WO2013172724A1 - Method for treating obesity and overweight and gastro-oesophageal reflux disease - Google Patents
Method for treating obesity and overweight and gastro-oesophageal reflux disease Download PDFInfo
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- WO2013172724A1 WO2013172724A1 PCT/PL2013/000063 PL2013000063W WO2013172724A1 WO 2013172724 A1 WO2013172724 A1 WO 2013172724A1 PL 2013000063 W PL2013000063 W PL 2013000063W WO 2013172724 A1 WO2013172724 A1 WO 2013172724A1
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- adrc
- cells
- gastro
- gastric
- regenerative cells
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- 238000000034 method Methods 0.000 title claims abstract description 42
- 208000021302 gastroesophageal reflux disease Diseases 0.000 title claims abstract description 16
- 208000008589 Obesity Diseases 0.000 title claims abstract description 13
- 206010033307 Overweight Diseases 0.000 title claims abstract description 13
- 235000020824 obesity Nutrition 0.000 title claims abstract description 13
- 230000002496 gastric effect Effects 0.000 claims abstract description 25
- 230000001172 regenerating effect Effects 0.000 claims abstract description 16
- 210000000577 adipose tissue Anatomy 0.000 claims abstract description 13
- 210000002318 cardia Anatomy 0.000 claims abstract description 13
- 210000002784 stomach Anatomy 0.000 claims abstract description 11
- 238000001356 surgical procedure Methods 0.000 claims abstract description 11
- 210000003205 muscle Anatomy 0.000 claims abstract description 7
- 210000004876 tela submucosa Anatomy 0.000 claims abstract description 7
- 230000006698 induction Effects 0.000 claims abstract description 5
- 230000036186 satiety Effects 0.000 claims abstract description 5
- 235000019627 satiety Nutrition 0.000 claims abstract description 5
- 238000002271 resection Methods 0.000 claims abstract description 4
- 230000000638 stimulation Effects 0.000 claims abstract description 4
- 238000007681 bariatric surgery Methods 0.000 claims abstract description 3
- 230000000295 complement effect Effects 0.000 claims abstract description 3
- 238000001839 endoscopy Methods 0.000 claims abstract description 3
- 239000007943 implant Substances 0.000 claims abstract description 3
- 230000004899 motility Effects 0.000 claims abstract description 3
- 101710163391 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase Proteins 0.000 claims abstract 8
- 210000004027 cell Anatomy 0.000 description 16
- 230000037406 food intake Effects 0.000 description 5
- 235000012631 food intake Nutrition 0.000 description 5
- 238000007443 liposuction Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
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- 235000019525 fullness Nutrition 0.000 description 4
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- 230000009471 action Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000000111 lower esophageal sphincter Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002278 reconstructive surgery Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
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- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 241001631457 Cannula Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
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- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
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- 239000008240 homogeneous mixture Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 238000002647 laser therapy Methods 0.000 description 1
- 230000004130 lipolysis Effects 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000002644 neurohormonal effect Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
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- 238000012797 qualification Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
Definitions
- the present invention relates to the method for treating obesity and overweight and gastro-oesophageal reflux disease (GERD).
- GSD gastro-oesophageal reflux disease
- Obesity and overweight are the major problems of the modern world due to the increasingly wide occurrence and its social consequences.
- Treatment of obesity and overweight includes usually a reduction of food intake (calories), and the increase of using and burning of stored fat.
- Conservative methods rely on the introduction of different diets and restrictions and lifestyle changes by increasing physical activity and regular eating. Sometimes these methods are associated with the intake of drugs or widely available slimming products.
- stomach capacity There are known and used surgical methods for reducing stomach capacity, such as: adjustable gastric band, gastric sleeve resection, duplications of the stomach wall from the outside or endoscopically (POSE, ROSE), Vertical Banded Gastroplasty or diversion- bypass procedures such as gastric bypass.
- Adjustd stomach creates a feeling of fullness occurring earlier than before the surgery.
- Gastric reduction is also carried out by implantation of intragastric balloons filling the part of the space inside the stomach to reduce its volume.
- Surgical methods are subject to considerable risk and the possibility of complications, hence can only be used in certain cases, considering the condition of the patient and the risks arising from obesity-related diseases. Important are appropriate qualifications and experience of the surgical center.
- Another method, known as the Full Sense Device is the introduction of prosthetic mesh in the area of over gastric cardia and fundus.
