WO2011125073A1 - Device for delivery of sterilant in uterus of female dog for transcervical sterilization - Google Patents

Device for delivery of sterilant in uterus of female dog for transcervical sterilization Download PDF

Info

Publication number
WO2011125073A1
WO2011125073A1 PCT/IN2011/000239 IN2011000239W WO2011125073A1 WO 2011125073 A1 WO2011125073 A1 WO 2011125073A1 IN 2011000239 W IN2011000239 W IN 2011000239W WO 2011125073 A1 WO2011125073 A1 WO 2011125073A1
Authority
WO
WIPO (PCT)
Prior art keywords
sterilant
uterus
cuffs
delivery
contraceptive
Prior art date
Application number
PCT/IN2011/000239
Other languages
French (fr)
Inventor
Sujoy Kumar Guha
Original Assignee
Sujoy Kumar Guha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sujoy Kumar Guha filed Critical Sujoy Kumar Guha
Publication of WO2011125073A1 publication Critical patent/WO2011125073A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/1204—Type of occlusion temporary occlusion
    • A61B17/12045—Type of occlusion temporary occlusion double occlusion, e.g. during anastomosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A61F6/18—Inserters or removers ; Apparatus for loading an intra-uterine device into an insertion tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00535—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
    • A61B2017/00557—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated inflatable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/12127—Double occlusion, e.g. for creating blood-free anastomosis site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A61B2017/22054—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation with two balloons

