WO2010123041A1

WO2010123041A1 - Catheter and medication administering device

Info

Publication number: WO2010123041A1
Application number: PCT/JP2010/057099
Authority: WO
Inventors: 剛外川; 広明小関; 香由木村; 正伸清原; 博英深澤
Original assignee: オリンパス株式会社
Priority date: 2009-04-22
Filing date: 2010-04-21
Publication date: 2010-10-28
Also published as: JP2010252924A

Abstract

A medication administering device comprising: a catheter (1) which is formed as an elongated tubular body (2) having an inner channel, the catheter (1) being provided with a first medication inlet (5) which introduces a medication into the inner channel, a second medication inlet (6) which introduces a medication into the inner channel, and through-holes (4) which are formed in the side surface of the tubular body (2) at positions between the first medication inlet (5) and the second medication inlet (6) and connect the inner channel and the outside; a pump (7) which communicates with the first medication inlet (5) of the catheter (1) and discharges the medication to the through-hole (4) side; and a pump (8) which communicates with the second medication inlet (6) of the catheter (1) and discharges the medication to the through-hole (4) side.

Description

Catheter and drug administration device

The present invention relates to a catheter which is inserted into a living body and which discharges a drug from a plurality of through holes provided on the side, and a drug administration device using the catheter.

Conventionally, a catheter inserted into a human or a mammal other than a human or the like has an elongated tubular shape having a channel inside. A portion of the tubular casing inserted into the body is provided with a through hole communicating the internal channel with the outside for the purpose of discharging the medicine and the like. Some such catheters are provided with a plurality of through holes on the side surface so that the medicine can be discharged to a wide area from the plurality of through holes on the side surface. In a catheter having a plurality of through holes on this side, the drug is delivered from a drug delivery source such as a pump, taken from the proximal side of the catheter toward the internal channel, and discharged into the body from the plurality of through holes (for example, , Patent Document 1).

Japanese Patent Publication No. 2003-504132

However, in the case of injecting a drug in one direction from the proximal end in the conventional catheter, the discharge amount of the drug is not the same in the through hole close to the proximal end and the through hole close to the distal end. That is, even if a sufficient discharge amount can be obtained by the through hole close to the proximal end, a state in which the drug is sequentially discharged by the through hole in the middle and the pressure of the drug in the internal channel decreases. As a result, in many cases, a sufficient discharge amount can not be obtained in the through hole near the distal end, and there has been a phenomenon that the discharge amount gradually decreases as the position of the through hole goes from the proximal end to the distal end.

Such a phenomenon in which the amount of discharge gradually decreases brings about a limit to the length of the region where a plurality of through holes are provided on the side of the catheter. That is, in the conventional catheter, there is a problem that the range in which the drug can be administered by one catheter is limited.

This invention is made in view of the above, Comprising: It aims at providing the catheter and drug administration device which can extend the administration range of medicine etc. by simple composition.

In order to solve the problems described above and to achieve the object, the catheter according to the present invention is an elongated tubular casing having an inner channel, and a first drug intake for introducing a drug into the inner channel; A second drug inlet for introducing drug into the inner channel, and a side of the tubular housing, located between the first drug inlet and the second drug inlet, the inner channel and the outer And a plurality of through holes communicating with each other.

In the above-mentioned invention, the catheter according to the present invention is characterized in that it has a bent portion bent in a U-shape in the middle of the elongated tubular housing.

Further, in the above-mentioned invention, the catheter according to the present invention further includes a branching device for branching one flow path from the drug delivery source toward the first drug intake and the second drug intake. It is characterized by having.

In the catheter according to the present invention, in the above-mentioned invention, the internal channel may be a first internal channel in communication with the first drug inlet, and a second internal in communication with the second drug inlet. And a plurality of second through holes connecting the first inner channel and the outside, and a plurality of second through holes connecting the second inner channel and the outside. A range in which the plurality of first through holes are located in the axial direction of the tubular housing and the plurality of second through holes, the through holes being included, the first internal channel and the second internal channel being separated from each other It is characterized in that at least a part overlaps with the range in which the through hole of the above is located.

Further, the drug administration device according to the present invention is an elongated tubular casing having an inner channel, and a first drug intake for introducing the drug into the inner channel and a second drug for introducing the drug into the inner channel. An inlet, and a plurality of through holes located between the first drug inlet and the second drug inlet, which are side surfaces of the tubular housing, and which communicate the inner channel with the outside; A catheter having at least one drug delivery source in direct or indirect communication with the first drug inlet and the second drug inlet of the catheter.