- patent US2010/0160995 discloses the method of modeling surrounding the gastric cardia, which consists of injecting a biocompatible material in the area of gastric cardia - injected is hyaluronic acid or another resorbable or non-resorbable formulation.
- a biocompatible material in the area of gastric cardia - injected is hyaluronic acid or another resorbable or non-resorbable formulation.
- gastro-oesophageal reflux disease Obese or overweight people often have so called gastro-oesophageal reflux disease.
- a method for preventing gastro-oesophageal reflux disease is reduced to taking the appropriate medications to minimize the discomfort.
- the method for treating obesity and overweight and gastro-oesophageal reflux disease lies in the fact that the stem and regenerative cells extracted from adipose tissue (ADRC - Adipose Derived Regenerative Cells) are injected into the submucosa tissue or muscle near the gastric cardia and fundus.
- ADRC Adipose Derived Regenerative Cells
- the isolated ADRC cells are given via endoscopy or surgical procedures, open or laparoscopic.
- the isolated ADRC cells are enriched with fat graft in the amount of at least 5 ml and not more than 25 ml.
- the method is complementary to other bariatric procedures reducing the size of the stomach - such as adjustable gastric band, gastric sleeve partial resection ,or filling the stomach - as intragastric implants, or affecting the motility or satiety induction by electrical stimulation (neurostimulators) .
- the stem and regenerative cells isolated from its own adipose tissue are injected into the submucosa or muscle tissue around gastric cardia.
- ADRC cell transfer begins to feel satiety after the adoption of a small amount of food, thus reduces food intake. It is also a combination of the two techniques treating overweight and obesity - the liposuction procedure widely used in the world and endoscopic ADRC cells transfer to the area of gastric cardia and fundus in order to enhance the response of the stomach and reduce food intake.
- the method according to the invention used in the treatment of obese or overweight people will also prevent gastro-oesophageal reflux disease.
- the method of obtaining and enriching ADRC cells from adipose tissue helps to produce relatively large amounts of ADRC and application of the method to almost every patient.
- the method according to the invention can also be applied in the treatment of other diseases, such as oncology-reconstructive surgery, particularly with the mammary gland, the treatment of complications after radiotherapy and classic burns, reconstructive surgery, cosmetic and aesthetic surgery, treatment of non-healing wounds, diseases of urinary incontinence.
- other diseases such as oncology-reconstructive surgery, particularly with the mammary gland, the treatment of complications after radiotherapy and classic burns, reconstructive surgery, cosmetic and aesthetic surgery, treatment of non-healing wounds, diseases of urinary incontinence.
- Autologous transfer process consists of three steps.
- fat is removed from the patient body from the place indicated by the doctor.
- Removing is technically identical to the liposuction surgery, which involves using a special cannulas to take from under the patient's skin excess of body fat. This is done by mechanical or vacuum-assisted method, ultrasound, laser and special fluids.
- the second stage is carried out as stepwise treatment / processing of adipose tissue using a special device or laboratory methods.
- This step involves exposing a standardized treatment of adipose tissue collected from the patient.
- adipose tissue is repeatedly washed in order to remove erythrocytes, the excess of saline, substances used in liposuction and other polluting tissue.
- the resulting substrate is subjected to enzymatic treatment with the method using a special enzyme.
- the final step of this stage is the concentration of substrate in order to obtain a cell suspension containing the stem cells and regenerative cells (ADRC) by centrifugation with the alternate washing of the substrate.
- the result of these steps is to obtain a homogeneous deposit of stem cells and regenerative ADRC cells directly applicable in surgical procedures.
- autologous transplant in which to the submucosa tissue or muscle in the area of the gastric cardia and fundus, are administered homogeneous mixture of ADRC with or without the addition of fat graft (purified adipose tissue).
- Administering a mixture of stem and regenerative ADRC cells in the area of gastric cardia and the fundus area leads to induce a feeling of gastric fullness, neurohormonal induction of satiety response, improvement of the function of the lower esophageal sphincter and humoral actions of own fat.
- Administration of a mixture of stem and regenerative ADRC cells in the area of the lower esophageal sphincter is carried out to regenerate and improve the functional activities of the area, thereby prevent gastro-oesophageal reflux.
