WO2010021973A3 - Controlled delivery of bioactive agents from decomposable films - Google Patents

Controlled delivery of bioactive agents from decomposable films Download PDF

Info

Publication number
WO2010021973A3
WO2010021973A3 PCT/US2009/054011 US2009054011W WO2010021973A3 WO 2010021973 A3 WO2010021973 A3 WO 2010021973A3 US 2009054011 W US2009054011 W US 2009054011W WO 2010021973 A3 WO2010021973 A3 WO 2010021973A3
Authority
WO
WIPO (PCT)
Prior art keywords
charge
bioactive agents
controlled delivery
thin film
decomposable
Prior art date
Application number
PCT/US2009/054011
Other languages
French (fr)
Other versions
WO2010021973A2 (en
Inventor
Renee Chivon Smith
Paula Hammond Cunningham
Original Assignee
Massachusetts Institute Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute Of Technology filed Critical Massachusetts Institute Of Technology
Publication of WO2010021973A2 publication Critical patent/WO2010021973A2/en
Publication of WO2010021973A3 publication Critical patent/WO2010021973A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Abstract

A decomposable thin film includes a plurality of multilayer units including a first layer having a first charge and a second layer having a second charge, wherein at least a portion of the multilayers includes a polymeric cyclodextrin associated with a bioactive agent, wherein decomposition of the thin film is characterized by sequential removal of at least a portion of the layers having the first charge and degradation of layers having the second charge and by release of the bioactive agent from a corresponding layers; wherein the decomposable thin film including at least one degradable polyelectrolyte layer that is hydro lyzable.
PCT/US2009/054011 2008-08-17 2009-08-17 Controlled delivery of bioactive agents from decomposable films WO2010021973A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8956008P 2008-08-17 2008-08-17
US61/089,560 2008-08-17

Publications (2)

Publication Number Publication Date
WO2010021973A2 WO2010021973A2 (en) 2010-02-25
WO2010021973A3 true WO2010021973A3 (en) 2011-01-13

Family

ID=41479028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/054011 WO2010021973A2 (en) 2008-08-17 2009-08-17 Controlled delivery of bioactive agents from decomposable films

Country Status (2)

Country Link
US (1) US9198875B2 (en)
WO (1) WO2010021973A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109609488A (en) * 2018-12-04 2019-04-12 万华化学集团股份有限公司 A kind of preparation method of immobilized lipase and the method for preparing 2 ethyl hexanoic acid

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008157372A2 (en) 2007-06-14 2008-12-24 Massachusetts Institute Of Technology Self assembled films for protein and drug delivery applications
US9198875B2 (en) 2008-08-17 2015-12-01 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
EP2566468A4 (en) * 2010-05-03 2014-06-18 Massachusetts Inst Technology Drug delivery coating and devices
CN103561769B (en) * 2011-04-08 2017-06-06 纳米西泰有限公司 pharmaceutical preparation
WO2012149492A1 (en) * 2011-04-27 2012-11-01 Massachusetts Institute Of Technology Coating compositions, methods and coated devices
GB2490782B (en) 2011-05-05 2013-12-04 Surface Innovations Ltd Delivery system for an active substance
CN102351436B (en) * 2011-07-01 2013-07-03 北京科技大学 Method for photoresponsive polymer self-assembled film to control adsorption of proteins
JP5777478B2 (en) * 2011-10-12 2015-09-09 信越化学工業株式会社 Water-dispersible pheromone sustained release formulation
EP2841056A4 (en) 2012-04-23 2015-09-16 Massachusetts Inst Technology Stable layer-by-layer coated particles
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
WO2014150074A1 (en) 2013-03-15 2014-09-25 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
US9956323B2 (en) 2014-12-18 2018-05-01 Cook Medical Technologies Llc Medical devices for local bioactive delivery
WO2017117188A1 (en) * 2015-12-29 2017-07-06 Massachusetts Institute Of Technology Biodegradable free-standing controlled drug release stickers
CN117323302A (en) * 2016-09-23 2024-01-02 密歇根大学董事会 Delivery device and method of manufacturing the same
DE102017113853A1 (en) * 2017-06-22 2018-12-27 B. Braun Avitum Ag Hemocompatible adsorbent for dialysis of protein-bound uremic toxins
CN107141474A (en) * 2017-07-04 2017-09-08 南开大学 It is poly- containing triclosan（β urethanes）Preparation method and the application in the streptococcus mutans biofilm of selectively killing oral cavity
WO2019089567A1 (en) 2017-10-30 2019-05-09 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
CN116410503A (en) * 2021-12-31 2023-07-11 江苏百赛飞生物科技有限公司 Multifunctional layer structure, preparation method and product thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050276841A1 (en) * 2004-06-07 2005-12-15 California Institute Of Technology Biodegradable drug-polymer delivery system
WO2006051227A1 (en) * 2004-11-15 2006-05-18 Universite Des Sciences Et Technologies De Lille Saic Biomaterials carrying cyclodextrines having improved absorption properties and used for the progressive and delayed release of therapeutic molecules
US20070020469A1 (en) * 2002-10-24 2007-01-25 Wood Kris C Methods of Making Decomposable Thin Films of Polyelectrolytes and Uses Thereof