Further, in the drug administration device according to the present invention, in the above-mentioned invention, the drug delivery source is a first drug delivery source in direct or indirect communication with a first drug intake of the catheter; And a second drug delivery source other than the first drug delivery source in direct or indirect communication with the second drug delivery port.

Further, the drug administration device according to the present invention is characterized in that, in the above-mentioned invention, a bending portion bent in a U-shape is provided in the middle of the elongated tubular housing of the catheter.

Further, in the drug administration device according to the present invention according to the above-mentioned invention, the drug delivery source is a single device, and the catheter is configured to transmit one flow path from the single drug delivery source to the first device. And a branching device for branching to the second drug inlet and the second drug inlet.

In the medicine administration device according to the present invention, in the above-mentioned invention, the internal channel is in communication with a first internal channel in communication with the first medicine intake, and a second in communication with the second medicine intake. A plurality of first through holes communicating the first internal channel with the outside, and a plurality of second through holes communicating the second internal channel with the outside And two or more through holes, wherein the first internal channel and the second internal channel are separated from each other, and a range in which the plurality of first through holes are located in the axial direction of the tubular housing It is characterized in that at least a part overlaps with the range in which the second through hole of (4) is located.

Further, a drug administration device according to the present invention has an elongated tubular housing having an inner channel, and a catheter having a plurality of through holes communicating the inner channel with the outside on the side, and the inner channel of the catheter And at least one drug delivery source for delivering the drug to the plurality of through holes through the internal channel in opposite directions from the opposite end sides of the catheter. It is characterized by sending out.

According to the invention, an elongated tubular casing having an inner channel is provided, a first drug inlet for introducing a drug into the inner channel, a second drug inlet for introducing a drug into the inner channel, and What is claimed is: 1. A catheter having a plurality of through holes located between the first drug inlet and the second drug inlet on the side surface of the tubular housing and communicating the internal channel with the outside. Since the medicine is discharged from the first medicine intake and the second medicine intake in the opposite direction to the plurality of through holes, and the medicine can be discharged from the plurality of through holes, The administration range of drugs etc. can be broadened by a simple configuration.

FIG. 1 is a schematic view showing a schematic configuration of a catheter according to Embodiment 1 of the present invention. FIG. 2 is a schematic view showing a schematic configuration of a drug administration device using the catheter shown in FIG. FIG. 3 is a view showing the discharge amount distribution of a plurality of through holes in the case where a drug is delivered from the first drug intake using only one pump. FIG. 4 is a diagram showing the discharge amount distribution of a plurality of through holes in the case where a drug is delivered from the second drug inlet using only one pump. FIG. 5 is a view showing the discharge amount distribution of a plurality of through holes when drugs are discharged from both ends of the first drug inlet and the second drug inlet by two pumps. FIG. 6 is a schematic view showing the configuration in the vicinity of the through hole of the catheter according to the second embodiment of the present invention. FIG. 7 is a schematic view showing the configuration in the vicinity of the through hole of the catheter according to the modification of the second embodiment of the present invention. FIG. 8 is a schematic view showing the configuration in the vicinity of the through hole of the catheter according to the third embodiment of the present invention. FIG. 9 is a schematic view showing the configuration in the vicinity of the through hole of the catheter according to a modification of the third embodiment of the present invention. FIG. 10 is a schematic view showing a schematic configuration of a catheter according to a fourth embodiment of the present invention. FIG. 11 is a schematic view showing a schematic configuration of a catheter according to a fifth embodiment of the present invention. FIG. 12 is a schematic view showing a schematic configuration of a catheter according to Embodiment 6 of the present invention. FIG. 13 is a schematic view showing a schematic configuration of a catheter according to Modification 1 of Embodiment 6 of the present invention. FIG. 14 is a schematic view showing the configuration in the vicinity of the through hole of the catheter according to the second modification of the sixth embodiment of the present invention. FIG. 15 is a schematic view showing the configuration in the vicinity of the through hole of the catheter according to the third modification of the sixth embodiment of the present invention.

Hereinafter, a catheter as a mode for carrying out the present invention and a drug administration device using the same will be described with reference to the drawings.

Embodiment 1
FIG. 1 is a schematic view showing a schematic configuration of a catheter according to Embodiment 1 of the present invention. As shown in FIG. 1, the catheter 1 is an elongated tubular housing 2 having an internal channel 3 and has a plurality of through holes 4 communicating the internal channel 3 with the outside on the side. The entire catheter 1 is made of a biocompatible material such as polyurethane, elastic silicone, Teflon (registered trademark), polyvinyl chloride, polyethylene and the like.