Definitions

  • the present invention relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization.
  • More particularly it relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization not only by overcoming difficulties of two right angles and mucous plug in the female dog cervix, but also by overcoming difficulties of very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
  • the main difficulty in sterilization, particularly the transcervical sterilization of female dogs is due to impossible approach to uterus due to two right angles and mucus plug in the female dog cervix. These problems are further enhanced due to very tighten muscles of cervical canal. Additionally, the spasmodic contraction of muscles of cervical canal adds further to these difficulties. Therefore, delivery of a sterilant, be. it a liquid, past these obstacles posses a very serious problem in transcervical sterilization of female dogs.
  • present inventions aims to solve above-described problems by providing a device for delivery of sterilant in uterus of female dog for transcervical sterilization which should be capable of overcoming difficulties of two right angles, mucus plug in the female dog cervix, as well as difficulties of very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
  • main object of present inventions is to provide a device for delivery of sterilant in uterus of female dog for transcervical sterilization which has been found to be capable of overcoming difficulties of two right angles, mucus plug in the female dog cervix, as well as difficulties of very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
  • Another object of present invention is to provide a device for delivery of sterilant in uterus of female dog for transcervical sterilization which has been found to be capable of delivering a liquid sterilant or semi-solid liquid sterilant or liquid of high viscosity sterilant upto uterus by overcoming difficulties posed by two right angle turns and mucus plug in the female dog cervix, as well as by very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
  • Figure 1 is schematic representation of the female dog's reproductive system showing interconnections of its uterus, cervical canal and vagina.
  • Figure 2 is a schematic representation of device for delivery of sterilant in uterus of female dog for transcervical sterilization in accordance with one of the preferred embodiments of present invention.
  • Figure 3 is a schematic representation of device for delivery of sterilant in uterus of female dog for transcervical sterilization in accordance with another preferred embodiment of present invention.
  • Figure 4 illustrates a prototype manufactured in accordance with one of the preferred embodiments of the present invention, wherein the device in accordance with Figure x 3 further comprises an inflating means, a vibrating means, a vacuum means, and a sterilant injecting (or supply) means.
  • Figure 5 illustrates X-ray of uterus region of sterilized female dog after injecting the sterilant with the help of prototype of Figure 4.
  • the present invention relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization comprising a cylindrical tube having a hole running through its length and provided with one or more vertical holes and at least one projection provided with inflatable and vibratable cuffs.
  • a device for delivery of sterilant in uterus of female dog for transcervical sterilization comprising a cylindrical tube having a hole running through its length and provided with one or more vertical holes, and at least two projections each provided with corresponding inflatable and vibratable cuffs, wherein at least one vacuum suction ring is provided in-between two projections.
  • the device further comprises a vacuum means, a vibrating means, an inflating means and a sterilant injecting (or supply) means.
  • the inventor confirms that the presently provided devices of above embodiments have been found to be capable of overcoming difficulties of two right angle turns, mucous plug in the cervix, as well as difficulties of tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal in the reproductive system of female dog during injecting sterilant.
  • a reference to 'uterus' or 'uterus region' is intended to include the uterus, uterine horns and fallopian tubes.
  • the reproductive system of female dog [Figure 1 ] comprises vagina 1 , cervical canal 2, uterine horn'3, mucous plug 4 which blocks the cervical canal, cervix-vaginal junction 5, and uterine horn-cervical canal junction ' 6.
  • the mucus plug 4 causes total blockage in cervical canal 2, and hence, blocks way of sterilant from vagina to uterus.
  • the muscles of cervical canal 2 are very tighten and continuously cause spasmodic contraction which have been found to cause reversal of sterilant if injected in the vagina, and hence, the sterilant does not flow from vagina to uterus.
  • the present invention relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization comprising a cylindrical tube 1 1 having a hole 12 running through its length and provided with one or more vertical holes 13 and at least one projection 14 provided with inflatable and vibratable cuffs 15 [Figure ?].
  • the device comprises at least two projections 14 each provided with corresponding inflatable and vibratable cuffs 15, wherein at least one vacuum suction ring 16 is provided in-between two projections 14 [Figure 3].
  • the device further comprises an inflating means 21 , a vibrating means 22, a vacuum means 23, and a sterilant injecting (or supply) means 24 [Figure 4].
  • the inventor confirms that the presently disclosed devices of above embodiments have overcome above-described difficulties caused by two right angles (90° angle) turns 5 and 6, mucous plug 4 in the cervix 2, as well as tighten muscles of cervical canal 2, and spasmodic contraction of muscles of cervical canal 2 in flow of sterilant, and hence, have demonstrated advantages of causing free flow of sterilant in reproductive system of female dog.
