WO2011143299A2 - Differentiation of human embryonic stem cells - Google Patents
Differentiation of human embryonic stem cells Download PDFInfo
- Publication number
- WO2011143299A2 WO2011143299A2 PCT/US2011/036043 US2011036043W WO2011143299A2 WO 2011143299 A2 WO2011143299 A2 WO 2011143299A2 US 2011036043 W US2011036043 W US 2011036043W WO 2011143299 A2 WO2011143299 A2 WO 2011143299A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- population
- markers characteristic
- cell
- stem cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0613—Cells from endocrine organs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factors [FGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Gynecology & Obstetrics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
Abstract
Description
Claims
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR112012028855A BR112012028855A2 (en) | 2010-05-12 | 2011-05-11 | differentiation of human embryonic stem cells |
RU2012153676/10A RU2587634C2 (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryo stem cells |
DK11781200.8T DK2569419T3 (en) | 2010-05-12 | 2011-05-11 | DIFFERENTIAL HUMAN EMBRYONIC STAMPS |
MX2012013156A MX351515B (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryonic stem cells. |
CA2800610A CA2800610C (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryonic stem cells |
CN201180023585.3A CN102884176B (en) | 2010-05-12 | 2011-05-11 | The differentiation of human embryo stem cell |
KR1020127031872A KR101903562B1 (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryonic stem cells |
EP19155795.8A EP3498825A1 (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryonic stem cells |
SG2012082855A SG185511A1 (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryonic stem cells |
KR1020187027613A KR101986176B1 (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryonic stem cells |
JP2013510273A JP6050225B2 (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryonic stem cells |
EP11781200.8A EP2569419B1 (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryonic stem cells |
AU2011250912A AU2011250912A1 (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryonic stem cells |
ES11781200T ES2728900T3 (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryonic stem cells |
ZA2012/09383A ZA201209383B (en) | 2010-05-12 | 2012-12-11 | Differentiation of human embryonic stem cells |
AU2015268659A AU2015268659B2 (en) | 2010-05-12 | 2015-12-11 | Differentiation of human embryonic stem cells |
AU2018202016A AU2018202016B2 (en) | 2010-05-12 | 2018-03-21 | Differentiation of human embryonic stem cells |
PH12018500672A PH12018500672A1 (en) | 2010-05-12 | 2018-03-26 | Differentation of human embryonic stem cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33383110P | 2010-05-12 | 2010-05-12 | |
US61/333,831 | 2010-05-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011143299A2 true WO2011143299A2 (en) | 2011-11-17 |
WO2011143299A3 WO2011143299A3 (en) | 2012-03-01 |
Family
ID=44912123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/036043 WO2011143299A2 (en) | 2010-05-12 | 2011-05-11 | Differentiation of human embryonic stem cells |
Country Status (17)
Country | Link |
---|---|
US (2) | US9752125B2 (en) |
EP (2) | EP2569419B1 (en) |
JP (4) | JP6050225B2 (en) |
KR (2) | KR101986176B1 (en) |
CN (2) | CN102884176B (en) |
AR (1) | AR081040A1 (en) |
AU (1) | AU2011250912A1 (en) |
BR (1) | BR112012028855A2 (en) |
CA (1) | CA2800610C (en) |
DK (1) | DK2569419T3 (en) |
ES (1) | ES2728900T3 (en) |
MX (1) | MX351515B (en) |
PH (1) | PH12018500672A1 (en) |
RU (2) | RU2587634C2 (en) |
SG (2) | SG185511A1 (en) |
WO (1) | WO2011143299A2 (en) |
ZA (1) | ZA201209383B (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2896688A1 (en) * | 2014-01-20 | 2015-07-22 | Centre National de la Recherche Scientifique (CNRS) | A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide |
JP2015522281A (en) * | 2012-06-26 | 2015-08-06 | セラクシス,インコーポレーテッド | Stem cells and pancreatic cells useful for the treatment of insulin-dependent diabetes |
JP2015528289A (en) * | 2012-09-03 | 2015-09-28 | ノヴォ ノルディスク アー/エス | Production of pancreatic endoderm from pluripotent stem cells using small molecules |
JP2015535175A (en) * | 2012-09-20 | 2015-12-10 | ケンブリッジ エンタープライズ リミティッド | Differentiation of mammalian pluripotent cells into pancreas in vitro |
JP2016503654A (en) * | 2012-12-31 | 2016-02-08 | ヤンセン バイオテツク,インコーポレーテツド | Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 modulators |
RU2668798C2 (en) * | 2011-12-22 | 2018-10-02 | Янссен Байотек, Инк. | Methods for in vitro of step-by-step differentiation of pluripotent cells |
EP2569419B1 (en) | 2010-05-12 | 2019-03-20 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
US10487313B2 (en) | 2011-06-21 | 2019-11-26 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
WO2020243666A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
WO2020243665A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
WO2020243663A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
WO2020243668A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
EP3710021A4 (en) * | 2017-11-15 | 2021-08-11 | Semma Therapeutics, Inc. | Islet cell manufacturing compositions and methods of use |
US11274280B2 (en) | 2016-02-24 | 2022-03-15 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
US11466256B2 (en) | 2018-08-10 | 2022-10-11 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
US11660377B2 (en) | 2008-11-14 | 2023-05-30 | Viacyte, Inc. | Cryopreserved in vitro cell culture of human pancreatic progenitor cells |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
RU2473685C2 (en) | 2007-07-31 | 2013-01-27 | Лайфскен, Инк. | Differentiation of human embryo stem cells |
