WO2011102914A3 - Automated polymer-synthesis system - Google Patents

Automated polymer-synthesis system Download PDF

Info

Publication number
WO2011102914A3
WO2011102914A3 PCT/US2011/000333 US2011000333W WO2011102914A3 WO 2011102914 A3 WO2011102914 A3 WO 2011102914A3 US 2011000333 W US2011000333 W US 2011000333W WO 2011102914 A3 WO2011102914 A3 WO 2011102914A3
Authority
WO
WIPO (PCT)
Prior art keywords
automated
polymer
carriers
synthesis systems
present
Prior art date
Application number
PCT/US2011/000333
Other languages
French (fr)
Other versions
WO2011102914A2 (en
Inventor
Hsing-Yeh Parker
John Tabone
John Mulligan
Original Assignee
Oligoco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oligoco filed Critical Oligoco
Publication of WO2011102914A2 publication Critical patent/WO2011102914A2/en
Publication of WO2011102914A3 publication Critical patent/WO2011102914A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

Embodiments of the present invention are directed to automated-polymer- synthesis systems that include discrete reagent-solution-addition, wait-time, and reagent- solution-draining sub-systems which together significantly increase throughput and decrease sub-system idle time. The automated-polymer-synthesis systems that represent embodiments of the present invention additionally include switches at points in which carriers can be received from multiple input paths or output to multiple different output paths. The automated-polymer-synthesis systems that represent embodiments of the present invention generally include an input spur and output spur in addition to a main loop, allowing carriers containing only completed polymers to be removed and new carriers input, so that carriers traverse the automated-polymer-synthesis systems independently from one another.
PCT/US2011/000333 2010-02-22 2011-02-22 Automated polymer-synthesis system WO2011102914A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30690110P 2010-02-22 2010-02-22
US61/306,901 2010-02-22
US31286210P 2010-03-11 2010-03-11
US61/312,862 2010-03-11

Publications (2)

Publication Number Publication Date
WO2011102914A2 WO2011102914A2 (en) 2011-08-25
WO2011102914A3 true WO2011102914A3 (en) 2012-02-16

Family

ID=44483524

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2011/000333 WO2011102914A2 (en) 2010-02-22 2011-02-22 Automated polymer-synthesis system
PCT/US2011/000332 WO2011102913A2 (en) 2010-02-22 2011-02-22 Wicking-based reagent-solution draining in an automated system

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2011/000332 WO2011102913A2 (en) 2010-02-22 2011-02-22 Wicking-based reagent-solution draining in an automated system

Country Status (1)

Country Link
WO (2) WO2011102914A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
WO2005110593A2 (en) * 2004-05-17 2005-11-24 Apibio Sas Process and automated system for the synthesis of polymers
US20060263534A1 (en) * 2003-02-28 2006-11-23 Apibio Sas System and process for the synthesis of polymers
US7160517B2 (en) * 2000-08-18 2007-01-09 Massachusetts Institute Of Technolgy Apparatus and methods for the automated synthesis of oligosaccharides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472672A (en) * 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US5762881A (en) * 1996-10-29 1998-06-09 Bohdan Automation, Inc. Apparatus for multiple, simultaneous synthesis of organic compounds
US6258323B1 (en) * 1998-11-16 2001-07-10 Rohm And Haas Company Apparatus and method used in multiple, simultaneous synthesis of general compounds
US6800250B1 (en) * 1999-03-19 2004-10-05 Scott P. Hunicke-Smith Polymer synthesizer
US8211370B2 (en) * 2007-12-07 2012-07-03 Thomas Downing Polymer synthesizer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
US7160517B2 (en) * 2000-08-18 2007-01-09 Massachusetts Institute Of Technolgy Apparatus and methods for the automated synthesis of oligosaccharides
US20060263534A1 (en) * 2003-02-28 2006-11-23 Apibio Sas System and process for the synthesis of polymers
WO2005110593A2 (en) * 2004-05-17 2005-11-24 Apibio Sas Process and automated system for the synthesis of polymers

Also Published As

Publication number Publication date
WO2011102913A2 (en) 2011-08-25
WO2011102914A2 (en) 2011-08-25
WO2011102913A3 (en) 2012-02-16

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