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB969808A (en) * 1962-06-08 1964-09-16 Boots Pure Drug Co Ltd Anthelmintic compositions and compounds
NO125853B (en) 1966-10-03 1972-11-13 Ford Motor Co
GB1213806A (en) 1966-10-03 1970-11-25 Ford Motor Co Siloxane-modified polycarboxylic acid resins, and paint binder compositions incorporating the same
US3710795A (en) * 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3962414A (en) * 1972-04-27 1976-06-08 Alza Corporation Structured bioerodible drug delivery device
US4191811A (en) * 1977-03-01 1980-03-04 Ionics, Incorported Ion exchange membranes based upon polyphenylene sulfide and fluorocarbon polymeric binder
US4250029A (en) * 1977-04-25 1981-02-10 Rohm And Haas Company Coated membranes
IT1148784B (en) * 1980-04-09 1986-12-03 Eurand Spa PROCEDURE FOR THE PREPARATION OF MICRO CAPSULES IN A LIQUID VEHICLE
US4946929A (en) * 1983-03-22 1990-08-07 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
US4794000A (en) 1987-01-08 1988-12-27 Synthetic Blood Corporation Coacervate-based oral delivery system for medically useful compositions
US4638045A (en) * 1985-02-19 1987-01-20 Massachusetts Institute Of Technology Non-peptide polyamino acid bioerodible polymers
US4806621A (en) * 1986-01-21 1989-02-21 Massachusetts Institute Of Technology Biocompatible, bioerodible, hydrophobic, implantable polyimino carbonate article
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US5804178A (en) 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US5736372A (en) * 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5114719A (en) * 1987-04-29 1992-05-19 Sabel Bernhard A Extended drug delivery of small, water-soluble molecules
US5019379A (en) * 1987-07-31 1991-05-28 Massachusetts Institute Of Technology Unsaturated polyanhydrides
US5010167A (en) * 1989-03-31 1991-04-23 Massachusetts Institute Of Technology Poly(amide-and imide-co-anhydride) for biological application
CA2036606A1 (en) 1990-02-20 1991-08-21 Michael Colvin Coated intraocular lens and coatings therefor
DE4026978A1 (en) * 1990-08-25 1992-02-27 Bayer Ag Coated substrates for electro=optical applications, etc.
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5364634A (en) 1991-11-08 1994-11-15 Southwest Research Institute Controlled-release PH sensitive capsule and adhesive system and method
PT627911E (en) * 1992-02-28 2001-04-30 Univ Texas PHOTOPOLYMERIZED BIODEGRADABLE HYDROGEES AS CONTACT MATERIALS FOR CONTROLLED LIBERTACAO FABRICS AND VEHICLES
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5399665A (en) * 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
US5630941A (en) * 1992-12-23 1997-05-20 Burger; Wolfgang Permanent hydrophilic modification of fluoropolymers
US5512600A (en) 1993-01-15 1996-04-30 Massachusetts Institute Of Technology Preparation of bonded fiber structures for cell implantation
US5514378A (en) * 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5518767A (en) * 1993-07-01 1996-05-21 Massachusetts Institute Of Technology Molecular self-assembly of electrically conductive polymers
US6180239B1 (en) * 1993-10-04 2001-01-30 President And Fellows Of Harvard College Microcontact printing on surfaces and derivative articles
US5512131A (en) * 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
DE69533569T2 (en) * 1994-03-07 2006-01-05 Dendritic Nanotechnologies, Inc., Mt. Pleasant BIOACTIVE AND / OR TARGETED DENDRIMERE CONJUGATES CONTAINING GENETIC MATERIAL
AUPM623994A0 (en) 1994-06-15 1994-07-07 Biomolecular Research Institute Limited Antiviral dendrimers
US5716709A (en) * 1994-07-14 1998-02-10 Competitive Technologies, Inc. Multilayered nanostructures comprising alternating organic and inorganic ionic layers
