WO2012071526A3 - Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds - Google Patents

Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds Download PDF

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Publication number
WO2012071526A3
WO2012071526A3 PCT/US2011/062067 US2011062067W WO2012071526A3 WO 2012071526 A3 WO2012071526 A3 WO 2012071526A3 US 2011062067 W US2011062067 W US 2011062067W WO 2012071526 A3 WO2012071526 A3 WO 2012071526A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
irreversible electroporation
vasculature
ire
organs
Prior art date
Application number
PCT/US2011/062067
Other languages
French (fr)
Other versions
WO2012071526A2 (en
Inventor
Michael Sano
Rafael Davalos
John Robertson
Paulo A. Garcia
Robert E. Neal
Original Assignee
Virginia Tech Intellectual Properties, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intellectual Properties, Inc. filed Critical Virginia Tech Intellectual Properties, Inc.
Priority to JP2013541050A priority Critical patent/JP2014501574A/en
Priority to EP11842994.3A priority patent/EP2642937A4/en
Priority to US13/989,175 priority patent/US9867652B2/en
Publication of WO2012071526A2 publication Critical patent/WO2012071526A2/en
Publication of WO2012071526A3 publication Critical patent/WO2012071526A3/en
Priority to US15/843,888 priority patent/US10537379B2/en
Priority to US16/747,219 priority patent/US20200197073A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1472—Probes or electrodes therefor for use with liquid electrolyte, e.g. virtual electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2218/00—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2218/001—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body having means for irrigation and/or aspiration of substances to and/or from the surgical site
    • A61B2218/002—Irrigation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation

Abstract

The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
PCT/US2011/062067 2008-04-29 2011-11-23 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds WO2012071526A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2013541050A JP2014501574A (en) 2010-11-23 2011-11-23 Irreversible electroporation using tissue vasculature to treat abnormal cell populations or generate tissue scaffolds
EP11842994.3A EP2642937A4 (en) 2010-11-23 2011-11-23 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US13/989,175 US9867652B2 (en) 2008-04-29 2011-11-23 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US15/843,888 US10537379B2 (en) 2008-04-29 2017-12-15 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US16/747,219 US20200197073A1 (en) 2008-04-29 2020-01-20 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41653410P 2010-11-23 2010-11-23
US61/416,534 2010-11-23

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US12/432,295 Continuation-In-Part US9598691B2 (en) 2008-04-29 2009-04-29 Irreversible electroporation to create tissue scaffolds
US12/491,151 Continuation-In-Part US8992517B2 (en) 2008-04-29 2009-06-24 Irreversible electroporation to treat aberrant cell masses

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/989,175 A-371-Of-International US9867652B2 (en) 2008-04-29 2011-11-23 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US15/843,888 Division US10537379B2 (en) 2008-04-29 2017-12-15 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds

Publications (2)

Publication Number Publication Date
WO2012071526A2 WO2012071526A2 (en) 2012-05-31
WO2012071526A3 true WO2012071526A3 (en) 2013-01-17

Family

ID=46146425

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/062067 WO2012071526A2 (en) 2008-04-29 2011-11-23 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds

Country Status (3)

Country Link
EP (1) EP2642937A4 (en)
JP (1) JP2014501574A (en)
WO (1) WO2012071526A2 (en)

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Also Published As

Publication number Publication date
EP2642937A4 (en) 2014-05-07
EP2642937A2 (en) 2013-10-02
WO2012071526A2 (en) 2012-05-31
JP2014501574A (en) 2014-01-23

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