WO2012121463A1

WO2012121463A1 - Bone-graft-substance production device

Info

Publication number: WO2012121463A1
Application number: PCT/KR2011/007020
Authority: WO
Inventors: 박창수; 이윤진; 이재영
Original assignee: Park Chang Soo; Lee Yun Jin; Lee Jae Young
Priority date: 2011-03-08
Filing date: 2011-09-23
Publication date: 2012-09-13
Also published as: KR20120102237A; KR101190710B1

Abstract

The present invention relates to a bone-graft-substance production device comprising: a chamber where biological hard tissue for constituting a material for the bone-graft substance is held immersed in a fluid; an ultrasound generating unit which processes/treats the biological hard tissue held in the chamber by irradiating ultrasound onto the biological hard tissue, via the medium of the fluid; and a pressure reducing unit which reduces the pressure in the chamber.

Description

Bone graft manufacturing apparatus

The present invention relates to a bone graft material manufacturing apparatus for producing a bone graft material that can be used for dental, etc. using a living hard tissue such as teeth or bones of an organism.

Bone graft material is used in the orthopedic and dental field, and is a medical material for promoting bone formation by applying to jaw defects.

Bone grafts can be categorized into applications such as autogenous grafts, allogenic grafts, xenografts, and synthetic bone substitutes.

Autograft refers to hard tissue, such as teeth or bones, obtained from the person undergoing surgery, not from another person, and allografts are implants obtained from other individuals of the same kind, usually obtained from the bones and teeth of a dead person. Xenografts refer to those obtained from other species of animals, and typically, degenerated right bones are used. Synthetic bone substitute refers to a material from which an organic substrate is removed, which is not obtained from humans or organic materials, and typically includes synthetic polymers and bioactive glass.

In particular, in the field of dentistry, implants (implants), which are a new treatment method that solves the disadvantages of existing prosthetic treatments, have become popular. Implant is a treatment method to fix the prosthesis by inserting artificial tooth root directly into the gum when the tooth is lost due to tooth decay or accident. During implantation, if the damaged tooth is left for a long time, the alveolar bone of the patient may be lost and insertion of artificial tooth roots may be difficult. In this case, an implant procedure is performed after inserting a bone graft into the damaged alveolar bone.

As a bone graft material used in the implantation procedure, a bone graft made of animal bone such as a bovine bone or a horse bone is used, and recently, a method of transplanting autologous teeth or bones is also used.

Autologous implants are the best option for patients because they have no risk of genetic or infectious infections and have a better prognosis than allogeneic or xenograft transplants. However, in the case of autologous bone, artificial bone or heterogenous bone graft was used a lot due to pain or burden of the patient due to the incision of the surgical site where the bone was collected.

The prior art related to autologous dental implants is Republic of Korea Patent Publication No. 2010-0040427. The prior art relates to a method of treatment using magnetic teeth, wherein the tooth of a patient undergoing an implant procedure is collected and used. The collected teeth are subjected to washing, dehydration, degreasing and deliming, and then lyophilized to be applied to the site to be treated. In the prior art, it takes more than 10 days to collect and process the patient's teeth and apply them to the treatment site, so that the patient needs to temporarily process the treatment site, which leads to a large number of hospital visits. There was a weighted downside.

It is an object of the present invention to provide an apparatus for producing a bone graft material, which can significantly shorten the time required for manufacturing a bone graft material using a living hard tissue such as teeth or bone.

In addition, it is an object of the present invention to provide a bone graft material manufacturing apparatus that can be conveniently used indoors, including a medical office, such as taking up less space and minimizing noise.

An apparatus for producing bone graft material according to an embodiment of the present invention for realizing the above object includes a chamber in which a living hard tissue serving as a material of a bone graft material is immersed in a liquid and a living hard tissue stored in the chamber. It may include an ultrasonic wave generating unit for processing and processing the living hard tissue by irradiating ultrasonic waves as a medium, and a pressure reducing unit for reducing the pressure in the chamber.