IT1268718B1 (en) 1994-07-26 1997-03-06 Fidia Advanced Biopolymers Srl SYNTHESIS OF CHEMICAL GEL FROM POLYSACCHARIDES POLYELECTROLYTES VIA GAMMA IRRADIATION
US5700559A (en) 1994-12-16 1997-12-23 Advanced Surface Technology Durable hydrophilic surface coatings
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US6123727A (en) 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US6095148A (en) 1995-11-03 2000-08-01 Children's Medical Center Corporation Neuronal stimulation using electrically conducting polymers
US5902599A (en) 1996-02-20 1999-05-11 Massachusetts Institute Of Technology Biodegradable polymer networks for use in orthopedic and dental applications
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
AUPO104496A0 (en) 1996-07-17 1996-08-08 Biomolecular Research Institute Limited Angiogenic inhibitory compounds
GB9623051D0 (en) 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
US6919373B1 (en) * 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
US6114099A (en) 1996-11-21 2000-09-05 Virginia Tech Intellectual Properties, Inc. Patterned molecular self-assembly
US5904927A (en) * 1997-03-14 1999-05-18 Northeastern University Drug delivery using pH-sensitive semi-interpenetrating network hydrogels
DE69841937D1 (en) 1997-04-21 2010-11-25 California Inst Of Techn MULTIFUNCTIONAL POLYMER COATING
US5837752A (en) 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
US6089853A (en) 1997-12-24 2000-07-18 International Business Machines Corporation Patterning device for patterning a substrate with patterning cavities fed by service cavities
US5926860A (en) * 1997-12-31 1999-07-27 Fluidmaster Low profile vacuum toilet
US6451871B1 (en) * 1998-11-25 2002-09-17 Novartis Ag Methods of modifying surface characteristics
SE514129C2 (en) * 1998-01-16 2001-01-08 Scania Cv Ab Stabilizers
EP1064088B1 (en) 1998-03-19 2002-12-04 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates
DE19812083A1 (en) 1998-03-19 1999-09-30 Max Planck Gesellschaft Simple preparation of coated particles, used to prepare systems for slow and/or targeted release of actives including pharmaceuticals, contrast agents, herbicides, pesticides, catalysts and pigments
US7101575B2 (en) * 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
US6123681A (en) * 1998-03-31 2000-09-26 Global Vascular Concepts, Inc. Anti-embolism stocking device
US5962520A (en) * 1998-04-02 1999-10-05 The University Of Akron Hydrolytically unstable, biocompatible polymer
US6103266A (en) * 1998-04-22 2000-08-15 Tapolsky; Gilles H. Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues
WO1999056878A1 (en) 1998-04-30 1999-11-11 Graffinity Pharmaceutical Design Gmbh Device for transporting liquids along predetermined guideways
US6699501B1 (en) * 1998-07-15 2004-03-02 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften. E.V. Polyelectrolyte coverings on biological templates
US6402918B1 (en) * 1998-11-16 2002-06-11 Joseph B. Schlenoff Apparatus for capillary electrophoresis and associated method
CA2351734A1 (en) 1998-11-20 2000-06-02 University Of Connecticut Generic integrated implantable potentiostat telemetry unit for electrochemical sensors
US6740643B2 (en) * 1999-01-21 2004-05-25 Mirus Corporation Compositions and methods for drug delivery using amphiphile binding molecules
JP4970678B2 (en) 1999-06-10 2012-07-11 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ Encapsulation of crystals by multilayer coating
US6447887B1 (en) * 1999-09-14 2002-09-10 Virginia Tech Intellectual Properties, Inc. Electrostrictive and piezoelectric thin film assemblies and method of fabrication therefor
DE10001172A1 (en) 2000-01-13 2001-07-26 Max Planck Gesellschaft Templating solid particles with polymer multilayers
AR027348A1 (en) 2000-02-04 2003-03-26 Novartis Ag PROCESS TO COVER A SURFACE
