | 2007-05-01 | Icon Medical Corp. | Vascular grafts with amphiphilic block copolymer coatings |
US20060088571A1 (en) * | 2004-10-21 | 2006-04-27 | Medtronic Vascular, Inc. | Biocompatible and hemocompatible polymer compositions |
US20070259101A1 (en) * | 2006-05-02 | 2007-11-08 | Kleiner Lothar W | Microporous coating on medical devices |
WO2008039749A2 (en) * | 2006-09-25 | 2008-04-03 | Surmodics, Inc. | Multi-layered coatings and methods for controlling elution of active agents |
-
2009
- 2009-06-09 WO PCT/US2009/046773 patent/WO2009152167A2/en active Application Filing
- 2009-06-09 US US12/481,400 patent/US20100040672A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050220829A1 (en) * | 2004-03-30 | 2005-10-06 | Chien-Min Sung | Healthcare and cosmetic compositions containing nanodiamond |
US20050281858A1 (en) * | 2004-06-18 | 2005-12-22 | Kloke Tim M | Devices, articles, coatings, and methods for controlled active agent release |
US20060051401A1 (en) * | 2004-09-07 | 2006-03-09 | Board Of Regents, The University Of Texas System | Controlled nanofiber seeding |
WO2008022258A2 (en) * | 2006-08-16 | 2008-02-21 | Surmodics, Inc. | Methods and materials for increasing the adhesion of elution control matrices to substrates |
US20090004241A1 (en) * | 2007-06-08 | 2009-01-01 | Northwestern University | Polymer nanofilm coatings |
Non-Patent Citations (4)
Title |
---|
EDWARD KAI-HUA CHOW ET AL.: "Copolymeric nanofilm platform for controlled and localized therapeutic delivery.", ACSNANO., vol. 2, no. 1, 22 December 2007 (2007-12-22), pages 33 - 40 * |
HUANG HOUJIN ET AL.: "Active nanodiamond hydrogels for chemotherapeutic delivery", NANO LETTERS, vol. 7, no. 11, 5 October 2007 (2007-10-05), pages 3305 - 3314 * |
HUANG HOUJIN ET AL.: "Protein-mediated assembly of nanodiamond hydrogels into a biocmpatible and biofunctional multilayer nanofilm.", ASCNANO., vol. 2, no. 2, 1 February 2008 (2008-02-01), pages 203 - 212 * |
ROBERT LAM ET AL.: "Nanodiamond-embedded microfilm devices for localized chemotherapeutic elution", ACSNANO, vol. 2, no. 10, 2 October 2008 (2008-10-02), pages 2095 - 2102 * |
Also Published As
Publication number | Publication date |
---|---|
WO2009152167A2 (en) | 2009-12-17 |
US20100040672A1 (en) | 2010-02-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20181353T1 (en) | The tuberculosis rv2386c protein, compositions and uses thereof | |
WO2011142858A3 (en) | Chlorotoxin variants, conjugates, and methods for their use | |
WO2011031896A3 (en) | Pi3 kinase inhibitors and uses thereof | |
UA104459C2 (en) | Anti-fgfr3 antibodies and methods using same | |
WO2012076293A9 (en) | Formulations comprising polysiloxanes having nitrogen-containing groups | |
IL220625A (en) | Isoindolinone compounds, compositions comprising the same and uses thereof | |
WO2012024526A3 (en) | Conjugates, particles, compositions, and related methods | |
AP2010005387A0 (en) | Use of defensins against tuberculosis. | |
WO2009152167A3 (en) | Delivery of therapeutics | |
WO2011072099A3 (en) | Compositions and methods comprising protease variants | |
MX2012007507A (en) | Heteroaryl compounds and uses thereof. | |
IL206148A0 (en) | Polymeric composition, method for the manufacture of the polymeric composition, articles based on this polymeric composition and use of these articles | |
WO2009067674A3 (en) | Polymorphs of sunitinib base and processes for preparation thereof | |
WO2009130479A3 (en) | Virus | |
WO2011133504A3 (en) | Nanozymes, methods of making nanozymes, and methods of using nanozymes | |
ZA201005278B (en) | Folates, compositions and uses thereof | |
EP2527404A4 (en) | Composition for ultraviolet ray-absorbable member, and ultraviolet ray-absorbable member comprising same | |
WO2011075636A3 (en) | Wise binding agents and epitopes | |
WO2009120380A3 (en) | Recombinant rhinovirus vectors | |
WO2012145680A3 (en) | Anti-microbial peptides and uses therefore | |
EP2643044A4 (en) | Biliary shunts, delivery systems, and methods of using the same | |
EP2298082A4 (en) | Composition for feed, and feed comprising the same | |
WO2009005718A8 (en) | Polypeptide microparticles having sustained release characteristics, methods and uses | |
WO2012024350A3 (en) | Anti-cancer adenoviruses | |
WO2011050188A8 (en) | Anti-hepsin antibodies and methods using same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 09763457 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 09763457 Country of ref document: EP Kind code of ref document: A2 |