The chamber may be characterized by having a plurality of housings, each of which can contain a container containing the living hard tissue.

The chamber may be provided with an opening and closing portion, and the opening and closing portion may be formed with a sealing member for blocking the inflow of air inside / outside.

The opening and closing portion may be made of a transparent material that can be seen from the outside.

The ultrasonic wave generating unit may include an ultrasonic vibrator attached to an outer surface or a lower portion of the chamber to irradiate ultrasonic waves to the living hard tissue stored in the chamber.

The ultrasonic wave generating unit may include an ultrasonic vibrator which is formed to be accessible to the inside of the container in which the bone graft material is accommodated in the chamber, and directly irradiates the ultrasonic hard tissue onto the living hard tissue through a medium inside the container.

The ultrasonic wave generation unit, by controlling the on / off of the current applied to the ultrasonic vibrator to control the operating time of the ultrasonic vibrator, the ultrasonic control unit that can adjust the ultrasonic frequency by adjusting the frequency of the high frequency current applied to the ultrasonic vibrator It may be characterized by further comprising.

It may further include a cooling unit attached to the outside of the chamber to maintain the chamber at a predetermined temperature.

The cooling unit may be characterized in that the thermoelectric element.

The apparatus may further include a cooling unit controller configured to control the temperature of the thermoelectric element by applying a current to the thermoelectric element, cutting off the applied current, or adjusting the intensity of the current.

Is disposed to surround the outer surface of the chamber, it may further include a cooling unit for maintaining the chamber at a predetermined temperature with a refrigerant contained therein.

It may further include a cooling unit controller for controlling the temperature of the chamber by measuring the temperature of the chamber and controlling the temperature of the chamber and the temperature of the refrigerant entering and exiting the cooling unit.

The decompression unit may be configured to include a vacuum pump connected to the chamber to reduce the pressure inside the chamber.

The decompression unit may be characterized in that the pressure controller is further formed on the outside of the vacuum pump to adjust the decompression level of the vacuum pump.

The decompression unit may further include a vacuum cycle controller configured to control the operation of the vacuum pump by turning on / off power applied to the vacuum pump so that the vacuum state and the atmospheric pressure state are repeated. You can do

The decompression unit may be configured to include a pressure display unit connected to the chamber to display the pressure inside the chamber to the outside.

A space surrounded by an outer wall may be formed to accommodate the chamber therein, and a sound absorbing case may be further formed on an inner surface of the outer wall to prevent a noise generated from the inside from leaking out.

According to the bone graft material manufacturing apparatus according to the present invention configured as described above, by using a living hard tissue such as teeth or bones significantly shortened the time required to manufacture the bone graft material to reduce the discomfort of patients and treatment period It can be shortened. In addition, it can be installed in a narrow space and less noise can be conveniently used indoors, such as a medical office.

1 is a perspective view schematically showing the overall appearance of the bone graft material manufacturing apparatus according to an embodiment of the present invention.

Figure 2 is a cross-sectional view schematically showing the overall appearance of the bone graft material manufacturing apparatus according to an embodiment of the present invention.

Figure 3 is a plan view of the chamber of the bone graft material manufacturing apparatus according to an embodiment of the present invention.

Figure 4 is a perspective view schematically showing the chamber and the cooling unit of the bone graft material manufacturing apparatus according to another embodiment of the present invention.

Figure 5 is a perspective view schematically showing the overall appearance of the bone graft material manufacturing apparatus according to another embodiment of the present invention.

Hereinafter, a bone graft material manufacturing apparatus according to a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings. In the present specification, the same or similar reference numerals are assigned to the same or similar configurations in different embodiments, and the description thereof is replaced with the first description.