  • the cuffs 15 are inflatable cuffs which have been found to have advantage of causing seal in vagina, and hence, avoiding reversal of sterilant once injected.
  • the cuffs are connectable to inflating means for causing inflation thereof.
  • the inflating means may be provided at any location which is convenient for construction of device, preferably the inflating means are provided on one end of the device or may also be provided on or around the cuffs as illustrated in accompanying Figure 4.
  • the cuffs 15 are inflatable cuffs as well as capable of vibrating which not only have advantage of causing seal in vagina, but also have advantage of causing vibration in the vagina.
  • the cuffs are inflated by means of inflating means, and their vibration is caused by means of vibrating means. Accordingly, in one embodiment, the cuffs are connectable to inflating means for causing inflation thereof and vibrating means for causing vibration thereof.
  • the vibrating means may be provided at any location which is convenient for construction of device, preferably the vibrating means are provided on one end of the device or may also be provided on or around the cuffs as illustrated in accompanying Figure 4.
  • the vibrating means is electromechanical vibrator which not only causes vibration in cuffs, but also inflates the cuffs. Therefore, in accordance with this preferred embodiment of present invention, the inflating means and vibrating means are one means.
  • the vibrating means which may also be capable of causing inflation of cuffs, is embedded within the sterilant or contraceptive source, or is provided on one end of the device or may also be provided on or around the cuffs.
  • vibration of cuffs also cause expansion of joining point 5 of cervical canal 2 and vagina 1, and joining point 6 of cervical canal 2 and uterus 3, which results in a comfortable and easy way for sterilant being injected through hole 12 and passing through holes 13 of present device to pass through the vagina 1 , cervical canal 2 and uterine horn 3 to yterus.
  • vibration of cuffs also results in loosening of muscles of cervical canal 2, and thereby effects of spasmodic contraction are greatly reduced, meaning thereby, reversal of sterilant injected in vagina is totally avoided, and hence, sterilant flows freely from vagina to uterus through cervical canal.
  • the vacuum suction ring
  • the opposite end 18 of present device is closed which has advantage of avoiding flow of sterilant without having caused dislodgement of mucous plug and expansion of junctions 5 and 6, and relaxing of muscles of cervical canal, because any such advance flow of sterilant causes hindrance in functioning of present device.
  • present device is capable of delivering a sterilant selected from a group comprising liquid sterilant, semi-solid liquid sterilant and liquid sterilant of high viscosity upto uterus for transcervical sterilization by overcoming difficulties posed by two right angle turns and mucous plug in; the female dog cervix, as well as by very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
  • a sterilant selected from a group comprising liquid sterilant, semi-solid liquid sterilant and liquid sterilant of high viscosity upto uterus for transcervical sterilization by overcoming difficulties posed by two right angle turns and mucous plug in; the female dog cervix, as well as by very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
  • present device has been described for application in delivering a liquid sterilant in uterus of a female dog.
  • the present device may also be employed to deliver a contraceptive selected from a group comprising a solid contraceptive, wire form contraceptive and a contraceptive capable of forming a plug in uterus.
  • present device may be employed to deliver any contraceptive in desired region of any animal or human being provided the dimensions of hole 12, holes 13 and cuffs 14 are made in accordance with animal and human being and the contraceptive to be injected.
  • the opposite end 18 may be kept open.
  • the device further comprises an endoscope so that its insertion and movement can be controlled for efficient delivery of sterilant.
  • the sterilant is a liquid polymer sterilant which is styrene maleic anhydride (SMA) complexed with dimethyl sulfoxide (DMSO) [RISUGTM], which is in Phase III trials as a human male contraceptive and already tested for toxicology and during the animal trials has also been found to be suitable as female contraceptive, or its modified form having diluted styrene maleic anhydride complexed with dimethyl sulfoxide (DMSO), or further modified form having magnetic particles.
  • SMA styrene maleic anhydride
  • DMSO dimethyl sulfoxide
  • the cuffs 15 are inflated by applying pressure through inflating means so as to cause seal in vagina, and thereafter, vibrating means is switched on so as to cause vibration of inflated cuffs, which results in relaxing of muscles of cervical canal, and expansion of junctions 5 and 6, and loosening of mucous plug, which slowly gets dislodged.
  • present device when present device is operated with pulsed alternating pressure it comfortably, easily and successfully forced the sterilant through the cervical canal.
  • This embodiment permits delivery of even thicker fluids than with continuous pressure. Alternating pulsed pressure with pulsed suction from the vacuum seal managed to dislodge the mucous plug more conveniently, which is a vital step in transcervical sterilization and has been achieved by present invention.
  • a reference to 'uterus' or 'uterus region' is intended to include the uterus, uterine horns and fallop an tubes.
  • the sterilant passes via uterus to the fallopian tubes.
  • the long term contraceptive action is achieved when sterilant reaches and lodges in the fallopian tubes.
  • the sterilant delivered through present device has been found to reach and lodge in the fallopian tubes as it is observed from the X-ray scan [ Figure 5].

