WO2012112489A3 - Compositions and methods for the therapy and diagnosis of influenza - Google Patents

Compositions and methods for the therapy and diagnosis of influenza Download PDF

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Publication number
WO2012112489A3
WO2012112489A3 PCT/US2012/024971 US2012024971W WO2012112489A3 WO 2012112489 A3 WO2012112489 A3 WO 2012112489A3 US 2012024971 W US2012024971 W US 2012024971W WO 2012112489 A3 WO2012112489 A3 WO 2012112489A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
influenza
compositions
diagnosis
therapy
Prior art date
Application number
PCT/US2012/024971
Other languages
French (fr)
Other versions
WO2012112489A2 (en
Inventor
Andres G. Grandea
Gordon King
Thomas C. Cox
Ole Olsen
Jennifer Mitcham
Matthew Moyle
Phil Hammond
Original Assignee
Theraclone Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP12747475.7A priority Critical patent/EP2675478A4/en
Application filed by Theraclone Sciences, Inc. filed Critical Theraclone Sciences, Inc.
Priority to SG2013061122A priority patent/SG192727A1/en
Priority to CA 2827301 priority patent/CA2827301A1/en
Priority to AU2012217867A priority patent/AU2012217867A1/en
Priority to JP2013553646A priority patent/JP2014506580A/en
Priority to KR20137024393A priority patent/KR20140012098A/en
Priority to NZ614215A priority patent/NZ614215B2/en
Priority to MX2013009357A priority patent/MX2013009357A/en
Priority to CN201280018154.2A priority patent/CN103687619A/en
Priority to BR112013020743A priority patent/BR112013020743A2/en
Publication of WO2012112489A2 publication Critical patent/WO2012112489A2/en
Publication of WO2012112489A3 publication Critical patent/WO2012112489A3/en
Priority to IL227947A priority patent/IL227947A0/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus

Abstract

The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides.
PCT/US2012/024971 2011-02-14 2012-02-14 Compositions and methods for the therapy and diagnosis of influenza WO2012112489A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
KR20137024393A KR20140012098A (en) 2011-02-14 2012-02-14 Compositions and methods for the therapy and diagnosis of influenza
SG2013061122A SG192727A1 (en) 2011-02-14 2012-02-14 Compositions and methods for the therapy and diagnosis of influenza
CA 2827301 CA2827301A1 (en) 2011-02-14 2012-02-14 Compositions and methods for the therapy and diagnosis of influenza
AU2012217867A AU2012217867A1 (en) 2011-02-14 2012-02-14 Compositions and methods for the therapy and diagnosis of influenza
JP2013553646A JP2014506580A (en) 2011-02-14 2012-02-14 Compositions and methods for the treatment and diagnosis of influenza
EP12747475.7A EP2675478A4 (en) 2011-02-14 2012-02-14 Compositions and methods for the therapy and diagnosis of influenza
NZ614215A NZ614215B2 (en) 2011-02-14 2012-02-14 Compositions and methods for the therapy and diagnosis of influenza
BR112013020743A BR112013020743A2 (en) 2011-02-14 2012-02-14 compositions and methods for influenza therapy and diagnosis
CN201280018154.2A CN103687619A (en) 2011-02-14 2012-02-14 Compositions and methods for the therapy and diagnosis of influenza
MX2013009357A MX2013009357A (en) 2011-02-14 2012-02-14 Compositions and methods for the therapy and diagnosis of influenza.
IL227947A IL227947A0 (en) 2011-02-14 2013-08-13 Compositions comprising antibodies binding the hemagglutinin (ha) glycoprotein and the extracellular domain of the matrix 2 ectodomain (m2e) polypeptide of an influenza virus and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161442733P 2011-02-14 2011-02-14
US61/442,733 2011-02-14

Publications (2)

Publication Number Publication Date
WO2012112489A2 WO2012112489A2 (en) 2012-08-23
WO2012112489A3 true WO2012112489A3 (en) 2013-01-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/024971 WO2012112489A2 (en) 2011-02-14 2012-02-14 Compositions and methods for the therapy and diagnosis of influenza

Country Status (13)

Country Link
US (2) US8916160B2 (en)
EP (1) EP2675478A4 (en)
JP (1) JP2014506580A (en)
KR (1) KR20140012098A (en)
CN (1) CN103687619A (en)
AU (1) AU2012217867A1 (en)
BR (1) BR112013020743A2 (en)
CA (1) CA2827301A1 (en)
IL (1) IL227947A0 (en)
MX (1) MX2013009357A (en)
SG (1) SG192727A1 (en)
TW (1) TW201245223A (en)
WO (1) WO2012112489A2 (en)

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US20110033476A1 (en) * 2007-11-12 2011-02-10 Theraclone Sciences Inc. Compositions and methods for the therapy and diagnosis of influenza
EP2220116B1 (en) * 2007-11-12 2012-09-05 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of influenza
BR112013023576A2 (en) * 2011-03-15 2016-12-06 Theraclone Sciences Inc compositions and methods for influenza therapy and diagnosis
MY181648A (en) 2012-08-24 2020-12-30 Univ California Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis
US20140363441A1 (en) * 2013-04-22 2014-12-11 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of influenza
EP3070167A4 (en) * 2013-11-06 2017-06-07 Osaka University Antibody having broad neutralizing activity in group 1 influenza a virus
TWI702229B (en) 2014-12-19 2020-08-21 美商再生元醫藥公司 Human antibodies to influenza hemagglutinin
US9890206B2 (en) * 2015-08-20 2018-02-13 Medigen Biotechnology Corporation H1N1 flu virus neutralizing antibodies
KR20190022752A (en) 2016-06-27 2019-03-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Cancer Treatment Combination
WO2018170273A1 (en) 2017-03-15 2018-09-20 University Of Washington De novo designed hemagglutinin binding proteins
JP7009625B2 (en) 2017-10-18 2022-01-25 シァメン・ユニヴァーシティ H3N2 subtype influenza virus hemagglutinin protein mutant and its use
EP3816290A4 (en) * 2018-06-26 2022-03-30 Kyowa Kirin Co., Ltd. Antibody binding to cell adhesion molecule 3
KR20210095781A (en) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 A multi-specific antibody comprising a fusion construct consisting of a Fab and a bioactive effector moiety
WO2021201677A1 (en) 2020-04-01 2021-10-07 Kiadis Pharma Intellectual Property B.V. Compositions and methods targeting influenza
US20240018218A1 (en) * 2020-09-08 2024-01-18 Novelgen Co., Ltd. Antiviral composition against influenza a virus

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