1 is a perspective view schematically showing the overall appearance of the bone graft material manufacturing apparatus according to an embodiment of the present invention, Figure 2 is a cross-sectional view schematically showing the overall appearance of the bone graft material manufacturing apparatus according to an embodiment of the present invention to be.

Bone graft material manufacturing apparatus according to an embodiment of the present invention may be composed of the chamber 10, the ultrasonic wave generation unit 20, the decompression unit 30 and the cooling unit 40.

The chamber 10 may be a place where the living body hard tissue B, which is a material for producing a bone graft material, is stored in a form immersed in the liquid L. The living hard tissue B may be a bone and dental tissue of a human body and an organism, and may be stored in the chamber 10 by immersing it in a predetermined liquid (L).

The chamber 10 may include an accommodating part 11 and an opening and closing part 12. Referring to FIG. 3, the accommodating part 11 may be a portion in which a space for accommodating the living hard tissue B is formed. Specifically, the receiving unit 11 may be provided with a plurality so that the container 13 containing the living hard tissue (B) can be accommodated, respectively. The container 13 containing the living hard tissue B is filled with a predetermined liquid L inside the cylindrical container 13, and the living hard tissue B is contained in the liquid L. The container 13 containing the living hard tissue B may be formed in various forms as well as a cylinder.

The accommodating part 11 may have the same shape as that of the container 13 in which the living hard tissue B is contained. The accommodating part 11 may form a space such that the container 13 containing the living hard tissue B is vertically inserted and not shaken. The accommodating part 11 may also be formed to be inclined at a predetermined angle.

The plurality of accommodating parts 11 may be arranged in a circular shape at a predetermined angle, or may be arranged in a single row, two rows, three rows, or the like at a predetermined interval, and may be arranged in a quadrangular shape. In addition, a plurality of accommodating parts 11 may be arranged in various forms.

The liquid L filled in the container 13 and containing the living hard tissue B may be used as a medium when ultrasonic waves are irradiated, and may serve to facilitate the processing and processing of the living hard tissue B. Specifically, the liquid L containing the living hard tissue B may be a kind of a chemical reagent or a mixed liquid required for processing and processing the living hard tissue B. The chemical reagent may be one containing an acid.

The container 13 containing the living hard tissue B may be maintained in a sterile state.

The opening and closing part 12 may be a part that divides the chamber 10 into an external space and an internal space. The opening and closing part 12 may serve to seal the chamber 10 by blocking air inflow between the inside and the outside of the chamber 10. The opening and closing part 12 may be in the form of a lid formed on one side of the chamber 10.

Opening and closing part 12 is preferably made of a transparent material that can be seen from the inside to the outside. This may be to facilitate the internal work progress. The opening and closing part 12 may be made of acrylic or tempered glass, or any material as long as it is a transparent material that can withstand a predetermined pressure and disinfection.

The opening and closing part 12 may be provided with a sealing member 14 to seal the inside of the chamber 10. The sealing member 14 may be in the form of an elastic body installed on one side of the opening and closing part 12. Specifically, the sealing member 14 may be an O-ring of a rubber material which is installed on one side of the opening and closing portion 12 in the form of a lid. The sealing member 14 may be a packing made of silicon material formed along the edge of the opening and closing part 12. The sealing member 14 may be any type as long as it can block the inflow of air so as to maintain the airtightness of the opening and closing part 12 to seal the inside of the chamber 10.

The ultrasonic wave generation unit 20 may irradiate ultrasonic waves through the medium using a predetermined liquid L containing the living hard tissue B contained in the chamber 10 as a medium. The irradiated ultrasound is delivered to the living hard tissue B through the liquid L medium to process and process the living hard tissue B.

As illustrated in FIG. 2, the ultrasonic wave generating unit 20 may include an ultrasonic vibrator 21 and an ultrasonic control unit 22.

The ultrasonic vibrator 21 may be attached to the outer side or the bottom of the chamber 10. Specifically, the ultrasonic vibrator 21 may include an ultrasonic vibrator 21 attached to the outer side or the bottom of the chamber 10.

