WO2014025981A1 - Shockwave valvuloplasty with multiple balloons - Google Patents
Shockwave valvuloplasty with multiple balloons Download PDFInfo
- Publication number
- WO2014025981A1 WO2014025981A1 PCT/US2013/054104 US2013054104W WO2014025981A1 WO 2014025981 A1 WO2014025981 A1 WO 2014025981A1 US 2013054104 W US2013054104 W US 2013054104W WO 2014025981 A1 WO2014025981 A1 WO 2014025981A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- balloon
- cusp
- shock wave
- elongate body
- balloons
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B17/22022—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement using electric discharge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B2017/22025—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement applying a shock wave
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22055—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation with three or more balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22062—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation to be filled with liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22098—Decalcification of valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1011—Multiple balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
Definitions
- Aortic valve stenosis results in the narrowing of the aortic valve.
- Aortic valve stenosis may be exacerbated by a congenital defect where the aortic valve has one leaflet (unicuspid) or two leaflets (bicuspid) instead of three leaflets.
- the narrowing of the valve is the result of aortic valve calcification, where calcified plaques accumulate on the leaflets and/or annulus of the aortic valve. For example, calcium plaques deposited on the cusps of the leaflets may stiffen the leaflets, thereby narrowing the valve opening and interfering with efficient blood flow across the valve.
- shock wave devices and methods for the treatment of calcified heart valves may help to crack and/or break the calcium deposits, thereby softening and/or loosening and/or removing calcium deposits that stiffen the mechanical properties of the valve. Softening and/or loosening and/or removing calcium deposits may allow the valve to regain at least a portion of its normal function.
- a device may comprise at least one balloon that is sized and shaped to fit within a concave portion of a valve cusp when inflated with a liquid and a shock wave source within the balloon.
- a device for treating a calcified heart valve may comprise three balloons that are each sized and shaped to fit within a concave portion of a valve cusp when inflated with a liquid and a shock wave source in each of the three balloons.
- Each balloon may be separately and/or independently inflatable, and each shock wave source may be separately and/or independently controllable.
- a shock wave device comprising three balloons and three shock wave sources may be used for treating a tricuspid valve, such as the pulmonary valve and the aortic valve.
- Shock wave devices comprising one or two balloons and one or two shock wave sources may be used for treating unicuspid, bicuspid and/or tricuspid valves.
- Methods of treating calcified heart valves using a shock wave device may comprise advancing a shock wave device having one or more balloons and a shock wave source in each of the balloons to contact a heart valve, inflating the one or more balloons with a liquid such that the balloon is seated within a concave portion of a valve cusp, and activating the shock wave source.
- the mechanical force of the shock waves may act to crack and/or break calcium deposits located within the concave portion of the valve cusp.
- Inflation of the one or more balloons with a liquid may act to automatically align and/or seat the balloon within the concave portion of a valve cusp.
- Balloons and shock wave sources may be inflated and activated sequentially or simultaneously for the treatment of all the cusps of a valve. Once the desired level of treatment has been attained, the balloons may be deflated and withdrawn.
- the description below describes and depicts the treatment of an aortic valve, it should be understood that similar devices and methods may be used to treat any heart valve, e.g., the pulmonary valve, mitral valve, tricuspid valve, as may be desirable.
- One variation of a device for the treatment of a heart valve may comprise a first elongate body, a first balloon sealably enclosing a portion of the first elongate body, a first shock wave source coupled to the first elongate body and enclosed within the first balloon, a second elongate body, a second balloon sealably enclosing a portion of the second elongate body, and a second shock wave source coupled to the second elongate body and enclosed within the second balloon.
- the first and second balloons may be independently inflatable with a liquid and may be sized and shaped such that when inflated with the liquid, a portion of the balloons contact the valve.
- the portion of the balloons that contact the valve may approximate the size and shape of a concave portion of a valvular cusp.
- the device may optionally comprise a third elongate body, a third balloon sealably enclosing a portion of the third elongate body, and a third shock wave source coupled to the third elongate body and enclosed within the third balloon, where the third balloon may be independently inflatable with a liquid.
- the shock wave source may be movable within their respective balloons.
- the shock wave sources may be rotatable about a longitudinal axis of their respective elongate bodies, and/or may be advanceable along a longitudinal axis of their respective elongate bodies.
- a device for treating a heart valve may comprise a first elongate body, a first balloon sealably enclosing a portion of the first elongate body, a first shock wave source coupled to the first elongate body and enclosed within the first balloon, a second elongate body, a second balloon sealably enclosing a portion of the second elongate body, a second shock wave source coupled to the second elongate body and enclosed within the second balloon, a third elongate body, a third balloon sealably enclosing a portion of the third elongate body, and a third shock wave source coupled to the third elongate body and enclosed within the third balloon.
- the first, second, and third balloons may be independently inflatable with a liquid and may be sized and shaped such that when inflated with the liquid, a portion of the balloons contact the valve.
- the portion of the balloons that contact the valve may approximate the size and shape of a concave portion of a valvular cusp.
- any of the devices described herein may further comprise at least one stand-off on the external surface of at least one of the balloons.
- the at least one stand-off may comprise a curved ridge along a segment of the external surface of the balloon.
- the elongate bodies of any of the devices described herein may comprise a compressed configuration and an expanded configuration, wherein in the compressed configuration, a distal portion of the elongate bodies may be relatively straight and in the expanded configuration, the distal portion of the elongate bodies may be curved.
- Also described herein are methods for applying shock waves to an aortic valve.
- One variation of a method may comprise introducing shock wave device into a patient' s vasculature, where the shock wave device may comprise a first elongate body, a first balloon sealably enclosing a portion of the first elongate body, a first shock wave source coupled to the first elongate body and enclosed within the first balloon, a second elongate body, a second balloon sealably enclosing a portion of the second elongate body, and a second shock wave source coupled to the second elongate body and enclosed within the second balloon, advancing the shock wave device within the vasculature to contact an aortic valve having a first cusp and a second cusp, inflating the first balloon with a liquid, where inflating the first balloon causes the first balloon to be aligned within a concave portion of the first cusp, and activating the first shock wave source to apply a shock wave to the first cusp.
- the first and second balloons may be independently inflatable with a liquid.
- the shock wave device may be advanced in a retrograde direction in the vasculature.
- the method may further comprise inflating the second balloon with a liquid, where inflating the second balloon causes the second balloon to be aligned within a concave portion of the second cusp, confirming that the first balloon and the second balloon are each aligned within the concave portions of the first and second cusp respectively, and deflating the second balloon before activating the first shock wave source.
- some methods may comprise deflating the first balloon after activating the first shock wave source, inflating the second balloon with a liquid, where inflating the second balloon causes the second balloon to be aligned within a concave portion of the second cusp, and activating the second shock wave source to apply a shock wave to the second cusp.
- a method may comprise inflating the second balloon with a liquid, where inflating the second balloon causes the second balloon to be aligned within a concave portion of the second cusp, confirming that the first balloon and the second balloon are each aligned within the concave portions of the first and second cusp respectively, and activating the second shock wave source to apply a shock wave to the second cusp.
- the first and second shock wave sources may be activated substantially simultaneously. These methods may be used to apply shock waves to a first cusp and a second cusp, where the first cusp is a right semilunar cusp and the second cusp is a posterior semilunar cusp, or the first cusp is a left semilunar cusp and the second cusp is a posterior semilunar cusp, or the first cusp is a right semilunar cusp and the second cusp is a left semilunar cusp. Shock waves may be applied to the first and second cusps simultaneously or sequentially.
- the shock wave devices used in any of these methods may comprise a third elongate body, a third balloon sealably enclosing a portion of the third elongate body, and a third shock wave source coupled to the third elongate body and enclosed within the third balloon, where the third balloon is independently inflatable with a liquid.
- Another variation of a method for applying shock waves to an aortic valve may comprise introducing shock wave device into a patient's vasculature, the shock wave device comprising a first elongate body, a first balloon sealably enclosing a portion of the first elongate body, a first shock wave source coupled to the first elongate body and enclosed within the first balloon, advancing the shock wave device within the vasculature to contact an aortic valve having a first cusp and a second cusp, inflating the first balloon with a liquid, where inflating the first balloon causes the first balloon to be aligned within a concave portion of only the first cusp, and treating the first cusp by activating the first shock wave source to apply a shock wave to the first cusp.
