WO2011079234A3 - Highly permeating terbinafine formulation for treating onychomycosis - Google Patents
Highly permeating terbinafine formulation for treating onychomycosis Download PDFInfo
- Publication number
- WO2011079234A3 WO2011079234A3 PCT/US2010/061940 US2010061940W WO2011079234A3 WO 2011079234 A3 WO2011079234 A3 WO 2011079234A3 US 2010061940 W US2010061940 W US 2010061940W WO 2011079234 A3 WO2011079234 A3 WO 2011079234A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fungal
- acid
- provides
- agent
- certain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2010336441A AU2010336441B2 (en) | 2009-12-23 | 2010-12-22 | Highly permeating terbinafine formulation for treating onychomycosis |
EP10801340A EP2544659A2 (en) | 2009-12-23 | 2010-12-22 | Highly permeating terbinafine formulation for treating onychomycosis |
JP2012546222A JP5829217B2 (en) | 2009-12-23 | 2010-12-22 | High penetrating terbinafine formulation |
CN2010800643152A CN102770123A (en) | 2009-12-23 | 2010-12-22 | Highly permeating terbinafine formulation for treating onychomycosis |
CA2785643A CA2785643A1 (en) | 2009-12-23 | 2010-12-22 | Highly permeating terbinafine formulation |
US13/525,108 US9084754B2 (en) | 2009-12-23 | 2012-06-15 | Highly permeating terbinafine formulation |
US14/738,554 US20150342871A1 (en) | 2009-12-23 | 2015-06-12 | Highly permeating terbinafine formulation |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28996709P | 2009-12-23 | 2009-12-23 | |
US28996209P | 2009-12-23 | 2009-12-23 | |
US61/289,967 | 2009-12-23 | ||
US61/289,962 | 2009-12-23 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/525,108 Continuation US9084754B2 (en) | 2009-12-23 | 2012-06-15 | Highly permeating terbinafine formulation |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011079234A2 WO2011079234A2 (en) | 2011-06-30 |
WO2011079234A3 true WO2011079234A3 (en) | 2011-08-18 |
Family
ID=43770418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/061940 WO2011079234A2 (en) | 2009-12-23 | 2010-12-22 | Highly permeating terbinafine formulation |
Country Status (7)
Country | Link |
---|---|
US (1) | US9084754B2 (en) |
EP (1) | EP2544659A2 (en) |
JP (1) | JP5829217B2 (en) |
CN (1) | CN102770123A (en) |
AU (1) | AU2010336441B2 (en) |
CA (1) | CA2785643A1 (en) |
WO (1) | WO2011079234A2 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2826741C (en) | 2011-02-11 | 2016-03-29 | Moberg Pharma Ab | High penetration antifungal compositions comprising an allylamine antifungal |
EP2793833B1 (en) | 2011-12-20 | 2020-06-24 | Vyome Therapeutics Limited | Topical oil composition for the treatment of fungal infections |
EP2664327A1 (en) | 2012-05-14 | 2013-11-20 | Almirall S.A. | Topical pharmaceutical compositions comprising terbinafide and urea |
NL2009669C2 (en) * | 2012-10-19 | 2014-04-23 | Dutch Renewable Energy B V | Enhanced nail penetrating composition. |
CN104936582B (en) | 2012-12-21 | 2018-12-21 | 帝国制药美国股份有限公司 | The composition percutaneously transmitted and method for hormone and other medicaments |
US8697753B1 (en) * | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
EP2952208A1 (en) * | 2014-06-04 | 2015-12-09 | Universidade de Santiago de Compostela | Hydroalcoholic system for nail treatment |
HUE056178T2 (en) | 2014-10-21 | 2022-01-28 | Hexima Ltd | A method of treatment of fungal infections |
KR101690765B1 (en) * | 2015-04-17 | 2016-12-28 | 동아제약 주식회사 | Transdermal formulation comprising antifungal agent |
GB201511799D0 (en) * | 2015-07-06 | 2015-08-19 | Blueberry Therapeutics Ltd | Composition and methods of treatment |
EP3337471A4 (en) * | 2015-08-17 | 2019-04-10 | Ohio State Innovation Foundation | Methods and compositions for enhanced transungual delivery of ar-12 |
US10272054B2 (en) * | 2015-10-07 | 2019-04-30 | Exodos Life Sciences Lp | Topical antifungal compositions |
GB201605127D0 (en) * | 2016-03-25 | 2016-05-11 | Blueberry Therapeutics Ltd | Composition and methods of treatment |
BR112018075998A2 (en) * | 2016-06-13 | 2019-04-02 | Vyome Therapeutics Limited. | synergistic antifungal compositions and methods thereof |
WO2017216722A2 (en) * | 2016-06-13 | 2017-12-21 | Vyome Biosciences Pvt. Ltd. | Synergistic antifungal compositions and methods thereof |