RU2473684C2 (en) | 2007-11-27 | 2013-01-27 | Лайфскен, Инк. | Differentiation of human embryo stem cells |
KR102026622B1 (en) | 2008-02-21 | 2019-09-30 | 얀센 바이오테크 인코포레이티드 | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
WO2010002846A1 (en) | 2008-06-30 | 2010-01-07 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
EP2350265B1 (en) | 2008-10-31 | 2019-04-17 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
CN102272291B (en) | 2008-10-31 | 2018-01-16 | 詹森生物科技公司 | Differentiation of the human embryo stem cell to pancreatic endocrine pedigree |
EP2366022B1 (en) | 2008-11-20 | 2016-04-27 | Janssen Biotech, Inc. | Methods and compositions for cell attachment and cultivation on planar substrates |
MX356756B (en) | 2008-11-20 | 2018-06-11 | Centocor Ortho Biotech Inc | Pluripotent stem cell culture on micro-carriers. |
KR102058901B1 (en) | 2009-07-20 | 2019-12-24 | 얀센 바이오테크 인코포레이티드 | Differentiation of human embryonic stem cells |
US9150833B2 (en) | 2009-12-23 | 2015-10-06 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
JP6013196B2 (en) | 2010-03-01 | 2016-10-25 | ヤンセン バイオテツク,インコーポレーテツド | Method for purifying cells derived from pluripotent stem cells |
SG10201506855RA (en) | 2010-08-31 | 2015-10-29 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
BR112013004514A2 (en) | 2010-08-31 | 2016-06-07 | Janssen Biotech Inc | differentiation of human embryonic stem cells |
WO2013134378A1 (en) | 2012-03-07 | 2013-09-12 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
CN108103006A (en) | 2012-06-08 | 2018-06-01 | 詹森生物科技公司 | Differentiation of the human embryo stem cell to pancreatic endocrine cell |
EP4039798A1 (en) | 2012-12-31 | 2022-08-10 | Janssen Biotech, Inc. | Suspension and clustering of human pluripotent cells |
US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
RU2658488C2 (en) * | 2012-12-31 | 2018-06-21 | Янссен Байотек, Инк. | Method for obtaining cells expressing markers characteristic for pancreatic endocrine cells |
KR102580225B1 (en) | 2013-06-11 | 2023-09-20 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
DK3143127T3 (en) | 2014-05-16 | 2021-09-13 | Janssen Biotech Inc | USE OF SMALL MOLECULES TO ENHANGE MAFA EXPRESSION IN ENDOCRINE PANCREAS CELLS |
WO2016038038A1 (en) * | 2014-09-08 | 2016-03-17 | Fundacion Publica Andaluza Progreso Y Salud | Method for obtaining pancreatic beta cell surrogates by increasing pancreatic and duodenal homeobox 1 (pdx-1) expression |
US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
US10190096B2 (en) | 2014-12-18 | 2019-01-29 | President And Fellows Of Harvard College | Methods for generating stem cell-derived β cells and uses thereof |
CN107614678B (en) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | Method for producing stem cell-derived beta cells and method for using same |
US20160175363A1 (en) * | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived beta cells and uses thereof |
WO2016205678A1 (en) | 2015-06-19 | 2016-12-22 | Emory University | Methods of measuring cell purity for making quality control determinations and related compositions |
MA45479A (en) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | DIFFERENTIATION OF PLURIPOTENT STEM CELLS IN ENDODERMAL CELLS OF MIDDLE INTESTINE |
JPWO2018159805A1 (en) * | 2017-03-03 | 2020-01-09 | 国立大学法人京都大学 | Method for producing pancreatic progenitor cells |
Family Cites Families (242)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US709392A (en) | 1902-05-06 | 1902-09-16 | Haydn Brown | Suture-clamp. |
US2232142A (en) | 1940-09-27 | 1941-02-18 | Schumann Seymour | Wound clip |
US2814296A (en) | 1954-04-15 | 1957-11-26 | S & R J Everett & Co Ltd | Surgical needles |
US3209652A (en) | 1961-03-30 | 1965-10-05 | Burgsmueller Karl | Thread whirling method |
AT326803B (en) | 1968-08-26 | 1975-12-29 | Binder Fa G | MESHWARE AND METHOD OF MANUFACTURING THE SAME |
US3935067A (en) | 1974-11-22 | 1976-01-27 | Wyo-Ben Products, Inc. | Inorganic support for culture media |
CA1201400A (en) | 1982-04-16 | 1986-03-04 | Joel L. Williams | Chemically specific surfaces for influencing cell activity during culture |
US4499802A (en) | 1982-09-29 | 1985-02-19 | Container Graphics Corporation | Rotary cutting die with scrap ejection |
US4537773A (en) | 1983-12-05 | 1985-08-27 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid derivatives |
US4557264A (en) | 1984-04-09 | 1985-12-10 | Ethicon Inc. | Surgical filament from polypropylene blended with polyethylene |
US5089396A (en) | 1985-10-03 | 1992-02-18 | Genentech, Inc. | Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
US5215893A (en) | 1985-10-03 | 1993-06-01 | Genentech, Inc. | Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
US4737578A (en) | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
US5567612A (en) | 1986-11-20 | 1996-10-22 | Massachusetts Institute Of Technology | Genitourinary cell-matrix structure for implantation into a human and a method of making |
US5759830A (en) | 1986-11-20 | 1998-06-02 | Massachusetts Institute Of Technology | Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo |
US4898156A (en) | 1987-05-18 | 1990-02-06 | Mitek Surgical Products, Inc. | Suture anchor |
NZ229354A (en) | 1988-07-01 | 1990-09-26 | Becton Dickinson Co | Treating polymer surfaces with a gas plasma and then applying a layer of endothelial cells to the surface |
EP0363125A3 (en) | 1988-10-03 | 1990-08-16 | Hana Biologics Inc. | Proliferated pancreatic endocrine cell product and process |
US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
ES2134212T3 (en) | 1991-04-25 | 1999-10-01 | Chugai Pharmaceutical Co Ltd | HUMAN ANTIBODY RECONSTITUTED AGAINST THE RECEIVER OF INTERLEUKIN 6 HUMAN. |
US5449383A (en) | 1992-03-18 | 1995-09-12 | Chatelier; Ronald C. | Cell growth substrates |