- the first and second balloons may be independently inflatable with a liquid.
- the shock wave device may be advanced in a retrograde direction in the vasculature.
- the method may further comprise deflating the first balloon after treating the first cusp, moving the first balloon to the second cusp, inflating the first balloon with a liquid, where inflating the first balloon causes the first balloon to be aligned within a concave portion of only the second cusp, and treating the second cusp by activating the first shock wave source to apply a shock wave to the second cusp.
- the shock wave device may further comprise a second elongate body, a second balloon sealably enclosing a portion of the second elongate body, a second shock wave source coupled to the second elongate body and enclosed within the second balloon.
- the second balloon may be inflatable with a liquid independently from the first balloon.
- a method using a shock wave device comprising two balloons may optionally comprise deflating the first balloon after treating the first cusp, inflating the second balloon with a liquid, where inflating the second balloon causes the second balloon to be aligned within a concave portion of only the second cusp, and treating the second cusp by activating the second shock wave source to apply a shock wave to the second cusp.
- a shock wave device used in any of the methods described herein may further comprise at least one stand-off on the external surface of at least one of the balloons such that when the at least one balloon is inflated with a liquid and is located with a concave portion of a cusp, the balloon does not obstruct blood flow to a coronary artery.
- FIG. 1A depicts a cutaway view of the heart (sectioned along the plane indicated in the inset.
- FIG. IB depicts a top view of the heart, as viewed from the base with the atria removed.
- FIG. 1C is a view of the aortic valve that has been cut anteriorly between the left cusp and the right cusp and splayed open.
- FIG. ID is a top view of a calcified aortic valve.
- FIG. IE is a top view of a bicuspid aortic valve.
- FIG. 2A schematically depicts one variation of a shock wave device for the treatment of calcified heart valves.
- FIG. 2B depicts a distal portion of the shock wave device of FIG. 2A.
- FIG. 2C depicts a proximal view of the distal portion of FIG. 2B.
- FIG. 2D is a side view of the distal portion of FIG. 2B.
- FIG. 2E is a top view of the device of FIGS. 2A-2D deployed within a cusp of an aortic valve.
- FIG. 2F is a side view of the device of FIGS. 2A- 2D deployed within a cusp of an aortic valve.
- FIG. 3 schematically depicts one variation of a shock wave device for the treatment of calcified heart valves comprising three balloons and three shock wave sources within the balloon.
- FIGS. 4A-4C depict one variation of method for treating a calcified heart valve using a shock wave device.
- FIG. 4D depicts a schematic top view of a shock wave device deployed in an aortic valve.
- FIGS. 5A-5C are flowchart representations of additional variations of methods for treating a calcified heart valve using a shock wave device.
- FIGS. 1A-1C depict various views of the valves of the heart.
- FIG. 1A is a cross- sectional view of a heart 100 taken along the plane indicated by the inset.
- the aortic valve 101 comprises a left semilunar leaflet or cusp 102, a right semilunar leaflet or cusp 104 and a posterior semilunar leaflet or cusp 106.
- Each cusp has a free margin, which articulates with the free margins of the other cusps when the valve closes, and an attached margin that attaches the cusp in a semilunar fashion to the aortic wall.
- the ventricular side of the cusps When the aortic valve is closed, the ventricular side of the cusps may have a convex surface and the aortic side of the cusps may have a concave surface.
- the concave portion of each of the cusps may be bordered by the concave surface of the cusp, the free margin of the cusp, the attached margin of the cusp, and may also include a portion of the valve wall.
- the concave portion of each of the cusps may include the aortic sinus associated with each cusp.
- IB depicts a top view (viewed from the base with the atria removed) of the aortic valve 101 in a closed configuration, showing the concave portion of each of the left semilunar cusp 102, right semilunar cusp 104 and posterior semilunar cusp 106. As illustrated there, the free margins 108 of each of the cusps articulate with each other to prevent the blood from passing through the valve when closed.
- the concave portions 110, 112, 114 of the left, right, and posterior cusps respectively are also shown in FIG. IB. As depicted in FIG.
- the concave portions of each cusp may also include a portion of the aortic sinus 111, 113, 115 associated with that cusp.
- the concave portion 110 or aortic sinus 111 of the left cusp 102 may comprise an opening 116 to the left coronary artery 118
- the concave portion 112 or aortic sinus 113 of the right cusp 104 may comprise an opening 120 to the right coronary artery 122.
- the concave portion 114 or aortic sinus 115 of the posterior cusp may not have any coronary artery openings.
- FIGS. ID and IE depict aortic valves that may be susceptible to stenosis.
- calcified plaques or deposits may accumulate on the aortic side of the leaflets, for example, along the concave portion of the cusp, as indicated by the dashed areas 130, 132.
- Calcium deposits on the aortic valve leaflets and walls may stiffen the valve considerably, and compromise its ability to open and close effectively.
- Nodular deposits 132 may accumulate along the free margins of the leaflets, and sheets of deposits 130 may accumulate within the concave portion of the leaflets (e.g., along the aortic side of the leaflets).
- Nodular deposits 132 may act to adhere the free margins of the cusps to each other, which would reduce the size of the valve opening.
- Sheet-like deposits along the aortic surface of the cusp e.g., the concave portion and/or aortic sinus
- FIG. IE depicts a bicuspid aortic valve, the function of which may be particularly compromised by the accumulation of calcified deposits along the free margins and/or concave portions of the two leaflets.
- the shock wave devices and methods described herein may be delivered to the concave portions of the aortic valve leaflets and/or aortic sinuses in order to crack, break, soften, remove and/or otherwise reduce the effect of calcium deposits on the function of the valve.
- a shock wave device that may be used to treat calcified regions of the aortic valve may comprise an elongate body, a balloon that sealably encloses a distal portion of the elongate body, and a shock wave source coupled to the elongate body and enclosed within the balloon.
- the balloon may be filled with a liquid, and when the shock wave source is activated, shock waves may propagate through the liquid and apply a mechanical force on the wall of the balloon.
- a calcified tissue region e.g., concave portion of a cusp and/or aortic sinus
- the mechanical force from the shock wave may be transferred to the calcium deposit, thereby cracking and/or breaking the deposit.
- the size and shape of the balloon may be selected so that when the balloon is inflated with a liquid, at least a portion of the balloon is capable of being seated and/or positioned within the concave portion and/or aortic sinus of a cusp.
- the balloon may be sized and shaped such that when the balloon is inflated in the proximity of an aortic valve cusp, the balloon automatically seats and/or positions itself within the concave portion and/or sinus of the cusp.
- the size and shape of the balloon may be tailored to the unique geometry of a patient's aortic valve (e.g., to match the geometry of the aortic cusps and/or aortic sinus).
- the diameter of a balloon may be from about 5 mm to about 15 mm, which may correspond to the size of a concave portion of a cusp.
- Balloons may be spherical, but may also have other shapes that may help to position it in a concave portion of a valve (e.g., tetrahedron with rounded and/or sharp corners or edges, pyramid with rounded and/or sharp corners or edges, square-circle - triangle block, etc.).
- the balloons may be made of a non-compliant material and may be molded to mimic the shape of a coronary sinus of the valve.
- the elongate body of the shock wave device may have shape memory such that it may be advanced through the vasculature in a relative straight configuration (e.g., constrained by a guide tube) and when deployed, may assume a curved or bent configuration that may help seat the balloon within (or in close proximity to) the aortic surface of the cusp prior to or during inflation.
- the elongate body may be biased to assume a bent and/or an expanded configuration when deployed at or near a valve cusp, which may help the device to self-align the balloons within the concave portion and/or sinus of the cusp.
- the balloon may be bonded to a distal portion of the elongate body, which may provide a fluid path to fill the balloon with saline or saline/contrast mixture.
- the elongate body may be formed of a compliant material to absorb the volume changes that may be caused by the steam bubble that may arise from shock waves generated in the balloon.
