WO2012156515A1 - Analyse moléculaire de la leucémie myéloïde aiguë - Google Patents

Analyse moléculaire de la leucémie myéloïde aiguë Download PDF

Info

Publication number
WO2012156515A1
WO2012156515A1 PCT/EP2012/059280 EP2012059280W WO2012156515A1 WO 2012156515 A1 WO2012156515 A1 WO 2012156515A1 EP 2012059280 W EP2012059280 W EP 2012059280W WO 2012156515 A1 WO2012156515 A1 WO 2012156515A1
Authority
WO
WIPO (PCT)
Prior art keywords
rnas
abundance
aml
rna
listed
Prior art date
Application number
PCT/EP2012/059280
Other languages
English (en)
Inventor
Joachim Schultze
Andrea Hofmann
Andrea Staratschek-Jox
Original Assignee
Rheinische Friedrich-Wilhelms-Universität Bonn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rheinische Friedrich-Wilhelms-Universität Bonn filed Critical Rheinische Friedrich-Wilhelms-Universität Bonn
Priority to EP12724304.6A priority Critical patent/EP2710147A1/fr
Publication of WO2012156515A1 publication Critical patent/WO2012156515A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention concerne un procédé d'analyse moléculaire de la leucémie myéloïde aiguë (LMA), basé sur l'abondance d'ARN particuliers provenant d'échantillons sanguins, ainsi que des outils diagnostiques tels que des trousses et des puces pouvant être utilisés dans ce procédé.
PCT/EP2012/059280 2011-05-18 2012-05-18 Analyse moléculaire de la leucémie myéloïde aiguë WO2012156515A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12724304.6A EP2710147A1 (fr) 2011-05-18 2012-05-18 Analyse moléculaire de la leucémie myéloïde aiguë

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11166626.9 2011-05-18
EP11166626 2011-05-18
EP11166775 2011-05-19
EP11166775.4 2011-05-19

Publications (1)

Publication Number Publication Date
WO2012156515A1 true WO2012156515A1 (fr) 2012-11-22

Family

ID=46178525

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/059280 WO2012156515A1 (fr) 2011-05-18 2012-05-18 Analyse moléculaire de la leucémie myéloïde aiguë

Country Status (2)

Country Link
EP (1) EP2710147A1 (fr)
WO (1) WO2012156515A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9714289B2 (en) 2015-02-19 2017-07-25 Compugen Ltd. Anti-PVRIG antibodies and methods of use
US10124061B2 (en) 2016-08-17 2018-11-13 Compugen Ltd. Anti-TIGIT antibodies, anti-PVRIG antibodies and combinations thereof
US10550173B2 (en) 2015-02-19 2020-02-04 Compugen, Ltd. PVRIG polypeptides and methods of treatment
WO2021178166A1 (fr) * 2020-03-06 2021-09-10 Denovo Biopharma Llc Compositions et procédés pour évaluer l'efficacité d'inhibiteurs de transporteurs de neurotransmetteurs
US11225523B2 (en) 2017-06-01 2022-01-18 Compugen Ltd. Triple combination antibody therapies
US11549146B2 (en) 2016-05-20 2023-01-10 Cedars-Sinai Medical Center Diagnosis of inflammatory bowel disease based on genes
WO2022256607A3 (fr) * 2021-06-04 2023-01-19 Duke University Compositions et méthodes d'évaluation de la formation et de la fonction de jonctions communicantes

