WO2012126745A3 - Infusion system and method of detecting and eliminating air - Google Patents

Infusion system and method of detecting and eliminating air Download PDF

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Publication number
WO2012126745A3
WO2012126745A3 PCT/EP2012/054074 EP2012054074W WO2012126745A3 WO 2012126745 A3 WO2012126745 A3 WO 2012126745A3 EP 2012054074 W EP2012054074 W EP 2012054074W WO 2012126745 A3 WO2012126745 A3 WO 2012126745A3
Authority
WO
WIPO (PCT)
Prior art keywords
infusion
priming
displacement volume
source
pump
Prior art date
Application number
PCT/EP2012/054074
Other languages
French (fr)
Other versions
WO2012126745A2 (en
Inventor
Olof Jansson
Bo Olde
Original Assignee
Gambro Lundia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gambro Lundia Ab filed Critical Gambro Lundia Ab
Publication of WO2012126745A2 publication Critical patent/WO2012126745A2/en
Publication of WO2012126745A3 publication Critical patent/WO2012126745A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14216—Reciprocating piston type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16809—Flow controllers by repeated filling and emptying of an intermediate volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features
    • A61M2005/1402—Priming
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/15—Detection of leaks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
    • A61M2205/702—General characteristics of the apparatus with testing or calibration facilities automatically during use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/1684—Monitoring, detecting, signalling or eliminating infusion flow anomalies by detecting the amount of infusate remaining, e.g. signalling end of infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
    • A61M5/16859—Evaluation of pressure response, e.g. to an applied pulse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A61M5/365—Air detectors

Abstract

An infusion system defines a fill path (4) for an infusion liquid from a source (5) to a displacement volume in a fluid chamber (8) of an infusion pump (1), and an infusion path (2) from the displacement volume to a connector (19a). The infusion pump (1) is operated to repeatedly draw infusion liquid from the source (5) into the displacement volume via the fill path (4) and push infusion liquid from the displacement volume through the connector (19a) via the infusion path (2). A controller (11) selectively effects a priming operation, by operating the infusion pump (1) to generate a priming fill stroke, in which a priming volume of the infusion liquid is drawn from the source (5) to the displacement volume, and a priming pump stroke, in which at least part of the priming volume is pushed from the displacement volume back to the source (5). The infusion system is thereby operable to be primed automatically, and proper priming may be verified by evaluating a measurement signal representative of fluid pressure in the displacement volume during either of the priming fill stroke and the priming pump stroke.
PCT/EP2012/054074 2011-03-18 2012-03-09 Methods and devices for operating an infusion system WO2012126745A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161453995P 2011-03-18 2011-03-18
SE1150245 2011-03-18
SE1150245-7 2011-03-18
US61/453,995 2011-03-18

Publications (2)

Publication Number Publication Date
WO2012126745A2 WO2012126745A2 (en) 2012-09-27
WO2012126745A3 true WO2012126745A3 (en) 2013-02-28

Family

ID=46879817

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/054074 WO2012126745A2 (en) 2011-03-18 2012-03-09 Methods and devices for operating an infusion system

Country Status (1)

Country Link
WO (1) WO2012126745A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105555340A (en) * 2013-09-20 2016-05-04 赛诺菲-安万特德国有限公司 Conditional required priming

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8092414B2 (en) 2005-11-09 2012-01-10 Nxstage Medical, Inc. Diaphragm pressure pod for medical fluids
DE112012002327T5 (en) 2011-05-31 2014-03-27 Nxstage Medical, Inc. Pressure measuring device, methods and systems
FR3010908A1 (en) * 2013-09-24 2015-03-27 Biocorp Rech Et Dev INJECTOR PEN
DK2921189T3 (en) 2014-03-17 2017-11-13 Hoffmann La Roche Initialization of a drug infusion dosing unit
JP2017525520A (en) * 2014-09-05 2017-09-07 ノボ・ノルデイスク・エー／エス Injection device adapted to detect air in the cartridge
JP2018500965A (en) * 2014-12-03 2018-01-18 ノボ・ノルデイスク・エー／エス Drug delivery device with air safety mechanism in cartridge
CN109219457B (en) * 2016-06-17 2021-10-29 贝克顿·迪金森公司 Method and apparatus for wetting an internal fluid path surface of a fluid port to enhance ultrasonic signal transmission
CN108939219B (en) * 2018-07-06 2021-03-19 深圳市国赛生物技术有限公司 Bubble removing method and bubble removing system in plunger pump cavity and storage medium
CN108832073B (en) * 2018-08-21 2024-01-02 无锡先导智能装备股份有限公司 Liquid injection equipment
US20200246603A1 (en) * 2019-01-31 2020-08-06 Becton, Dickinson And Company Catheter flush device, system, and methods
CN112007236A (en) * 2020-10-10 2020-12-01 四川大学华西医院 Infusion apparatus and monitoring device based on same
NL2027928B1 (en) * 2021-04-07 2022-10-19 Inreda Diabetic B V System for regulating the concentration of glucose in the blood of a person and use thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993012825A1 (en) * 1991-12-20 1993-07-08 Abbott Laboratories Automated drug infusion system with autopriming
US5935105A (en) * 1991-11-15 1999-08-10 Deka Products Limited Partnership Intravenous-line air-elimination system
WO2002013890A1 (en) * 2000-08-10 2002-02-21 Abbott Laboratories Autopriming a micro-cassette while minimizing the formation of air bubbles in a pumping chamber
US6416293B1 (en) * 1999-07-20 2002-07-09 Deka Products Limited Partnership Pumping cartridge including a bypass valve and method for directing flow in a pumping cartridge
EP1319417A1 (en) * 2001-12-17 2003-06-18 B. Braun Medizintechnologie GmbH Method and apparatus for monitoring a fluid conduit system of a medical instrument
WO2009044221A1 (en) * 2007-10-04 2009-04-09 Gambro Lundia Ab An infusion apparatus

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4137913A (en) 1975-02-28 1979-02-06 Ivac Corporation Fluid flow control system
US4278084A (en) 1979-10-19 1981-07-14 Baxter Travenol Laboratories, Inc. Non air-blocking filter
DE19750062A1 (en) 1997-11-12 1999-05-20 Jostra Medizintechnik Ag Device for the filtration and degassing of body fluids, especially blood
DE19840992A1 (en) 1998-09-08 2000-03-09 Disetronic Licensing Ag Pressure monitoring of a product fluid to be administered in doses during an infusion or injection
IL136512A0 (en) 2000-06-01 2001-06-14 Medivice Systems Ltd Intravenous infusion administration set

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935105A (en) * 1991-11-15 1999-08-10 Deka Products Limited Partnership Intravenous-line air-elimination system
WO1993012825A1 (en) * 1991-12-20 1993-07-08 Abbott Laboratories Automated drug infusion system with autopriming
US6416293B1 (en) * 1999-07-20 2002-07-09 Deka Products Limited Partnership Pumping cartridge including a bypass valve and method for directing flow in a pumping cartridge
WO2002013890A1 (en) * 2000-08-10 2002-02-21 Abbott Laboratories Autopriming a micro-cassette while minimizing the formation of air bubbles in a pumping chamber
EP1319417A1 (en) * 2001-12-17 2003-06-18 B. Braun Medizintechnologie GmbH Method and apparatus for monitoring a fluid conduit system of a medical instrument
WO2009044221A1 (en) * 2007-10-04 2009-04-09 Gambro Lundia Ab An infusion apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105555340A (en) * 2013-09-20 2016-05-04 赛诺菲-安万特德国有限公司 Conditional required priming

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