Abstract

The present invention relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization comprising a cylindrical tube (11) having a hole (12) running through its length and provided with one or more vertical holes (13) and at least one projection (14) provided with inflatable and vibratable cuffs (15). In one embodiment, the device comprises at least two projections (14) each provided with corresponding inflatable and vibratable cuffs (15), wherein at least one vacuum suction ring (16) is provided in-between two projections (14). In one embodiment, the device further comprises an inflating means (21), a vibrating means (22), a vacuum means (23), and a sterilant injecting (or supply) means (24).

Description

Title of the Invention:-
Device for delivery of sterilant in uterus of female dog for transcervical sterilization.
Field of the Invention:- The present invention relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization.
Particularly it relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization by overcoming difficulties of two right angles and mucous plug in the female dog cervix.
More particularly it relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization not only by overcoming difficulties of two right angles and mucous plug in the female dog cervix, but also by overcoming difficulties of very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
Background of the Invention:-
The sterilization of female dogs is now becoming concern of public administration due to their increasing population.
The main difficulty in sterilization, particularly the transcervical sterilization of female dogs is due to impossible approach to uterus due to two right angles and mucus plug in the female dog cervix. These problems are further enhanced due to very tighten muscles of cervical canal. Additionally, the spasmodic contraction of muscles of cervical canal adds further to these difficulties. Therefore, delivery of a sterilant, be. it a liquid, past these obstacles posses a very serious problem in transcervical sterilization of female dogs.
It may be noted that when delivery of a liquid sterilant is difficult, then delivery of semi-solid liquid or liquid of high viscosity cannot be thought of.
Presently, no device is available for delivery of sterilant in uterus of female dog for transcervical sterilization.
Therefore, delivery of a sterilant, be it a liquid, past above-defined obstacles posses a very serious problem in transcervical^ sterilization of female dogs.
Problem to be solved by the Invention:
Therefore, present inventions aims to solve above-described problems by providing a device for delivery of sterilant in uterus of female dog for transcervical sterilization which should be capable of overcoming difficulties of two right angles, mucus plug in the female dog cervix, as well as difficulties of very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
Objects and Advantages of the Invention:
Accordingly, main object of present inventions is to provide a device for delivery of sterilant in uterus of female dog for transcervical sterilization which has been found to be capable of overcoming difficulties of two right angles, mucus plug in the female dog cervix, as well as difficulties of very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
Another object of present invention is to provide a device for delivery of sterilant in uterus of female dog for transcervical sterilization which has been found to be capable of delivering a liquid sterilant or semi-solid liquid sterilant or liquid of high viscosity sterilant upto uterus by overcoming difficulties posed by two right angle turns and mucus plug in the female dog cervix, as well as by very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
Further objects and advantages of present invention will become more apparent from the ' following description when read in conjunction with the accompanying figures, which are incorporated only to illustrate the manner of performing the invention and are not intended to limit scope of present invention, and are not to the scale.
Brief Description of Accompanying Figures:
Figure 1 is schematic representation of the female dog's reproductive system showing interconnections of its uterus, cervical canal and vagina.
Figure 2 is a schematic representation of device for delivery of sterilant in uterus of female dog for transcervical sterilization in accordance with one of the preferred embodiments of present invention.
Figure 3 is a schematic representation of device for delivery of sterilant in uterus of female dog for transcervical sterilization in accordance with another preferred embodiment of present invention.
Figure 4 illustrates a prototype manufactured in accordance with one of the preferred embodiments of the present invention, wherein the device in accordance with Figure x 3 further comprises an inflating means, a vibrating means, a vacuum means, and a sterilant injecting (or supply) means.
Figure 5 illustrates X-ray of uterus region of sterilized female dog after injecting the sterilant with the help of prototype of Figure 4. Summary of the Invention:
It is understood from foregoing description, absence of device to deliver sterilant in uterus of female dog for transcervical sterilization, is posing a very serious problem in transcervical sterilization of female dogs.
Accordingly, the present invention relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization comprising a cylindrical tube having a hole running through its length and provided with one or more vertical holes and at least one projection provided with inflatable and vibratable cuffs.
In accordance with one of the preferred embodiments of the present invention, it relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization comprising a cylindrical tube having a hole running through its length and provided with one or more vertical holes, and at least two projections each provided with corresponding inflatable and vibratable cuffs, wherein at least one vacuum suction ring is provided in-between two projections.