At least one ultrasonic vibrator 21 may be attached to an outer surface or a bottom of the chamber 10. The ultrasonic vibrator 21 may be attached to a plurality of at regular intervals. The ultrasonic vibrator 21 may also be attached to the chamber 10 by being inclined at an angle so as to be advantageous at the time of ultrasonic irradiation. In this case, the ultrasonic vibrator 21 irradiates ultrasonic waves to the outer wall of the chamber 10 so that the ultrasonic waves transmitted through the outer wall of the chamber 10 are delivered to the container 13 containing the living hard tissue B so that the biological hard tissue ( Ultrasound may be irradiated to B).

The ultrasonic controller 22 may control the on / off of the current applied to the ultrasonic vibrator 21 and control the operation of the ultrasonic vibrator. When the current applied to the ultrasonic vibrator 21 is turned on, the ultrasonic vibrator 21 may irradiate ultrasonic waves to the living hard tissue B through a medium to perform processing and processing operations. When the current applied to the ultrasonic vibrator 21 is turned off, the ultrasonic processing and processing work can be paused or terminated. The ultrasonic control unit 22 may play a role of adjusting the processing time of the living hard tissue B through the current on / off control.

In addition, the ultrasonic controller 22 may control the range of the ultrasonic frequency in order to optimize the operating intensity of the ultrasonic vibrator 21. This may be controlled by adjusting the frequency of the high frequency current applied to the ultrasonic vibrator 21. The ultrasonic controller 22 may be separately installed outside the chamber 10. The ultrasonic controller 22 may be connected to the ultrasonic vibrator 21 and the wire in the chamber 10 to control the current applied to the ultrasonic vibrator 21.

The decompression unit 30 is a device for lowering the pressure inside the chamber 10 in which the living hard tissue B is accommodated. In addition, the pressure reduction unit 30 may serve to lower the pressure inside the chamber 10 or return it to an atmospheric pressure state.

Here, the pressure reduction unit 30 may be composed of a vacuum pump 31, a pressure display unit 32, a pressure controller 33 and a vacuum cycle control unit 34.

The vacuum pump 31 may be connected to the chamber 10 to suck air in the chamber 10 to lower the air pressure in the chamber 10. When the vacuum pump 31 is in the on state, the vacuum pump 31 sucks air in the chamber 10 and sells it to the outside, thereby lowering the air pressure inside the chamber. In addition, when the vacuum pump 31 is in the off state, the air pressure inside the chamber 10 may rise to return to the atmospheric pressure state.

In the case where the inside of the chamber 10 is desired to quickly return from the reduced pressure state to the atmospheric pressure state, a communication hole (not shown) communicating with the outside may be formed in a portion of the chamber 10. When the pressure inside the chamber 10 drops and the operation of the vacuum pump 31 is turned off, when a rapid return of the chamber 10 to the atmospheric pressure is performed, a communication hole is opened to allow external air to flow into the chamber 10 quickly. It is possible to be introduced in time.

The pressure display unit 32 is to display the pressure value inside the chamber 10 and may be installed anywhere the user can check the outside of the chamber 10.

The pressure controller 33 may be separately formed on the outside of the chamber 10 and the vacuum pump 31, and installed to adjust the decompression level of the pressure inside the chamber 10 by the operation of the vacuum pump 31. Can be. The pressure controller 33 may check the pressure inside the chamber 10 and operate the vacuum pump 31 until the pressure inside the chamber 10 is reduced to a predetermined level. In addition, by increasing or decreasing the operating amount of the vacuum pump 31 according to the decompression level inside the desired chamber 10 may serve to adjust the time until the desired decompression level is reached quickly or slowly.

