WO2011079017A3 - Differentiation of human embryonic stem cells - Google Patents
Differentiation of human embryonic stem cells Download PDFInfo
- Publication number
- WO2011079017A3 WO2011079017A3 PCT/US2010/060756 US2010060756W WO2011079017A3 WO 2011079017 A3 WO2011079017 A3 WO 2011079017A3 US 2010060756 W US2010060756 W US 2010060756W WO 2011079017 A3 WO2011079017 A3 WO 2011079017A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- differentiation
- stem cells
- embryonic stem
- human embryonic
- present
- Prior art date
Links
- 230000004069 differentiation Effects 0.000 title abstract 2
- 210000001671 embryonic stem cell Anatomy 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 102000051325 Glucagon Human genes 0.000 abstract 1
- 108060003199 Glucagon Proteins 0.000 abstract 1
- 102100028096 Homeobox protein Nkx-6.2 Human genes 0.000 abstract 1
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 abstract 1
- 101000578258 Homo sapiens Homeobox protein Nkx-6.2 Proteins 0.000 abstract 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
- 229960004666 glucagon Drugs 0.000 abstract 1
- 230000009996 pancreatic endocrine effect Effects 0.000 abstract 1
- 210000001778 pluripotent stem cell Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
- C12N5/063—Kereatinocyte stem cells; Keratinocyte progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- Health & Medical Sciences (AREA)
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- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Developmental Biology & Embryology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10840005.2A EP2516625A4 (en) | 2009-12-23 | 2010-12-16 | Differentiation of human embryonic stem cells |
MX2012007413A MX343786B (en) | 2009-12-23 | 2010-12-16 | Differentiation of human embryonic stem cells. |
SG2012043659A SG181687A1 (en) | 2009-12-23 | 2010-12-16 | Differentiation of human embryonic stem cells |
RU2012131400A RU2610176C2 (en) | 2009-12-23 | 2010-12-16 | Differentiation of human embryonic stem cells |
KR1020177023914A KR101867369B1 (en) | 2009-12-23 | 2010-12-16 | Differentiation of human embryonic stem cells |
AU2010333839A AU2010333839C1 (en) | 2009-12-23 | 2010-12-16 | Differentiation of human embryonic stem cells |
CN201080059059.8A CN102741395B (en) | 2009-12-23 | 2010-12-16 | The differentiation of human embryo stem cell |
BR112012017761A BR112012017761A2 (en) | 2009-12-23 | 2010-12-16 | differentiation of human embryonic stem cells |
CA2784415A CA2784415C (en) | 2009-12-23 | 2010-12-16 | Differentiation of human embryonic stem cells |
JP2012546058A JP6392496B2 (en) | 2009-12-23 | 2010-12-16 | Differentiation of human embryonic stem cells |
KR1020127018929A KR101773538B1 (en) | 2009-12-23 | 2010-12-16 | Differentiation of human embryonic stem cells |
ZA2012/05487A ZA201205487B (en) | 2009-12-23 | 2012-07-20 | Differentiation of human embryonic stem cells |
AU2016202260A AU2016202260B2 (en) | 2009-12-23 | 2016-04-12 | Differentiation of human embryonic stem cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28967109P | 2009-12-23 | 2009-12-23 | |
US61/289,671 | 2009-12-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2011079017A2 WO2011079017A2 (en) | 2011-06-30 |
WO2011079017A3 true WO2011079017A3 (en) | 2011-10-20 |
WO2011079017A9 WO2011079017A9 (en) | 2011-12-22 |
Family
ID=44151662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/060756 WO2011079017A2 (en) | 2009-12-23 | 2010-12-16 | Differentiation of human embryonic stem cells |
Country Status (13)
Country | Link |
---|---|
US (4) | US9150833B2 (en) |
EP (1) | EP2516625A4 (en) |
JP (2) | JP6392496B2 (en) |
KR (2) | KR101867369B1 (en) |
CN (1) | CN102741395B (en) |
AU (2) | AU2010333839C1 (en) |
BR (1) | BR112012017761A2 (en) |
CA (1) | CA2784415C (en) |
MX (1) | MX343786B (en) |
RU (2) | RU2610176C2 (en) |
SG (2) | SG10201408552YA (en) |
WO (1) | WO2011079017A2 (en) |
ZA (1) | ZA201205487B (en) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