GB9206861D0 (en) | 1992-03-28 | 1992-05-13 | Univ Manchester | Wound healing and treatment of fibrotic disorders |
CA2114282A1 (en) | 1993-01-28 | 1994-07-29 | Lothar Schilder | Multi-layered implant |
JP3525221B2 (en) | 1993-02-17 | 2004-05-10 | 味の素株式会社 | Immunosuppressants |
US5341922A (en) | 1993-02-24 | 1994-08-30 | Ethicon, Inc. | Peelable foil suture packaging |
JP2813467B2 (en) | 1993-04-08 | 1998-10-22 | ヒューマン・セル・カルチャーズ・インコーポレーテッド | Cell culture methods and media |
US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
GB9310557D0 (en) | 1993-05-21 | 1993-07-07 | Smithkline Beecham Plc | Novel process and apparatus |
TW257671B (en) | 1993-11-19 | 1995-09-21 | Ciba Geigy | |
US6703017B1 (en) | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
US5834308A (en) | 1994-04-28 | 1998-11-10 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of Langerhans |
US6001647A (en) | 1994-04-28 | 1999-12-14 | Ixion Biotechnology, Inc. | In vitro growth of functional islets of Langerhans and in vivo uses thereof |
US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
KR100252743B1 (en) | 1994-12-29 | 2000-09-01 | 나가야마 오사무 | Antitumor agent potentiator comprising il-6 antagonist |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US5718922A (en) | 1995-05-31 | 1998-02-17 | Schepens Eye Research Institute, Inc. | Intravitreal microsphere drug delivery and method of preparation |
US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
EP1028954B1 (en) | 1997-04-24 | 2003-07-02 | Ortho-McNeil Pharmaceutical, Inc. | Substituted imidazoles useful in the treatment of inflammatory diseases |
AU8476698A (en) | 1997-07-03 | 1999-01-25 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells from peripheral blood |
AU9393398A (en) | 1997-09-16 | 1999-04-05 | Egea Biosciences, Inc. | Method for the complete chemical synthesis and assembly of genes and genomes |
US6670127B2 (en) | 1997-09-16 | 2003-12-30 | Egea Biosciences, Inc. | Method for assembly of a polynucleotide encoding a target polypeptide |
CA2307807C (en) | 1997-10-23 | 2008-09-02 | Andrea G. Bodnar | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
ZA9811898B (en) | 1997-12-29 | 2000-06-28 | Ortho Mcneil Pharm Inc | Anti-Inflammatory Compounds. |
AU755888B2 (en) | 1998-03-18 | 2003-01-02 | Mesoblast International Sarl | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
MY132496A (en) | 1998-05-11 | 2007-10-31 | Vertex Pharma | Inhibitors of p38 |
US6413773B1 (en) | 1998-06-01 | 2002-07-02 | The Regents Of The University Of California | Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation |
US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
US6610540B1 (en) | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
US6413556B1 (en) | 1999-01-08 | 2002-07-02 | Sky High, Llc | Aqueous anti-apoptotic compositions |
AU2515600A (en) | 1999-01-21 | 2000-08-07 | Vitro Diagnostics, Inc. | Immortalized cell lines and methods of making the same |
US6815203B1 (en) | 1999-06-23 | 2004-11-09 | Joslin Diabetes Center, Inc. | Methods of making pancreatic islet cells |
US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
US6306424B1 (en) | 1999-06-30 | 2001-10-23 | Ethicon, Inc. | Foam composite for the repair or regeneration of tissue |
CA2385628A1 (en) | 1999-09-27 | 2001-04-05 | Ammon B. Peck | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
US6685936B2 (en) | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
US20030082155A1 (en) | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
EP1240518A4 (en) | 1999-12-13 | 2006-05-17 | Scripps Research Inst | Markers for identification and isolation of pancreatic islet alpha and beta cell progenitors |
US7439064B2 (en) | 2000-03-09 | 2008-10-21 | Wicell Research Institute, Inc. | Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium |
US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
US6458589B1 (en) | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
WO2002000849A1 (en) | 2000-06-26 | 2002-01-03 | Renomedix Institute Inc. | Cell fraction containing cells capable of differentiating into nervous system cells |
CA2426654C (en) | 2000-10-23 | 2010-12-21 | Smithkline Beecham Corporation | 2,4,8-trisubstituted-8h-pyrido[2,3-d}pyrimidin-7-one compounds |
PT1362047E (en) | 2000-12-08 | 2006-09-29 | Ortho Mcneil Pharm Inc | SUBSTITUTED PYRROLINE COMPOUNDS WITH INDAZOLYL AS KINASE INHIBITORS |
EP1345946B1 (en) | 2000-12-08 | 2005-08-10 | Ortho-McNeil Pharmaceutical, Inc. | Macroheterocylic compounds useful as kinase inhibitors |
US6599323B2 (en) | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
US20040121460A1 (en) | 2001-01-24 | 2004-06-24 | Lumelsky Nadya L | Differentiation of stem cells to pancreatic endocrine cells |
EP3078667B1 (en) | 2001-01-25 | 2018-11-21 | The United States of America, represented by the Secretary, Department of Health and Human Services | Formulation of boronic acid compounds |
US6656488B2 (en) | 2001-04-11 | 2003-12-02 | Ethicon Endo-Surgery, Inc. | Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering |
DE10290025T1 (en) | 2001-04-19 | 2003-10-09 | Develogen Ag | Procedure for differentiating stem cells into insulin-producing cells |
ATE421991T1 (en) | 2001-04-24 | 2009-02-15 | Ajinomoto Kk | STEM CELLS AND METHOD FOR SEPARATING THEM |
CA2447015A1 (en) | 2001-05-15 | 2002-11-21 | Rappaport Family Institute For Research In The Medical Sciences | Insulin producing cells derived from human embryonic stem cells |
US6626950B2 (en) | 2001-06-28 | 2003-09-30 | Ethicon, Inc. | Composite scaffold with post anchor for the repair and regeneration of tissue |
KR100418195B1 (en) | 2001-07-05 | 2004-02-11 | 주식회사 우리기술 | Apparatus and method for multi-testing insulation of power cables |