In this catheter 1, one end of a tubular housing 2 introduces a drug into the internal channel 3 and a first drug intake port 5 which is an opening communicating with the internal channel 3 and the other end of the tubular housing 2 A drug is introduced into the channel 3 and has a second drug inlet 6 which is an opening communicating with the internal channel 3. Also, the plurality of through holes 4 are located between the first drug inlet 5 and the second drug inlet 6 on the side surface of the tubular housing 2.

Here, when the drug is delivered from the two openings of the first drug inlet 5 and the second drug inlet toward the inside of the inner channel 3, that is, the side of the plurality of through holes 4, Drugs introduced from both ends flow in the internal channel 3 in the opposite direction, and eventually, the drug is discharged into the body from the plurality of through holes 4 between the two openings.

FIG. 2 is a schematic view showing a schematic configuration of a drug administration device using the catheter shown in FIG. As shown in FIG. 2, the catheter 1 is inserted into the administration target 10 such as a tumor in the body via the body surface 11, and the through hole 4 is disposed in the administration target 10.

A pump 7 as a first drug delivery source is connected to and in communication with the first drug inlet 5 of the catheter 1, and a second drug delivery source is connected to the second drug inlet 6. The pump 8 is connected and in communication. Although the pump 7 and the pump 8 are directly connected to the catheter 1 in FIG. 2 respectively, they may be connected and communicated indirectly via other members. Moreover, although the

pumps

7 and 8 are attached to the body surface 11, it may be not only this but may be embedded in the body, and may be spaced apart and provided outside the body.

Here, the drug discharge amount distribution from each through hole 4 when using the catheter 1 and the

pumps

7 and 8 will be described. Note that, as shown in FIG. 1, the plurality of through holes 4 are described as sequentially arranged through

holes

4a, 4b, 4c, 4d of the same diameter in the axial direction from the first medicine intake 5 side. Do.

First, FIG. 3 is a diagram showing the discharge amount distribution of the through holes 4a to 4d when only the pump 7 is used. In this case, the discharge amount is successively reduced in the order of the through holes 4 a → 4 b → 4 c → 4 d. This is a pressure reducing effect in which the drug is sequentially discharged from the through holes as it is separated from the pump 7, and the discharge pressure is gradually reduced, and as a result, the discharge amount is reduced.

Similarly, FIG. 4 is a view showing the discharge amount distribution of the through holes 4a to 4d when only the pump 8 is used. In this case, the discharge amount is successively reduced in the order of the through holes 4 d → 4 c → 4 b → 4 a. This is a pressure reducing effect in which the drug is sequentially discharged from the through holes as it is separated from the pump 8, and the discharge pressure gradually decreases, and as a result, the discharge amount decreases.

On the other hand, FIG. 5 shows the discharge amount distribution of the through holes 4a to 4d when the medicine is discharged from both ends of the first medicine intake 5 and the second medicine intake 6 by the

pumps

7, 8 FIG. In this case, the discharge amount distribution obtained by combining the discharge amount distributions shown in FIGS. 3 and 4 is obtained, the influence of the pressure reduction effect due to the positions of the through holes 4a to 4d is reduced, and a substantially uniform discharge amount distribution is obtained. That is, as shown in FIG. 2, the amount of discharge of each through hole 4 (4a to 4d) is made almost constant by delivering the medicine from both ends of the catheter 1 and discharging it from the plurality of through holes 4 on the side. can do. In addition, since the influence of the pressure reduction effect is reduced, the axial region in which the through hole 4 is provided can be widened. The effects of making the discharge amount distribution uniform and widening the discharge area are obtained when a plurality of through holes 4 are provided.

Second Embodiment
Next, a second embodiment of the present invention will be described. In the first embodiment described above, the tubular casing 2 is straight, but in the second embodiment, as shown in FIG. 6, the tubular casing 2 is U-shaped in the middle of the elongated tubular casing 2 of the catheter 1. A bent portion 12 is provided. The plurality of through holes 4 are provided on one side surface of the bending portion 12. In the second embodiment, when the bending portion 12 is inserted into the administration target 10, the insertion of the catheter 1 into the administration target 10 can be performed from one direction, so that the procedure can be simplified.

As shown in FIG. 7, a through hole 4 ′ may be further provided on the other side surface of the bending portion 12 so that the medicine can be discharged from both sides of the side surface of the bending portion 12.