- the shock wave source enclosed within the balloon may be movable within the balloon, such that shock waves can be initiated from any location within the balloon to apply mechanical forces to a targeted region of tissue.
- the shock wave source may be advanced or retracted
- the shock wave source may be located at a distal tip of a steerable catheter and/or a catheter with shape memory such that it assumes a bent
- the balloon of a shock wave device may comprise one or more standoff structures on its external surface.
- stand-off structures may include, but are not limited to, ridges, bumps, protrusions, struts, etc. These stand-off structures may help to keep an inflated balloon that is seated within the concave portion and/or sinus of a cusp from blocking any arterial openings that may be in the sinus.
- having one or more stand-off structures on balloons that have been inflated in the left cusp or right cusp may help to prevent the balloon from blocking the openings of the left or right coronary arteries.
- a shock wave device that comprises a single elongate body, balloon and shock wave source may be used to treat one cusp of a valve at a time (i.e., after treatment of a first cusp, the device may be repositioned and seated in a concave portion of a second cusp to treat the second cusp, and so on).
- a shock wave device may comprise two or three sets of elongate bodies, balloons and shock wave sources, which may allow for the treatment of multiple cusps simultaneously, as well as for the treatment of bicuspid aortic valves. Additional balloons may also help to seat and/or position the shock wave device within the concave portion of the valve cusps more efficiently and/or precisely. While certain features and structures are described for particular variations of shock wave devices, it should be understood that those features and structures may also be incorporated into other variations of shock wave devices.
- Shock wave device 200 may comprise an elongate body 202, a balloon 204 sealably enclosing a portion of the elongate body, and a shock wave source 206 within the balloon.
- the balloon 204 may be located at the distal end of the elongate body 202, and may be inflatable by the introduction of fluid (e.g., liquid) at the proximal end of the elongate body (e.g., via a port 210, which may be a luer lock connector of a proximal handle portion 211).
- the elongate body may have a separate fluid lumen for inflating the balloon.
- the balloon 204 may comprise two elongated protrusions or ridges 212a, 212b along its external surface, which may act as standoffs to prevent occlusion of coronary artery openings when the balloon is inflated in a sinus of a cusp.
- the shock wave source 206 may comprise a shaft 208 and at least one electrode pair 207 located at the distal end of the shaft which are connected to a high voltage power supply.
- the shock wave source 206 may be advanced along the longitudinal axis of the elongate body 202 (e.g., into and out of the elongate body 202, according to arrows 201), and/or may be rotated around the longitudinal axis of the elongate body 202 (e.g., according to arrows 203, and/or may be bent at an angle) by turning and/or pushing and/or pulling a knob 213 of the proximal handle portion 211.
- the shaft 208 may be a steerable shaft where an actuating mechanism (e.g., pull wires) may be used to cause the shaft to bend, and/or may have shape memory, where the shaft is pre-shaped to have a bend 205 when in an unconstrained configuration.
- an actuating mechanism e.g., pull wires
- shock wave source 206 depicted in the drawings comprises an electrode pair 207 in a coaxial configuration at the distal tip of the shaft 208, it should be understood that there may be more than one electrode pair along the shaft, and that the electrode pair may have a variety of configurations. In some variations, the shock wave electrode pair may be located along a side of the shaft 208. Examples of shock wave electrode configurations are described in U.S. Pub. No. 2009/0312768 filed June 11, 2009 and U.S. Application Serial No. 13/831,543 filed March 14, 2013, which are both hereby incorporated by reference in their entirety. Alternatively or additionally, a shock wave source may comprise optical fibers or lasers that are configured to generate shock waves.
- FIGS. 2C and 2D depict top and side views of the balloon 204, ridges 212a and 212b, and shock wave source 206.
- FIG. 2E depicts a top view
- FIG. 2F depicts a side view of the shock wave device deployed at the aortic valve 230 (only the left cusp 232 of the valve is depicted).
- the balloon 204 is inflated with a liquid and is seated within a concave portion 234 of the left cusp 232.
- Inflation of the balloon 204 and/or shape memory of the elongate body 202 may help the balloon 204 to self-align into the concave portion 234 of the left cusp 232.
- the balloon may be seated within the concave portion 234 of the cusp such that the balloon is bordered by the valve wall 240 (e.g., wall of the sinus), the concave surface 242 (on the aortic side) of the cusp, and the free edge 244 of the cusp.
- the balloon When seated within the concave portion of a cusp, the balloon may be pressed against the valve wall 240 such that the balloon does not cross the free edge of the cusp and intersect with the free edge of another cusp (e.g., the balloon does not span across two cusps, and/or the balloon does not extend within the aortic valve orifice).
- the balloon does not cross the free edge of the cusp and intersect with the free edge of another cusp (e.g., the balloon does not span across two cusps, and/or the balloon does not extend within the aortic valve orifice).
- the balloon is seated within the concave portion 234 such that it is bordered by the valve wall 240 and the free edge 244 of the cusp.
- the balloon may also comprise ridges 212a, 212b help to ensure that the balloon does not obstruct the opening 236 of the left coronary artery. While two ridges are depicted, it should be understood that there may be any number of ridges or protrusions as may be desirable for ensuring that there is a space between the balloon wall and the aortic wall (e.g., 1, 2, 3, 4, 5, 6, 8, 10, 12, 15, etc. protrusions or ridges).
- a shock wave device for the treatment of calcified heart valves may comprise additional sets of elongate bodies, balloons, and shock wave devices. Some variations may have two elongate bodies, two balloons (each of which sealably encloses a portion of one of the two elongate bodies), and two shock wave sources (one in each of the two balloons). Other variations may have three sets of elongate bodies, balloons, and shock wave devices, such as the shock wave device 300 depicted in FIG. 3.
- the shock wave device 300 may comprise a first elongate body 302, a first balloon 304 sealably enclosing a portion of the first elongate body, a first shock wave source 306, a second elongate body 312, a second balloon 314 sealably enclosing a portion of the second elongate body, a second shock wave source 316, a third elongate body 322, a third balloon 324 sealably enclosing a portion of the third elongate body, and a third shock wave source 326.
- the shock wave sources may be connected at a proximal end to a high voltage pulse generator 301, where a positive terminal of each shock wave source may be connected to a positive port of the pulse generator and a negative terminal of each shock wave source may be connected to a common ground terminal.
- the first, second and third balloons may be separately and/or independently inflatable (e.g., have separate inflation lumens). In some variations, the first, second and third balloons may be inflated one at a time (e.g., sequentially), and/or two at a time. All the balloons of a shock wave device may also be inflated simultaneously. For example, as depicted in FIG.
- the first, second and third shock wave sources may be separately and/or independently activated.
- Each of the shock wave sources 306, 316, 326 may comprise an insulating shaft 307, 317, 327 which may house the wiring between the high voltage pulse generator and the shock wave electrodes 305, 315, 325 at the distal end of the shaft.
- the pulse generator may be controlled by a controller that is programmed to provide voltage pulses to each of the shock wave sources sequentially (e.g., one at a time) or simultaneously (e.g., two at a time, three at a time).
- Each of the three balloons and corresponding shock wave sources may be inflated, actuated, and activated by three separate proximal handle portions, each similar to the handle portion described and depicted in FIG. 2A. Additional fluid ports and/or actuating mechanism for moving the shock wave source may be included at a proximal portion as may be desirable.
- the insulating shafts 307, 317, 327 and/or the elongate bodies 302, 312, 322 may have be biased to expand when unconstrained (e.g., by an overtube or catheter).
- the shafts and/or elongate bodies may be spring-biased, and/or may have shape memory such that when unconstrained, they assume a bent and/or expanded configuration. Expansion and/or bending of the shafts and/or elongate bodies may help to position the balloons along the aortic valve such that when inflated, the balloons may self-align with the cusps and may be seated and/or positioned within a concave portion of the cusp and/or the sinus of the cusp.
- FIGS. 4A-4C depict one variation of a method for treating a calcified heart valve (e.g., an aortic valve) using a shock wave device.
- a shock wave device comprising two balloons
- this method may be performed using any of the shock wave devices disclosed herein (e.g., shock wave devices having one balloon or three balloons).