CN101952415B (en) | 2007-07-31 | 2017-06-27 | 生命扫描有限公司 | The differentiation of human embryo stem cell |
CA3123528A1 (en) | 2007-11-27 | 2009-06-04 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
CA2715878C (en) | 2008-02-21 | 2017-06-13 | Centocor Ortho Biotech Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
EP2942392B1 (en) | 2008-06-30 | 2018-10-03 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
AU2009308967C1 (en) | 2008-10-31 | 2017-04-20 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
ES2727950T3 (en) | 2008-10-31 | 2019-10-21 | Janssen Biotech Inc | Differentiation of human embryonic stem cells in pancreatic endocrine lineage |
CN102282254B (en) | 2008-11-14 | 2015-12-16 | 维赛特公司 | Come from the encapsulating of the pancreatic cell of human pluripotent stem cells |
CN107267442A (en) | 2008-11-20 | 2017-10-20 | 詹森生物科技公司 | Multipotential stem cell culture on microcarrier |
KR101687344B1 (en) | 2008-11-20 | 2016-12-16 | 얀센 바이오테크 인코포레이티드 | Methods and compositions for cell attachment and cultivation on planar substrates |
KR20170118969A (en) | 2009-07-20 | 2017-10-25 | 얀센 바이오테크 인코포레이티드 | Differentiation of human embryonic stem cells |
MX343786B (en) | 2009-12-23 | 2016-11-22 | Janssen Biotech Inc | Differentiation of human embryonic stem cells. |
CN107189979B (en) | 2010-03-01 | 2021-05-04 | 詹森生物科技公司 | Method for purifying cells derived from pluripotent stem cells |
SG10201503652WA (en) | 2010-05-12 | 2015-08-28 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
AU2015268659B2 (en) * | 2010-05-12 | 2017-12-21 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
PL2853589T3 (en) | 2010-08-31 | 2018-05-30 | Janssen Biotech, Inc | Differentiation of human embryonic stem cells |
AU2011296381B2 (en) | 2010-08-31 | 2016-03-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
JP6163104B2 (en) | 2010-11-15 | 2017-07-12 | アクセラレイテッド・バイオサイエンシズ・コーポレーション | Generation of neural stem cells from human trophoblast stem cells |
WO2012175633A1 (en) | 2011-06-21 | 2012-12-27 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
WO2013016194A1 (en) * | 2011-07-22 | 2013-01-31 | Yale University | Endometrial derived stem cells and their methods of use |
RU2668798C2 (en) | 2011-12-22 | 2018-10-02 | Янссен Байотек, Инк. | Methods for in vitro of step-by-step differentiation of pluripotent cells |
CA2866590A1 (en) | 2012-03-07 | 2013-09-12 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
US20150104430A1 (en) * | 2012-04-30 | 2015-04-16 | University Health Network | Methods and Compositions for Generating Pancreatic Progenitors and Functional Beta Cells from hPSCs |
DK3450542T3 (en) * | 2012-06-08 | 2021-11-01 | Janssen Biotech Inc | DIFFERENTIATION OF HUMAN EMBRYONAL STEM CELLS TO ENDOCRINE PANCREATIC CELLS |
CN104903440B (en) | 2012-09-03 | 2018-04-06 | 诺和诺德股份有限公司 | Using small molecule pancreas entoderm is produced from multipotential stem cell |
AU2013352307B2 (en) | 2012-11-30 | 2018-11-15 | Accelerated Biosciences Corp. | Methods of differentiating stem cells by modulating miR-124 |
RU2018108090A (en) | 2012-12-31 | 2019-02-25 | Янссен Байотек, Инк. | SUSPENDING AND CLUSTERING OF HUMAN PLURIPOTENT CELLS FOR THEIR DIFFERENTIATION IN PANCREATIC ENDOCRINE CELLS |
US10138465B2 (en) | 2012-12-31 | 2018-11-27 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators |
US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
RU2658488C2 (en) | 2012-12-31 | 2018-06-21 | Янссен Байотек, Инк. | Method for obtaining cells expressing markers characteristic for pancreatic endocrine cells |
US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
JP6514689B2 (en) | 2013-06-11 | 2019-05-15 | プレジデント アンド フェローズ オブ ハーバード カレッジ | SC-β cells and compositions and methods for producing the same |
RU2694311C2 (en) | 2014-05-16 | 2019-07-11 | Янссен Байотек, Инк. | Use of small molecules to increase expression of mafa in pancreatic endocrine cells |
WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
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