GB0117583D0 (en) | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
CA2456981C (en) | 2001-08-06 | 2012-02-28 | Bresagen, Inc. | Alternative compositions and methods for the culture of stem cells |
US6617152B2 (en) | 2001-09-04 | 2003-09-09 | Corning Inc | Method for creating a cell growth surface on a polymeric substrate |
EP1298201A1 (en) | 2001-09-27 | 2003-04-02 | Cardion AG | Process for the production of cells exhibiting an islet-beta-cell-like state |
US20030138951A1 (en) | 2001-10-18 | 2003-07-24 | Li Yin | Conversion of liver stem and progenitor cells to pancreatic functional cells |
DE60233248D1 (en) | 2001-11-15 | 2009-09-17 | Childrens Medical Center | PROCESS FOR THE ISOLATION, EXPANSION AND DIFFERENTIATION OF FEDERAL STRAIN CELLS FROM CHORION ZOTTE, FRUIT WATER AND PLAZENTA AND THERAPEUTIC USES THEREOF |
CN1630526B (en) | 2001-12-07 | 2010-05-05 | 马克罗珀尔生物外科公司 | Systems and methods for treating patients with processed lipoaspirate cells |
IL162131A0 (en) | 2001-12-07 | 2005-11-20 | Geron Corp | Islet cells from human embryonic stem cells |
AU2002218893A1 (en) | 2001-12-21 | 2003-07-09 | Thromb-X Nv | Compositions for the in vitro derivation and culture of embryonic stem (es) cell lines with germline transmission capability |
IL162663A0 (en) | 2001-12-28 | 2005-11-20 | Cellartis Ab | A method for the establishment of apluripotent human blastocyst-derived stem cell line |
US20030162290A1 (en) | 2002-01-25 | 2003-08-28 | Kazutomo Inoue | Method for inducing differentiation of embryonic stem cells into functioning cells |
AU2003231358A1 (en) | 2002-04-17 | 2003-10-27 | Otsuka Pharmaceutical Co., Ltd. | METHOD OF FORMING PANCREATIC Beta CELLS FROM MESENCHYMAL CELLS |
US20040161419A1 (en) | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
WO2003095452A1 (en) | 2002-05-08 | 2003-11-20 | Janssen Pharmaceutica N.V. | Substituted pyrroline kinase inhibitors |
US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
AU2003273573A1 (en) | 2002-05-28 | 2003-12-19 | Becton, Dickinson And Company | Expansion and transdifferentiation of human acinar cells |
KR20050008787A (en) | 2002-06-05 | 2005-01-21 | 얀센 파마슈티카 엔.브이. | Bisindolyl-maleimid derivatives as kinase inhibitors |
GB0212976D0 (en) | 2002-06-06 | 2002-07-17 | Tonejet Corp Pty Ltd | Ejection method and apparatus |
CN1171991C (en) | 2002-07-08 | 2004-10-20 | 徐如祥 | Culture process of human nerve stem cell |
US6877147B2 (en) | 2002-07-22 | 2005-04-05 | Broadcom Corporation | Technique to assess timing delay by use of layout quality analyzer comparison |
US7838290B2 (en) | 2002-07-25 | 2010-11-23 | The Scripps Research Institute | Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith |
EP1539930A4 (en) | 2002-07-29 | 2006-08-09 | Es Cell Int Pte Ltd | Multi-step method for the differentiation of insulin positive, glucose |
WO2004016747A2 (en) | 2002-08-14 | 2004-02-26 | University Of Florida | Bone marrow cell differentiation |
WO2004023100A2 (en) | 2002-09-06 | 2004-03-18 | Amcyte Inc. | Cd56 positive human adult pancreatic endocrine progenitor cells |
US9969977B2 (en) | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
US20040062753A1 (en) | 2002-09-27 | 2004-04-01 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
AU2003285172A1 (en) | 2002-11-08 | 2004-06-03 | The Johns Hopkins University | Human embryonic stem cell cultures, and compositions and methods for growing same |
US7144999B2 (en) | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
EP1567639A4 (en) | 2002-12-05 | 2005-12-21 | Technion Res & Dev Foundation | Cultured human pancreatic islets, and uses thereof |
CN100549163C (en) | 2002-12-16 | 2009-10-14 | 技术研究及发展基金有限公司 | The stem cell culture for preparing the method for no feeder cell, no allogenic human embryo stem cell and use this method preparation |
RU2359671C2 (en) | 2003-01-29 | 2009-06-27 | Такеда Фармасьютикал Компани Лимитед | Method of obtaining of preparation with covering |
KR101114808B1 (en) | 2003-01-29 | 2012-02-15 | 다케다 야쿠힌 고교 가부시키가이샤 | Process for producing coated preparation |
WO2005045001A2 (en) | 2003-02-14 | 2005-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Insulin-producing cells derived from stem cells |
US20070155661A1 (en) | 2003-02-14 | 2007-07-05 | The Board Of Trustees Of The Leland Standord Junior University | Methods and compositions for modulating the development of stem cells |
US20070020242A1 (en) | 2003-03-27 | 2007-01-25 | Ixion Biotechnology, Inc. | Method for transdifferentiation of non-pancreatic stem cells to the pancreatic pathway |
US20060194315A1 (en) | 2003-03-31 | 2006-08-31 | Condie Brian G | Compositions and methods for the control, differentiaton and/or manipulation of pluripotent cells through a gamma-secretase signaling pathway |
US20090203141A1 (en) | 2003-05-15 | 2009-08-13 | Shi-Lung Lin | Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant RNA agents |
CA2530533C (en) | 2003-06-27 | 2015-02-10 | Ethicon, Incorporated | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
IL161903A0 (en) | 2003-07-17 | 2005-11-20 | Gamida Cell Ltd | Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs |
ITRM20030395A1 (en) | 2003-08-12 | 2005-02-13 | Istituto Naz Per Le Malattie Infettive Lazz | CULTURE GROUND FOR MAINTENANCE, PROLIFERATION AND DIFFERENTIATION OF MAMMALIAN CELLS. |
WO2005017117A2 (en) | 2003-08-14 | 2005-02-24 | Martin Haas | Multipotent amniotic fetal stem cells (mafsc) and banking of same |
US7157275B2 (en) | 2003-08-15 | 2007-01-02 | Becton, Dickinson And Company | Peptides for enhanced cell attachment and growth |
CA2536067A1 (en) | 2003-08-27 | 2005-03-10 | Stemcells California, Inc. | Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for these populations |