Citations (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5405783A (en) 1989-06-07 1995-04-11 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of an array of polymers
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
US5436327A (en) 1988-09-21 1995-07-25 Isis Innovation Limited Support-bound oligonucleotides
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5532128A (en) 1991-11-19 1996-07-02 Houston Advanced Research Center Multi-site detection apparatus
US5545331A (en) 1991-04-08 1996-08-13 Romar Technologies, Inc. Recycle process for removing dissolved heavy metals from water with iron particles
US5554501A (en) 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5561071A (en) 1989-07-24 1996-10-01 Hollenberg; Cornelis P. DNA and DNA technology for the construction of networks to be used in chip construction and chip production (DNA-chips)
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5658734A (en) 1995-10-17 1997-08-19 International Business Machines Corporation Process for synthesizing chemical compounds
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
WO2004097051A2 (fr) * 2003-04-29 2004-11-11 Wyeth Techniques et appareils de diagnostic de lam et de mds
WO2006048270A2 (fr) * 2004-11-04 2006-05-11 Roche Diagnostics Gmbh Procedes permettant de detecter une leucemie
WO2006071088A1 (fr) 2004-12-29 2006-07-06 Digital Genomics Inc. Marqueurs servant a diagnostiquer aml, b-all et t-all
WO2006125195A2 (fr) * 2005-05-18 2006-11-23 Wyeth Genes de la leucemie et leurs utilisations
WO2010143941A1 (fr) 2009-06-12 2010-12-16 Erasmus University Medical Center Rotterdam Classification et évaluation des risques de leucémie myéloïde aiguë (lma) de l'enfant par des signatures d'expression génique

Patent Citations (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5436327A (en) 1988-09-21 1995-07-25 Isis Innovation Limited Support-bound oligonucleotides
US5445934A (en) 1989-06-07 1995-08-29 Affymax Technologies N.V. Array of oligonucleotides on a solid substrate
US5405783A (en) 1989-06-07 1995-04-11 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of an array of polymers
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5561071A (en) 1989-07-24 1996-10-01 Hollenberg; Cornelis P. DNA and DNA technology for the construction of networks to be used in chip construction and chip production (DNA-chips)
US5545331A (en) 1991-04-08 1996-08-13 Romar Technologies, Inc. Recycle process for removing dissolved heavy metals from water with iron particles
US5532128A (en) 1991-11-19 1996-07-02 Houston Advanced Research Center Multi-site detection apparatus
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5554501A (en) 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US5529756A (en) 1993-10-22 1996-06-25 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5593839A (en) 1994-05-24 1997-01-14 Affymetrix, Inc. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5658734A (en) 1995-10-17 1997-08-19 International Business Machines Corporation Process for synthesizing chemical compounds
WO2004097051A2 (fr) * 2003-04-29 2004-11-11 Wyeth Techniques et appareils de diagnostic de lam et de mds
WO2006048270A2 (fr) * 2004-11-04 2006-05-11 Roche Diagnostics Gmbh Procedes permettant de detecter une leucemie
WO2006071088A1 (fr) 2004-12-29 2006-07-06 Digital Genomics Inc. Marqueurs servant a diagnostiquer aml, b-all et t-all
WO2006125195A2 (fr) * 2005-05-18 2006-11-23 Wyeth Genes de la leucemie et leurs utilisations
WO2010143941A1 (fr) 2009-06-12 2010-12-16 Erasmus University Medical Center Rotterdam Classification et évaluation des risques de leucémie myéloïde aiguë (lma) de l'enfant par des signatures d'expression génique

Non-Patent Citations (37)

