WO2010078376A3 - Fc-specific polymer-conjugated antibodies and their diagnostic use - Google Patents

Fc-specific polymer-conjugated antibodies and their diagnostic use Download PDF

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Publication number
WO2010078376A3
WO2010078376A3 PCT/US2009/069748 US2009069748W WO2010078376A3 WO 2010078376 A3 WO2010078376 A3 WO 2010078376A3 US 2009069748 W US2009069748 W US 2009069748W WO 2010078376 A3 WO2010078376 A3 WO 2010078376A3
Authority
WO
WIPO (PCT)
Prior art keywords
specific polymer
conjugated antibodies
diagnostic use
conjugates
present
Prior art date
Application number
PCT/US2009/069748
Other languages
French (fr)
Other versions
WO2010078376A2 (en
Inventor
Casey A. Kernag
Christopher Bieniarz
Danielle Brands
Julia Ashworth-Sharpe
Original Assignee
Ventana Medical Systems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Medical Systems, Inc. filed Critical Ventana Medical Systems, Inc.
Publication of WO2010078376A2 publication Critical patent/WO2010078376A2/en
Publication of WO2010078376A3 publication Critical patent/WO2010078376A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention provides molecular conjugates of antibodies and hydrophilic, non-immunogenic polymers. More particularly, the present invention provides Fc-specific polymer-conjugated antibody signal- generating moiety conjugates and methods for making and using the conjugates.
PCT/US2009/069748 2008-12-30 2009-12-29 Fc-specific polymer-conjugated antibodies and their diagnostic use WO2010078376A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14160208P 2008-12-30 2008-12-30
US61/141,602 2008-12-30

Publications (2)

Publication Number Publication Date
WO2010078376A2 WO2010078376A2 (en) 2010-07-08
WO2010078376A3 true WO2010078376A3 (en) 2010-09-16

Family

ID=42021649

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/069748 WO2010078376A2 (en) 2008-12-30 2009-12-29 Fc-specific polymer-conjugated antibodies and their diagnostic use

Country Status (1)

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WO (1) WO2010078376A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103764665A (en) 2011-06-28 2014-04-30 怀特黑德生物医学研究所 Using sortases to install click chemistry handles for protein ligation
BR112015021764B1 (en) * 2013-03-05 2022-07-19 Hanmi Pharm. Co., Ltd. IMPROVED PREPARATION METHOD FOR HIGH YIELD PRODUCTION OF PHYSIOLOGICALLY ACTIVE POLYPEPTIDE CONJUGATE
WO2014183066A2 (en) 2013-05-10 2014-11-13 Whitehead Institute For Biomedical Research Protein modification of living cells using sortase
US10471099B2 (en) 2013-05-10 2019-11-12 Whitehead Institute For Biomedical Research In vitro production of red blood cells with proteins comprising sortase recognition motifs
WO2015073746A2 (en) 2013-11-13 2015-05-21 Whitehead Institute For Biomedical Research 18f labeling of proteins using sortases
RU2744836C2 (en) * 2014-05-08 2021-03-16 Новодиакс, Инк. Direct immunohistochemical analysis
CN117491623A (en) * 2015-08-20 2024-02-02 豪夫迈·罗氏有限公司 Particle-based immunoassays using pegylated analyte-specific binding agents
EP4218833A1 (en) * 2015-10-01 2023-08-02 Whitehead Institute for Biomedical Research Labeling of antibodies
CN112326953A (en) * 2020-11-03 2021-02-05 广东海洋大学深圳研究院 Method for directionally labeling polybiotin by using antibody
CN116836235A (en) * 2022-03-25 2023-10-03 中国科学院上海药物研究所 Affinity fragment-directed cleavable fragments, their design, synthesis and use in the preparation of site-directed drug conjugates

Citations (3)

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US20070117153A1 (en) * 2005-11-23 2007-05-24 Christopher Bieniarz Molecular conjugate
US20070122408A1 (en) * 2005-10-20 2007-05-31 The Scripps Research Institute Fc Labeling for Immunostaining and Immunotargeting

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US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
US20070122408A1 (en) * 2005-10-20 2007-05-31 The Scripps Research Institute Fc Labeling for Immunostaining and Immunotargeting
US20070117153A1 (en) * 2005-11-23 2007-05-24 Christopher Bieniarz Molecular conjugate

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Title
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CUNNINGHAM-RUNDLES C ET AL: "Biological activities of polyethylene-glycol immunoglobulin conjugates resistance to enzymatic degradation", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 152, no. 2, 10 August 1992 (1992-08-10), pages 177 - 190, XP023945030, ISSN: 0022-1759, [retrieved on 19920810] *
EKINS R ET AL: "IMMUNOASSAY AND OTHER LIGAND ASSAYS: PRESENT STATUS AND FUTURE TRENDS", INTERNATIONAL FEDERATION OF CLINICAL CHEMISTRY. JOURNAL, XX, XX, vol. 9, no. 3, 1 September 1997 (1997-09-01), pages 100,102 - 109, XP001153007 *
FISCHER-DURAND NATHALIE ET AL: "Synthesis of metal-carbonyl-dendrimer-antibody immunoconjugates: towards a new format for carbonyl metallo immunoassay", CHEMBIOCHEM - A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY, WILEY VCH, WEINHEIM, DE, vol. 5, no. 4, 2 April 2004 (2004-04-02), pages 519 - 525, XP002495438, ISSN: 1439-4227 *
HARLOW ET AL.: "Antibodies: a laboratory manual", 1988, COLD SPRING HARBOR PRESS, New York, ISBN: 0-87969-314-2, pages: 321 - 321, XP002586742 *
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