WO2010063265A3 - Method and device for the stimulation of cells - Google Patents

Method and device for the stimulation of cells Download PDF

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Publication number
WO2010063265A3
WO2010063265A3 PCT/DE2009/001681 DE2009001681W WO2010063265A3 WO 2010063265 A3 WO2010063265 A3 WO 2010063265A3 DE 2009001681 W DE2009001681 W DE 2009001681W WO 2010063265 A3 WO2010063265 A3 WO 2010063265A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
stimulation
force
bring
arranging
Prior art date
Application number
PCT/DE2009/001681
Other languages
German (de)
French (fr)
Other versions
WO2010063265A2 (en
Inventor
Friedrich-Wilhelm Bach
Marten Bierbaum
Christian Krause
Original Assignee
Gottfried Wilhelm Leibniz Universität Hannover
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gottfried Wilhelm Leibniz Universität Hannover filed Critical Gottfried Wilhelm Leibniz Universität Hannover
Publication of WO2010063265A2 publication Critical patent/WO2010063265A2/en
Publication of WO2010063265A3 publication Critical patent/WO2010063265A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2527/00—Culture process characterised by the use of mechanical forces, e.g. strain, vibration

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Mechanical Engineering (AREA)
  • Magnetic Treatment Devices (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

The invention relates to a method for mechanically stimulating cells (14), comprising the steps of arranging the cells (14) so as to bring them in mechanical contact with an output part (28) of a drive unit (16), and permanently applying a force to the cells (14) which has a predefined force curve.
PCT/DE2009/001681 2008-12-01 2009-11-26 Method and device for the stimulation of cells WO2010063265A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008059731.7 2008-12-01
DE200810059731 DE102008059731A1 (en) 2008-12-01 2008-12-01 Method and device for stimulating cells

Publications (2)

Publication Number Publication Date
WO2010063265A2 WO2010063265A2 (en) 2010-06-10
WO2010063265A3 true WO2010063265A3 (en) 2010-12-02

Family

ID=42134087

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2009/001681 WO2010063265A2 (en) 2008-12-01 2009-11-26 Method and device for the stimulation of cells

Country Status (2)

Country Link
DE (1) DE102008059731A1 (en)
WO (1) WO2010063265A2 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051985A2 (en) * 2000-12-22 2002-07-04 Keele University Culturing tissue using magnetically generated mechanical stresses
US20030100108A1 (en) * 2001-11-16 2003-05-29 Altman Gregory H. Matrix for the production of tissue engineered ligaments, tendons and other tissue
EP1428869A1 (en) * 2001-08-30 2004-06-16 Takagi Industrial Co., Ltd. Cell and structure incubator
US20050153437A1 (en) * 2002-09-04 2005-07-14 Miwatec Incorporated Method for controlling biological function with mechanical vibration and device therefor
DE102004012010A1 (en) * 2004-03-10 2005-09-29 Fachhochschule Gießen-Friedberg Invention concerning bioreactors and bioreactor systems
WO2006113382A2 (en) * 2005-04-15 2006-10-26 Wake Forest University Health Sciences Bioreactor system and method of enhancing functionality of muscle cultured in vitro
EP1780266A1 (en) * 2004-06-17 2007-05-02 Ken Nakata Cell culturing method by biomechanical stimulus load and its device

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10151822B9 (en) * 2001-10-17 2004-10-21 Jürgen Dr. Heubach Device and method for electrical and mechanical stimulation of cells and / or tissues

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051985A2 (en) * 2000-12-22 2002-07-04 Keele University Culturing tissue using magnetically generated mechanical stresses
EP1428869A1 (en) * 2001-08-30 2004-06-16 Takagi Industrial Co., Ltd. Cell and structure incubator
US20030100108A1 (en) * 2001-11-16 2003-05-29 Altman Gregory H. Matrix for the production of tissue engineered ligaments, tendons and other tissue
US20050153437A1 (en) * 2002-09-04 2005-07-14 Miwatec Incorporated Method for controlling biological function with mechanical vibration and device therefor
DE102004012010A1 (en) * 2004-03-10 2005-09-29 Fachhochschule Gießen-Friedberg Invention concerning bioreactors and bioreactor systems
EP1780266A1 (en) * 2004-06-17 2007-05-02 Ken Nakata Cell culturing method by biomechanical stimulus load and its device
WO2006113382A2 (en) * 2005-04-15 2006-10-26 Wake Forest University Health Sciences Bioreactor system and method of enhancing functionality of muscle cultured in vitro

Also Published As

Publication number Publication date
WO2010063265A2 (en) 2010-06-10
DE102008059731A1 (en) 2010-06-02

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