WO2012154680A3 - MODIFIED AND DERIVATIZED β-GLUCAN COMPOUNDS, COMPOSITIONS, AND METHODS - Google Patents

MODIFIED AND DERIVATIZED β-GLUCAN COMPOUNDS, COMPOSITIONS, AND METHODS Download PDF

Info

Publication number
WO2012154680A3
WO2012154680A3 PCT/US2012/036795 US2012036795W WO2012154680A3 WO 2012154680 A3 WO2012154680 A3 WO 2012154680A3 US 2012036795 W US2012036795 W US 2012036795W WO 2012154680 A3 WO2012154680 A3 WO 2012154680A3
Authority
WO
WIPO (PCT)
Prior art keywords
modified
derivatized
compositions
methods
glucan compounds
Prior art date
Application number
PCT/US2012/036795
Other languages
French (fr)
Other versions
WO2012154680A2 (en
Inventor
Nandita BOSE
William J. GROSSMAN
Michael Danielson
Andrew Magee
Natalie ELMASRY
Paul Will
Kyle S. MICHEL
Vanessa A. IIAMS
Xiaohong Qiu
Mary ANTONYSAMY
Original Assignee
Biothera, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biothera, Inc. filed Critical Biothera, Inc.
Priority to US14/115,824 priority Critical patent/US20140228543A1/en
Publication of WO2012154680A2 publication Critical patent/WO2012154680A2/en
Publication of WO2012154680A3 publication Critical patent/WO2012154680A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides

Abstract

Modified and/or derivativized β-glucans with an enhanced capacity to modulate human immune response as compared to the parent, unmodified and/or underivatized β-glucans are demonstrated.
PCT/US2012/036795 2011-05-06 2012-05-07 MODIFIED AND DERIVATIZED β-GLUCAN COMPOUNDS, COMPOSITIONS, AND METHODS WO2012154680A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/115,824 US20140228543A1 (en) 2011-05-06 2012-05-07 MODIFIED AND DERIVATIZED ß-GLUCAN COMPOUNDS, COMPOSITIONS, AND METHODS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161483353P 2011-05-06 2011-05-06
US61/483,353 2011-05-06

Publications (2)

Publication Number Publication Date
WO2012154680A2 WO2012154680A2 (en) 2012-11-15
WO2012154680A3 true WO2012154680A3 (en) 2013-02-21

Family

ID=47139928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/036795 WO2012154680A2 (en) 2011-05-06 2012-05-07 MODIFIED AND DERIVATIZED β-GLUCAN COMPOUNDS, COMPOSITIONS, AND METHODS

Country Status (2)

Country Link
US (1) US20140228543A1 (en)
WO (1) WO2012154680A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012167061A1 (en) 2011-06-03 2012-12-06 Biothera, Inc. OPSONIZED β-GLUCAN PREPARATIONS AND METHODS
EP3354319A1 (en) 2011-09-09 2018-08-01 Biothera, Inc. Compositions including beta-glucans and methods of use
US11229701B2 (en) * 2012-04-30 2022-01-25 Hibercell, Inc. Methods for identifying beta-glucan binding to immune cells
JP6163698B2 (en) * 2013-03-21 2017-07-19 国立大学法人 千葉大学 Novel polysaccharide metal complex compound recognizing macrophage mannose receptor and pharmaceutical composition thereof
WO2015084732A1 (en) 2013-12-05 2015-06-11 Biothera, Inc. β-GLUCAN ASSAY METHODS
EP3851111A1 (en) 2014-07-10 2021-07-21 Biothera, Inc. Beta-glucan in combination with anti-cancer agents affecting the tumor microenvironment
JP6887378B2 (en) 2014-11-06 2021-06-16 バイオセラ，インク． Beta-glucan methods and compositions that affect the intratumoral microenvironment
US11815435B2 (en) 2017-02-24 2023-11-14 Hibercell, Inc. Beta glucan immunopharmacodynamics
JP6329302B2 (en) * 2017-05-10 2018-05-23 国立大学法人千葉大学 Novel polysaccharide metal complex compound recognizing macrophage mannose receptor and pharmaceutical composition thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014873A2 (en) * 1994-11-16 1996-05-23 Sri International COVALENTLY BOUND β-GLUCAN CONJUGATES IN TARGETED DELIVERY
US20060084149A1 (en) * 2001-03-13 2006-04-20 Taro Kimura Gene carriers with the use of polysaccharide and process for producing the same
US20090004201A1 (en) * 2006-01-17 2009-01-01 Rolf Einar Engstad Therapy-Enhancing Glucan