- FIG. 4A depicts a cross- sectional schematic view of an aortic valve 400 with the left cusp 402 and the right cusp 404 (the posterior cusp is not shown for the sake of simplicity).
- the concave portion 403 of the left cusp 402 includes the left sinus and the opening 407 of the left coronary artery 406.
- the concave portion 405 of the right cusp 404 includes the right sinus and the opening 409 of the right coronary artery 408.
- a guide catheter 410 may be introduced into the vasculature and advanced in a retrograde direction (e.g., via a femoral artery) to the aortic valve 400.
- the guide catheter 410 (as well as any of components of the shock wave device) may comprise a radiopaque band or marker so that the location of the catheter may be determined using fluoroscopy. Alternatively or additionally, the location of the catheter and/or any shock wave devices may be determined using ultrasound.
- the guide catheter 410 may be positioned just downstream (e.g., above) from the cusps.
- a shock wave device 412 may then be advanced through the guide catheter 410 to the aortic valve.
- the shock wave device 412 may comprise a first elongate body 414, a first balloon 416 sealably attached to the distal end of the first elongate body 414, a first shock wave source 418 enclosed within the first balloon 416, a second elongate body 424, a second balloon 426 sealably attached to the distal end of the second elongate body 424, and a second shock wave source 428 enclosed within the second balloon 426.
- the shock wave device may be any of the shock wave devices described herein.
- the first and second elongate bodies and/or the shafts of the first and second shock wave sources may be biased such that they bend at an angle and/or expand when unconstrained.
- the shock wave device 412 may be advanced through the guide catheter 410 in a compressed configuration, where the first and second elongate bodies and/or the shafts of the first and second shock wave sources may be generally aligned with the longitudinal axis of the guide catheter 410.
- advancing the shock wave device 412 distally beyond the distal end of the guide catheter may allow the first and second elongate bodies and/or the shafts of the first and second shock wave sources to assume their bent configuration, thereby expanding the shock wave device such that the first and second balloons 416, 426 (deflated during delivery) contact the aortic valve wall.
- the expansion of the shock wave device may at least partially align the balloons with the concave portions 403, 405 of the left and right cusps, and help to position the balloons away from the valve orifice and along the valve wall.
- one or both of the balloons may be inflated with a liquid, which may cause the balloons to self-align within the concave portions of the cusps, and may help reduce the amount of maneuvering of the shock wave device needed to position the balloons within the concave portions and/or sinuses of the cusps.
- only one balloon may be inflated at a time, or two balloons may be inflated simultaneously. Inflating fewer balloons than the number of cusps of a valve may allow blood to flow through at least a portion of the valve, which may help to reduce the risk of an ischemic incident during the procedure.
- the balloons may comprise one or more ridges 417, 427 (not shown in FIGS. 4A and 4B, but shown in FIG. 4C) that may act to maintain a space between the inflated balloon and the valve wall (e.g., such that the inflated balloon does not block the artery openings 407, 409). This may allow for continuous perfusion through the valve and around the cusps, as well as blood flow into the left and right coronary arteries 406, 408 through the artery openings 407, 409. FIG.
- FIG. 4D depicts a top view of a shock wave device comprising three balloons 433, 434, 435 (inflated with a fluid) enclosing three shock wave sources 436, 437, 438 that may be deployed to an aortic valve 440.
- Each balloon may comprise at least two ridges 430 that help to maintain a space between the balloon and the valve wall, which may help to prevent obstruction of the openings to the coronary arteries 432, 434.
- each of the three balloons is seated within a concave portion and/or sinus 441, 442, 443 of each of the cusps of the aortic valve.
- the location of the balloons may be determined based on fluoroscopy and/or ultrasound, as previously indicated.
- a portion of the ridges 417, 427 may be made of a radiopaque material that may be visualized using fluoroscopy.
- a radiopaque ridge may allow a practitioner to confirm that the balloons are seated within a concave portion and/or sinus of the cusps, as well as to confirm that the ridges themselves are not obstructing the openings to the coronary arteries and/or confirm that the balloons are not inserted through and/or obstructing the valve orifice.
- the bias of the elongate body and/or shock wave shaft, along with inflation of the balloons may help to self-align the balloons with the concave portions of the cusps and/or automatically seat the balloons within the concave portions of the cusps. Such bias may also help to ensure that none of the balloons obstruct and/or extend through the valve orifice, but are instead pressed along the wall of the valve.
- one or more of the shock wave sources may be activated to produce shock waves.
- the location of the balloons and/or shock wave devices may be monitored throughout the treatment procedure as needed to confirm that the balloons are in close proximity to and/or in contact with calcified regions of the valve.
- the mechanical force from the shock waves may propagate through the liquid to apply a mechanical force on any calcified deposit along the surface of the cusp.
- a plurality of shock waves may be applied to the cusps and/or other valve structures.
- the shock wave devices may be moved within a balloon so that the mechanical forces from the shock waves may be focused on different areas of a cusp without moving the balloon.
- shock wave treatment of a calcified cusp may comprise initiating shock waves from the shock wave source at a first location (which may, for example, apply mechanical force to calcified deposits along the attached edge of the cusp), then moving the shock wave source in the balloon to a second location, and then initiating shock waves from the shock wave source at a second location (which may, for example, focus the mechanical force to calcified deposits along the free edge of the cusp).
- Efficacy of the treatment may be subsequently evaluated based on imaging techniques (e.g., fluoroscopy and/or ultrasound) and/or physiological parameters.
- Examples of techniques that may be used to evaluate the efficacy of the treatment may include, but are not limited to, visual observation by ultrasound of leaflet activity (e.g., leaflet opening and closing) when the balloons are deflated or withdrawn from the valve, measuring ejection fraction, Duke Activity Status Index (DASI), peak velocity, peak gradient, valve effective orifice area, Doppler velocity, etc.
- leaflet activity e.g., leaflet opening and closing
- DASI Duke Activity Status Index
- peak velocity peak gradient
- valve effective orifice area e.g., Doppler velocity
- a transcatheter aortic valve implantation (TAVI) procedure may be performed. Cracking and/or breaking the calcium deposits on an aortic valve may help to improve the outcome of a subsequent TAVI procedure. Described below are additional methods that may comprise one or more of the steps described above.
- FIGS. 5A-5C depicts flowchart diagrams representing variations of methods for cracking and/or breaking calcified deposits that may be located along the surface of a cusp on the aorta side. In one variation, such as is depicted in FIG.
- a shock wave device with a single balloon and shock wave source within the balloon may be used to treat a first calcified cusp (e.g., the right cusp), then a second calcified cusp (e.g., the left cusp) and then a calcified third cusp (e.g., the posterior cusp) sequentially.
- a guide catheter is advanced in a retrograde direction to the aortic valve (502) and the shock wave device is advanced through the guide catheter (504), as previously described.
- a balloon is deployed to a first cusp (506), where it is inflated with a fluid (508), and its position within the concave portion and/or sinus of the cusp is confirmed (510).
- the shock wave source within the balloon may be activated (512) and the mechanical force from plurality of shock waves may act to crack and/or break the calcium deposits within the first cusp.
- the shock wave device may be moved (e.g., rotated), such that the balloon is moved from the first cusp to the concave portion of a second cusp (step 514) the balloon may or may not be deflated prior to moving it to the second cup).
- the shock wave source within the balloon may be activated (516). The process may then be repeated for the third cusp (steps 518-520).
- a shock wave device with two balloons and two shock wave sources may be used to sequentially treat one calcified cusp at a time.
- the shock wave device is advanced to the aortic valve, as previously described (steps 532, 534), and then both balloons may be deployed (536) and inflated simultaneously to seat the balloons within the concave portion of the cusps (538).
- a shock wave device with three balloons and three shock wave sources may have all three balloons inflated simultaneously.
- a first balloon in a first cusp may be deflated while a second balloon in a second cusp may remain inflated (542).
- a third balloon in a third cusp may be deflated.
- the shock wave source in the second balloon may be activated to crack and/or break the calcified deposits within the second cusp (544). Inflating more than one balloon may be helpful to position and/or seat the balloons within the concave portion of a cusp.
- Deflating all but one of the balloons during treatment may help to reduce the obstruction of blood flow through the valve during a procedure, thus extending the time available to perform the whole procedure.