KR102567089B1 (en) | 2016-11-28 | 2023-08-17 | 셀릭스 바이오 프라이빗 리미티드 | Compositions and methods for the treatment of fungal infections |
WO2019214838A1 (en) * | 2018-05-09 | 2019-11-14 | Eviderm Institute Ab | Use of an alcohol-containing composition for improving the skin barrier function |
US20210154215A1 (en) * | 2018-06-04 | 2021-05-27 | Zenvision Pharma Llp | Antifungal Cuticle Oil Composition |
EP3603650A1 (en) | 2018-08-01 | 2020-02-05 | Edix O Sarl | Injectable and prolonged action compositions for use in the treatment of diseases of the nail and/or to accelerate nail growth |
CN112888443A (en) | 2018-08-01 | 2021-06-01 | 爱迪克斯-欧有限公司 | Injectable composition with prolonged duration of action for its use in the treatment of nail diseases and/or for accelerating nail growth |
CN113208937A (en) * | 2020-01-21 | 2021-08-06 | 中国医学科学院北京协和医院 | Cutin softening composition, preparation method and application thereof, external compound for treating onychomycosis, and preparation method and application thereof |
CN113234028B (en) * | 2021-04-29 | 2022-08-26 | 上海大学 | 5-fluorouracil and sarcosine cocrystal and preparation method and application thereof |
CN113786382A (en) * | 2021-11-04 | 2021-12-14 | 浙江得恩德制药股份有限公司 | Terbinafine hydrochloride gel and preparation method thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006042059A1 (en) * | 2004-10-08 | 2006-04-20 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
WO2006131721A2 (en) * | 2005-06-06 | 2006-12-14 | Medpharm Limited | Topical ungual formulations |
WO2011014850A2 (en) * | 2009-07-31 | 2011-02-03 | Nuvo Research Inc. | Topical eutectic-based formulations |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7713618L (en) | 1977-12-01 | 1979-06-02 | Astra Laekemedel Ab | LOCAL ANESTHETIC MIXTURE |
IT1180295B (en) | 1984-10-08 | 1987-09-23 | Durst Phototechnik Srl | COLOR ENLARGER OR PHOTOGRAPHIC REPRODUCER |
FR2673537B1 (en) | 1991-03-08 | 1993-06-11 | Oreal | USE OF HYDROPHILIC PENETRATION AGENTS IN DERMATOLOGICAL COMPOSITIONS FOR THE TREATMENT OF ONYCHOMYCOSES, AND CORRESPONDING COMPOSITIONS. |
CA2289966A1 (en) | 1997-05-14 | 1998-11-19 | Galen (Chemicals) Limited | Topical compositions |
CA2325553A1 (en) * | 1998-04-17 | 1999-10-28 | Penederm Inc. | Topical formulations for the treatment of nail fungal diseases |
US6368618B1 (en) | 1999-07-01 | 2002-04-09 | The University Of Georgia Research Foundation, Inc. | Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs |
DE10035991A1 (en) * | 2000-07-24 | 2002-02-14 | Polichem Sa | Nail polish composition |
ES2299630T3 (en) * | 2001-09-04 | 2008-06-01 | TROMMSDORFF GMBH & CO.KG ARZNEIMITTEL | EMPLASTS FOR PROFILAXIS AND / OR THE TREATMENT OF DYSFUNCTIONS OR DISORDERS OF GROWTH OF THE NAILS. |
US20030091666A1 (en) * | 2001-11-14 | 2003-05-15 | Howard Murad | Methods and compositions for treating dermatological disorders with Morinda citrifolia |
US7138394B2 (en) | 2002-09-27 | 2006-11-21 | Alpharx Inc. | Vehicle for topical delivery of anti-inflammatory compounds |
PL2106805T3 (en) * | 2003-03-21 | 2011-10-31 | Nexmed Holdings Inc | Antifungal nail coat and method of use |
CA2536482C (en) | 2003-08-25 | 2012-07-24 | Foamix Ltd. | Penetrating pharmaceutical foam |
US20060078599A1 (en) | 2004-10-12 | 2006-04-13 | Mathew Ebmeier | Pharmaceutical composition applicable to body tissue |
CA2500907A1 (en) | 2005-03-15 | 2006-09-15 | Alpharx Inc. | Vehicle for topical delivery of anti-inflammatory compounds |
WO2006096955A1 (en) | 2005-03-16 | 2006-09-21 | Alpharx Inc. | Vehicle for topical delivery of anti-inflammatory compounds |
US20070224261A1 (en) | 2006-03-22 | 2007-09-27 | Peter Draper | Eutectic liquid drug formulation |
MX2008015599A (en) | 2006-06-14 | 2009-03-06 | Reddys Lab Ltd Dr | Topical compositions. |
WO2008121709A1 (en) * | 2007-03-30 | 2008-10-09 | Transport Pharmaceuticals, Inc. | Pharmaceutical formulations for iontophoretic delivery of an anti-fungal drug |
CN102159202A (en) * | 2008-07-23 | 2011-08-17 | 靶向递送技术有限公司 | Methods of administering topical antifungal formulations for treatment of fungal infections |
-
2010