US7045087B2 (en) * 2000-03-28 2006-05-16 The Board Of Regents For Oklahoma State University Assembly of free-standing films using a layer-by-layer process
DE10027393B4 (en) 2000-06-02 2007-05-16 Wella Ag Poly- and oligoesters of cationic hydroxy acids, process for their preparation and their use
WO2002017888A2 (en) * 2000-08-28 2002-03-07 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Controlled and sustained release properties of polyelectrolyte multilayer capsules
US6860980B2 (en) * 2000-09-15 2005-03-01 The United States Of America As Represented By The Secretary Of Commerce Polyelectrolyte derivatization of microfluidic devices
US7427394B2 (en) 2000-10-10 2008-09-23 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US6998115B2 (en) * 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US6716813B2 (en) * 2000-11-28 2004-04-06 House Ear Institute Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
US7223327B2 (en) * 2001-04-18 2007-05-29 Florida State University Research Foundation, Inc. Method of preparing free polyelectrolyte membranes
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US7112361B2 (en) * 2001-10-25 2006-09-26 Massachusetts Institute Of Technology Methods of making decomposable thin films of polyelectrolytes and uses thereof
CA2473355C (en) 2002-01-18 2012-01-03 Michael E. Snyder Sustained release ophthalmological device and method of making and using the same
US7101947B2 (en) * 2002-06-14 2006-09-05 Florida State University Research Foundation, Inc. Polyelectrolyte complex films for analytical and membrane separation of chiral compounds
US7033602B1 (en) * 2002-06-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
US6752868B2 (en) * 2002-07-31 2004-06-22 Mcnc Research & Development Institute Layer-by-layer assembly of photonic crystals
US20050019404A1 (en) * 2003-06-30 2005-01-27 Hsing-Wen Sung Drug-eluting biodegradable stent
US7090868B2 (en) * 2002-09-13 2006-08-15 University Of Florida Materials and methods for drug delivery and uptake
US20060216494A1 (en) * 2002-11-25 2006-09-28 Helga Furedi-Milhofer Organic-inorganic nanocomposite coatings for implant materials and methods of preparation thereof
US7251893B2 (en) * 2003-06-03 2007-08-07 Massachusetts Institute Of Technology Tribological applications of polyelectrolyte multilayers
US7364585B2 (en) * 2003-08-11 2008-04-29 Boston Scientific Scimed, Inc. Medical devices comprising drug-loaded capsules for localized drug delivery
US7544770B2 (en) * 2003-08-29 2009-06-09 Louisiana Tech Foundation, Inc. Multilayer films, coatings, and microcapsules comprising polypeptides
US7348399B2 (en) * 2003-08-29 2008-03-25 Louisiana Tech University Foundation, Inc. Nanofabricated polypeptide multilayer films, coatings, and microcapsules
JP2007526793A (en) * 2003-11-07 2007-09-20 ジーピー メディカル インコーポレイテッド Biodegradable drug-eluting stent
EP1535952B1 (en) * 2003-11-28 2013-01-16 Universite Louis Pasteur Method for preparing crosslinked polyelectrolyte multilayer films
US20050152955A1 (en) * 2003-12-16 2005-07-14 Akhave Jay R. Electrostatically self-assembled antimicrobial coating for medical applications
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
US20060127437A1 (en) * 2004-12-13 2006-06-15 Misty Anderson Kennedy Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids
US20090088679A1 (en) * 2005-02-07 2009-04-02 Massachusetts Institute Of Technology Electronically-Degradable Layer-by-Layer Thin Films
WO2006116683A1 (en) * 2005-04-27 2006-11-02 The Trustees Of The University Of Pennsylvania Nanostructure enhanced luminescence
EP1931417A2 (en) * 2005-09-30 2008-06-18 Transcutaneous Technologies Inc. Transdermal drug delivery systems, devices, and methods employing novel pharmaceutical vehicles
WO2007038966A1 (en) 2005-10-05 2007-04-12 Sca Hygiene Products Ab Absorbent article comprising a thin film including an active agent
