WO2012091518A3 - Phospholipid nanoparticles for mr-induced high-intensity focused ultrasonic treatment and diagnosis, and method for producing same - Google Patents

Phospholipid nanoparticles for mr-induced high-intensity focused ultrasonic treatment and diagnosis, and method for producing same Download PDF

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Publication number
WO2012091518A3
WO2012091518A3 PCT/KR2011/010378 KR2011010378W WO2012091518A3 WO 2012091518 A3 WO2012091518 A3 WO 2012091518A3 KR 2011010378 W KR2011010378 W KR 2011010378W WO 2012091518 A3 WO2012091518 A3 WO 2012091518A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
intensity focused
phospholipid nanoparticles
induced high
ultrasonic treatment
Prior art date
Application number
PCT/KR2011/010378
Other languages
French (fr)
Korean (ko)
Other versions
WO2012091518A2 (en
Inventor
최규실
최세영
임효근
임현철
김영선
Original Assignee
삼성전자주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 삼성전자주식회사 filed Critical 삼성전자주식회사
Publication of WO2012091518A2 publication Critical patent/WO2012091518A2/en
Publication of WO2012091518A3 publication Critical patent/WO2012091518A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1809—Micelles, e.g. phospholipidic or polymeric micelles

Abstract

The present invention relates to phospholipid nanoparticles for MR-induced high-intensity focused ultrasonic treatment and diagnosis, and to a method for producing same. More particularly, the present invention relates to phospholipid nanoparticles for MR-induced high-intensity focused ultrasound treatment and diagnosis, in which an MRI contrast agent is bonded to gas-containing phospholipid nanoparticles to enable high-intensity focused ultrasound treatment and monitoring by MR to be simultaneously performed. The present invention also relates to a method for producing the phospholipid nanoparticles.
PCT/KR2011/010378 2010-12-31 2011-12-30 Phospholipid nanoparticles for mr-induced high-intensity focused ultrasonic treatment and diagnosis, and method for producing same WO2012091518A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100140070A KR101292939B1 (en) 2010-12-31 2010-12-31 A phospholipid nanoparticle for theragnostics of MR-guided high-intensity focused ultrasound and a method for preparation thereof
KR10-2010-0140070 2010-12-31

Publications (2)

Publication Number Publication Date
WO2012091518A2 WO2012091518A2 (en) 2012-07-05
WO2012091518A3 true WO2012091518A3 (en) 2012-08-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/010378 WO2012091518A2 (en) 2010-12-31 2011-12-30 Phospholipid nanoparticles for mr-induced high-intensity focused ultrasonic treatment and diagnosis, and method for producing same

Country Status (2)

Country Link
KR (1) KR101292939B1 (en)
WO (1) WO2012091518A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10667790B2 (en) 2012-03-26 2020-06-02 Teratech Corporation Tablet ultrasound system
US9877699B2 (en) 2012-03-26 2018-01-30 Teratech Corporation Tablet ultrasound system
WO2014107055A1 (en) * 2013-01-04 2014-07-10 연세대학교 산학협력단 Mri contrast agent including t1 contrast material coated on surface of nanoparticle support
CN103449530A (en) * 2013-09-06 2013-12-18 南京东纳生物科技有限公司 Preparation method of high-performance magnetic manganese zinc ferrite nanostars and nanoclusters

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030039613A1 (en) * 1993-11-30 2003-02-27 Unger Evan C. Novel therapeutic delivery systems
US20030216638A1 (en) * 2002-05-16 2003-11-20 Rohan Dharmakumar Microbubble construct for sensitivity enhanced MR manometry
US20070081946A1 (en) * 2003-12-22 2007-04-12 Bracco Research S.A. Assembly of gas-filled microvesicle with active component for contrast imaging
WO2008130137A1 (en) * 2007-04-20 2008-10-30 Korea Research Institute Of Chemical Technology Anionic lipid nanosphere and preparation method of the same
US20090117052A1 (en) * 2005-01-10 2009-05-07 Zhibiao Wang Enhancement agent for high intensity focused ultrasound treatment and method for screening the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030039613A1 (en) * 1993-11-30 2003-02-27 Unger Evan C. Novel therapeutic delivery systems
US20030216638A1 (en) * 2002-05-16 2003-11-20 Rohan Dharmakumar Microbubble construct for sensitivity enhanced MR manometry
US20070081946A1 (en) * 2003-12-22 2007-04-12 Bracco Research S.A. Assembly of gas-filled microvesicle with active component for contrast imaging
US20090117052A1 (en) * 2005-01-10 2009-05-07 Zhibiao Wang Enhancement agent for high intensity focused ultrasound treatment and method for screening the same
WO2008130137A1 (en) * 2007-04-20 2008-10-30 Korea Research Institute Of Chemical Technology Anionic lipid nanosphere and preparation method of the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. M. CHOW ET AL.: "Enhancement of gas-filled microtubule R2* by iron oxide nanoparticles for MRI", MAGNETIC RESONANCE IN MEDICINE, vol. 3, January 2010 (2010-01-01), pages 224 - 229 *
F. YANG ET AL.: "The preparation and application of microbubble contrast agent combining ultrasound imaging and magnetic resonance imaging", CHINESE SCIENCE BULLETIN, vol. 54, 2009, pages 2934 - 2939 *

Also Published As

Publication number Publication date
KR20120077931A (en) 2012-07-10
KR101292939B1 (en) 2013-08-02
WO2012091518A2 (en) 2012-07-05

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