WO2012028310A3 - Compositions comprising a taxane for coating medical devices - Google Patents

Compositions comprising a taxane for coating medical devices Download PDF

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Publication number
WO2012028310A3
WO2012028310A3 PCT/EP2011/004384 EP2011004384W WO2012028310A3 WO 2012028310 A3 WO2012028310 A3 WO 2012028310A3 EP 2011004384 W EP2011004384 W EP 2011004384W WO 2012028310 A3 WO2012028310 A3 WO 2012028310A3
Authority
WO
WIPO (PCT)
Prior art keywords
taxane
medical devices
pharmaceutical composition
compositions
polyol
Prior art date
Application number
PCT/EP2011/004384
Other languages
French (fr)
Other versions
WO2012028310A2 (en
Inventor
Torsten Heilmann
Heiko Noack
Christian Richter
Sabine Post
Original Assignee
Avidal Vascular Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avidal Vascular Gmbh filed Critical Avidal Vascular Gmbh
Publication of WO2012028310A2 publication Critical patent/WO2012028310A2/en
Publication of WO2012028310A3 publication Critical patent/WO2012028310A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Abstract

The present invention relates inter alia to a pharmaceutical composition comprising a taxane, an antioxidant and a polyol and to a pharmaceutical composition comprising a taxane, a statin and a polyol. The pharmaceutical compositions of the invention can be used to coat medical devices such as implants. Such implant can be an expansible hollow part, having at least one opening, which consists of an elastic biocompatible material that comprises elongated micro-cavities in its surface. Medical devices coated with a pharmaceutical composition of the invention exhibit an enhanced transfer of taxane from the surface of said medical device into the target tissue.
PCT/EP2011/004384 2010-08-31 2011-08-31 Pharmaceutical compositions comprising a taxane WO2012028310A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37858610P 2010-08-31 2010-08-31
US61/378,586 2010-08-31

Publications (2)

Publication Number Publication Date
WO2012028310A2 WO2012028310A2 (en) 2012-03-08
WO2012028310A3 true WO2012028310A3 (en) 2012-06-07

Family

ID=44741248

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/004384 WO2012028310A2 (en) 2010-08-31 2011-08-31 Pharmaceutical compositions comprising a taxane

Country Status (1)

Country Link
WO (1) WO2012028310A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8974811B2 (en) 2013-03-14 2015-03-10 Hikma Pharmaceuticals Stabilized pharmaceutical formulations comprising antineoplastic compounds
KR102093100B1 (en) * 2018-07-11 2020-03-26 대화제약 주식회사 An oral pharmaceutical composition comprising taxane having improved oxidation stability

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004022124A1 (en) * 2002-09-06 2004-03-18 Abbott Laboratories Medical device having hydration inhibitor
WO2004091506A2 (en) * 2003-04-10 2004-10-28 Ivax Research, Inc. Taxane-based compositions and methods of use
US20040234575A1 (en) * 2002-05-09 2004-11-25 Roland Horres Medical products comprising a haemocompatible coating, production and use thereof
US20050129731A1 (en) * 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
WO2007090385A2 (en) * 2006-02-09 2007-08-16 B.Braun Melsungen Ag Coating method for a folded balloon
CN101455640A (en) * 2007-12-12 2009-06-17 张文芳 Composition containing taxone
WO2009121565A2 (en) * 2008-03-31 2009-10-08 Avidal Vascular Gmbh Expansible biocompatible coats comprising a biologically active substance
US20100209472A1 (en) * 2006-11-20 2010-08-19 Lixiao Wang Drug releasing coatings for medical devices

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1521603B1 (en) 2002-07-12 2011-01-19 Cook Incorporated Coated medical device

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040234575A1 (en) * 2002-05-09 2004-11-25 Roland Horres Medical products comprising a haemocompatible coating, production and use thereof
WO2004022124A1 (en) * 2002-09-06 2004-03-18 Abbott Laboratories Medical device having hydration inhibitor
WO2004091506A2 (en) * 2003-04-10 2004-10-28 Ivax Research, Inc. Taxane-based compositions and methods of use
US20050129731A1 (en) * 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
WO2007090385A2 (en) * 2006-02-09 2007-08-16 B.Braun Melsungen Ag Coating method for a folded balloon
US20100209472A1 (en) * 2006-11-20 2010-08-19 Lixiao Wang Drug releasing coatings for medical devices
CN101455640A (en) * 2007-12-12 2009-06-17 张文芳 Composition containing taxone
WO2009121565A2 (en) * 2008-03-31 2009-10-08 Avidal Vascular Gmbh Expansible biocompatible coats comprising a biologically active substance

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BODO CREMERS ET AL: "Comparison of two different paclitaxel-coated balloon catheters in the porcine coronary restenosis model", CLINICAL RESEARCH IN CARDIOLOGY, STEINKOPFF-VERLAG, DA, vol. 98, no. 5, 12 March 2009 (2009-03-12), pages 325 - 330, XP019712552, ISSN: 1861-0692 *
TARDIF J-C ET AL: "PROBUCOL AND MULTIVITAMINS IN THE PREVENTION OF RESTENOSIS AFTER CORONARY ANGIOPLASTY", NEW ENGLAND JOURNAL OF MEDICINE, THE, MASSACHUSETTS MEDICAL SOCIETY, WALTHAM, MA, US, vol. 337, no. 6, 7 August 1997 (1997-08-07), pages 365 - 372, XP000972459, ISSN: 0028-4793, DOI: 10.1056/NEJM199708073370601 *
TORSTEN HEILMANN ET AL: "Drug Release Profiles of Different Drug-coated Balloon Platforms", EUROPEAN CARDIOLOGY, vol. 6, no. 4, 1 October 2010 (2010-10-01), pages 40 - 44, XP055012965, ISSN: 1758-3756 *

Also Published As

Publication number Publication date
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