In accordance with one of the preferred embodiments of the present invention, the device further comprises a vacuum means, a vibrating means, an inflating means and a sterilant injecting (or supply) means.
The inventor confirms that the presently provided devices of above embodiments have been found to be capable of overcoming difficulties of two right angle turns, mucous plug in the cervix, as well as difficulties of tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal in the reproductive system of female dog during injecting sterilant.
In the description a reference to 'uterus' or 'uterus region' is intended to include the uterus, uterine horns and fallopian tubes.
Description and Preferred Embodiments of the Invention:
The present invention is now described with reference to accompanying figures, which are incorporated only to illustrate the invention and are not intended to limit scope of present invention, and are not to the scale.
The reproductive system of female dog [Figure 1 ] comprises vagina 1 , cervical canal 2, uterine horn'3, mucous plug 4 which blocks the cervical canal, cervix-vaginal junction 5, and uterine horn-cervical canal junction' 6.
The right angle (90° angle) turn at joining point 5 of cervical canal 2 and vagina 1 , and second right angle (90° angle) turn at joining point 6 of cervical canal 2 and uterine horn 3, poses difficulty for flow of sterilant particularly if it is semi-liquid or liquid of high viscosity.
Further, the mucus plug 4 causes total blockage in cervical canal 2, and hence, blocks way of sterilant from vagina to uterus.
Further, the muscles of cervical canal 2 are very tighten and continuously cause spasmodic contraction which have been found to cause reversal of sterilant if injected in the vagina, and hence, the sterilant does not flow from vagina to uterus.
The above problems have been overcome by judiciously constructed device of present invention.
Accordingly, the present invention relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization comprising a cylindrical tube 1 1 having a hole 12 running through its length and provided with one or more vertical holes 13 and at least one projection 14 provided with inflatable and vibratable cuffs 15 [Figure ?].
In accordance with one of the preferred embodiments of the present invention, the device comprises at least two projections 14 each provided with corresponding inflatable and vibratable cuffs 15, wherein at least one vacuum suction ring 16 is provided in-between two projections 14 [Figure 3].
In accordance with one of the preferred embodiments of the present invention, the device further comprises an inflating means 21 , a vibrating means 22, a vacuum means 23, and a sterilant injecting (or supply) means 24 [Figure 4].
The inventor confirms that the presently disclosed devices of above embodiments have overcome above-described difficulties caused by two right angles (90° angle) turns 5 and 6, mucous plug 4 in the cervix 2, as well as tighten muscles of cervical canal 2, and spasmodic contraction of muscles of cervical canal 2 in flow of sterilant, and hence, have demonstrated advantages of causing free flow of sterilant in reproductive system of female dog.
In accordance with present invention, the cuffs 15 are inflatable cuffs which have been found to have advantage of causing seal in vagina, and hence, avoiding reversal of sterilant once injected.
In accordance with one of the embodiments of the present invention, the cuffs are connectable to inflating means for causing inflation thereof. In accordance with present invention, the inflating means may be provided at any location which is convenient for construction of device, preferably the inflating means are provided on one end of the device or may also be provided on or around the cuffs as illustrated in accompanying Figure 4.
In accordance with present invention, the cuffs 15 are inflatable cuffs as well as capable of vibrating which not only have advantage of causing seal in vagina, but also have advantage of causing vibration in the vagina.
In accordance with one of the embodiments of the present invention, the cuffs are inflated by means of inflating means, and their vibration is caused by means of vibrating means. Accordingly, in one embodiment, the cuffs are connectable to inflating means for causing inflation thereof and vibrating means for causing vibration thereof. In accordance with present invention, the vibrating means may be provided at any location which is convenient for construction of device, preferably the vibrating means are provided on one end of the device or may also be provided on or around the cuffs as illustrated in accompanying Figure 4.
In accordance with one of the preferred embodiments of present invention, the vibrating means is electromechanical vibrator which not only causes vibration in cuffs, but also inflates the cuffs. Therefore, in accordance with this preferred embodiment of present invention, the inflating means and vibrating means are one means.
In accordance with one of the preferred embodiments of present invention, the vibrating means, which may also be capable of causing inflation of cuffs, is embedded within the sterilant or contraceptive source, or is provided on one end of the device or may also be provided on or around the cuffs.
It has been surprisingly observed that when cuffs inflate they cause seal in vagina, which surprisingly and unexpectedly has been found to have advantage of avoiding reversal of sterilant, and when cuffs vibrate they cause vibration in vagina, which surprisingly and unexpectedly has been found to have advantage of resulting in loosening of the mucous plug 4 which on continuous vibration of cuffs gets dislodged, and hence, problem of total blockage caused due to mucous plug 4 in cervical canal 2 is overcome^by present device, and thereby the sterilant easily flows from vagina to uterus through cervical canal. , ι ;
