WO2013056612A1 - Degradable or detachable digestive tract support - Google Patents

Degradable or detachable digestive tract support Download PDF

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Publication number
WO2013056612A1
WO2013056612A1 PCT/CN2012/081622 CN2012081622W WO2013056612A1 WO 2013056612 A1 WO2013056612 A1 WO 2013056612A1 CN 2012081622 W CN2012081622 W CN 2012081622W WO 2013056612 A1 WO2013056612 A1 WO 2013056612A1
Authority
WO
WIPO (PCT)
Prior art keywords
titanium alloy
digestive tract
nickel
alloy metal
degradable
Prior art date
Application number
PCT/CN2012/081622
Other languages
French (fr)
Chinese (zh)
Inventor
刘吉勇
王传栋
刘瑾
李俊起
Original Assignee
Liu Jiyong
Wang Chuandong
Liu Jin
Li Junqi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liu Jiyong, Wang Chuandong, Liu Jin, Li Junqi filed Critical Liu Jiyong
Priority to DE212012000019U priority Critical patent/DE212012000019U1/en
Publication of WO2013056612A1 publication Critical patent/WO2013056612A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/16—Materials with shape-memory or superelastic properties

Definitions

  • the present invention relates to the field of medical device devices, and more particularly to a digestive tract support that is degradable or disassemblable.
  • Digestive tract stenosis is a common clinical disease. Placement of stent is one of the main ways to conservatively treat digestive tract stenosis. However, the currently used stent is easy to displace and is not easy to remove after displacement.
  • the present invention to invent a digestive tract stent that can be degraded or disassembled for removal.
  • Its technical scheme is: upper right third round nickel-titanium alloy metal sheet 1, upper left third round nickel-titanium alloy metal sheet 4 and lower third round nickel-titanium alloy metal sheet 3 through polylactic acid
  • the material lines or the windings of the surgical line 2 connect them together.
  • the invention has the advantages that: the digestive tract stent has novelity, creativity and practicability, and the nickel-titanium alloy metal sheet has excellent elasticity and softness, good tissue compatibility, light foreign matter sensation, good supporting force and easy displacement.
  • Polylactic acid material is an excellent biomedical polymer polymer material, non-toxic, non-irritating, biocompatible, etc., can be hydrolyzed in vivo Lactic acid, and can eventually degrade into carbon dioxide and water, its metabolites are non-toxic, and its molecular weight can be adjusted to control the degradation rate to achieve the degradation time we need;
  • the connecting line can be removed under the endoscope. After the polylactic acid material is decomposed or the connecting wire is removed, the stent is broken into several pieces and naturally taken out of the body or taken out under the endoscope.
  • the wire made of the wire is connected to a nickel-titanium alloy metal piece, which can be absorbed in a certain time; and the connecting wire can be removed under the endoscope, and the bracket is decomposed into several pieces. Naturally excreted or removed under endoscopy.
  • Figure 1 is a front view
  • Figure 2 is a rear view
  • Figure 3 is a cross-sectional view at Figure 1A-A.
  • Upper right third round nickel-titanium alloy metal piece 2. Polylactic acid material or surgical line
  • Lower third round nickel-titanium alloy metal piece 4. Upper left three-point A round nickel-titanium alloy sheet.
  • the connecting portion between the alloy metal sheet 4 and the lower third round nickel-titanium alloy metal sheet 3, the polylactic acid material line 2 can be degraded in a certain period of time in the body or the surgical line 2 can be removed under the endoscope; the stent is decomposed into Several pieces are taken out naturally or ex vivo.

Abstract

A degradable or detachable digestive tract support comprises a nickel-titanium alloy metal piece (1) in the shape of the right upper one-third of a circle, a nickel-titanium alloy metal piece (4) in the shape of the left upper one-third of the circle, and a nickel-titanium alloy metal piece (3) in the shape of the bottom one-third of the circle. The metal pieces are connected together by a wire of polyactic acid material or a surgical suture (2).

