WO2010028336A3 - Fatty acid c16:1n7-palmitoleate a lipokine and biomarker for metabolic status - Google Patents

Fatty acid c16:1n7-palmitoleate a lipokine and biomarker for metabolic status Download PDF

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Publication number
WO2010028336A3
WO2010028336A3 PCT/US2009/056176 US2009056176W WO2010028336A3 WO 2010028336 A3 WO2010028336 A3 WO 2010028336A3 US 2009056176 W US2009056176 W US 2009056176W WO 2010028336 A3 WO2010028336 A3 WO 2010028336A3
Authority
WO
WIPO (PCT)
Prior art keywords
palmitoleate
lipokine
biomarker
fatty acid
metabolic status
Prior art date
Application number
PCT/US2009/056176
Other languages
French (fr)
Other versions
WO2010028336A2 (en
Inventor
Haiming Cao
Gokhan S. Hotamisligil
Original Assignee
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by President And Fellows Of Harvard College filed Critical President And Fellows Of Harvard College
Priority to US13/062,527 priority Critical patent/US9239334B2/en
Publication of WO2010028336A2 publication Critical patent/WO2010028336A2/en
Publication of WO2010028336A3 publication Critical patent/WO2010028336A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders

Abstract

The present invention provides for a novel lipokine, C16:1n7-palmitoleate, which also serves as a biomarker for metabolic status. More specifically, a low concentration of C16: ln7- palmitoleate in the free fatty acid component of the serum indicates a risk of metabolic disease, and that de novo lipogenesis should be stimulated. Additionally, administering C16:1n7- palmitoleate to a subject (via nutraceutical or other means), positively impacts lipid metabolism.
PCT/US2009/056176 2008-09-08 2009-09-08 Fatty acid c16:1n7-palmitoleate a lipokine and biomarker for metabolic status WO2010028336A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/062,527 US9239334B2 (en) 2008-09-08 2009-09-08 Fatty acid C16: 1N7-palmitoleate a lipokine and biomarker for metabolic status

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9510908P 2008-09-08 2008-09-08
US61/095,109 2008-09-08

Publications (2)

Publication Number Publication Date
WO2010028336A2 WO2010028336A2 (en) 2010-03-11
WO2010028336A3 true WO2010028336A3 (en) 2010-07-01

Family

ID=41797911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/056176 WO2010028336A2 (en) 2008-09-08 2009-09-08 Fatty acid c16:1n7-palmitoleate a lipokine and biomarker for metabolic status

Country Status (2)

Country Link
US (1) US9239334B2 (en)
WO (1) WO2010028336A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889739B2 (en) 2010-07-09 2014-11-18 President And Fellows Of Harvard College Use of trans-palmitoleate in identifying and treating metabolic disease
EP3510998A1 (en) * 2011-03-03 2019-07-17 Tersus Pharmaceuticals, LLC Compositions and methods comprising c16:1n7-palmitoleate
EP2975400B1 (en) * 2013-03-15 2019-09-04 Otsuka Pharmaceutical Co., Ltd. Composition for use in a method for measuring sugar/fatty acid combustion ratio
MX2016008045A (en) * 2013-12-20 2016-10-12 Metabolon Inc Biomakers of de novo lipogenesis and methods using the same.
WO2018075622A1 (en) * 2016-10-19 2018-04-26 University Of Miami Materials and methods for modulating insulin signaling and preserving podocyte function

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090202519A1 (en) * 2005-07-20 2009-08-13 The Scripps Research Institute Compositions and methods for treating gram positive bacterial infection in a mammalian subject
US20090215681A1 (en) * 2005-02-15 2009-08-27 Joslin Diabetes Center Methods of Diagnosis and Treatment of Metabolic Disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198250A (en) 1990-07-16 1993-03-30 Lipotech Partners Limited Partnership Food and pharmaceutical compositions containing short chain monounsaturated fatty acids and methods of using
EP0827402A2 (en) 1995-05-17 1998-03-11 Cedars-Sinai Medical Center Compositions containing fatty acids for improving digestion and absorption in the small intestine
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
ATE311113T1 (en) 1999-12-10 2005-12-15 Loders Croklaan Bv PALMITOLIC ACID AND ITS USE IN FOODS
US7025984B1 (en) 2000-06-26 2006-04-11 The Procter & Gamble Company Compositions and methods for body weight management
IL142535A0 (en) 2001-04-11 2002-03-10 Yeda Res & Dev Pharmaceutical compositions for the treatment of inflammation
DK1406641T3 (en) 2001-06-18 2009-05-04 Neptune Technologies & Bioress Curly extracts for the prevention and / or treatment of cardiovascular diseases
ATE443264T1 (en) 2001-09-24 2009-10-15 Lipomics Technologies Inc METHOD FOR USING QUANTITATIVE LIPIDE METABOLONE DATA

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090215681A1 (en) * 2005-02-15 2009-08-27 Joslin Diabetes Center Methods of Diagnosis and Treatment of Metabolic Disorders
US20090202519A1 (en) * 2005-07-20 2009-08-13 The Scripps Research Institute Compositions and methods for treating gram positive bacterial infection in a mammalian subject

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HANNAH J. WELTERS ET AL.: "Mono-unsaturated fatty acids protect against L-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exporere", FEBS LETTERS 2004, vol. 560, no. 1, 27 February 2004 (2004-02-27), pages 103 - 108 *

Also Published As

Publication number Publication date
US9239334B2 (en) 2016-01-19
US20110213032A1 (en) 2011-09-01
WO2010028336A2 (en) 2010-03-11

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