- ADRC cells Method of administration, place and number of cells in each case depends on the circumstances and the decision of the medical doctor. In case of a additional amount of ADRC cells, they may be placed in storage or subsequent use for example in the case of difficult to obtain from a patient in the future.
Abstract
The present invention relates to the method for treating obesity and overweight and gastro-oesophageal reflux disease (GERD). According to the invention the method for treating obesity and overweight and gastro-oesophageal reflux disease lies in the fact that the stem and regenerative cells extracted from adipose tissue (ADRC - Adipose Derived Regenerative Cells) are injected into the submucosa tissue or muscle near the gastric cardia and fundus. The isolated ADRC cells are given via endoscopy or surgical procedures, open or laparoscopic. The isolated ADRC cells are enriched with fat graft in the amount of at least 5 ml and not more than 25 ml. The method is complementary to other bariatric procedures reducing the size of the stomach - such as adjustable gastric band, gastric sleeve partial resection,or filling the stomach - as intragastric implants, or affecting the motility or satiety induction by electrical stimulation (neurostimulators). It is preferred when the method is applied while other surgical procedures to obese or overwieght patients. In the treatment of gastro-oesophageal reflux disease the stem and regenerative cells isolated from its own adipose tissue (ADRC - Adipose Derived Regenerative Cells) are injected into the submucosa or muscle tissue around gastric cardia.
Description
Method for treating obesity and overweight and gastro-oesophageal reflux disease
The present invention relates to the method for treating obesity and overweight and gastro-oesophageal reflux disease (GERD).
Obesity and overweight are the major problems of the modern world due to the increasingly wide occurrence and its social consequences.
On one hand, lowering the standard of life of patients with obesity, reducing their efficiency, on the other accompanying diseases resulting from excess body weight (degenerative joint disease, hypertension, diabetes, cardiovascular disease) and their serious complications determine the need to fight with excessive food intake.
Treatment of obesity and overweight includes usually a reduction of food intake (calories), and the increase of using and burning of stored fat. Conservative methods rely on the introduction of different diets and restrictions and lifestyle changes by increasing physical activity and regular eating. Sometimes these methods are associated with the intake of drugs or widely available slimming products. There are also physical methods of action on body fat to cause its elimination or reduction - by liposuction surgery or by the use of external physical factors and electrical stimulation devices as well as lymphatic massage, laser therapy, ultrasound current or cryogenic lipolysis.
If conservative methods fail to achieve the desired effect, there exist a bariatric treatment, leading to more or less invasive surgical or endoscopic techniques in order to reduce the possibility of food intake or reduce the absorption of eaten food.
There are known methods for treating obesity or overweight that lead to the induction and increase of feeling of fullness.
There are known and used surgical methods for reducing stomach capacity, such as: adjustable gastric band, gastric sleeve resection, duplications of the stomach wall from the outside or endoscopically (POSE, ROSE), Vertical Banded Gastroplasty or diversion- bypass procedures such as gastric bypass. Reduced stomach creates a feeling of fullness occurring earlier than before the surgery. Gastric reduction is also carried out by implantation of intragastric balloons filling the part of the space inside the stomach to reduce its volume.
Surgical methods are subject to considerable risk and the possibility of complications, hence can only be used in certain cases, considering the condition of the patient and the risks arising from obesity-related diseases. Important are appropriate qualifications and experience of the surgical center.
Another method, known as the Full Sense Device is the introduction of prosthetic mesh in the area of over gastric cardia and fundus.
However, patent US2010/0160995 discloses the method of modeling surrounding the gastric cardia, which consists of injecting a biocompatible material in the area of gastric cardia - injected is hyaluronic acid or another resorbable or non-resorbable formulation. Thus obtained narrowing of the gastric cardia, as in the case of prosthetic mesh, reduces the amount of food taken by the obese person, which in turn leads to a reduction in body weight.
Obese or overweight people often have so called gastro-oesophageal reflux disease. A method for preventing gastro-oesophageal reflux disease is reduced to taking the appropriate medications to minimize the discomfort.
According to the invention the method for treating obesity and overweight and gastro-oesophageal reflux disease lies in the fact that the stem and regenerative cells extracted from adipose tissue (ADRC - Adipose Derived Regenerative Cells) are injected into the submucosa tissue or muscle near the gastric cardia and fundus.
The isolated ADRC cells are given via endoscopy or surgical procedures, open or laparoscopic.
