WO2011084458A3 - Polymer-based compositions and methods for treatment of peritoneal disorders - Google Patents

Polymer-based compositions and methods for treatment of peritoneal disorders Download PDF

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Publication number
WO2011084458A3
WO2011084458A3 PCT/US2010/060458 US2010060458W WO2011084458A3 WO 2011084458 A3 WO2011084458 A3 WO 2011084458A3 US 2010060458 W US2010060458 W US 2010060458W WO 2011084458 A3 WO2011084458 A3 WO 2011084458A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer
treatment
methods
based compositions
disorders
Prior art date
Application number
PCT/US2010/060458
Other languages
French (fr)
Other versions
WO2011084458A2 (en
Inventor
Jie Fu
Justin Hanes
Ming Yang
Original Assignee
The Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Johns Hopkins University filed Critical The Johns Hopkins University
Publication of WO2011084458A2 publication Critical patent/WO2011084458A2/en
Publication of WO2011084458A3 publication Critical patent/WO2011084458A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention relates to therapeutic compounds encapsulated within polyether-anhydride polymers. Biodegradable particles made from these polymers have a hydrophobic polyanhydride core and a hydrophilic PEG shell. Therapeutic compounds are encapsulated for prolonged drug delivery and are effective for use in treating peritoneal disorders.
PCT/US2010/060458 2009-12-15 2010-12-15 Polymer-based compositions and methods for treatment of peritoneal disorders WO2011084458A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28647509P 2009-12-15 2009-12-15
US61/286,475 2009-12-15

Publications (2)

Publication Number Publication Date
WO2011084458A2 WO2011084458A2 (en) 2011-07-14
WO2011084458A3 true WO2011084458A3 (en) 2011-11-24

Family

ID=44306031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/060458 WO2011084458A2 (en) 2009-12-15 2010-12-15 Polymer-based compositions and methods for treatment of peritoneal disorders

Country Status (1)

Country Link
WO (1) WO2011084458A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030086895A1 (en) * 2001-06-22 2003-05-08 Justin Hanes Biodegradable polymer compositions, compositions and uses related thereto
US20030170202A1 (en) * 1999-04-23 2003-09-11 Rutgers, The State University Of New Jersey Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
US20050226843A1 (en) * 2004-03-15 2005-10-13 Nektar Therapeutics Al, Corporation Polymer-based compositions and conjuates of HIV entry inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170202A1 (en) * 1999-04-23 2003-09-11 Rutgers, The State University Of New Jersey Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
US20030086895A1 (en) * 2001-06-22 2003-05-08 Justin Hanes Biodegradable polymer compositions, compositions and uses related thereto
US20050226843A1 (en) * 2004-03-15 2005-10-13 Nektar Therapeutics Al, Corporation Polymer-based compositions and conjuates of HIV entry inhibitors

Also Published As

Publication number Publication date
WO2011084458A2 (en) 2011-07-14

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