WO2012021733A3 - Photodamage mitigation compounds and systems - Google Patents

Photodamage mitigation compounds and systems Download PDF

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Publication number
WO2012021733A3
WO2012021733A3 PCT/US2011/047468 US2011047468W WO2012021733A3 WO 2012021733 A3 WO2012021733 A3 WO 2012021733A3 US 2011047468 W US2011047468 W US 2011047468W WO 2012021733 A3 WO2012021733 A3 WO 2012021733A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
photodamage
compounds
reaction
mitigation
Prior art date
Application number
PCT/US2011/047468
Other languages
French (fr)
Other versions
WO2012021733A2 (en
Inventor
Stephen Yue
Robert Weber
Xiangxu Kong
Andrei Fedorov
John Lyle
Original Assignee
Pacific Biosciences Of California, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Biosciences Of California, Inc. filed Critical Pacific Biosciences Of California, Inc.
Publication of WO2012021733A2 publication Critical patent/WO2012021733A2/en
Publication of WO2012021733A3 publication Critical patent/WO2012021733A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/91245—Nucleotidyltransferases (2.7.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

Abstract

Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photoprotective compounds to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.
PCT/US2011/047468 2010-08-12 2011-08-11 Photodamage mitigation compounds and systems WO2012021733A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40147110P 2010-08-12 2010-08-12
US61/401,471 2010-08-12
US201161466734P 2011-03-23 2011-03-23
US61/466,734 2011-03-23

Publications (2)

Publication Number Publication Date
WO2012021733A2 WO2012021733A2 (en) 2012-02-16
WO2012021733A3 true WO2012021733A3 (en) 2012-08-02

Family

ID=45568198

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/047468 WO2012021733A2 (en) 2010-08-12 2011-08-11 Photodamage mitigation compounds and systems

Country Status (2)

Country Link
US (2) US8834847B2 (en)
WO (1) WO2012021733A2 (en)

Families Citing this family (10)

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US9127259B2 (en) 2008-03-31 2015-09-08 Pacific Biosciences Of California, Inc. Enzymes resistant to photodamage
US8956816B2 (en) 2012-06-05 2015-02-17 Pacific Biosciences Of California, Inc. Methods and compositions for performing analytical operations
US9637782B2 (en) 2012-09-28 2017-05-02 Pacific Biosciences Of California, Inc. Charged triplet-state quenchers for mitigation of photo-induced damage
US10302972B2 (en) 2015-01-23 2019-05-28 Pacific Biosciences Of California, Inc. Waveguide transmission
CN108350487B (en) 2015-11-19 2022-05-27 加利福尼亚太平洋生物科学股份有限公司 Compounds and systems for improved signal detection
EP3538093B1 (en) 2016-11-09 2023-10-25 Qiagen Sciences, LLC Photoprotective mixtures as imaging reagents in sequencing-by-synthesis
US11332787B2 (en) 2018-06-29 2022-05-17 Pacific Biosciences Of California, Inc. Methods and compositions for delivery of molecules and complexes to reaction sites
CA3157457A1 (en) 2019-11-27 2021-06-03 Xiaolin Wu Cyclooctatetraene containing dyes and compositions
WO2022241246A1 (en) * 2021-05-13 2022-11-17 Fluid-Screen, Inc. Techniques for optimizing detection of particles captured by a microfluidic system
WO2023060527A1 (en) * 2021-10-11 2023-04-20 深圳华大智造科技股份有限公司 Use of saponin compound in nucleic acid sequencing

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Also Published As

Publication number Publication date
US20150079603A1 (en) 2015-03-19
US8834847B2 (en) 2014-09-16
WO2012021733A2 (en) 2012-02-16
US20120052488A1 (en) 2012-03-01
US9732382B2 (en) 2017-08-15

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