Description

一种可降解或拆卸的消化道支架 技术领域  Digestible or disassembled digestive tract stent
本发明涉及医疗器械装置技术领域， 更具体的讲是一种可降解或拆卸的消化道支 架。  The present invention relates to the field of medical device devices, and more particularly to a digestive tract support that is degradable or disassemblable.
背景技术 Background technique
消化道狭窄是临床常见疾病， 放置支架是保守治疗消化道狭窄主要方式之一， 但是 目前应用的支架容易移位而且移位后不易取出。  Digestive tract stenosis is a common clinical disease. Placement of stent is one of the main ways to conservatively treat digestive tract stenosis. However, the currently used stent is easy to displace and is not easy to remove after displacement.
发明内容 Summary of the invention
为克服上述缺点， 本发明的目的是发明一种可降解或拆卸以便取出的消化道支架。 它的技术方案为： 上右三分之一圆镍钛合金金属片 1、 上左三分之一圆镍钛合金金属片 4和下三分之一圆镍钛合金金属片 3通过多聚乳酸材料线或手术线 2的绕线把它们连接 在一起。 该发明的优点是： 该消化道支架具有新颖性、 创造性和实用性， 镍钛合金金属 片具有优良的弹性和柔软性， 组织相容性好， 异物感轻， 支撑力好、 不易移位可持久发 挥扩张作用， 有效的解除消化道狭窄； 多聚乳酸材料是一种优良的生物医用高分子聚酷 材料， 具有无毒， 无刺激性， 生物相容性好等特点， 在体内可水解为乳酸， 并可最终降 解为二氧化碳和水， 其代谢产物均无毒， 并且可以调节其分子量大小控制降解速度， 以 达到我们需要的降解时间； 连接线可在内镜下拆除。 多聚乳酸材料分解或连接线拆除后 支架分解成数片， 自然排出体外或内镜下取出。 为解决上述存在的问题， 特别设计利用 可吸收材料， 将其制成的丝线连接镍钛合金金属片， 可在一定时间内吸收； 且连接线可 在内镜下拆除， 支架分解成数片， 自然排出体外或内镜下取出。  To overcome the above disadvantages, it is an object of the present invention to invent a digestive tract stent that can be degraded or disassembled for removal. Its technical scheme is: upper right third round nickel-titanium alloy metal sheet 1, upper left third round nickel-titanium alloy metal sheet 4 and lower third round nickel-titanium alloy metal sheet 3 through polylactic acid The material lines or the windings of the surgical line 2 connect them together. The invention has the advantages that: the digestive tract stent has novelity, creativity and practicability, and the nickel-titanium alloy metal sheet has excellent elasticity and softness, good tissue compatibility, light foreign matter sensation, good supporting force and easy displacement. Long-lasting expansion, effective elimination of digestive tract stenosis; Polylactic acid material is an excellent biomedical polymer polymer material, non-toxic, non-irritating, biocompatible, etc., can be hydrolyzed in vivo Lactic acid, and can eventually degrade into carbon dioxide and water, its metabolites are non-toxic, and its molecular weight can be adjusted to control the degradation rate to achieve the degradation time we need; the connecting line can be removed under the endoscope. After the polylactic acid material is decomposed or the connecting wire is removed, the stent is broken into several pieces and naturally taken out of the body or taken out under the endoscope. In order to solve the above problems, it is specially designed to use an absorbable material, and the wire made of the wire is connected to a nickel-titanium alloy metal piece, which can be absorbed in a certain time; and the connecting wire can be removed under the endoscope, and the bracket is decomposed into several pieces. Naturally excreted or removed under endoscopy.
附图说明 DRAWINGS
图 1主视图， 图 2后视图， 图 3为在图 1A-A处剖视图。 附图中： 1、 上右三分之一 圆镍钛合金金属片， 2、 多聚乳酸材料或手术线， 3、 下三分之一圆镍钛合金金属片， 4、 上左三分之一圆镍钛合金金属片。  Figure 1 is a front view, Figure 2 is a rear view, and Figure 3 is a cross-sectional view at Figure 1A-A. In the drawing: 1. Upper right third round nickel-titanium alloy metal piece, 2. Polylactic acid material or surgical line, 3. Lower third round nickel-titanium alloy metal piece, 4. Upper left three-point A round nickel-titanium alloy sheet.
具体实施方式 detailed description
根据下述实施例， 可以更好地理解本发明。 然而， 本领域的技术人员容易理解， 实 施例所描述的内容仅用于说明本发明，而不应当也不会限制权利要求书中所详细描述的 本发明。 上右三分之一圆镍钛合金金属片 1、 上左三分之一圆镍钛合金金属片 4和下三分之 一圆镍钛合金金属片 3通过多聚乳酸材料线或手术线 2的绕线把它们连接在一起。为解 决上述存在的问题，特别设计利用可吸收的多聚乳酸材料线 2或可拆除的手术线 2构成 上右三分之一圆镍钛合金金属片 1、 上左三分之一圆镍钛合金金属片 4和下三分之一圆 镍钛合金金属片 3的之间连接部分， 多聚乳酸材料线 2可在体内一定时间内降解或手术 线 2可在内镜下拆除； 支架分解成数片， 自然排出体外或内镜下取出。 The invention can be better understood in light of the following examples. However, those skilled in the art will understand that the description of the embodiments is only intended to illustrate the invention and should not be construed as limiting the invention as described in the claims. Upper right third round nickel-titanium alloy sheet 1, upper left third round nickel-titanium alloy sheet 4 and lower third round nickel-titanium alloy sheet 3 through polylactic acid material line or surgical line 2 The windings connect them together. In order to solve the above problems, it is specially designed to use the absorbable polylactic acid material line 2 or the removable surgical line 2 to form an upper right third round nickel-titanium alloy sheet 1, and a top left third round nickel titanium. The connecting portion between the alloy metal sheet 4 and the lower third round nickel-titanium alloy metal sheet 3, the polylactic acid material line 2 can be degraded in a certain period of time in the body or the surgical line 2 can be removed under the endoscope; the stent is decomposed into Several pieces are taken out naturally or ex vivo.