- the second balloon may be deflated and the first balloon inflated for treating the first cusp (546).
- the shock wave source in the first balloon may be activated to crack and/or break the calcified deposits within the first cusp (548). These steps may be repeated as may be desirable (e.g., for the treatment of a third cusp, and/or repeated treatment of the first and second cusps).
- FIG. 5C depicts an example of a method 550 for treating two (or three) calcified cusps simultaneously.
- a shock wave device comprising two balloons and two corresponding shock wave sources may be advanced to the aortic valve, as described previously (steps 552, 554).
- a three -balloon shock wave device instead of a two-balloon shock wave device.
- Two balloons may be deployed (556) inflated simultaneously (558) to seat the balloons within the concave portion of the cusps (with a three-balloon device, the third balloon may optionally be inflated).
- the two shock wave sources within the two balloons may be activated simultaneously to apply mechanical forces to the calcified deposits in both cusps (562). After the two cusps have been treated, at least one of the balloons may be deflated (564).
- the third cusp may be treated by rotating the shock wave device so that a balloon is aligned with and/or seated within the third cusp (e.g., in the case of a two-balloon shock wave system), inflating the balloon within the third cusp (566), confirming its location within the third cusp (568) and activating the shock wave source within that balloon to treat the third cusp (570).
- a balloon may be inflated (566), to seat it within the third cusp and the third shock wave source may be activated (570).
- Confirming the position of the third balloon within the third cusp may be optional.
- the third balloon when the third balloon is inflated, one or both of the other two balloons may be deflated.
- three balloons may be inflated
- a three balloon system may be capable of inflating more than one balloon to treat more than one cusp at a time
- a three balloon system may be used to treat a single cusp at a time (i.e., inflating only one balloon at a time). Sequential inflation of a single balloon at a time may be desirable in cases where a practitioner desires to reduce the level of obstruction of the aortic valve orifice during treatment.
- one of the cusps may have a coronary artery opening in its sinus (e.g., a right or left cusp) while the other cusp may not have a coronary artery opening in its sinus (e.g., the posterior cusp).
- Leaving the third cusp (e.g., the left or right cusp) unobstructed by a balloon while the other two cusps are undergoing treatment may help ensure a consistent flow of blood to the coronary artery associated with that cusp, as well as to keep a portion of the valve orifice open during treatment.
- balloons may be inflated in the left cusp and the posterior (noncoronary) cusp to treat those cusps, while the balloon aligned and/or positioned within the concave portion of the right cusp may remain deflated.
- the left cusp has been treated, its corresponding balloon may be deflated and the balloon in the right cusp may be inflated.
- the shock wave source in the balloon in the right cusp may then be activated to treat the right cusp.
- the balloon within the posterior cusp may remain inflated for continued treatment (e.g., simultaneously with treatment of the right cusp), or the balloon may be deflated. These steps may be repeated as desired.
- the right and left cusps may be treated simultaneously, where the balloons seated in those cusps are inflated at the same time.
- balloons may have one or more stand-off structures (e.g., ridges and the like) which may help to maintain a space between the balloon and the wall of the coronary sinus where the openings of the coronary arteries are located. Maintaining this space may allow blood to continue to flow to the coronary arteries and reduce the degree to which the inflated balloons obstruct the openings of the coronary arteries.
- one or both of the balloons in the right and left cusps may be deflated and the balloon in the posterior cusp may be inflated.
- balloons may be seated and inflated in the three cusps of the aortic valve so that the three cusps may be treated simultaneously.
- a method for treating a calcified bicuspid aortic valve may comprise inflating only one balloon of a shock wave device to treat only one cusp at a time.
- methods for treating a calcified bicuspid aortic valve may comprise inflating two balloons at a time for simultaneous shock wave treatment of both of the cusps.
- a TAVI procedure may be performed after treating the valve with the shock wave device.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13750808.1A EP2882357A1 (en) | 2012-08-08 | 2013-08-08 | Shockwave valvuloplasty with multiple balloons |
CA2881211A CA2881211A1 (en) | 2012-08-08 | 2013-08-08 | Shockwave valvuloplasty with multiple balloons |
CN201380041211.3A CN104519809B (en) | 2012-08-08 | 2013-08-08 | Shock wave valvoplasty with multiple sacculus |
JP2015526700A JP2015524709A (en) | 2012-08-08 | 2013-08-08 | Shock wave valve formation with multiple balloons |
AU2013299562A AU2013299562C1 (en) | 2012-08-08 | 2013-08-08 | Shockwave valvuloplasty with multiple balloons |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261681068P | 2012-08-08 | 2012-08-08 | |
US61/681,068 | 2012-08-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2014025981A1 true WO2014025981A1 (en) | 2014-02-13 |
Family
ID=49001085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/054104 WO2014025981A1 (en) | 2012-08-08 | 2013-08-08 | Shockwave valvuloplasty with multiple balloons |
Country Status (7)
Country | Link |
---|---|
US (4) | US9554815B2 (en) |
EP (1) | EP2882357A1 (en) |
JP (1) | JP2015524709A (en) |
CN (1) | CN104519809B (en) |
AU (1) | AU2013299562C1 (en) |
CA (1) | CA2881211A1 (en) |
WO (1) | WO2014025981A1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10201387B2 (en) | 2013-03-13 | 2019-02-12 | The Spectranetics Corporation | Laser-induced fluid filled balloon catheter |
US10786661B2 (en) | 2013-03-13 | 2020-09-29 | The Spectranetics Corporation | Apparatus and method for balloon angioplasty |
US10842567B2 (en) | 2013-03-13 | 2020-11-24 | The Spectranetics Corporation | Laser-induced fluid filled balloon catheter |
US10850078B2 (en) | 2014-12-30 | 2020-12-01 | The Spectranetics Corporation | Electrically-induced fluid filled balloon catheter |
US10898213B2 (en) | 2014-12-30 | 2021-01-26 | The Spectranetics Corporation | Electrically-induced pressure wave emitting catheter sheath |
US11058492B2 (en) | 2014-12-30 | 2021-07-13 | The Spectranetics Corporation | Laser-induced pressure wave emitting catheter sheath |
US11246659B2 (en) | 2014-08-25 | 2022-02-15 | The Spectranetics Corporation | Liquid laser-induced pressure wave emitting catheter sheath |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9044618B2 (en) | 2008-11-05 | 2015-06-02 | Shockwave Medical, Inc. | Shockwave valvuloplasty catheter system |
US9730790B2 (en) | 2009-09-29 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Replacement valve and method |
US8574247B2 (en) | 2011-11-08 | 2013-11-05 | Shockwave Medical, Inc. | Shock wave valvuloplasty device with moveable shock wave generator |