The vacuum cycle controller 34 may turn on / off the power supplied to the vacuum pump 31. The vacuum cycle controller 34 may be installed separately from the vacuum pump 31, and may serve to control power applied to the vacuum pump 31. This may be to repeatedly perform the process of making the inside of the chamber 10 under reduced pressure, that is, such as vacuum, and then returning the inside of the chamber 10 back to the atmospheric pressure after a predetermined time.

The vacuum cycle control unit 34 may be formed because it is necessary to adjust the pressure in the chamber 10 in the process of processing and processing the living hard tissue (B). Therefore, by controlling the operation of the vacuum pump 31 according to a predetermined time interval may be to adjust the inside of the chamber 10 alternately in a vacuum state and an atmospheric pressure state.

The cooling unit 40 may serve to cool the temperature of the chamber 10 in which the temperature is raised by the heat generated by the ultrasonic operation and maintain the temperature at a predetermined temperature. Cooling unit 40 may be to cool the temperature of the chamber 10 in various forms or to maintain a constant temperature.

The cooling unit 40 may be formed to surround an outer surface of the chamber 10 containing the living hard tissue B, and may have a shape in which the refrigerant C may be accommodated. That is, as the form surrounding the outer surface of the chamber 10 may be able to maintain the temperature of the chamber 10 at a predetermined temperature using the refrigerant (C). The cooling unit 40 may include an inlet 15 communicating with the outside so as to introduce a refrigerant C such as cooling water into one side. In addition, a separate discharge port 16 may be provided to communicate with the outside so that the refrigerant C may be discharged to the outside.

Specifically, the cooling unit 40 of this type may be provided with a refrigerant injector 41 formed outside the chamber 10. The refrigerant injector 41 accommodates the refrigerant C therein and injects the refrigerant C into the cooling unit 40 through the inlet of the cooling unit 40 surrounding the outer surface of the chamber 10. And, to cool the heat of the chamber 10 and to receive the refrigerant (C) coming out through the outlet 16 may be to serve to circulate inside. The refrigerant injector 41 and the inlet 15 and the outlet 16 of the cooling unit may be connected to the hose, respectively, and the material may be any material as long as the material is not oxidized by the internal liquid (L).

The cooling unit controller 42 may be installed separately from the cooling unit 40 and the refrigerant injector 41. The cooling unit controller 42 may serve to measure the temperature of the chamber 10 when the temperature of the chamber 10 rises by ultrasonic scanning, and maintain the temperature of the chamber 10 at a constant temperature.

Specifically, after setting a predetermined temperature in the cooling unit control unit 42, when the temperature of the chamber 10 rises above the set temperature, the refrigerant (C) is sent from the refrigerant injector 41 to the cooling unit 40, the chamber ( You can drop the temperature of 10). When the temperature of the chamber 10 reaches a setting temperature, the cooling operation of the chamber 10 may be terminated by reducing the amount of the refrigerant C passing through the refrigerant injector 41 or stopping the operation. In addition, when the temperature of the chamber 10 rises above the set temperature, the cooling unit controller 42 may lower the temperature of the refrigerant C passing through the refrigerant injector 41 to efficiently cool the chamber 10. . The cooling unit controller 42 may adjust the temperature of the chamber 10 by stopping the temperature drop of the refrigerant C or adjusting the temperature of the refrigerant C when the chamber 10 returns to the set temperature.

The ultrasonic wave generation unit 20 may be configured as shown in FIG. As illustrated in FIG. 4, the ultrasonic wave generating unit 20 may have a shape capable of entering and exiting the container 13 containing the living hard tissue B accommodated in the chamber 10. In this case, the upper ultrasonic vibrator 21a and the lower ultrasonic vibrator 21b may be configured, and the lower ultrasonic vibrator 21a is filled in the container 13 in which the living body hard tissue B is stored in the form of a long rod up and down. It may be immersed in the liquid (L).