The isolated ADRC cells are enriched with fat graft in the amount of at least 5 ml and not more than 25 ml.
The method is complementary to other bariatric procedures reducing the size of the stomach - such as adjustable gastric band, gastric sleeve partial resection ,or filling the stomach - as intragastric implants, or affecting the motility or satiety induction by electrical stimulation (neurostimulators) .
It is preferred when the method is applied while other surgical procedures to obese or overwieght patients.
In the treatment of gastro-oesophageal reflux disease the stem and regenerative cells isolated from its own adipose tissue (ADRC - Adipose Derived Regenerative Cells) are injected into the submucosa or muscle tissue around gastric cardia.
A person who had autologous (ie, back to the body of the person who had the fat removed previously) ADRC cell transfer according to the method of the invention, begins to feel satiety after the adoption of a small amount of food, thus reduces food intake. It is also a combination of the two techniques treating overweight and obesity - the liposuction procedure widely used in the world and endoscopic ADRC cells transfer to the area of gastric cardia and fundus in order to enhance the response of the stomach and reduce food
intake. The method according to the invention used in the treatment of obese or overweight people, will also prevent gastro-oesophageal reflux disease. The method of obtaining and enriching ADRC cells from adipose tissue helps to produce relatively large amounts of ADRC and application of the method to almost every patient. An important innovation is the ease of the removal of the material necessary for the patient's treatment and the whole procedure. Removing the fat technically is no different from liposuction procedures. The use of autologous transplant instead of transplant "from a donor" substantially reduces the possibility of complications during treatment. It also greatly simplifies the legal aspects of transplantation.
From the point of view of the good of the patient it is an improvement in medical technology by reducing the possible complications of the treatment, a significant decrease of the intake of medicines, pain, general periprocedural discomfort. It also shortens the time of postoperative rehabilitation. Simultaneous execution of the therapeutic process reduces the cost of treatment, optimizing the therapeutic process and its impact on the environment by reducing the use of materials and medical substances. The method of the invention may be combined with the known, above-described methods leading to induce gastric fullness. The method according to the invention can also be applied in the treatment of other diseases, such as oncology-reconstructive surgery, particularly with the mammary gland, the treatment of complications after radiotherapy and classic burns, reconstructive surgery, cosmetic and aesthetic surgery, treatment of non-healing wounds, diseases of urinary incontinence.
Autologous transfer process consists of three steps. In the first stage, fat is removed from the patient body from the place indicated by the doctor. Removing is technically identical to the liposuction surgery, which involves using a special cannulas to take from under the patient's skin excess of body fat. This is done by mechanical or vacuum-assisted method, ultrasound, laser and special fluids.
The second stage is carried out as stepwise treatment / processing of adipose tissue using a special device or laboratory methods. This step involves exposing a standardized treatment of adipose tissue collected from the patient. First, adipose tissue is repeatedly washed in order to remove erythrocytes, the excess of saline, substances used in liposuction and other polluting tissue. Then the resulting substrate is subjected to enzymatic treatment with the method using a special enzyme. At this stage there is a fat and intercellular connections digestion and a release of active ADRC cells. The final step of this stage, and also the most time-consuming, is the concentration of substrate in order
to obtain a cell suspension containing the stem cells and regenerative cells (ADRC) by centrifugation with the alternate washing of the substrate. The result of these steps is to obtain a homogeneous deposit of stem cells and regenerative ADRC cells directly applicable in surgical procedures.
The last step is autologous transplant (autograft), in which to the submucosa tissue or muscle in the area of the gastric cardia and fundus, are administered homogeneous mixture of ADRC with or without the addition of fat graft (purified adipose tissue).
Administering a mixture of stem and regenerative ADRC cells in the area of gastric cardia and the fundus area according to the method of the invention leads to induce a feeling of gastric fullness, neurohormonal induction of satiety response, improvement of the function of the lower esophageal sphincter and humoral actions of own fat.
Administration of a mixture of stem and regenerative ADRC cells in the area of the lower esophageal sphincter is carried out to regenerate and improve the functional activities of the area, thereby prevent gastro-oesophageal reflux.
Method of administration, place and number of cells in each case depends on the circumstances and the decision of the medical doctor. In case of a additional amount of ADRC cells, they may be placed in storage or subsequent use for example in the case of difficult to obtain from a patient in the future.