Additionally, it has been observed that vibration of cuffs also cause expansion of joining point 5 of cervical canal 2 and vagina 1, and joining point 6 of cervical canal 2 and uterus 3, which results in a comfortable and easy way for sterilant being injected through hole 12 and passing through holes 13 of present device to pass through the vagina 1 , cervical canal 2 and uterine horn 3 to yterus. Further, additionally, it has been observed that vibration of cuffs also results in loosening of muscles of cervical canal 2, and thereby effects of spasmodic contraction are greatly reduced, meaning thereby, reversal of sterilant injected in vagina is totally avoided, and hence, sterilant flows freely from vagina to uterus through cervical canal.
In accordance with one of the preferred embodiments, the vacuum suction ring
16 preferably provided in-between two projections 14 has been found to have advantage of further enhancing or improving the stability of the seal generated by inflatable cuffs 15 provided on projections 14.
The opposite end 18 of present device is closed which has advantage of avoiding flow of sterilant without having caused dislodgement of mucous plug and expansion of junctions 5 and 6, and relaxing of muscles of cervical canal, because any such advance flow of sterilant causes hindrance in functioning of present device.
It has been found that present device is capable of delivering a sterilant selected from a group comprising liquid sterilant, semi-solid liquid sterilant and liquid sterilant of high viscosity upto uterus for transcervical sterilization by overcoming difficulties posed by two right angle turns and mucous plug in; the female dog cervix, as well as by very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
It may be noted that present device has been described for application in delivering a liquid sterilant in uterus of a female dog. However, as can be understood from foregoing description, the present device may also be employed to deliver a contraceptive selected from a group comprising a solid contraceptive, wire form contraceptive and a contraceptive capable of forming a plug in uterus.
It may be noted that present device may be employed to deliver any contraceptive in desired region of any animal or human being provided the dimensions of hole 12, holes 13 and cuffs 14 are made in accordance with animal and human being and the contraceptive to be injected. In case a wire form or plug form of contraceptive, the opposite end 18 may be kept open.
Further, in one embodiment, the device further comprises an endoscope so that its insertion and movement can be controlled for efficient delivery of sterilant.
In accordance with one of the preferred embodiments of present invention, the sterilant (contraceptive) is a liquid polymer sterilant which is styrene maleic anhydride (SMA) complexed with dimethyl sulfoxide (DMSO) [RISUG™], which is in Phase III trials as a human male contraceptive and already tested for toxicology and during the animal trials has also been found to be suitable as female contraceptive, or its modified form having diluted styrene maleic anhydride complexed with dimethyl sulfoxide (DMSO), or further modified form having magnetic particles.
It has been observed that present device works more efficiently with pulsed alternating pressure, wherein pressure and vacuum suction are applied alternatively.
Accordingly, in one embodiment, once present device has been inserted in vagina and it reaches junction 5 in such a manner that at least one projection 14 is before junction 5 so that seal caused due to inflation of cuff 15 can block reversal of sterilant and if device comprises at least two projections 14 then second projection is preferably after junction 5 so that zone between two projections 14 accommodates opening of cervical canal. Once device is accommodated in this position, the cuffs 15 are inflated by applying pressure through inflating means so as to cause seal in vagina, and thereafter, vibrating means is switched on so as to cause vibration of inflated cuffs, which results in relaxing of muscles of cervical canal, and expansion of junctions 5 and 6, and loosening of mucous plug, which slowly gets dislodged. Thereafter, the vacuum suction and pressure are applied alternately which causes further relaxation of muscles of cervical canal, and complete dislodgement of mucous plug, and hence " results in a comfortable and easy way for the sterilant. At this moment the sterilant is injected through hole 12 which comfortably passes , through holes 13 and then passes through cervical canal, uterine horn and reaches uterus. Deposition of radiopaque sterilant in uterus region as confirmed by X-ray imaging [Figure 5, wherein relevant area has been encircled] confirms that sterilant has reached the uterus region which also confirmsjthat mucous plug was dislodged. Light Ketamine tranquilization was required for the procedure, but recovery time was minimal and complications were nil due to low dose and nonsurgical nature of entire procedure.
Accordingly, when present device is operated with pulsed alternating pressure it comfortably, easily and successfully forced the sterilant through the cervical canal. This embodiment permits delivery of even thicker fluids than with continuous pressure. Alternating pulsed pressure with pulsed suction from the vacuum seal managed to dislodge the mucous plug more conveniently, which is a vital step in transcervical sterilization and has been achieved by present invention.
In the. above description, a reference to 'uterus' or 'uterus region' is intended to include the uterus, uterine horns and fallop an tubes. The sterilant passes via uterus to the fallopian tubes. The long term contraceptive action is achieved when sterilant reaches and lodges in the fallopian tubes. The sterilant delivered through present device has been found to reach and lodge in the fallopian tubes as it is observed from the X-ray scan [Figure 5].
Accordingly, it may be noted that with cervical barrier surmounted in female dogs and a permanently-retained spermicidal and antimicrobial polymer available, transcervical delivery of sterilant is now possible.