The lower ultrasonic vibrator 21b is immersed in the liquid L to irradiate the liquid L directly with ultrasonic waves, thereby irradiating ultrasonic waves directly onto the living hard tissue B to attach the ultrasonic vibrator 21 to the outer wall of the chamber 10. Strong processing and processing effects can be obtained rather than ultrasonic irradiation.

The lower ultrasonic vibrators 21b may be provided in plural numbers so that the lower ultrasonic vibrators 21b may be inserted one by one into the container 13 containing the living hard tissue B. At this time, the lower ultrasonic vibrator 21b is inserted into the lower portion from the upper portion of the chamber 10 through the opening and closing part 12 such that one of the plurality of lower ultrasonic vibrators 21b is contained in the medium filled in one container 13. Can be. The plurality of lower ultrasonic vibrators 21b may be divided from one upper ultrasonic vibrator 21a positioned at an upper portion thereof, and each of the plurality of lower ultrasonic vibrators 21b from which ultrasonic waves radiated from the upper ultrasonic vibrator 21a are divided. Ultrasound can be irradiated as it is delivered to.

The form of the ultrasonic vibrator (21a, 21b) according to another embodiment of the present invention, that is, the form in and out of the container 13 containing the living hard tissue (B) is penetrated through the opening and closing portion 12 the chamber 10 It may be formed to be connected from the outside to the inside. In this case, the connecting part 23 formed while the upper ultrasonic vibrator 21a penetrates the opening and closing part 12 may be manufactured to maintain airtightness so that air does not enter. This connection 23 may be inserted into the O-ring or silicon aid for sealing at the edge.

Here, the cooling unit 40, unlike the Figure 2, is attached to the outside of the chamber 10, it may serve to maintain the chamber 10 at a predetermined temperature. The cooling unit 40 is preferably a thermoelectric element. The thermoelectric element changes in temperature as a current is applied. In the thermoelectric element, the temperature of the thermoelectric element decreases by applying a current. Therefore, the thermoelectric element may be attached to the outer surface of the chamber 10 to cool the temperature of the chamber 10.

In addition, in the case of using the cooling unit 40 of the thermoelectric element type after setting the desired temperature of the chamber 10, the temperature of the chamber 10 is measured and the temperature of the chamber 10 rises above the set temperature. In this case, the current applied to the thermoelectric device may be turned on or the strength of the current may be increased. When the current applied to the thermoelectric element is turned on or the strength of the current is increased, the temperature of the thermoelectric element may be lowered while the temperature of the thermoelectric element is lowered. When the temperature of the chamber 10 returns to the set temperature, the current applied to the thermoelectric element may be turned off to stop the temperature of the chamber 10 from further decreasing.

Figure 5 shows the bone graft material manufacturing apparatus according to another embodiment of the present invention, the soundproof case 50 may be configured on the outside of the chamber.

The soundproof case 50 may be such that the noise generated during the process of manufacturing the bone graft material is not leaked to the outside by processing and processing the living hard tissue B. The soundproof case 50 may accommodate the chamber 10 therein. The soundproof case 50 may accommodate the vacuum pump 31 therein. Of course, if necessary, the soundproof case 50 can accommodate all the devices for generating noise therein.

The soundproof case 50 may be installed by attaching a sound absorbing material along the inside of the wall. The sound absorbing material 51 can be any material as long as it can absorb noise. For example, various materials such as perforated plate, foamed resin, cork, polyester, etc. may be used, and a general sponge material is also possible. In addition, the sound absorbing material 51 may have a curved surface in order to refrain the wave of the noise generated therein so as not to leak to the outside.

The soundproof case 50 may be provided with an opening and closing port 52 that can be opened and closed at a position corresponding to an upper portion of the space in which the chamber 10 is stored in order to withdraw the living body hard tissue B and the like into the chamber 10 stored therein. have. The soundproof case 50 may be made of any material, and may be used in a plastic material or an acrylic material in order to easily install and manufacture and reduce weight.