Claims
1. Method for treating obesity and overweight and gastro-oesophageal reflux disease, characterized in that the stem and regenerative cells extracted from patient's own adipose tissue (ADRC - Adipose Derived Regenerative Cells) are injected into the submucosa tissue or muscle near the gastric cardia and fundus.
2. Method according to claim 1, characterized in that the isolated ADRC cells are given via endoscopy or surgical procedures, open or laparoscopic.
3. Method according to claim 1, characterized in that the isolated ADRC cells are enriched with fat graft in the amount of at least 5 ml and not more than 25 ml.
4 Method according to claim 1 , characterized in that is complementary to other bariatric procedures reducing the size of the stomach - such as adjustable gastric band, gastric sleeve partial resection, or filling the stomach - as intragastric implants, or affecting the motility or satiety induction by electrical stimulation (neurostimulators) .
5. Method according to claim 1, characterized in that it is used while other surgical procedures to obese or overwieght patients.
6. Method according to claim 1, characterized in that in treating gastro-oesophageal reflux diseasethe stem and regenerative cells extracted from patient's own adipose tissue (ADRC - Adipose Derived Regenerative Cells) are injected into the submucosa tissue or muscle near the gastric cardia and fundus.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PLP.399176 | 2012-05-14 | ||
| PL399176A PL399176A1 (en) | 2012-05-14 | 2012-05-14 | Method for treatment of obesity and overweight, and diseases gastro-oesophageal reflux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2013172724A1 true WO2013172724A1 (en) | 2013-11-21 |
Family
ID=48949200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/PL2013/000063 WO2013172724A1 (en) | 2012-05-14 | 2013-05-14 | Method for treating obesity and overweight and gastro-oesophageal reflux disease |
Country Status (2)
| Country | Link |
|---|---|
| PL (1) | PL399176A1 (en) |
| WO (1) | WO2013172724A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2813155C1 (en) * | 2023-09-21 | 2024-02-06 | федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет имени И.И. Мечникова" Министерства здравоохранения Российской Федерации | Method of endoscopic treatment of patients with gastroesophageal reflux disease |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010130968A (en) * | 2008-12-05 | 2010-06-17 | Nippon Menaade Keshohin Kk | Method for inducing differentiation of stem cell to brown fat cell |
| US20100160995A1 (en) | 2008-12-18 | 2010-06-24 | Jerome Dargent | Method for treating obesity |
| WO2012155209A1 (en) * | 2011-05-19 | 2012-11-22 | Mesoblast, Inc | Methods for treating obesity and/or metabolic syndrome |
| WO2013003595A1 (en) * | 2011-06-29 | 2013-01-03 | Biorestorative Therapies, Inc. | Brown fat cell compositions and methods |
-
2012
- 2012-05-14 PL PL399176A patent/PL399176A1/en unknown
-
2013
- 2013-05-14 WO PCT/PL2013/000063 patent/WO2013172724A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010130968A (en) * | 2008-12-05 | 2010-06-17 | Nippon Menaade Keshohin Kk | Method for inducing differentiation of stem cell to brown fat cell |
| US20100160995A1 (en) | 2008-12-18 | 2010-06-24 | Jerome Dargent | Method for treating obesity |
| WO2012155209A1 (en) * | 2011-05-19 | 2012-11-22 | Mesoblast, Inc | Methods for treating obesity and/or metabolic syndrome |
| WO2013003595A1 (en) * | 2011-06-29 | 2013-01-03 | Biorestorative Therapies, Inc. | Brown fat cell compositions and methods |
Non-Patent Citations (1)
| Title |
|---|
| TRAN THIEN T ET AL: "Transplantation of adipose tissue and stem cells: role in metabolism and disease", NATURE REVIEWS. ENDOCRINOLOGY, NATURE PUBL. GROUP, US, vol. 6, no. 4, 1 April 2010 (2010-04-01), pages 195 - 213, XP002636571, ISSN: 1759-5029, [retrieved on 20100302], DOI: 10.1038/NRENDO.2010.20 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2813155C1 (en) * | 2023-09-21 | 2024-02-06 | федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет имени И.И. Мечникова" Министерства здравоохранения Российской Федерации | Method of endoscopic treatment of patients with gastroesophageal reflux disease |
Also Published As
| Publication number | Publication date |
|---|---|
| PL399176A1 (en) | 2013-11-25 |
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