EP2879597B1 (en) | 2012-08-06 | 2016-09-21 | Shockwave Medical, Inc. | Shockwave catheter |
US9554815B2 (en) | 2012-08-08 | 2017-01-31 | Shockwave Medical, Inc. | Shockwave valvuloplasty with multiple balloons |
US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
US20160135828A1 (en) | 2014-11-14 | 2016-05-19 | Shockwave Medical, Inc. | Shock wave valvuloplasty device and methods |
US10226265B2 (en) | 2016-04-25 | 2019-03-12 | Shockwave Medical, Inc. | Shock wave device with polarity switching |
EP4309608A2 (en) * | 2016-10-06 | 2024-01-24 | Shockwave Medical, Inc. | Aortic leaflet repair using shock wave applicators |
US10357264B2 (en) | 2016-12-06 | 2019-07-23 | Shockwave Medical, Inc. | Shock wave balloon catheter with insertable electrodes |
NL2019807B1 (en) | 2017-10-26 | 2019-05-06 | Boston Scient Scimed Inc | Shockwave generating device |
US11071557B2 (en) | 2017-10-19 | 2021-07-27 | Medtronic Vascular, Inc. | Catheter for creating pulse wave within vasculature |
US11103262B2 (en) | 2018-03-14 | 2021-08-31 | Boston Scientific Scimed, Inc. | Balloon-based intravascular ultrasound system for treatment of vascular lesions |
CN109223100A (en) * | 2018-09-03 | 2019-01-18 | 沛嘉医疗科技(苏州)有限公司 | It is a kind of for treating the device and its application method of heart valve and angiosteosis |
US11622779B2 (en) | 2018-10-24 | 2023-04-11 | Boston Scientific Scimed, Inc. | Photoacoustic pressure wave generation for intravascular calcification disruption |
US11464658B2 (en) | 2018-10-25 | 2022-10-11 | Medtronic Vascular, Inc. | Implantable medical device with cavitation features |
US11266817B2 (en) | 2018-10-25 | 2022-03-08 | Medtronic Vascular, Inc. | Cavitation catheter |
US11357958B2 (en) | 2018-10-25 | 2022-06-14 | Medtronic Vascular, Inc. | Devices and techniques for cardiovascular intervention |
WO2020089876A1 (en) * | 2018-11-02 | 2020-05-07 | Med-Innov Sas | Devices for treating calcified heart valves |
WO2020256898A1 (en) | 2019-06-19 | 2020-12-24 | Boston Scientific Scimed, Inc. | Balloon surface photoacoustic pressure wave generation to disrupt vascular lesions |
US11717139B2 (en) | 2019-06-19 | 2023-08-08 | Bolt Medical, Inc. | Plasma creation via nonaqueous optical breakdown of laser pulse energy for breakup of vascular calcium |
US11660427B2 (en) | 2019-06-24 | 2023-05-30 | Boston Scientific Scimed, Inc. | Superheating system for inertial impulse generation to disrupt vascular lesions |
US11517713B2 (en) | 2019-06-26 | 2022-12-06 | Boston Scientific Scimed, Inc. | Light guide protection structures for plasma system to disrupt vascular lesions |
CN110604607A (en) * | 2019-08-06 | 2019-12-24 | 沛嘉医疗科技(苏州)有限公司 | Shock wave device for treating calcification of heart valve |
US11583339B2 (en) | 2019-10-31 | 2023-02-21 | Bolt Medical, Inc. | Asymmetrical balloon for intravascular lithotripsy device and method |
US11672599B2 (en) | 2020-03-09 | 2023-06-13 | Bolt Medical, Inc. | Acoustic performance monitoring system and method within intravascular lithotripsy device |
US20210290286A1 (en) | 2020-03-18 | 2021-09-23 | Bolt Medical, Inc. | Optical analyzer assembly and method for intravascular lithotripsy device |
US11707323B2 (en) | 2020-04-03 | 2023-07-25 | Bolt Medical, Inc. | Electrical analyzer assembly for intravascular lithotripsy device |
US20220071704A1 (en) * | 2020-09-09 | 2022-03-10 | Bolt Medical, Inc. | Valvuloplasty treatment system and method |
WO2022125525A1 (en) * | 2020-12-11 | 2022-06-16 | Bolt Medical, Inc. | Catheter system for valvuloplasty procedure |
JP2024500359A (en) * | 2020-12-11 | 2024-01-09 | リサーチ ディベロップメント ファウンデーション | Systems and methods for laser-induced calcium fragmentation |
US11672585B2 (en) | 2021-01-12 | 2023-06-13 | Bolt Medical, Inc. | Balloon assembly for valvuloplasty catheter system |
CN112971915B (en) | 2021-05-08 | 2021-08-20 | 上海百心安生物技术股份有限公司 | Pulse balloon and application thereof |
US11648057B2 (en) | 2021-05-10 | 2023-05-16 | Bolt Medical, Inc. | Optical analyzer assembly with safety shutdown system for intravascular lithotripsy device |
US11806075B2 (en) | 2021-06-07 | 2023-11-07 | Bolt Medical, Inc. | Active alignment system and method for laser optical coupling |
WO2023275122A1 (en) * | 2021-07-01 | 2023-01-05 | Koninklijke Philips N.V. | Systems, apparatuses, and methods for image-guided valvuloplasty catheter procedures to treat stenotic valves, incorporating valvuloplasty balloon and pressure sensors |
US11801066B2 (en) | 2021-08-05 | 2023-10-31 | Nextern Innovation, Llc | Systems, devices and methods for selection of arc location within a lithoplasty balloon spark gap |
US11896248B2 (en) | 2021-08-05 | 2024-02-13 | Nextern Innovation, Llc | Systems, devices and methods for generating subsonic pressure waves in intravascular lithotripsy |
US11877761B2 (en) | 2021-08-05 | 2024-01-23 | Nextern Innovation, Llc | Systems, devices and methods for monitoring voltage and current and controlling voltage of voltage pulse generators |
US11839391B2 (en) | 2021-12-14 | 2023-12-12 | Bolt Medical, Inc. | Optical emitter housing assembly for intravascular lithotripsy device |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3038445A1 (en) * | 1980-10-11 | 1982-05-27 | Dornier Gmbh, 7990 Friedrichshafen | Pressure wave generator for diagnosis and therapy - has spark gap in inflatable balloon at end of catheter |
US20030163081A1 (en) * | 2002-02-28 | 2003-08-28 | Constantz Brent R. | Localized fluid delivery devices having a porous applicator and methods for using the same |
US20090312768A1 (en) * | 2008-06-13 | 2009-12-17 | Aspen Medtech, Inc. | Shockwave balloon catheter system |
US20100094209A1 (en) * | 2008-10-10 | 2010-04-15 | Intervalve, Inc. | Valvuloplasty Catheter And Methods |
US20100114020A1 (en) * | 2008-11-05 | 2010-05-06 | Daniel Hawkins | Shockwave valvuloplasty catheter system |
US20100324554A1 (en) * | 2004-12-09 | 2010-12-23 | The Foundry, Llc | Aortic Valve Repair |
WO2011069025A1 (en) * | 2009-12-05 | 2011-06-09 | Pi-R-Squared Ltd. | Fracturing calcifications in heart valves |
Family Cites Families (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3413976A (en) | 1963-07-29 | 1968-12-03 | G Elektrotekhnichesky Zd Vef | Arrangement for removal of concretions from urinary tract |
US3902499A (en) | 1974-01-02 | 1975-09-02 | Hoffman Saul | Stone disintegrator |
US4027674A (en) | 1975-06-06 | 1977-06-07 | Tessler Arthur N | Method and device for removing concretions within human ducts |
US4030505A (en) | 1975-11-28 | 1977-06-21 | Calculus Instruments Ltd. | Method and device for disintegrating stones in human ducts |
US4900303A (en) | 1978-03-10 | 1990-02-13 | Lemelson Jerome H | Dispensing catheter and method |
US4671254A (en) | 1985-03-01 | 1987-06-09 | Memorial Hospital For Cancer And Allied Diseases | Non-surgical method for suppression of tumor growth |
DE3543881C1 (en) | 1985-12-12 | 1987-03-26 | Dornier Medizintechnik | Underwater electrode for non-contact lithotripsy |
US4878495A (en) | 1987-05-15 | 1989-11-07 | Joseph Grayzel | Valvuloplasty device with satellite expansion means |
US5154722A (en) | 1988-05-05 | 1992-10-13 | Circon Corporation | Electrohydraulic probe having a controlled discharge path |
WO1989011311A1 (en) | 1988-05-18 | 1989-11-30 | Kasevich Associates, Inc. | Microwave balloon angioplasty |