US6939633B2 (en) | 2003-09-17 | 2005-09-06 | General Motors Corporation | Fuel cell shutdown and startup using a cathode recycle loop |
JP2007515433A (en) | 2003-12-17 | 2007-06-14 | アラーガン インコーポレイテッド | Methods of treating retinoid responsive disorders using selective inhibitors of CYP26A and CYP26B |
US20060030042A1 (en) | 2003-12-19 | 2006-02-09 | Ali Brivanlou | Maintenance of embryonic stem cells by the GSK-3 inhibitor 6-bromoindirubin-3'-oxime |
MX2009009225A (en) | 2003-12-23 | 2009-09-28 | Cythera Inc | Definitive endoderm. |
US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
CN1946838A (en) | 2003-12-23 | 2007-04-11 | 赛瑟拉公司 | Definitive endoderm |
US7625753B2 (en) | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
US20050233446A1 (en) | 2003-12-31 | 2005-10-20 | Parsons Xuejun H | Defined media for stem cell culture |
TWI334443B (en) | 2003-12-31 | 2010-12-11 | Ind Tech Res Inst | Method of single cell culture of undifferentiated human embryonic stem cells |
US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
US20080241107A1 (en) | 2004-01-23 | 2008-10-02 | Copland Iii John A | Methods and Compositions For Preparing Pancreatic Insulin Secreting Cells |
WO2005080551A2 (en) | 2004-02-12 | 2005-09-01 | University Of Newcastle Upon Tyne | Stem cells |
US7964401B2 (en) | 2004-02-19 | 2011-06-21 | Kyoto University | Screening method for somatic cell nuclear reprogramming substance affecting ECAT2 and ECAT3 |
AU2005221095A1 (en) | 2004-03-09 | 2005-09-22 | John J. O'neil | Methods for generating insulin-producing cells |
CA2558486A1 (en) | 2004-03-10 | 2005-09-22 | Alberto Hayek | Compositions and methods for growth of embryonic stem cells |
WO2005097980A2 (en) | 2004-03-26 | 2005-10-20 | Geron Corporation | New protocols for making hepatocytes from embryonic stem cells |
WO2005097977A2 (en) | 2004-04-01 | 2005-10-20 | Wisconsin Alumni Research Foundation | Differentiation of stem cells to endoderm and pancreatic lineage |
KR101278421B1 (en) | 2004-04-27 | 2013-07-15 | 비아싸이트, 인크. | Pdx1 expressing endoderm |
GB0410011D0 (en) * | 2004-05-05 | 2004-06-09 | Novartis Forschungsstiftung | Neural cell differentiation method |
CA2966883A1 (en) | 2004-07-09 | 2006-02-16 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
EP1791952A4 (en) | 2004-08-13 | 2008-06-11 | Univ Georgia Res Found | Compositions and methods for self-renewal and differentiation in human embryonic stem cells |
US20080268533A1 (en) | 2004-08-25 | 2008-10-30 | University Of Georgia Research Foundation, Inc. | Methods and Compositions Utilizing Myc and Gsk3Beta to Manipulate the Pluripotency of Embryonic Stem Cells |
DE102004043256B4 (en) | 2004-09-07 | 2013-09-19 | Rheinische Friedrich-Wilhelms-Universität Bonn | Scalable process for culturing undifferentiated stem cells in suspension |
JP2008518585A (en) | 2004-09-08 | 2008-06-05 | ウイスコンシン アラムニ リサーチ ファンデーション | Human embryonic stem cell culture |
AU2005282510B2 (en) | 2004-09-08 | 2010-12-02 | Wisconsin Alumni Research Foundation | Medium and culture of embryonic stem cells |
AU2006210955A1 (en) | 2005-01-31 | 2006-08-10 | Es Cell International Pte Ltd. | Directed differentiation of embryonic stem cells and uses thereof |
SG160373A1 (en) | 2005-03-04 | 2010-04-29 | John Oaeneil | Adult pancreatic derived stromal cells |
GB0505970D0 (en) | 2005-03-23 | 2005-04-27 | Univ Edinburgh | Culture medium containing kinase inhibitor, and uses thereof |
CN103361303B (en) | 2005-03-31 | 2015-09-30 | 斯丹姆涅恩有限公司 | Prepare a kind of method of the highly purified cell mass from amnion |
CN100425694C (en) | 2005-04-15 | 2008-10-15 | 北京大学 | Method of inducing embryo stem cell to differentiate toward pancreatic cell |
ATE553198T1 (en) | 2005-04-15 | 2012-04-15 | Geron Corp | TREATMENT OF CANCER THROUGH THE COMBINED INHIBITION OF PROTEASOME AND TELOMERASE ACTIVITIES |
US20080208351A1 (en) | 2005-04-26 | 2008-08-28 | Aarhus Universitet | Biocompatible Material for Surgical Implants and Cell Guiding Tissue Culture Surfaces |
JP4557797B2 (en) | 2005-05-20 | 2010-10-06 | 株式会社日立製作所 | Optical disk device |
CA2610598A1 (en) | 2005-06-10 | 2006-12-21 | Irm Llc | Compounds that maintain pluripotency of embryonic stem cells |
WO2006138433A2 (en) | 2005-06-14 | 2006-12-28 | The Regents Of The University Of California | Induction of cell differentiation by class i bhlh polypeptides |
WO2006137787A1 (en) | 2005-06-21 | 2006-12-28 | Ge Healthcare Bio-Sciences Ab | Method for cell culture |
EP1910516B1 (en) | 2005-06-22 | 2019-06-19 | Asterias Biotherapeutics, Inc. | Suspension culture of human embryonic stem cells |
JP5345388B2 (en) | 2005-06-30 | 2013-11-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Cyclic anilino-pyridinotriazine |
WO2007016485A2 (en) | 2005-07-29 | 2007-02-08 | Athersys, Inc. | Use of a gsk-3 inhibitor to maintain potency of cultured cells |
GB2443370A (en) | 2005-07-29 | 2008-04-30 | Australian Stem Cell Ct Ltd | Compositions and methods for growth of pluripotent cells |
WO2007025234A2 (en) | 2005-08-26 | 2007-03-01 | The Trustees Of Columbia University In The City Of New York | Generation of pancreatic endocrine cells from primary duct cell cultures and methods of use for treatment of diabetes |
WO2007027156A1 (en) | 2005-09-02 | 2007-03-08 | Agency For Science, Technology And Research | Method of deriving mesenchymal stem cells |
WO2007030870A1 (en) | 2005-09-12 | 2007-03-22 | Es Cell International Pte Ltd | Cardiomyocyte production |
EP1941032A2 (en) | 2005-10-14 | 2008-07-09 | Regents Of The University Of Minnesota | Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype |
ES2743202T3 (en) | 2005-10-27 | 2020-02-18 | Viacyte Inc | Endoderm of the dorsal and ventral proximal intestine expressing PDX1 |
EP4223769A3 (en) | 2005-12-13 | 2023-11-01 | Kyoto University | Nuclear reprogramming factor |
