WO2011018541A3 - Hydrogels based on poloxamers with a star structure for the controlled release of active substances - Google Patents

Hydrogels based on poloxamers with a star structure for the controlled release of active substances Download PDF

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Publication number
WO2011018541A3
WO2011018541A3 PCT/ES2010/070538 ES2010070538W WO2011018541A3 WO 2011018541 A3 WO2011018541 A3 WO 2011018541A3 ES 2010070538 W ES2010070538 W ES 2010070538W WO 2011018541 A3 WO2011018541 A3 WO 2011018541A3
Authority
WO
WIPO (PCT)
Prior art keywords
poloxamers
active substances
controlled release
star structure
hydrogels based
Prior art date
Application number
PCT/ES2010/070538
Other languages
Spanish (es)
French (fr)
Other versions
WO2011018541A2 (en
Inventor
Francisco Jesús PARRA RUIZ
Blanca VÁZQUEZ LASA
Julio SAN ROMÁN DEL BARRIO
Lucena RODRÍGUEZ ALONSO
María del Rocío HERRERO VANRELL
Original Assignee
Consejo Superior De Investigaciones Cientificas (Cisc)
Universidad Complutense De Madrid (Ucm)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior De Investigaciones Cientificas (Cisc), Universidad Complutense De Madrid (Ucm) filed Critical Consejo Superior De Investigaciones Cientificas (Cisc)
Publication of WO2011018541A2 publication Critical patent/WO2011018541A2/en
Publication of WO2011018541A3 publication Critical patent/WO2011018541A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/106—Esters of polycondensation macromers
    • C08F222/1063—Esters of polycondensation macromers of alcohol terminated polyethers

Abstract

The invention relates to a compound based on poloxamers and a hydrogel comprising said compounds, and to the use of said hydrogels as vehicles for administering active substances or as adjuvants in pharmaceutical compositions, especially those administered in an ocular topical manner.
PCT/ES2010/070538 2009-08-10 2010-08-04 Hydrogels based on poloxamers with a star structure for the controlled release of active substances WO2011018541A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200930587 2009-08-10
ES200930587A ES2352634B1 (en) 2009-08-10 2009-08-10 HYDROGELS BASED ON POLOXAMEROS WITH STAR STRUCTURE FOR CONTROLLED RELEASE OF ACTIVE SUBSTANCES

Publications (2)

Publication Number Publication Date
WO2011018541A2 WO2011018541A2 (en) 2011-02-17
WO2011018541A3 true WO2011018541A3 (en) 2011-07-14

Family

ID=43557972

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2010/070538 WO2011018541A2 (en) 2009-08-10 2010-08-04 Hydrogels based on poloxamers with a star structure for the controlled release of active substances

Country Status (2)

Country Link
ES (1) ES2352634B1 (en)
WO (1) WO2011018541A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6316011B1 (en) * 1998-08-04 2001-11-13 Madash, Llc End modified thermal responsive hydrogels
US20050165208A1 (en) * 2002-06-11 2005-07-28 Popp Andreas A. (Meth)acrylic esters of polyalkoxylated glycerine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6316011B1 (en) * 1998-08-04 2001-11-13 Madash, Llc End modified thermal responsive hydrogels
US20050165208A1 (en) * 2002-06-11 2005-07-28 Popp Andreas A. (Meth)acrylic esters of polyalkoxylated glycerine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BADI, N ET AL.: "PEG-based thermogthes: Applicability in physiological media", JOURNAL OF CONTROLLED RELEASE, vol. 140, 2009, pages 224 - 229, XP026778497, DOI: doi:10.1016/j.jconrel.2009.04.012 *

Also Published As

Publication number Publication date
ES2352634B1 (en) 2011-12-30
ES2352634A1 (en) 2011-02-22
WO2011018541A2 (en) 2011-02-17

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