US4909252A (en) | 1988-05-26 | 1990-03-20 | The Regents Of The Univ. Of California | Perfusion balloon catheter |
US4955377A (en) | 1988-10-28 | 1990-09-11 | Lennox Charles D | Device and method for heating tissue in a patient's body |
US5046503A (en) | 1989-04-26 | 1991-09-10 | Advanced Cardiovascular Systems, Inc. | Angioplasty autoperfusion catheter flow measurement method and apparatus |
DE3937904C2 (en) | 1989-11-15 | 1994-05-11 | Dornier Medizintechnik | Improvement of the ignition behavior on an underwater spark gap |
DE4016054A1 (en) | 1990-05-18 | 1991-11-21 | Dornier Medizintechnik | SPARK RANGE FOR LITHOTRIPSY |
US5295958A (en) | 1991-04-04 | 1994-03-22 | Shturman Cardiology Systems, Inc. | Method and apparatus for in vivo heart valve decalcification |
US5505702A (en) | 1992-04-09 | 1996-04-09 | Scimed Life Systems, Inc. | Balloon catheter for dilatation and perfusion |
DE69417465T2 (en) | 1993-02-05 | 1999-07-22 | Joe W And Dorothy Dorsett Brow | Ultrasound balloon catheter for angioplasty |
US5417208A (en) | 1993-10-12 | 1995-05-23 | Arrow International Investment Corp. | Electrode-carrying catheter and method of making same |
WO1996009621A1 (en) | 1994-09-21 | 1996-03-28 | Hmt High Medical Technologies Entwicklungs- Und Vertriebs Ag | Method and device for generating shock waves for medical treatment, in particular for electro-hydraulic lithotripsy |
US5582578A (en) | 1995-08-01 | 1996-12-10 | Duke University | Method for the comminution of concretions |
US6544276B1 (en) | 1996-05-20 | 2003-04-08 | Medtronic Ave. Inc. | Exchange method for emboli containment |
US5846218A (en) | 1996-09-05 | 1998-12-08 | Pharmasonics, Inc. | Balloon catheters having ultrasonically driven interface surfaces and methods for their use |
US6352535B1 (en) | 1997-09-25 | 2002-03-05 | Nanoptics, Inc. | Method and a device for electro microsurgery in a physiological liquid environment |
US6083232A (en) | 1996-09-27 | 2000-07-04 | Advanced Cardivascular Systems, Inc. | Vibrating stent for opening calcified lesions |
DE19717790A1 (en) | 1997-04-26 | 1998-10-29 | Convergenza Ag | Device with a therapeutic catheter |
DE19718513C5 (en) | 1997-05-02 | 2010-06-02 | Sanuwave, Inc., | Device for generating acoustic shock waves, in particular for medical use |
US6024740A (en) | 1997-07-08 | 2000-02-15 | The Regents Of The University Of California | Circumferential ablation device assembly |
US5931805A (en) | 1997-06-02 | 1999-08-03 | Pharmasonics, Inc. | Catheters comprising bending transducers and methods for their use |
US6755821B1 (en) | 1998-12-08 | 2004-06-29 | Cardiocavitational Systems, Inc. | System and method for stimulation and/or enhancement of myocardial angiogenesis |
DE19929112A1 (en) | 1999-06-24 | 2001-01-11 | Ferton Holding Sa | Medical instrument for the treatment of biological tissue and method for transmitting pressure waves |
US20040249401A1 (en) | 1999-10-05 | 2004-12-09 | Omnisonics Medical Technologies, Inc. | Apparatus and method for an ultrasonic medical device with a non-compliant balloon |
US6652547B2 (en) | 1999-10-05 | 2003-11-25 | Omnisonics Medical Technologies, Inc. | Apparatus and method of removing occlusions using ultrasonic medical device operating in a transverse mode |
US6440061B1 (en) | 2000-03-24 | 2002-08-27 | Donald E. Wenner | Laparoscopic instrument system for real-time biliary exploration and stone removal |
US20010044596A1 (en) | 2000-05-10 | 2001-11-22 | Ali Jaafar | Apparatus and method for treatment of vascular restenosis by electroporation |
EP2275174B1 (en) | 2000-07-13 | 2016-04-20 | ReCor Medical, Inc. | Thermal treatment apparatus with ultrasound energy application |
US6638246B1 (en) | 2000-11-28 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device for delivery of a biologically active material to a lumen |
US6666828B2 (en) | 2001-06-29 | 2003-12-23 | Medtronic, Inc. | Catheter system having disposable balloon |
FR2834202B1 (en) * | 2001-12-28 | 2004-03-19 | Cie Euro Etude Rech Paroscopie | MULTI-POCKET INTRA-GASTRIC BALLOON, SURGICAL EXPANSION DEVICE FOR SAID BALLOON AND MANUFACTURING METHOD THEREOF |
US7087061B2 (en) | 2002-03-12 | 2006-08-08 | Lithotech Medical Ltd | Method for intracorporeal lithotripsy fragmentation and apparatus for its implementation |
US20040082859A1 (en) | 2002-07-01 | 2004-04-29 | Alan Schaer | Method and apparatus employing ultrasound energy to treat body sphincters |
JP2004357792A (en) | 2003-06-02 | 2004-12-24 | Keio Gijuku | Vascular restenosis preventive therapeutic apparatus by sound pressure wave induced by irradiation of high strength pulse light |
US7744620B2 (en) | 2003-07-18 | 2010-06-29 | Intervalve, Inc. | Valvuloplasty catheter |
WO2005009309A1 (en) * | 2003-07-23 | 2005-02-03 | Lightswitch Safety Systems, Inc. | Remote control for auto-darkening lens systems and method |
MXPA06007623A (en) | 2003-12-31 | 2007-01-30 | Johnson & Johnson | Circumferential ablation device assembly with an expandable member. |
US20050165288A1 (en) * | 2004-01-27 | 2005-07-28 | Scimed Life Systems, Inc. | Systems and methods for treating breast tissue |
US7754047B2 (en) | 2004-04-08 | 2010-07-13 | Boston Scientific Scimed, Inc. | Cutting balloon catheter and method for blade mounting |
CN101043914A (en) | 2004-07-14 | 2007-09-26 | 旁路公司 | Material delivery system |
US20070299392A1 (en) | 2004-07-14 | 2007-12-27 | By-Pass, Inc. | Material Delivery System |
US9974607B2 (en) | 2006-10-18 | 2018-05-22 | Vessix Vascular, Inc. | Inducing desirable temperature effects on body tissue |
US20060069385A1 (en) * | 2004-09-28 | 2006-03-30 | Scimed Life Systems, Inc. | Methods and apparatus for tissue cryotherapy |
AU2004324043A1 (en) | 2004-10-02 | 2006-04-20 | Christoph Hans Huber | Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support |
US20060178685A1 (en) * | 2004-12-30 | 2006-08-10 | Cook Incorporated | Balloon expandable plaque cutting device |
EP1714642A1 (en) | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery |
US8162859B2 (en) | 2005-06-09 | 2012-04-24 | General Patent , LLC | Shock wave treatment device and method of use |
US20070088380A1 (en) | 2005-10-14 | 2007-04-19 | Endocross Ltd. | Balloon catheter system for treating vascular occlusions |
US20090227992A1 (en) | 2006-02-02 | 2009-09-10 | Releaf Medical Ltd | Shock-Wave Generating Device, Such as for the Treatment of Calcific Aortic Stenosis |
US8402974B2 (en) | 2006-05-30 | 2013-03-26 | Coherex Medical, Inc. | Methods, systems, and devices for sensing, measuring, and controlling closure of a patent foramen ovale |
US7920921B2 (en) | 2006-06-21 | 2011-04-05 | Intrapace, Inc. | Endoscopic device delivery system |
US8663318B2 (en) | 2007-07-23 | 2014-03-04 | Hocor Cardiovascular Technologies Llc | Method and apparatus for percutaneous aortic valve replacement |
JP4945360B2 (en) * | 2007-07-27 | 2012-06-06 | 株式会社日立製作所 | Design apparatus, design method, and program |
JP2011500249A (en) | 2007-10-22 | 2011-01-06 | エンドクロス リミテッド | Balloon and balloon catheter system for treating vascular occlusion |
US20100036294A1 (en) | 2008-05-07 | 2010-02-11 | Robert Mantell | Radially-Firing Electrohydraulic Lithotripsy Probe |
US20100016862A1 (en) | 2008-07-16 | 2010-01-21 | Daniel Hawkins | Method of providing embolic protection and shockwave angioplasty therapy to a vessel |
EP2326264B1 (en) | 2008-07-27 | 2017-11-15 | Pi-R-Squared Ltd. | Fracturing calcifications in heart valves |