Third Embodiment
Next, a third embodiment of the present invention will be described. In the third embodiment, as shown in FIG. 8, branching devices 13 are further provided at both ends of the catheter of the second embodiment having the bending portion 12. The branching device 13 branches one flow path 14 from the drug delivery source toward the first drug inlet 5 and the second drug inlet 6. This makes it possible to use one pump as a drug delivery source. The branching unit 13 may further have a flow rate adjustment function or the like.

As in FIG. 7, through holes may be further provided in the other side surface of the bending portion 12 so that the medicine can be discharged from both sides of the side surface of the bending portion 12 (see FIG. 9).

Embodiment 4
Next, the fourth embodiment of the present invention will be described. In the third embodiment described above, it is assumed that the catheter has the bending portion 12. However, in the fourth embodiment, as shown in FIG. 10, the catheter having no bending portion 12 shown in FIG. A branching device 13a is provided, which connects both ends of one, that is, the first drug inlet 5 and the second drug inlet 6, and also connects the flow path 14 to which one pump is connected. That is, the branch portion 13 a branches the medicine flowing in through the flow path 14 and delivers the medicine from the first medicine intake 5 and the second medicine intake 6 toward the through hole 4. . Also in this case, the same function and effect as the first embodiment can be obtained with a simple configuration in which only one pump is used.

Fifth Embodiment
A fifth embodiment of the present invention will next be described. In the fifth embodiment, as shown in FIG. 11, the casing 2 of the catheter 1 can be inserted into the medicine ejection portion 20 where the plurality of through holes 4 are located and the medicine ejection portion 20, and the through holes The two

non-conduit portions

21 and 22 are separately configured. The positions of the

conduits

21 and 22 with respect to the medicine ejection unit 20 can be adjusted in the axial direction. That is, after the

conduits

21 and 22 are moved to appropriate positions with respect to the medicine ejection unit 20, the desired catheter is obtained by fixing the position with an adhesive or the like.

By this configuration, the medicine is discharged only from the through hole 31 not covered by the

conduits

21 and 22 among the plurality of through holes 4, and the medicine from the through holes 30 covered by the

conduits

21 and 22 is medicine Is not discharged. Therefore, by appropriately adjusting the positions of the

conduits

21 and 22 with respect to the medicine ejection unit 20, it is possible to limit the through holes to be used depending on the situation. Thereby, according to the conditions, such as the magnitude | size of the administration target 10, an appropriate drug administration site | part can be selected and set precisely.

Sixth Embodiment
A sixth embodiment of the present invention will next be described. In the catheter 41 according to the sixth embodiment, as shown in FIG. 12, a first internal channel 43a in which the internal channel 43 corresponding to the internal channel 3 communicates with the first medicine intake 45, and a second medicine And a second internal channel 43 b in communication with the inlet 46.

Then, since the first internal channel 43a and the second internal channel 43b are separated by, for example, the partition wall 47, the drug can not move across the two

internal channels

43a and 43b. The plurality of through holes are a plurality of first through holes 44 communicating the first inner channel 43 a with the outside, and a plurality of second through holes 48 communicating the second inner channel 43 b with the outside. It is divided. That is, the drug that has passed through the first inner channel 43 a is discharged from the plurality of first through holes 44, and the drug that has passed through the second inner channel 43 b is discharged from the plurality of second through holes 48. That is, there are two combinations of the

internal channels

43a and 43b and the through

holes

44 and 48, respectively.

Here, in the axial direction of the tubular housing 42, at least a part of the range in which the plurality of first through holes 44 are positioned and the range in which the plurality of second through holes 48 are disposed are overlapped. There is. For this reason, the discharge amount distribution from the first through hole 44 has a profile as shown in FIG. 3, and the discharge amount distribution from the second through hole 48 has a profile as shown in FIG. Since, in this overlapping range, the sum of the discharge amounts of the first through holes 44 and the second through holes 48 contributes, the discharge amount distribution as a whole becomes a profile as shown in FIG. It becomes almost uniform at the through hole position.

(Modification 1 of Embodiment 6)
Next, a first modification of the sixth embodiment of the present invention will be described. This modification 1 applies the configuration of the sixth embodiment to the second embodiment, and has a bending portion 52 corresponding to the bending portion 12 as shown in FIG. The bent portion 52 is coupled by the coupling member 51. In the first modification of the sixth embodiment, as in the second embodiment, when the bending portion 52 is inserted into the administration target 10, insertion of the catheter 41 into the administration target 10 can be performed from one direction. The procedure can be simplified.

