WO2013176538A3 - Tenogenic medium for mesenchymal stem cells differentation into tenogenic lineage - Google Patents

Tenogenic medium for mesenchymal stem cells differentation into tenogenic lineage Download PDF

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Publication number
WO2013176538A3
WO2013176538A3 PCT/MY2013/000108 MY2013000108W WO2013176538A3 WO 2013176538 A3 WO2013176538 A3 WO 2013176538A3 MY 2013000108 W MY2013000108 W MY 2013000108W WO 2013176538 A3 WO2013176538 A3 WO 2013176538A3
Authority
WO
WIPO (PCT)
Prior art keywords
tenogenic
mesenchymal stem
stem cells
lineage
mscs
Prior art date
Application number
PCT/MY2013/000108
Other languages
French (fr)
Other versions
WO2013176538A2 (en
Inventor
Tunku Kamarul Zaman Tunku Zainol Abidin MADYA
Sik Loo TAN
Original Assignee
University Of Malaya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Malaya filed Critical University Of Malaya
Publication of WO2013176538A2 publication Critical patent/WO2013176538A2/en
Publication of WO2013176538A3 publication Critical patent/WO2013176538A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/066—Tenocytes; Tendons, Ligaments
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/19—Growth and differentiation factors [GDF]

Abstract

Tenocytes are highly differentiated cells which have a limited potential for replication. Therefore, in vitro propagation of tenocytes may still not be able to supply enough seed cells for tendon tissue engineering. Bone marrow mesenchymal stem cells (MSCs) are able to self-renew and capable to differentiate into multi lineage including tenocytes. Therefore, it is possible that MSCs could serve as seed cells in tendon tissue engineering. In the present invention, method and culture medium for promoting human bone marrow mesenchymal stem cells (MSCs) differentiation into tenogenic lineage is provided.
PCT/MY2013/000108 2012-05-22 2013-06-13 Tenogenic medium for mesenchymal stem cells differentation into tenogenic lineage WO2013176538A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MYPI2012002249 2012-05-22
MYPI2012002249 2012-05-22

Publications (2)

Publication Number Publication Date
WO2013176538A2 WO2013176538A2 (en) 2013-11-28
WO2013176538A3 true WO2013176538A3 (en) 2014-03-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MY2013/000108 WO2013176538A2 (en) 2012-05-22 2013-06-13 Tenogenic medium for mesenchymal stem cells differentation into tenogenic lineage

Country Status (1)

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WO (1) WO2013176538A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110295140A (en) * 2019-06-04 2019-10-01 河北贝特赛奥生物科技有限公司 A kind of method of free serum culture mesenchymal stem cell
EP3872168A1 (en) 2020-02-28 2021-09-01 Cline Scientific AB Chondrocyte differentiation
WO2024000073A1 (en) * 2022-06-30 2024-01-04 Stemcell Technologies Canada Inc. Media, kits and methods for differentiating tenocytes or chondrocytes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012013969A1 (en) * 2010-07-26 2012-02-02 The University Of Manchester Targeted differentiation of stem cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012013969A1 (en) * 2010-07-26 2012-02-02 The University Of Manchester Targeted differentiation of stem cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
MAZZOCCA, AUGUSTUS D. ET AL.: "Bone marrow-derived mesenchymal stem cells obtained during arthroscopic rotator cuff repair surgery show potential for tendon cell differentiation after treatment with insulin", ARTHROSCOPY: THE JOURNAL OF ARTHROSCOPIC & RELATED SURGERY, vol. 27, no. 11, 2011, pages 1459 - 1471 *
PARK, ANDREW ET AL.: "Adipose-derived mesenchymal stem cells treated with growth differentiation factor-5 express tendon-specific markers", TISSUE ENGINEERING, vol. 16, no. 9, 2010, pages 2941 - 2951 *
TAN, SIK-LOO ET AL.: "Effect of growth differentiation factor 5 on the proliferation and tenogenic differentiation potential of human mesenchymal stem cells in vitro", CELLS TISSUES ORGANS, vol. 196, no. 4, 30 May 2012 (2012-05-30), pages 325 - 338 *
WANG, XIAOLI ET AL.: "Characterization of mesenchymal stem cells isolated from mouse fetal bone marrow", STEM CELLS, vol. 24, 2006, pages 482 - 493 *
ZHANG, JIANYING ET AL.: "Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes", THE AMERICAN JOURNAL OF SPORTS MEDICINE, vol. 38, no. 12, 2010, pages 2477 - 2486 *

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