Claims

Claims
A device for delivery of sterilant in uterus of female dog for transcervical sterilization comprising a cylindrical tube 1 1 having a hole 12 running through its length and provided with one or more vertical holes 13 and at least one projection 14 provided with inflatable and vibratable cuffs 15.
A device as claimed in claim 1 , wherein it comprises at least two projections
14 each provided with corresponding inflatable and vibratable cuffs 15.
A device as claimed in claim 2, wherein in-between said two projections 14 is provided at least one vacuum suction ring 16.
A device as claimed in any one of preceding claims 1 to 3, wherein the device further comprises an inflating means 21, a vibrating means 22, a vacuum mean,s 23, and a sterilant injecting (or supply) means 24.
A device as claimed in any one of preceding claims 1 to 4, wherein said cuffs
15 are connectable to inflating means 21 for causing inflation thereof.
A device as claimed in any one of preceding claims 1 to 5, wherein said cuffs 15 are connectable to vibrating means 22 for causing vibration thereof.
A device as claimed in any one of claims 4 or 6, wherein said vibrating means 22 is electromechanical vibrator.
A device as claimed in any one of claims 4, 6 or 7, wherein said vibrating means 22 is embedded within the sterilant or is provided on one end of the device or is provided on or around the cuffs.
A device as claimed in any one of claims 2 to 8, wherein said vacuum suction ring 16 is connectable to vacuum means 23.
A device as claimed in any one of claims 2 to 9, wherein said vacuum means 23 is'capable of providing pulsed alternating pressure.
A device as claimed in any one of claims 1 to 10, wherein opposite end 18 is closed.
12. A device as claimed in any one of claims 1 to 1 1 , wherein said device further comprises an endoscope.
A device as claimed in any one of claims 1 to 12, wherein said sterilant is selected from a group comprising liquid sterilant, semi-solid liquid sterilant and liquid sterilant of high viscosity.
A device as claimed in any one of claims 1 to 12, wherein said sterilant is contraceptive selected from a group comprising a solid contraceptive, wire form contraceptive and a contraceptive capable of forming a plug in uterus.
15. A device as claimed in any one of claims 1 to 13, wherein said sterilant is a liquid polymer sterilant selected from a group comprising styrene maleic anhydride (SMA) complexed with dimethyl sulfoxide (DMSO) or further modified SMA having magnetic particles.
16. A device for delivery of sterilant in uterus of female dog for transcervical sterilization substantially as herein described with reference to and as illustrated in the accompanying figures.
PCT/IN2011/000239 2010-04-09 2011-04-06 Device for delivery of sterilant in uterus of female dog for transcervical sterilization WO2011125073A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN881/DEL/2010 2010-04-09
IN881DE2010 2010-04-09

Publications (1)

Publication Number Publication Date
WO2011125073A1 true WO2011125073A1 (en) 2011-10-13

Family

ID=44120374

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000239 WO2011125073A1 (en) 2010-04-09 2011-04-06 Device for delivery of sterilant in uterus of female dog for transcervical sterilization

Country Status (1)