AU2006311820A1 (en) * 2005-11-04 2007-05-18 Merck Sharp & Dohme Corp. Methods of using SAHA and erlotinib for treating cancer
WO2008057127A2 (en) * 2006-02-06 2008-05-15 Massachusetts Institute Of Technology Self-assembly of macromolecules on multilayered polymer surfaces
CA2644694C (en) 2006-03-10 2014-05-13 Sangeeta N. Bhatia Triggered self-assembly conjugates and nanosystems
GB0605688D0 (en) * 2006-03-21 2006-05-03 Novartis Ag Organic compounds
WO2007115033A2 (en) * 2006-03-31 2007-10-11 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Layered nanoparticles for sustained release of small molecules
EP2029357A1 (en) 2006-05-30 2009-03-04 Massachusetts Institute of Technology Inc. Methods of making decomposable thin films of polyelectrolytes and uses thereof
WO2008008483A2 (en) * 2006-07-12 2008-01-17 The Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
JP2010502433A (en) * 2006-09-08 2010-01-28 マサチューセッツ・インスティテュート・オブ・テクノロジー Automatic layer-by-layer spraying technology
US20080248108A1 (en) * 2006-10-06 2008-10-09 Jain Krotz Multilayered polyelectrolyte-based capsules for cell encapsulation and delivery of therapeutic compositions
WO2008157372A2 (en) 2007-06-14 2008-12-24 Massachusetts Institute Of Technology Self assembled films for protein and drug delivery applications
US20110038939A1 (en) * 2007-07-16 2011-02-17 Northeastern University Therapeutic stable nanoparticles
WO2009049092A1 (en) * 2007-10-09 2009-04-16 Wisconsin Alumni Research Foundation Covalent assembly of ultrathin polymeric films
US8974814B2 (en) * 2007-11-12 2015-03-10 California Institute Of Technology Layered drug delivery polymer monofilament fibers
CA2707424A1 (en) 2007-11-28 2009-06-04 Tragara Pharmaceuticals, Inc. Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
US9603980B2 (en) * 2008-02-26 2017-03-28 CARDINAL HEALTH SWITZERLAND 515 GmbH Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices
WO2009117473A2 (en) 2008-03-18 2009-09-24 Massachusetts Institute Of Technology Structures including antimicrobial peptides
TWI531362B (en) * 2008-07-21 2016-05-01 艾爾康股份有限公司 Ophthalmic device having therapeutic agent delivery capability
US9198875B2 (en) 2008-08-17 2015-12-01 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
US20100189683A1 (en) * 2008-11-14 2010-07-29 Ascenta Therapeutics, Inc. Pulsatile Dosing of Gossypol for Treatment of Disease
US20120058697A1 (en) 2009-04-01 2012-03-08 Strickland Aaron D Conformal particle coatings on fiber materials for use in spectroscopic methods for detecting targets of interest and methods based thereon
US20120058355A1 (en) * 2009-06-02 2012-03-08 Hyomin Lee Coatings
US20110143127A1 (en) * 2009-12-11 2011-06-16 Biomet Manufacturing Corp. Methods for coating implants
EP2566468A4 (en) 2010-05-03 2014-06-18 Massachusetts Inst Technology Drug delivery coating and devices
US20120027837A1 (en) * 2010-07-27 2012-02-02 Massachusetts Institute Of Technology Multilayer coating compositions, coated substrates and methods thereof
WO2012149492A1 (en) 2011-04-27 2012-11-01 Massachusetts Institute Of Technology Coating compositions, methods and coated devices
WO2013110047A1 (en) 2012-01-20 2013-07-25 Massachusetts Institute Of Technology Compositions and methods for coating
EP2841056A4 (en) 2012-04-23 2015-09-16 Massachusetts Inst Technology Stable layer-by-layer coated particles
US9511222B2 (en) * 2012-08-03 2016-12-06 Boston Scientific Neuromodulation Corporation System and method for post-stroke neural rehabilitation
US9610252B2 (en) 2012-10-12 2017-04-04 Massachusetts Institute Of Technology Multilayer compositions, coated devices and use thereof
WO2014066862A2 (en) 2012-10-26 2014-05-01 Massachusetts Institute Of Technology Devices and methods for layer-by-layer assembly