WO2007082963A1 (en) | 2006-01-18 | 2007-07-26 | Fundación Instituto Valenciano De Infertilidad | Human embryo stem-cell lines and methods for using same |
CN101410509B (en) | 2006-02-23 | 2016-05-18 | 维亚赛特公司 | For cultivate can noble cells composition and method |
US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
WO2007103282A2 (en) | 2006-03-02 | 2007-09-13 | Cythera, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
EP3527658A1 (en) | 2006-04-28 | 2019-08-21 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
US8685730B2 (en) | 2006-05-02 | 2014-04-01 | Wisconsin Alumni Research Foundation | Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage |
US20070259423A1 (en) | 2006-05-02 | 2007-11-08 | Jon Odorico | Method of differentiating stem cells into cells of the endoderm and pancreatic lineage |
US7964402B2 (en) | 2006-05-25 | 2011-06-21 | Sanford-Burnham Medical Research Institute | Methods for culture and production of single cell populations of human embryonic stem cells |
CN101541953A (en) | 2006-06-02 | 2009-09-23 | 佐治亚大学研究基金会 | Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems |
CA2654196A1 (en) | 2006-06-02 | 2007-12-13 | University Of Georgia Research Foundation, Inc. | Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems |
WO2007149182A2 (en) | 2006-06-19 | 2007-12-27 | Geron Corporation | Differentiation and enrichment of islet-like cells from human pluripotent stem cells |
CN100494359C (en) | 2006-06-23 | 2009-06-03 | 中日友好医院 | Method for in vitro amplifying and in 3D solid culturing for nerve stem cell |
US20080003676A1 (en) | 2006-06-26 | 2008-01-03 | Millipore Corporation | Growth of embryonic stem cells |
ES2610812T3 (en) | 2006-06-26 | 2017-05-03 | Lifescan, Inc. | Culture of pluripotent stem cells |
GB2454386B (en) | 2006-07-06 | 2011-07-06 | Es Cell Int Pte Ltd | Method for embryonic stem cell culture on a positively charged support surface |
WO2008013664A2 (en) | 2006-07-26 | 2008-01-31 | Cythera, Inc. | Methods of producing pancreatic hormones |
KR101331510B1 (en) | 2006-08-30 | 2013-11-20 | 재단법인서울대학교산학협력재단 | Media compostions containing low concentrations of glucose useful for human embryonic stem cells, differentiation method of human embryonic stem cells into insulin-producing cells or cell clusters using thereof, and insulin-producing cells or cell clusters differentiated thereby |
JP2008099662A (en) | 2006-09-22 | 2008-05-01 | Institute Of Physical & Chemical Research | Method for culturing stem cell |
WO2008039521A2 (en) | 2006-09-26 | 2008-04-03 | Nmt Medical, Inc. | Method for modifying a medical implant surface for promoting tissue growth |
CN101611016B (en) | 2006-10-17 | 2012-01-25 | 斯蒂菲尔实验室公司 | Talarazole metabolites |
WO2008048647A1 (en) | 2006-10-17 | 2008-04-24 | Cythera, Inc. | Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells |
CA2666789C (en) | 2006-10-18 | 2016-11-22 | Yong Zhao | Embryonic-like stem cells derived from adult human peripheral blood and methods of use |
WO2008056779A1 (en) | 2006-11-09 | 2008-05-15 | Japan As Represented By The President Of International Medical Center Of Japan | Method for culture and passage of primate embryonic stem cell, and method for induction of differentiation of the embryonic stem cell |
EP2084269A2 (en) * | 2006-11-20 | 2009-08-05 | Octagene GmbH | Genetic ablation of the prp gene cells using a targeted promoter trap strategy for production of serum-free recombinant proteins as therapeuticals |
WO2008086005A1 (en) | 2007-01-09 | 2008-07-17 | University Of South Florida | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
CN101641436A (en) | 2007-01-30 | 2010-02-03 | 佐治亚大学研究基金会 | Be used to produce the promptly stable mesendoderm cell mass of early stage mesoblastema of entoderm and mesoblastema system and multipotency wandering cell (MMC) |
GB0703188D0 (en) | 2007-02-19 | 2007-03-28 | Roger Land Building | Large scale production of stem cells |
US7688908B2 (en) | 2007-03-12 | 2010-03-30 | Samsung Electronics Co., Ltd. | System and method for processing wireless high definition video data using a shortened last codeword |
WO2008148105A1 (en) | 2007-05-25 | 2008-12-04 | Medistem Laboratories, Inc. | Endometrial stem cells and methods of making and using same |
KR101555824B1 (en) | 2007-07-18 | 2015-09-25 | 라이프스캔, 인코포레이티드 | Differentiation of human embryonic stem cells |
RU2010107181A (en) | 2007-07-31 | 2011-09-20 | Лайфскен, Инк. (Us) | DIFFERENTIATION OF PLURIPOTENT STEM CELLS USING HUMAN FEEDING CELLS |
RU2473685C2 (en) | 2007-07-31 | 2013-01-27 | Лайфскен, Инк. | Differentiation of human embryo stem cells |
WO2009027644A2 (en) | 2007-08-24 | 2009-03-05 | Stichting Het Nederlands Kanker Instituut | Composition |
WO2009061442A1 (en) | 2007-11-06 | 2009-05-14 | Children's Medical Center Corporation | Method to produce induced pluripotent stem (ips) cells form non-embryonic human cells |
RU2473684C2 (en) * | 2007-11-27 | 2013-01-27 | Лайфскен, Инк. | Differentiation of human embryo stem cells |
SG154367A1 (en) | 2008-01-31 | 2009-08-28 | Es Cell Int Pte Ltd | Method of differentiating stem cells |
WO2009096049A1 (en) | 2008-02-01 | 2009-08-06 | Kyoto University | Differentiated cells originating in artificial pluripotent stem cells |
EP2250252A2 (en) | 2008-02-11 | 2010-11-17 | Cambridge Enterprise Limited | Improved reprogramming of mammalian cells, and the cells obtained |
KR102026622B1 (en) | 2008-02-21 | 2019-09-30 | 얀센 바이오테크 인코포레이티드 | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
WO2009110215A1 (en) | 2008-03-03 | 2009-09-11 | 独立行政法人 科学技術振興機構 | Method for induction of ciliated cell differentiation |
WO2009116951A2 (en) | 2008-03-17 | 2009-09-24 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