Referring to the operation of the bone graft material manufacturing apparatus of the present invention configured as described above are as follows. First, the living hard tissue (B) to be prepared as a bone graft material is collected. After dipping the collected biological hard tissue (B) in the liquid (L) filled in the container, the opening and closing portion 12 of the chamber 10 is opened to insert the container into the storage portion (11). In this case, it is also possible to manufacture a plurality of bone grafts at a time by inserting the plurality of containers 13 into the receiving portion 11.

After inserting the container 13 containing the living hard tissue B into the chamber 10, the opening and closing part 12 is closed to seal the inside of the chamber 10 with the outside. When the soundproof case 50 is installed, it is possible to close the cash register 52 of the soundproof case 50 to prevent noise from leaking out during the operation. Thereafter, in order to perform the processing and processing of the living hard tissue B, the ultrasonic control unit 22 for controlling the on / off of the ultrasonic generating unit 20 is set. Since the ultrasonic controller 22 can control the operating time of the ultrasonic vibrator 21, it sets the required time. For example, after operating the ultrasonic vibrator 21 at a constant intensity for 10 minutes, the operation of the ultrasonic vibrator 21 may be stopped by cutting off the current for 10 minutes.

Next, in order to reduce the pressure inside the chamber 10, the pressure controller 33 may set a desired pressure reduction level, and set an operating strength of the vacuum pump 31 to reach a desired pressure within a predetermined time. In addition, the vacuum cycle control unit 34 may set the desired decompression and atmospheric pressure time. Specifically, after setting the desired degree of vacuum through the pressure controller 33, the vacuum cycle control unit 34 maintains the depressurization state of the chamber 10 for a predetermined time, and again the atmosphere inside the chamber 10 After adjusting to a state it can be performed repeatedly to maintain a certain time. Next, the temperature that the chamber 10 should maintain is determined, and the temperature is set in the cooling unit controller 42.

For example, the ultrasonic frequency is set to 20 kHz to 40 kHz, and the degree of vacuum inside the chamber 10 is set to 100 mmHg to 600 mmHg. Thereafter, the time for maintaining the degree of vacuum of 100 mmHg to 600 mmHg may be set to 10 minutes, and then to maintain the atmospheric pressure at intervals of 10 minutes to proceed with the bone graft manufacturing process. The temperature of the chamber 10 during the process is set to the cooling unit controller 42 so as not to exceed 60 ° C or more.

When the setting of all process conditions is completed, the ultrasonic wave generating unit 20, the decompression unit 30 and the cooling unit 40 are operated simultaneously. The vacuum pump 31 is operated to repeat the pressure inside the chamber 10 at a reduced pressure and an atmospheric pressure in accordance with the set vacuum degree and vacuum cycle. In addition, the ultrasonic vibrator 21 performs ultrasonic irradiation in accordance with the set ultrasonic frequency to perform a processing and processing process of the living hard tissue B accommodated in the chamber 10. When the heat generated by the ultrasonic wave raises the temperature of the chamber 10 to increase the temperature of the chamber 10 above the set temperature, the cooling unit 40 is operated to maintain the temperature of the chamber 10 at a constant temperature. Let's go.

When all processes are completed, the living hard tissue B inside the chamber 10 is made of bone graft material, and the user returns the inside of the chamber 10 to an atmospheric pressure state and then removes the container 13 stored therein. Implants can be obtained. Thereafter, additional treatment with other reagents may be performed to wash and improve the properties of the implant in the same manner.

Such bone graft material manufacturing apparatus is not limited to the configuration and manner of operation of the embodiments described above. The above embodiments may be configured such that various modifications may be made by selectively combining all or part of the embodiments.