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070020469A1 (en) * 2002-10-24 2007-01-25 Wood Kris C Methods of Making Decomposable Thin Films of Polyelectrolytes and Uses Thereof
US20050276841A1 (en) * 2004-06-07 2005-12-15 California Institute Of Technology Biodegradable drug-polymer delivery system
WO2006051227A1 (en) * 2004-11-15 2006-05-18 Universite Des Sciences Et Technologies De Lille Saic Biomaterials carrying cyclodextrines having improved absorption properties and used for the progressive and delayed release of therapeutic molecules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KATSUHIKO, S. ET AL: "Layered assemblies composed of sulfonated cyclodextrin and poly(allylamine)", COLLOID AND POLYMER SCIENCE, no. 282, 1 May 2003 (2003-05-01), pages 287 - 290, XP002607629, DOI: 10.1007/s00396-003-0911-4 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109609488A (en) * 2018-12-04 2019-04-12 万华化学集团股份有限公司 A kind of preparation method of immobilized lipase and the method for preparing 2 ethyl hexanoic acid
CN109609488B (en) * 2018-12-04 2020-06-02 万华化学集团股份有限公司 Preparation method of immobilized lipase and method for preparing 2-ethylhexanoic acid

Also Published As

Publication number Publication date
WO2010021973A2 (en) 2010-02-25
US20100040674A1 (en) 2010-02-18
US9198875B2 (en) 2015-12-01

Similar Documents

Publication Publication Date Title
WO2010021973A3 (en) Controlled delivery of bioactive agents from decomposable films
WO2012149494A3 (en) Coating compositions, methods and coated devices
WO2008076535A3 (en) Multi-layer films comprising propylene-based polymers
WO2006058234A3 (en) Medical devices with highly flexible coated hypotube
WO2009036253A3 (en) Medical devices having bioerodable layers for the release of therapeutic agents
NZ588549A (en) Stents having bioabsorbable layers
ATE515529T1 (en) FILM MADE OF REINFORCED SILICONE RESIN AND NANOFIBER FILLED SILICONE COMPOSITION
WO2009108490A3 (en) Bioabsorbable stent with layers having different degradation rates
WO2008036357A3 (en) Medical devices having biodegradable polymeric regions with overlying hard, thin layers
WO2014059269A3 (en) Multilayer compositions, coated devices and use thereof
WO2010120552A3 (en) Coated stents
WO2010021757A3 (en) Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
WO2007126606A3 (en) Controlled degradation and drug release in stents
NZ589376A (en) Innerliner with nylon skin layer and a sealant layer
CA2527666A1 (en) Multi-layer drug delivery device and method of manufacturing same
EP2465548A3 (en) Implantable polymeric films
MY163892A (en) Drug delivery system
WO2006086391A3 (en) Electrochemically-degradable layer-by-layer thin films
WO2010111196A3 (en) Peripheral stents having layers
WO2011140136A3 (en) Drug delivery coating and devices
WO2008079549A3 (en) Polymer coating for medical devices
WO2009117241A3 (en) Controlled degradation of magnesium stents
WO2008039658A3 (en) Metallized films, articles, and methods of making the same
EP2211760A4 (en) Polymeric drug delivery systems and thermoplastic extrusion processes for producing such systems
MX2009011248A (en) Stents having biodegradable layers.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09791571

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09791571

Country of ref document: EP

Kind code of ref document: A2