DK2727998T3 (en) | 2008-04-21 | 2019-08-26 | Viacyte Inc | Methods for purifying pancreatic endoderm cells derived from human embryonic stem cells |
US8338170B2 (en) * | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
US8728812B2 (en) * | 2008-04-22 | 2014-05-20 | President And Fellows Of Harvard College | Compositions and methods for promoting the generation of PDX1+ pancreatic cells |
US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
US7939322B2 (en) | 2008-04-24 | 2011-05-10 | Centocor Ortho Biotech Inc. | Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm |
US20090298178A1 (en) | 2008-06-03 | 2009-12-03 | D Amour Kevin Allen | Growth factors for production of definitive endoderm |
DK2993226T3 (en) | 2008-06-03 | 2021-02-22 | Viacyte Inc | GROWTH FACTORS FOR THE PRODUCTION OF A DEFINITIVE ENDODERM |
DE102008032236A1 (en) | 2008-06-30 | 2010-04-01 | Eberhard-Karls-Universität Tübingen | Isolation and / or identification of stem cells with adipocytic, chondrocytic and pancreatic differentiation potential |
WO2010002846A1 (en) | 2008-06-30 | 2010-01-07 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
US20100028307A1 (en) | 2008-07-31 | 2010-02-04 | O'neil John J | Pluripotent stem cell differentiation |
CN102272291B (en) | 2008-10-31 | 2018-01-16 | 詹森生物科技公司 | Differentiation of the human embryo stem cell to pancreatic endocrine pedigree |
EP2350265B1 (en) | 2008-10-31 | 2019-04-17 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
US8008075B2 (en) | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
WO2010053472A1 (en) | 2008-11-04 | 2010-05-14 | Novocell, Inc. | Stem cell aggregate suspension compositions and methods for differentiation thereof |
EP2356227B1 (en) | 2008-11-14 | 2018-03-28 | Viacyte, Inc. | Encapsulation of pancreatic cells derived from human pluripotent stem cells |
MX356756B (en) | 2008-11-20 | 2018-06-11 | Centocor Ortho Biotech Inc | Pluripotent stem cell culture on micro-carriers. |
US20110229441A1 (en) | 2008-12-05 | 2011-09-22 | Association Francaise Contre Les Myopathies | Method and Medium for Neural Differentiation of Pluripotent Cells |
WO2010091241A2 (en) * | 2009-02-06 | 2010-08-12 | President And Fellows Of Harvard College | Compositions and methods for promoting the generation of definitive endoderm |
KR102058901B1 (en) | 2009-07-20 | 2019-12-24 | 얀센 바이오테크 인코포레이티드 | Differentiation of human embryonic stem cells |
RU2540016C2 (en) | 2009-07-20 | 2015-01-27 | Янссен Байотек, Инк. | Differentiating human embryonic stem cells |
FI20096288A0 (en) | 2009-12-04 | 2009-12-04 | Kristiina Rajala | Formulations and Methods for Culturing Stem Cells |
US9150833B2 (en) | 2009-12-23 | 2015-10-06 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
US20120322152A1 (en) | 2010-03-02 | 2012-12-20 | Michael Raghunath | Culture Additives To Boost Stem Cell Proliferation And Differentiation Response |
CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
US9234170B2 (en) | 2010-04-25 | 2016-01-12 | Mount Sinai School Of Medicine | Generation of anterior foregut endoderm from pluripotent cells |
EP2569419B1 (en) | 2010-05-12 | 2019-03-20 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
EP2601288B1 (en) | 2010-08-05 | 2016-04-06 | Wisconsin Alumni Research Foundation | Simplified basic media for human pluripotent cell culture |
CA2809305C (en) | 2010-08-31 | 2019-06-11 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
MY177150A (en) | 2011-02-28 | 2020-09-08 | Stempeutics Res Malaysia Sdn Bhd | Isolation and expansion of adult stem cells, their therapeutic composition and uses thereof |
WO2013055834A2 (en) | 2011-10-11 | 2013-04-18 | The New York Stem Cell Foundation | Er stress relievers in beta cell protection |
KR102203056B1 (en) | 2011-12-22 | 2021-01-14 | 얀센 바이오테크 인코포레이티드 | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
US10519422B2 (en) | 2012-02-29 | 2019-12-31 | Riken | Method of producing human retinal pigment epithelial cells |
CN108103006A (en) | 2012-06-08 | 2018-06-01 | 詹森生物科技公司 | Differentiation of the human embryo stem cell to pancreatic endocrine cell |
TW201522637A (en) | 2013-03-15 | 2015-06-16 | Jackson Lab | Isolation of non-embryonic stem cells and uses thereof |
-
2011
- 2011-05-11 EP EP11781200.8A patent/EP2569419B1/en active Active
- 2011-05-11 CN CN201180023585.3A patent/CN102884176B/en active Active
- 2011-05-11 ES ES11781200T patent/ES2728900T3/en active Active
- 2011-05-11 AU AU2011250912A patent/AU2011250912A1/en not_active Abandoned
- 2011-05-11 DK DK11781200.8T patent/DK2569419T3/en active
- 2011-05-11 KR KR1020187027613A patent/KR101986176B1/en active IP Right Grant
- 2011-05-11 JP JP2013510273A patent/JP6050225B2/en active Active
- 2011-05-11 MX MX2012013156A patent/MX351515B/en active IP Right Grant
- 2011-05-11 BR BR112012028855A patent/BR112012028855A2/en not_active Application Discontinuation
- 2011-05-11 RU RU2012153676/10A patent/RU2587634C2/en active
- 2011-05-11 CN CN201710695469.5A patent/CN107338217B/en active Active
- 2011-05-11 RU RU2016118225A patent/RU2663339C1/en active
- 2011-05-11 CA CA2800610A patent/CA2800610C/en active Active
- 2011-05-11 SG SG2012082855A patent/SG185511A1/en unknown
- 2011-05-11 SG SG10201503652WA patent/SG10201503652WA/en unknown
- 2011-05-11 WO PCT/US2011/036043 patent/WO2011143299A2/en active Application Filing
- 2011-05-11 EP EP19155795.8A patent/EP3498825A1/en active Pending
- 2011-05-11 KR KR1020127031872A patent/KR101903562B1/en active IP Right Grant
- 2011-05-11 US US13/105,285 patent/US9752125B2/en active Active
- 2011-05-12 AR ARP110101645A patent/AR081040A1/en unknown
-
2012
- 2012-12-11 ZA ZA2012/09383A patent/ZA201209383B/en unknown
-
2016
- 2016-07-29 JP JP2016149481A patent/JP6469047B2/en active Active