- 2010-12-22 CA CA2785643A patent/CA2785643A1/en not_active Abandoned
- 2010-12-22 WO PCT/US2010/061940 patent/WO2011079234A2/en active Application Filing
- 2010-12-22 EP EP10801340A patent/EP2544659A2/en not_active Withdrawn
- 2010-12-22 AU AU2010336441A patent/AU2010336441B2/en not_active Ceased
- 2010-12-22 JP JP2012546222A patent/JP5829217B2/en not_active Expired - Fee Related
- 2010-12-22 CN CN2010800643152A patent/CN102770123A/en active Pending
-
2012
- 2012-06-15 US US13/525,108 patent/US9084754B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006042059A1 (en) * | 2004-10-08 | 2006-04-20 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
WO2006131721A2 (en) * | 2005-06-06 | 2006-12-14 | Medpharm Limited | Topical ungual formulations |
WO2011014850A2 (en) * | 2009-07-31 | 2011-02-03 | Nuvo Research Inc. | Topical eutectic-based formulations |
Also Published As
Publication number | Publication date |
---|---|
JP2013515742A (en) | 2013-05-09 |
CN102770123A (en) | 2012-11-07 |
EP2544659A2 (en) | 2013-01-16 |
CA2785643A1 (en) | 2011-06-30 |
US20120309843A1 (en) | 2012-12-06 |
AU2010336441A1 (en) | 2012-08-02 |
WO2011079234A2 (en) | 2011-06-30 |
JP5829217B2 (en) | 2015-12-09 |
US9084754B2 (en) | 2015-07-21 |
AU2010336441B2 (en) | 2015-02-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2011079234A3 (en) | Highly permeating terbinafine formulation for treating onychomycosis | |
WO2012085523A3 (en) | Skin sanitizer compositions comprising alcohol based emulsion | |
BRPI0905733B8 (en) | composition, pharmaceutical formulation, method for producing a pharmaceutical composition and use of a pharmaceutical formulation | |
WO2006063864A3 (en) | Compositions for preventing, reducing or treating keratinocyte-mediated inflammation | |
WO2007077541A3 (en) | Cosmetic composition comprising glaucine and its use | |
JP2013515742A5 (en) | ||
WO2008157635A3 (en) | Synthetic bile acid composition, method, and preparation | |
CA2818187C (en) | Bromodomain inhibitors and uses thereof | |
WO2013098066A3 (en) | Aqueous hair and skin cleaning compositions comprising biotensides | |
WO2012064126A3 (en) | Medical adhesive composition | |
BRPI0906463A2 (en) | A method for treating or reducing caries protection early enamel caries, reducing the size of existing early enamel lesions and improving systemic health through the regular application of an oral care product, use of a basic amino acid, and combined preparation | |
WO2009150408A3 (en) | Topical antimuscarinic formulations | |
BRPI0608077A2 (en) | dermatologically acceptable composition and composition of alcoholic gel, method of manufacture and uses | |
WO2013016668A3 (en) | Methylphenidate-prodrugs, processes of making and using the same | |
WO2012154122A3 (en) | A topical formulation for treatment of hyperkeratotic skin | |
WO2009026446A8 (en) | Hdac inhibitors | |
WO2010092088A3 (en) | Use of hydrophobin as a spreading agent | |
WO2012058675A3 (en) | Zinc oxide complexes | |
IL205968A0 (en) | Mixed butyric formic esters of acid polysaccharides, and their preparation and use as skin cosmetics | |
WO2009032843A3 (en) | Deuterated ethambutols and their use | |
WO2012161497A3 (en) | Peptide derivatives having a superior moisturizing effect and uses thereof | |
WO2011001111A3 (en) | Use of jasmonic acid to treat oily skin | |
CL2013001232A1 (en) | Cosmetic use of compositions comprising petroselinic acid and other active ingredients to treat and / or prevent skin color imperfections. | |
WO2014178789A9 (en) | Topical composition and carrier for administration of pharmaceutically or cosmetically active ingredients | |
BR112014001829A2 (en) | antioxidant topical compositions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 201080064315.2 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 10801340 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2012546222 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2785643 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010801340 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010336441 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2010336441 Country of ref document: AU Date of ref document: 20101222 Kind code of ref document: A |