Country Link
WO (1) WO2011125073A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013061341A1 (en) * 2011-10-28 2013-05-02 Sujoy Kumar Guha An improved intra-uterine contraceptive device
CN104127954A (en) * 2014-08-18 2014-11-05 梁季鸿 Disposable self-service artificial fertilization device
CN104665954A (en) * 2013-12-02 2015-06-03 绍兴万佳器械有限公司 Efficient veterinary injection gun
EP2723673B1 (en) * 2011-06-24 2020-01-22 Heidi Hall Bit and system for sending a viscous and/or liquid substance into an animal's mouth

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050245902A1 (en) * 2002-02-08 2005-11-03 Brian Cornish Substance delivery device
US20070015965A1 (en) * 2005-07-13 2007-01-18 Usgi Medical Inc. Methods and apparatus for colonic cleaning
US20100022947A1 (en) * 2007-02-12 2010-01-28 Noam Hassidov Inflatable chamber device for motion through a passage

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050245902A1 (en) * 2002-02-08 2005-11-03 Brian Cornish Substance delivery device
US20070015965A1 (en) * 2005-07-13 2007-01-18 Usgi Medical Inc. Methods and apparatus for colonic cleaning
US20100022947A1 (en) * 2007-02-12 2010-01-28 Noam Hassidov Inflatable chamber device for motion through a passage

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2723673B1 (en) * 2011-06-24 2020-01-22 Heidi Hall Bit and system for sending a viscous and/or liquid substance into an animal's mouth
WO2013061341A1 (en) * 2011-10-28 2013-05-02 Sujoy Kumar Guha An improved intra-uterine contraceptive device
CN104665954A (en) * 2013-12-02 2015-06-03 绍兴万佳器械有限公司 Efficient veterinary injection gun
CN104127954A (en) * 2014-08-18 2014-11-05 梁季鸿 Disposable self-service artificial fertilization device

Similar Documents

Publication Publication Date Title
US20080178890A1 (en) Method and apparatus for transcervical reversible cornual sterilization
WO2011125073A1 (en) Device for delivery of sterilant in uterus of female dog for transcervical sterilization
JP4750782B2 (en) Method and apparatus for occluding a conduit
AU743932B2 (en) Apparatus and methods for fallopian tube occlusion
US8100129B2 (en) Methods and devices for occluding an ovarian pathway
FR2522959A1 (en) Tubular pessary for reversible pregnancy protection - has soft central tubular section with proximal and distal loop of fibrous material
TW200950764A (en) An intrauterine system
WO2007035316A3 (en) Fallopian tube occlusion devices and methods
EP3711750A1 (en) Implantable drug delivery devices for genitourinary sites
CA2646800A1 (en) Contraceptive transcervical fallopian tube occlusion devices and methods
US5860916A (en) Dissolvable tip for a colon hydrotherapy speculum system and method of manufacture and use thereof
CN103221089A (en) Biliary shunts, delivery systems, and methods of using the same
Schmitz-Rode et al. Experimental nonsurgical female sterilization: transcervical implantation of microspindles in fallopian tubes
EP1162948B1 (en) An improved reversible contraceptive for male and female
CN109700558A (en) A kind of ewe uterus reset auxiliary therapeutic apparatus
Dahan et al. Congenital interruption of the ampullary portion of the fallopian tube
US20100160936A1 (en) Devices and methods for reversal of permanent sterilization
US20140283844A1 (en) Intra-Uterine Contraceptive Device
JP3115795U (en) Vaginal artificial insemination equipment for canines
Deffieux et al. Intrauterine fallopian tube incarceration: an uncommon complication of termination of pregnancy by vacuum aspiration
US11337849B2 (en) Occlusion device for reversible occlusion of a biological tube
Tumolo Complete loss of the anus and rectum due to crushing injury to the pelvis-treatment using a reversed ileal loop: Report of a case
CN202801727U (en) Urinary stone minimally invasive stone-breaking surgical instrument
Richart Female sterilization using pharmacologically active agents
Kalu et al. Endometriosis-associated ileo-cecal perforation in a woman on the pseudopregnancy regimen

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11722920

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11722920

Country of ref document: EP

Kind code of ref document: A1