-
2017
- 2017-08-04 US US15/669,461 patent/US20170327793A1/en not_active Abandoned
-
2018
- 2018-03-26 PH PH12018500672A patent/PH12018500672A1/en unknown
-
2019
- 2019-01-15 JP JP2019004483A patent/JP7149190B2/en active Active
-
2022
- 2022-07-06 JP JP2022109280A patent/JP2022133411A/en active Pending
Non-Patent Citations (2)
Title |
---|
LYTTLE ET AL.: "NKX6-1 co-localised only with insulin cells, indicating that NKX6-1 is exclusively involved in human beta cell development", DIABETOLOGIA, vol. 51, no. 7, July 2008 (2008-07-01), pages 1169 - 80 |
NATURE CHEMICAL BIOLOGY, vol. 5, April 2009 (2009-04-01), pages 195 - 196 |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11660377B2 (en) | 2008-11-14 | 2023-05-30 | Viacyte, Inc. | Cryopreserved in vitro cell culture of human pancreatic progenitor cells |
EP2569419B1 (en) | 2010-05-12 | 2019-03-20 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
US10487313B2 (en) | 2011-06-21 | 2019-11-26 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
RU2705001C2 (en) * | 2011-12-22 | 2019-11-01 | Янссен Байотек, Инк. | Differentiation of human embryonic stem cells into single-hormonal insulin-positive cells |
RU2668798C2 (en) * | 2011-12-22 | 2018-10-02 | Янссен Байотек, Инк. | Methods for in vitro of step-by-step differentiation of pluripotent cells |
US9968639B2 (en) | 2012-06-26 | 2018-05-15 | Seraxis, Inc. | Stem cells and pancreatic cells useful for the treatment of insulin-dependent diabetes mellitus |
JP2018193394A (en) * | 2012-06-26 | 2018-12-06 | セラクシス,インコーポレーテッド | Stem cells and pancreatic cells useful for treatment of insulin-dependent diabetes mellitus |
JP2015522281A (en) * | 2012-06-26 | 2015-08-06 | セラクシス,インコーポレーテッド | Stem cells and pancreatic cells useful for the treatment of insulin-dependent diabetes |
JP2015528289A (en) * | 2012-09-03 | 2015-09-28 | ノヴォ ノルディスク アー/エス | Production of pancreatic endoderm from pluripotent stem cells using small molecules |
JP2019000126A (en) * | 2012-09-03 | 2019-01-10 | ノヴォ ノルディスク アー/エス | Generation of pancreatic endoderm from pluripotent stem cells using small molecules |
US10221392B2 (en) | 2012-09-03 | 2019-03-05 | Novo Nordisk A/S | Generation of pancreatic endoderm from pluripotent stem cells using small molecules |
JP2015535175A (en) * | 2012-09-20 | 2015-12-10 | ケンブリッジ エンタープライズ リミティッド | Differentiation of mammalian pluripotent cells into pancreas in vitro |
JP2020141704A (en) * | 2012-12-31 | 2020-09-10 | ヤンセン バイオテツク,インコーポレーテツド | Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators |
JP2016503654A (en) * | 2012-12-31 | 2016-02-08 | ヤンセン バイオテツク,インコーポレーテツド | Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 modulators |
JP2019088316A (en) * | 2012-12-31 | 2019-06-13 | ヤンセン バイオテツク,インコーポレーテツド | Differentiation of human embryonic stem cell to pancreas endocrine cell using hb9 adjuster |
EP2896688A1 (en) * | 2014-01-20 | 2015-07-22 | Centre National de la Recherche Scientifique (CNRS) | A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide |
US11274280B2 (en) | 2016-02-24 | 2022-03-15 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
EP3710021A4 (en) * | 2017-11-15 | 2021-08-11 | Semma Therapeutics, Inc. | Islet cell manufacturing compositions and methods of use |
US11945795B2 (en) | 2017-11-15 | 2024-04-02 | Vertex Pharmaceuticals Incorporated | Islet cell manufacturing compositions and methods of use |
US11466256B2 (en) | 2018-08-10 | 2022-10-11 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
US11525120B2 (en) | 2018-08-10 | 2022-12-13 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
WO2020243666A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
WO2020243665A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
WO2020243663A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
WO2020243668A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7149190B2 (en) | Differentiation of human embryonic stem cells | |
US20200291360A1 (en) | Use of noggin, an alk5 inhibitor and a protein kinase c activator, to produce endocrine cells | |
CA2768644A1 (en) | Differentiation of human embryonic stem cells | |
AU2018202016B2 (en) | Differentiation of human embryonic stem cells | |
RU2805433C1 (en) | Differentiation of human embryonic stem cells | |
RU2782271C2 (en) | Differentiation of human embryonic stem cells | |
US20230151332A1 (en) | Methods for making insulin in vivo |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 201180023585.3 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 11781200 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12012502189 Country of ref document: PH |
|
ENP | Entry into the national phase |
Ref document number: 2800610 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2013510273 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1201005876 Country of ref document: TH Ref document number: MX/A/2012/013156 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2011781200 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2011250912 Country of ref document: AU Date of ref document: 20110511 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10242/DELNP/2012 Country of ref document: IN |
|
ENP | Entry into the national phase |
Ref document number: 20127031872 Country of ref document: KR Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 2012153676 Country of ref document: RU Kind code of ref document: A |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01A Ref document number: 112012028855 Country of ref document: BR |
|
ENP | Entry into the national phase |
Ref document number: 112012028855 Country of ref document: BR Kind code of ref document: A2 Effective date: 20121112 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12018500672 Country of ref document: PH |