US8974445B2 (en) * | 2009-01-09 | 2015-03-10 | Recor Medical, Inc. | Methods and apparatus for treatment of cardiac valve insufficiency |
US8556813B2 (en) | 2009-07-08 | 2013-10-15 | Sanuwave, Inc. | Extracorporeal pressure shock wave device |
KR20130108067A (en) | 2010-04-09 | 2013-10-02 | 베식스 바스큘라 인코포레이티드 | Power generating and control apparatus for the treatment of tissue |
US9192790B2 (en) | 2010-04-14 | 2015-11-24 | Boston Scientific Scimed, Inc. | Focused ultrasonic renal denervation |
WO2012064404A1 (en) | 2010-11-09 | 2012-05-18 | Daniel Hawkins | Shockwave valvuloplasty device with guidewire and debris basket |
CN201906330U (en) * | 2010-12-03 | 2011-07-27 | 上海硕创生物医药科技有限公司 | Balloon catheter with strip-shaped surface |
US8998893B2 (en) | 2010-12-07 | 2015-04-07 | Boaz Avitall | Catheter systems for cardiac arrhythmia ablation |
US11246653B2 (en) | 2010-12-07 | 2022-02-15 | Boaz Avitall | Catheter systems for cardiac arrhythmia ablation |
US10849879B2 (en) | 2011-10-19 | 2020-12-01 | Mercator Medsystems, Inc. | Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation |
US8574247B2 (en) | 2011-11-08 | 2013-11-05 | Shockwave Medical, Inc. | Shock wave valvuloplasty device with moveable shock wave generator |
CN104023656B (en) | 2011-12-05 | 2017-02-15 | Pi-R-方形有限公司 | Fracturing calcifications in heart valves |
US8574248B2 (en) | 2011-12-12 | 2013-11-05 | Kassab Kughn Endovascular Devices | Catheter system with balloon-mounted plaque-modifying elements |
US9642673B2 (en) | 2012-06-27 | 2017-05-09 | Shockwave Medical, Inc. | Shock wave balloon catheter with multiple shock wave sources |
EP2879607B1 (en) | 2012-08-06 | 2019-02-27 | Shockwave Medical, Inc. | Low profile electrodes for an angioplasty shock wave catheter |
EP2879597B1 (en) | 2012-08-06 | 2016-09-21 | Shockwave Medical, Inc. | Shockwave catheter |
US9554815B2 (en) | 2012-08-08 | 2017-01-31 | Shockwave Medical, Inc. | Shockwave valvuloplasty with multiple balloons |
US9237984B2 (en) | 2012-08-10 | 2016-01-19 | Shockwave Medical, Inc. | Shockwave nerve therapy system and method |
US9138249B2 (en) | 2012-08-17 | 2015-09-22 | Shockwave Medical, Inc. | Shock wave catheter system with arc preconditioning |
US9333000B2 (en) | 2012-09-13 | 2016-05-10 | Shockwave Medical, Inc. | Shockwave catheter system with energy control |
US9522012B2 (en) | 2012-09-13 | 2016-12-20 | Shockwave Medical, Inc. | Shockwave catheter system with energy control |
US9730715B2 (en) | 2014-05-08 | 2017-08-15 | Shockwave Medical, Inc. | Shock wave guide wire |
US20160135828A1 (en) | 2014-11-14 | 2016-05-19 | Shockwave Medical, Inc. | Shock wave valvuloplasty device and methods |
CN107106189B (en) | 2014-11-19 | 2019-12-13 | 捷迈有限公司 | Gap calibration femur measurer |
US10226265B2 (en) | 2016-04-25 | 2019-03-12 | Shockwave Medical, Inc. | Shock wave device with polarity switching |
EP4309608A2 (en) | 2016-10-06 | 2024-01-24 | Shockwave Medical, Inc. | Aortic leaflet repair using shock wave applicators |
-
2013
- 2013-08-08 US US13/962,315 patent/US9554815B2/en active Active
- 2013-08-08 JP JP2015526700A patent/JP2015524709A/en active Pending
- 2013-08-08 CA CA2881211A patent/CA2881211A1/en not_active Abandoned
- 2013-08-08 EP EP13750808.1A patent/EP2882357A1/en not_active Withdrawn
- 2013-08-08 WO PCT/US2013/054104 patent/WO2014025981A1/en active Application Filing
- 2013-08-08 CN CN201380041211.3A patent/CN104519809B/en active Active
- 2013-08-08 AU AU2013299562A patent/AU2013299562C1/en active Active
-
2016
- 2016-12-13 US US15/377,090 patent/US10758255B2/en active Active
-
2020
- 2020-07-29 US US16/942,605 patent/US11766271B2/en active Active
-
2023
- 2023-08-08 US US18/231,535 patent/US20240008886A1/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3038445A1 (en) * | 1980-10-11 | 1982-05-27 | Dornier Gmbh, 7990 Friedrichshafen | Pressure wave generator for diagnosis and therapy - has spark gap in inflatable balloon at end of catheter |
US20030163081A1 (en) * | 2002-02-28 | 2003-08-28 | Constantz Brent R. | Localized fluid delivery devices having a porous applicator and methods for using the same |
US20100324554A1 (en) * | 2004-12-09 | 2010-12-23 | The Foundry, Llc | Aortic Valve Repair |
US20090312768A1 (en) * | 2008-06-13 | 2009-12-17 | Aspen Medtech, Inc. | Shockwave balloon catheter system |
US20100094209A1 (en) * | 2008-10-10 | 2010-04-15 | Intervalve, Inc. | Valvuloplasty Catheter And Methods |
US20100114020A1 (en) * | 2008-11-05 | 2010-05-06 | Daniel Hawkins | Shockwave valvuloplasty catheter system |
WO2011069025A1 (en) * | 2009-12-05 | 2011-06-09 | Pi-R-Squared Ltd. | Fracturing calcifications in heart valves |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10201387B2 (en) | 2013-03-13 | 2019-02-12 | The Spectranetics Corporation | Laser-induced fluid filled balloon catheter |
US10786661B2 (en) | 2013-03-13 | 2020-09-29 | The Spectranetics Corporation | Apparatus and method for balloon angioplasty |
US10842567B2 (en) | 2013-03-13 | 2020-11-24 | The Spectranetics Corporation | Laser-induced fluid filled balloon catheter |
US11246659B2 (en) | 2014-08-25 | 2022-02-15 | The Spectranetics Corporation | Liquid laser-induced pressure wave emitting catheter sheath |
US10850078B2 (en) | 2014-12-30 | 2020-12-01 | The Spectranetics Corporation | Electrically-induced fluid filled balloon catheter |
US10898213B2 (en) | 2014-12-30 | 2021-01-26 | The Spectranetics Corporation | Electrically-induced pressure wave emitting catheter sheath |
US11058492B2 (en) | 2014-12-30 | 2021-07-13 | The Spectranetics Corporation | Laser-induced pressure wave emitting catheter sheath |
Also Published As
Publication number | Publication date |
---|---|
AU2013299562B2 (en) | 2017-07-13 |
AU2013299562C1 (en) | 2017-11-30 |
US20140046353A1 (en) | 2014-02-13 |
US20170086867A1 (en) | 2017-03-30 |
CA2881211A1 (en) | 2014-02-13 |
US20210038237A1 (en) | 2021-02-11 |
US9554815B2 (en) | 2017-01-31 |
CN104519809B (en) | 2018-01-02 |
JP2015524709A (en) | 2015-08-27 |
US10758255B2 (en) | 2020-09-01 |
US11766271B2 (en) | 2023-09-26 |
EP2882357A1 (en) | 2015-06-17 |
CN104519809A (en) | 2015-04-15 |
US20240008886A1 (en) | 2024-01-11 |
AU2013299562A1 (en) | 2015-02-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11766271B2 (en) | Shock wave valvuloplasty with multiple balloons | |
US20230056062A1 (en) | Aortic leaflet repair using shock wave applicators | |
US20160135828A1 (en) | Shock wave valvuloplasty device and methods | |
US20090209955A1 (en) | Prosthetic valve implant site preparation techniques | |
CN112930146A (en) | Devices and techniques for cardiovascular intervention | |
JP2008522755A (en) | Aortic valve repair | |
JP7298826B2 (en) | Transcatheter device for treating calcified heart valve leaflets | |
US20220304749A1 (en) | Catheter, sheath or dilator for heart valve decalcification treatment and method of use thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 13750808 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2015526700 Country of ref document: JP Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 2881211 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2013299562 Country of ref document: AU Date of ref document: 20130808 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2013750808 Country of ref document: EP |