(Modification 2 of Embodiment 6)
Next, a second modification of the sixth embodiment of the present invention will be described. This modification 2 is obtained by applying the configuration of the sixth embodiment to the third embodiment, and as shown in FIG. 14, it branches further to both ends of the catheter of the modification 1 having the bending portion 52. The vessel 13 is provided. The branching device 13 branches one flow path 14 from the drug delivery source toward the first drug inlet 45 and the second drug inlet 46. This makes it possible to use one pump as a drug delivery source.

(Modification 3 of Embodiment 6)
Next, a third modification of the sixth embodiment of the present invention will be described. This modification 3 applies the configuration of the sixth embodiment to the fourth embodiment, and as shown in FIG. 15, both ends of the catheter 41, that is, the first drug intake 45 and the second A branching device 13a is provided which connects with the medicine inlet 46 and also connects with the flow path 14 to which one pump is connected. That is, the branch unit 13 a branches the medicine flowing in through the flow path 14 and delivers the medicine from the first medicine intake 45 and the second medicine intake 46 to the through

holes

44 and 45 respectively. I have to. Also in this case, the same function and effect as the first embodiment can be obtained with a simple configuration in which only one pump is used.

1, 41

catheters

2, 42

tubular housings

3, 43, 43a, 43b

internal channels

4, 30, 31, 44, 48 through

holes

5, 45

first drug intake

6, 46 second drug intake 7, Reference Signs List 8 pump 10 administration target 11

body surface

12, 52 bent portion 13 bifurcater 14 flow path 20

drug discharge portion

21, 22 conduit portion 47 partition wall 51 coupling member

Claims

It has an elongated tubular housing with an internal channel,
A first drug intake for introducing a drug into the internal channel;
A second drug inlet for introducing drug into the internal channel;
A plurality of through holes located between the first drug inlet and the second drug inlet on the side surface of the tubular housing and communicating the internal channel with the outside;
A catheter characterized by having:
The catheter according to claim 1, further comprising a U-shaped bent portion in the middle of the elongated tubular housing.
The catheter according to claim 1, further comprising a bifurcating device for branching one flow path from a drug delivery source toward the first drug intake and the second drug intake.
The inner channel includes a first inner channel in communication with the first drug inlet and a second inner channel in communication with the second drug inlet.
The plurality of through holes includes a plurality of first through holes communicating the first internal channel with the outside, and a plurality of second through holes communicating the second internal channel with the outside.
The first internal channel and the second internal channel are separated from one another,
The range in which the plurality of first through holes are located in the axial direction of the tubular housing and the range in which the plurality of second through holes are located at least partially overlap each other. Description catheter.
An elongated tubular rod having an inner channel, wherein a first drug inlet for introducing a drug into the inner channel, a second drug inlet for receiving a drug into the inner channel, and a side surface of the tubular rod A catheter having a plurality of through holes located between the first drug intake and the second drug intake and communicating the internal channel with the outside;
At least one drug delivery source in direct or indirect communication with the first drug inlet and the second drug inlet of the catheter;
A drug administration device characterized by having.
The drug delivery source may be a first drug delivery source in direct or indirect communication with a first drug intake of the catheter, and the first in direct communication with the second drug intake of the catheter. 6. The drug delivery device according to claim 5, comprising a second drug delivery source separate from the drug delivery source.
The drug administration device according to claim 5, further comprising a U-shaped bent portion in the middle of the elongated tubular housing of the catheter.
The drug delivery source is a single device,
The catheter is characterized in that it further comprises a bifurcating device for branching one flow path from the single drug delivery source towards the first drug intake and the second drug intake. The drug administration device according to Item 5.
The inner channel includes a first inner channel in communication with the first drug inlet and a second inner channel in communication with the second drug inlet.
The plurality of through holes includes a plurality of first through holes communicating the first internal channel with the outside, and a plurality of second through holes communicating the second internal channel with the outside. ,
The first internal channel and the second internal channel are separated from one another,
The area in which the plurality of first through holes are located in the axial direction of the tubular housing and the area in which the plurality of second through holes are located at least partially overlap each other. Drug administration device as described.
A catheter having an elongated tubular housing having an internal channel, and a plurality of through holes communicating with the external channel from the internal channel on the side surface;
At least one drug delivery source for delivering a drug to the internal channel of the catheter;
Have
The drug delivery device according to claim 1, wherein the drug delivery source delivers the drug toward the plurality of through holes through the internal channel in opposite directions from both ends of the catheter.