* Cited by examiner, † Cited by third party
Title
A. BHATTACHARJEE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 98, 2001, pages 13790 - 13795
A. DUPUY A; R.M. SIMON, J NATL CANCER INST, vol. 99, 2007, pages 147 - 157
A. ROSENWALD ET AL., NEW ENGLAND J. MED., vol. 346, 2002, pages 1937 - 1947
A.M. GLAS ET AL., BMC GENOMICS, vol. 7, 2006, pages 278
B. J. WOUTERS ET AL: "A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects", BLOOD, vol. 113, no. 2, 2 October 2008 (2008-10-02), pages 291 - 298, XP055015531, ISSN: 0006-4971, DOI: 10.1182/blood-2008-04-153239 *
BERHARD SCHÖLKOPF: "Alex Smola: Learning with Kernels: Support Vector Machines, Regularization, Optimization, and Beyond", 2002, MIT PRESS
D.G. BEER ET AL., NAT. MED., vol. 8, 2002, pages 816 - 824
DEREK L. STIREWALT ET AL: "Identification of genes with abnormal expression changes in acute myeloid leukemia", GENES, CHROMOSOMES AND CANCER, vol. 47, no. 1, 1 January 2008 (2008-01-01), pages 8 - 20, XP055015530, ISSN: 1045-2257, DOI: 10.1002/gcc.20500 *
E.J. YEOH ET AL., CANCER CELL, vol. 1, 2002, pages 133 - 143
F.M. GOODSAID ET AL., NAT REV DRUG DISCOV, vol. 9, 2010, pages 435 - 445
FDA, FDA CLEARS BREAST CANCER SPECIFIC MOLECULAR PROGNOSTIC TEST, 2007
HAFERLACH TORSTEN ET AL: "Global approach to the diagnosis of leukemia using gene expression profiling", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 106, no. 4, 1 August 2005 (2005-08-01), pages 1189 - 1198, XP002361704, ISSN: 0006-4971, DOI: 10.1182/BLOOD-2004-12-4938 *
HOCHREITER ET AL., BIOINFORMATICS, vol. 22, no. 8, 2006, pages 943 - 9
IRIZARRY ET AL., BIOSTATISTICS, vol. 4, 2003, pages 249 - 264
J.A. LUDWIG; J.N. WEINSTEIN, NAT. REV. CANCER, vol. 5, 2005, pages 845 - 856
J.P. IOANNIDIS ET AL., NAT GENET, vol. 41, 2009, pages 149 - 155
KERN W ET AL: "GENE EXPRESSION PROFILING AS A DIAGNOSTIC TOOL IN ACUTE MYELOID LEUKEMIA", AMERICAN JOURNAL OF PHARMACOGENOMICS, WOLTERS KLUWER HEALTH, XX, vol. 4, no. 4, 1 January 2004 (2004-01-01), pages 225 - 237, XP009059426, ISSN: 1175-2203, DOI: 10.2165/00129785-200404040-00002 *
L. EIN-DOR ET AL., BIOINFORMATICS, vol. 21, 2005, pages 171 - 178
L. EIN-DOR ET AL., PROC NATL ACAD SCI U S A, vol. 103, 2006, pages 5923 - 5928
L. SHI ET AL., CURR OPIN BIOTECHNOL, vol. 19, 2008, pages 10 - 18
L. SHI ET AL., NAT BIOTECHNOL, vol. 24, 2006, pages 1151 - 1161
L. SHI ET AL., NAT BIOTECHNOL, vol. 28, 2010, pages 827 - 838
L.J. VAN 'T VEER ET AL., NATURE, vol. 415, 2002, pages 530 - 536
M.D. RADMACHER ET AL., J COMPUT BIOL, vol. 9, 2002, pages 505 - 511
M.P. BERRY ET AL., NATURE, vol. 466, 2010, pages 973 - 977
MIESNER ET AL., BLOOD, vol. 116, 2010, pages 2742 - 51
Q. LIU ET AL., PLOS ONE, vol. 4, 2009, pages E8250
R. SIMON: "Diagnostic and prognostic prediction using gene expression profiles in high-dimensional microarray data", BRITISH JOURNAL OF CANCER, vol. 89, 2003, pages 1599 - 1604, XP002661447, DOI: doi:10.1038/sj.bjc.6601326
R.M: PARRY ET AL., PHARMACOGENOMICS J., vol. 10, 2010, pages 292 - 309
S. DUDOIT ET AL., J. AM. STAT. ASSOC., vol. 97, 2002, pages 77 - 87
S. KOTSIANTIS, INFORMATICA J., vol. 31, 2007, pages 249 - 268
S. MICHIELS ET AL., LANCET, vol. 365, 2005, pages 488 - 492
S. RAMASWAMY ET AL., NAT. GENET., vol. 33, 2003, pages 49 - 54
S.L. POMEROY ET AL., NATURE, vol. 415, 2002, pages 436 - 442
T. REME ET AL., BMC BIOINFORMATICS, vol. 9, 2008, pages 16
T.R. GOLUB ET AL., SCIENCE, vol. 286, 1999, pages 531 - 537
W. WAPNIK: "The Nature of Statistical Learning Theory", 1995, SPRINGER VERLAG