Claims

权 利 要 求 书 Claim
1、 一种可降解或拆卸的消化道支架， 其特征是： 上右三分之一圆镍钛合金金属片 ( 1 )、 上左三分之一圆镍钛合金金属片 （4)和下三分之一圆镍钛合金金属片 （3)通过 多聚乳酸材料线或手术线 （2) 的绕线把它们连接在一起。 1. A digestible or disassembled digestive tract support, characterized by: upper right third round nickel-titanium alloy metal sheet (1), upper left third round nickel-titanium alloy metal sheet (4) and lower One-third round nitinol metal sheets (3) are joined together by a polylactic acid material line or a surgical wire (2).
PCT/CN2012/081622 2011-10-21 2012-09-19 Degradable or detachable digestive tract support WO2013056612A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE212012000019U DE212012000019U1 (en) 2011-10-21 2012-09-19 Degradable or removable support for the digestive tract

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2011103230995A CN102380131B (en) 2011-10-21 2011-10-21 Degradable or detachable digestive tract bracket
CN201110323099.5 2011-10-21

Publications (1)

Publication Number Publication Date
WO2013056612A1 true WO2013056612A1 (en) 2013-04-25

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CN (1) CN102380131B (en)
DE (1) DE212012000019U1 (en)
WO (1) WO2013056612A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102380131B (en) * 2011-10-21 2013-12-04 刘吉勇 Degradable or detachable digestive tract bracket
CN108938157A (en) * 2018-06-07 2018-12-07 佳木斯大学 Alimentary stent that is a kind of degradable or removing

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258117B1 (en) * 1999-04-15 2001-07-10 Mayo Foundation For Medical Education And Research Multi-section stent
CN101822578A (en) * 2010-03-29 2010-09-08 张发明 Composite type orifice bracket
US7862607B2 (en) * 2005-12-30 2011-01-04 C. R. Bard, Inc. Stent with bio-resorbable connector and methods
CN102380131A (en) * 2011-10-21 2012-03-21 山东省立医院 Degradable or detachable digestive tract bracket

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006296559A (en) * 2005-04-18 2006-11-02 Univ Kansai Medical Medical stent formed of composite material comprising metal and bioabsorbable material, its manufacturing method and knitting machine used therefor
US20070043418A1 (en) * 2005-08-19 2007-02-22 Medlogics Device Corporation Hybrid lumen-supporting stents having self-expanding end segments
CN101491467A (en) * 2008-01-25 2009-07-29 令狐恩强 Semi-naked recoverable metal rack capable of treating digestive lumen narrowness
CN101513367B (en) * 2009-04-02 2010-10-27 中国人民解放军总医院第二附属医院 Degradable esophagus tubular intervention support and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258117B1 (en) * 1999-04-15 2001-07-10 Mayo Foundation For Medical Education And Research Multi-section stent
US7862607B2 (en) * 2005-12-30 2011-01-04 C. R. Bard, Inc. Stent with bio-resorbable connector and methods
CN101822578A (en) * 2010-03-29 2010-09-08 张发明 Composite type orifice bracket
CN102380131A (en) * 2011-10-21 2012-03-21 山东省立医院 Degradable or detachable digestive tract bracket

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Publication number Publication date
CN102380131B (en) 2013-12-04
DE212012000019U1 (en) 2013-06-13
CN102380131A (en) 2012-03-21

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