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU760669B2 (en) * 1998-04-28 2003-05-22 Galenica Pharmaceuticals, Inc. Polysaccharide-antigen conjugates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014873A2 (en) * 1994-11-16 1996-05-23 Sri International COVALENTLY BOUND β-GLUCAN CONJUGATES IN TARGETED DELIVERY
US20060084149A1 (en) * 2001-03-13 2006-04-20 Taro Kimura Gene carriers with the use of polysaccharide and process for producing the same
US20090004201A1 (en) * 2006-01-17 2009-01-01 Rolf Einar Engstad Therapy-Enhancing Glucan

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLARK, S. M. ET AL.: "Synthetic Entry to Functionalised Morpholine and [1,4]-Oxazepanes via Reductive Amination Reactions of Carbohydrate Derived Dialdehydes.", TET. ASYMM., vol. 15, 2004, pages 3643 - 3652 *
NUMATA, M. ET AL.: "Polysaccharide-Polynucleotide Complexes (15): Thermal Stability of Schizophyllan(SPG)/Poly(C) Triple Strands Is Controllable by alpha-Amino Acid Modification.", BIOORG. CHEM., vol. 31, 2003, pages 163 - 171 *

Also Published As

Publication number Publication date
WO2012154680A2 (en) 2012-11-15
US20140228543A1 (en) 2014-08-14

Similar Documents

Publication Publication Date Title
WO2012154680A3 (en) MODIFIED AND DERIVATIZED β-GLUCAN COMPOUNDS, COMPOSITIONS, AND METHODS
WO2015010009A3 (en) Compositions and methods comprising a lipolytic enzyme variant
EP3055318A4 (en) Dihydroxyalkyl substituted polygalactomannan, and methods for producing and using the same
EP2675292B8 (en) Puree compositions having specific carbohydrate ratios and methods for using same
BR112013025862A2 (en) lignin compositions, methods of producing the compositions, methods of using lignin compositions and products thereby produced
WO2014197849A3 (en) Anti-c10orf54 antibodies and uses thereof
IL233934B (en) Cd47 antibodies, compositions comprising the same and uses thereof
EP2690951B8 (en) Cyclodextrin compositions, articles, and methods
IL236348A0 (en) Anti-jagged antibodies, compositions comprising the same and uses thereof
WO2011089183A3 (en) Anticoagulant antidotes
WO2012061603A3 (en) Compositions comprising and methods for forming functionalized carbon-based nanostructures
EP3041484A4 (en) HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS
EP2983514A4 (en) Carbohydrate compositions
WO2013021279A3 (en) Highly galactosylated antibodies
WO2013142440A3 (en) Mixtures, methods and compositions pertaining to conductive materials
ZA201404634B (en) Compositions comprising c5 and c6 oligosaccharides
IL226383B (en) Anti-ccl20 antibodies, compositions comprising the same and uses thereof
AU2011278165A8 (en) Adhesive composition including deacetylated chitosan
WO2012087327A3 (en) Polymer systems
EP2971030B8 (en) Oligosaccharide compositions, glycoproteins and methods to produce the same in prokaryotes
BR112015010597A2 (en) drying by mixing nanofibrillated polysaccharide ".
WO2012024350A3 (en) Anti-cancer adenoviruses
EP3036264A4 (en) High molecular weight polymers having high olefin content
WO2012064743A3 (en) Methods for improving heart function
WO2012010880A3 (en) Cellulosic material such as tobacco comprising one or more smoke diluents

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12781980

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 14115824

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 12781980

Country of ref document: EP

Kind code of ref document: A2