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11220542B2 (en) 2015-02-19 2022-01-11 Compugen Ltd. Anti-PVRIG antibodies and methods of use
US10351625B2 (en) 2015-02-19 2019-07-16 Compugen Ltd. Anti-PVRIG antibodies and methods of use
US11795220B2 (en) 2015-02-19 2023-10-24 Compugen Ltd. Anti-PVRIG antibodies and methods of use
US10227408B2 (en) 2015-02-19 2019-03-12 Compugen Ltd. Anti-PVRIG antibodies and methods of use
US9714289B2 (en) 2015-02-19 2017-07-25 Compugen Ltd. Anti-PVRIG antibodies and methods of use
US10550173B2 (en) 2015-02-19 2020-02-04 Compugen, Ltd. PVRIG polypeptides and methods of treatment
US11795209B2 (en) 2015-02-19 2023-10-24 Compugen Ltd. PVRIG polypeptides and methods of treatment
US11623955B2 (en) 2015-02-19 2023-04-11 Compugen Ltd. Anti-PVRIG antibodies and methods of use
US11549146B2 (en) 2016-05-20 2023-01-10 Cedars-Sinai Medical Center Diagnosis of inflammatory bowel disease based on genes
US10751415B2 (en) 2016-08-17 2020-08-25 Compugen Ltd. Anti-TIGIT antibodies, anti-PVRIG antibodies and combinations thereof
US11701424B2 (en) 2016-08-17 2023-07-18 Compugen Ltd. Anti-TIGIT antibodies, anti-PVRIG antibodies and combinations thereof
US10124061B2 (en) 2016-08-17 2018-11-13 Compugen Ltd. Anti-TIGIT antibodies, anti-PVRIG antibodies and combinations thereof
US10213505B2 (en) 2016-08-17 2019-02-26 Compugen Ltd. Anti-TIGIT anibodies, anti-PVRIG antibodies and combinations thereof
US11225523B2 (en) 2017-06-01 2022-01-18 Compugen Ltd. Triple combination antibody therapies
WO2021178166A1 (fr) * 2020-03-06 2021-09-10 Denovo Biopharma Llc Compositions et procédés pour évaluer l'efficacité d'inhibiteurs de transporteurs de neurotransmetteurs
WO2022256607A3 (fr) * 2021-06-04 2023-01-19 Duke University Compositions et méthodes d'évaluation de la formation et de la fonction de jonctions communicantes

Also Published As

Publication number Publication date
EP2710147A1 (fr) 2014-03-26

Similar Documents

Publication Publication Date Title
US20220112562A1 (en) Prognostic tumor biomarkers
US20220396842A1 (en) Method for using gene expression to determine prognosis of prostate cancer
US20210062275A1 (en) Methods to predict clinical outcome of cancer
EP2553118B1 (fr) Procédé pour prédire la récurrence du cancer du sein sous traitement endocrinien
US10196691B2 (en) Colon cancer gene expression signatures and methods of use
US20080020379A1 (en) Diagnosis and prognosis of infectious diseases clinical phenotypes and other physiologic states using host gene expression biomarkers in blood
EP2710147A1 (fr) Analyse moléculaire de la leucémie myéloïde aiguë
EP2132343A1 (fr) Procédé pour la détermination et la classification de conditions rhumatismales
US20100298160A1 (en) Method and tools for prognosis of cancer in er-patients
AU2020201779A1 (en) Method for using gene expression to determine prognosis of prostate cancer
Belder et al. From RNA isolation to microarray analysis: comparison of methods in FFPE tissues
US20110306507A1 (en) Method and tools for prognosis of cancer in her2+partients
WO2013163134A2 (fr) Révélation d'évènements biomoléculaires dans le cancer par des métagènes attracteurs
US20220259674A1 (en) Compositions and methods for treating breast cancer
US20150105272A1 (en) Biomolecular events in cancer revealed by attractor metagenes
EP2524966A1 (fr) Molecular analysis of tuberculosis

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12724304

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2012724304

Country of ref document: EP