WO2011047387A3 - Treatment planning for electroporation-based therapies - Google Patents

Treatment planning for electroporation-based therapies Download PDF

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Publication number
WO2011047387A3
WO2011047387A3 PCT/US2010/053077 US2010053077W WO2011047387A3 WO 2011047387 A3 WO2011047387 A3 WO 2011047387A3 US 2010053077 W US2010053077 W US 2010053077W WO 2011047387 A3 WO2011047387 A3 WO 2011047387A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
electroporation
based therapies
methods
devices
Prior art date
Application number
PCT/US2010/053077
Other languages
French (fr)
Other versions
WO2011047387A2 (en
Inventor
Robert E. Neal
Paulo A. Garcia
Rafael V. Davalos
John H. Rossmeisl
John L. Robertson
Original Assignee
Virginia Tech Intellectual Properties, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intellectual Properties, Inc. filed Critical Virginia Tech Intellectual Properties, Inc.
Priority to EP10824248.8A priority Critical patent/EP2488251A4/en
Publication of WO2011047387A2 publication Critical patent/WO2011047387A2/en
Publication of WO2011047387A3 publication Critical patent/WO2011047387A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

The present invention provides systems, methods, and devices for electroporation- based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
PCT/US2010/053077 2009-10-16 2010-10-18 Treatment planning for electroporation-based therapies WO2011047387A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10824248.8A EP2488251A4 (en) 2009-10-16 2010-10-18 Treatment planning for electroporation-based therapies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25244509P 2009-10-16 2009-10-16
US61/252,445 2009-10-16

Publications (2)

Publication Number Publication Date
WO2011047387A2 WO2011047387A2 (en) 2011-04-21
WO2011047387A3 true WO2011047387A3 (en) 2011-09-29

Family

ID=43876931

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/053077 WO2011047387A2 (en) 2009-10-16 2010-10-18 Treatment planning for electroporation-based therapies

Country Status (2)

Country Link
EP (1) EP2488251A4 (en)
WO (1) WO2011047387A2 (en)

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US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
EP2280741A4 (en) 2008-04-29 2012-06-13 Virginia Tech Intell Prop Irreversible electroporation to create tissue scaffolds
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
WO2010118387A1 (en) 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
WO2012088149A2 (en) 2010-12-20 2012-06-28 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
RU2524194C2 (en) * 2012-06-07 2014-07-27 Андрей Леонидович Шпади Method of treating cancer tumours
JP6345759B2 (en) * 2013-03-15 2018-06-20 エンピ・インコーポレイテッド Personalized image-based guidance for energy-based therapy devices
WO2015175570A1 (en) 2014-05-12 2015-11-19 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
WO2016017045A1 (en) * 2014-07-28 2016-02-04 ネッパジーン株式会社 Electric pulse generator for electroporator, and electroporator system provided with electric pulse generator
US10694972B2 (en) 2014-12-15 2020-06-30 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
CN115737104A (en) * 2015-03-31 2023-03-07 昂科赛克医疗公司 Systems and methods for improved tissue sensing-based electroporation
EP3359074A4 (en) 2015-10-07 2019-09-18 Mayo Foundation for Medical Education and Research Electroporation for obesity or diabetes treatment
AU2017289267B2 (en) 2016-06-27 2021-08-12 Galvanize Therapeutics, Inc. Generator and a catheter with an electrode and a method for treating a lung passageway
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
WO2020016840A1 (en) * 2018-07-18 2020-01-23 Novocure Gmbh Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields)
CN110135073B (en) * 2019-05-17 2023-06-16 沈阳大学 Ultrahigh-strength aluminum alloy pulse current regulation casting and rolling simulation method
WO2021111186A1 (en) * 2019-12-02 2021-06-10 Novocure Gmbh Methods and apparatuses for optimizing transducer array placement
EP4105890A1 (en) 2019-12-31 2022-12-21 Novocure GmbH Methods, systems, and apparatuses for image segmentation
WO2023167747A2 (en) * 2021-11-26 2023-09-07 Old Dominion University Research Foundation Enhanced focal stimulation by spatiotemporal summation of nanosecond electric pulses

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US6482619B1 (en) * 1999-07-21 2002-11-19 The Regents Of The University Of California Cell/tissue analysis via controlled electroporation
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US6482619B1 (en) * 1999-07-21 2002-11-19 The Regents Of The University Of California Cell/tissue analysis via controlled electroporation
US20040009459A1 (en) * 2002-05-06 2004-01-15 Anderson James H. Simulation system for medical procedures
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Non-Patent Citations (1)

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Also Published As

Publication number Publication date
EP2488251A2 (en) 2012-08-22
WO2011047387A2 (en) 2011-04-21
EP2488251A4 (en) 2014-02-19

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