10: chamber 11: storage

12: opening and closing portion 13: container

14: sealing member 15: inlet

16: outlet 20: ultrasonic generation unit

21: ultrasonic vibrator 22: ultrasonic control unit

23: connecting portion 30: pressure reducing unit

31: vacuum pump 32: pressure display

33: pressure controller 34: vacuum cycle control unit

40: cooling unit 41: refrigerant injector

42: cooling unit control unit 50: soundproof case

51: sound absorbing material 52: cashier

B: living hard tissue L: liquid

C: refrigerant

Claims

A chamber in which a living hard tissue serving as a material of a bone graft material is immersed in a liquid;

An ultrasonic wave generating unit for processing and processing the living hard tissue by irradiating ultrasonic waves with the liquid as a medium to the living hard tissue stored in the chamber; And

Decompression unit for reducing the pressure in the chamber; comprising, bone graft material manufacturing apparatus.
The method according to claim 1,

The chamber is

A bone graft material manufacturing apparatus, characterized in that it comprises a plurality of housings, each container containing the living hard tissue therein.
The method according to claim 1,

The chamber is provided with an opening and closing portion, the opening and closing portion is formed bone graft material manufacturing apparatus for blocking the inflow of air inside / outside.
The method according to claim 3,

The opening and closing portion, characterized in that made of a transparent material that can be seen from the outside, bone graft material manufacturing apparatus.
The method according to claim 1,

The ultrasonic wave generating unit,

And an ultrasonic vibrator attached to an outer side or a bottom of the chamber to irradiate the living hard tissue stored in the chamber with ultrasonic waves.
The method according to claim 1,

The ultrasonic wave generating unit,

And an ultrasonic vibrator which is formed to be accessible to the inside of the container in which the bone graft material is accommodated in the chamber, and directly irradiates the living body hard tissue with ultrasonic waves through a medium inside the container.
The method according to claim 6,

The ultrasonic wave generating unit,

And controlling an operation time of the ultrasonic vibrator by controlling the on / off of the current applied to the ultrasonic vibrator, and further comprising an ultrasonic control unit for controlling the ultrasonic frequency by adjusting the frequency of the high frequency current applied to the ultrasonic vibrator. A bone graft material production apparatus.
The method according to claim 1,

Attached to the outside of the chamber further comprises a cooling unit for maintaining the chamber at a constant temperature, bone graft material manufacturing apparatus.
The method according to claim 8,

The cooling unit is characterized in that the thermoelectric element, bone graft material manufacturing apparatus.
The method according to claim 9,

And a cooling unit controller configured to control the temperature of the thermoelectric element by applying a current to the thermoelectric element, cutting off the applied current, or adjusting the intensity of the current.
The method according to claim 1,

Arranged to surround the outer surface of the chamber, further comprising a cooling unit for maintaining the chamber at a constant temperature with a refrigerant contained therein, bone graft material manufacturing apparatus.
The method according to claim 11,

And a cooling unit controller configured to control the temperature of the chamber by measuring the temperature of the chamber and controlling the temperature of the chamber and the temperature of the refrigerant entering and exiting the cooling unit.
The method according to claim 1,

The decompression unit,

And a vacuum pump connected to the chamber to reduce the pressure inside the chamber.
The method according to claim 13,

The decompression unit,

The apparatus for producing bone graft material, characterized in that the pressure controller is further formed on the outside of the vacuum pump so as to adjust the decompression level of the vacuum pump.
The method according to claim 14,

The decompression unit,

In the manner of controlling the operation of the vacuum pump by turning on / off the power applied to the vacuum pump, characterized in that the vacuum cycle control unit for adjusting the inside of the chamber to repeat the vacuum state and atmospheric pressure is further formed, bone graft material Manufacturing device.
The method according to claim 1,

The decompression unit,

And a pressure indicator connected to the chamber to display the pressure inside the chamber to the outside.
The method according to claim 1,

A space surrounded by an outer wall is formed to accommodate the chamber therein,

The inner surface of the outer wall is attached to the sound absorbing material is characterized in that the soundproof case is further formed so as not to leak the noise generated from the inside, bone graft material manufacturing apparatus.