WO2014072820A3 - Chronoamperometric methods and devices for electrochemical quantification of analytes - Google Patents

Chronoamperometric methods and devices for electrochemical quantification of analytes Download PDF

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Publication number
WO2014072820A3
WO2014072820A3 PCT/IB2013/002926 IB2013002926W WO2014072820A3 WO 2014072820 A3 WO2014072820 A3 WO 2014072820A3 IB 2013002926 W IB2013002926 W IB 2013002926W WO 2014072820 A3 WO2014072820 A3 WO 2014072820A3
Authority
WO
WIPO (PCT)
Prior art keywords
concentration
methods
devices disclosed
relate
diffusion
Prior art date
Application number
PCT/IB2013/002926
Other languages
French (fr)
Other versions
WO2014072820A2 (en
Inventor
Thomas William Beck
Original Assignee
Thomas William Beck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas William Beck filed Critical Thomas William Beck
Publication of WO2014072820A2 publication Critical patent/WO2014072820A2/en
Publication of WO2014072820A3 publication Critical patent/WO2014072820A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/49—Systems involving the determination of the current at a single specific value, or small range of values, of applied voltage for producing selective measurement of one or more particular ionic species

Abstract

Methods and devices disclosed herein relate to the use of a band electrode to create a two-component current in an electrochemical sensor, preferably for use with a blood glucose monitor. The dimensions of the band electrode are smaller than that of the solution deposited on it, hence one component of the current will result from planar diffusion and the second from edge diffusion. By analyzing the plotted currents, both the concentration and the diffusion coefficient of the target analyte can be determined simultaneously, which offers an improved accuracy over the art in concentration measurement. Methods and devices disclosed herein also relate to the use of multiple band electrodes of different widths to increase the speed of measurement without adversely affecting accuracy. Methods and devices disclosed herein further relate to the use of alternating pulse voltages to measure the concentration of an analyte, taking advantage of the faster recovery time for the concentration profile. The alternating pulses also tend to perturb the concentration profile in only a thin diffusion layer, allowing various layers of the sample to be interrogated.
PCT/IB2013/002926 2012-11-08 2013-11-08 Chronoamperometric methods and devices for electrochemical quantification of analytes WO2014072820A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261724265P 2012-11-08 2012-11-08
US61/724,265 2012-11-08

Publications (2)

Publication Number Publication Date
WO2014072820A2 WO2014072820A2 (en) 2014-05-15
WO2014072820A3 true WO2014072820A3 (en) 2014-07-17

Family

ID=50685266

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/002926 WO2014072820A2 (en) 2012-11-08 2013-11-08 Chronoamperometric methods and devices for electrochemical quantification of analytes

Country Status (1)

Country Link
WO (1) WO2014072820A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230375495A1 (en) * 2022-05-20 2023-11-23 Lifescan Ip Holdings, Llc Biosensor and related method of manufacture

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110354A (en) * 1996-11-01 2000-08-29 University Of Washington Microband electrode arrays
US20070235346A1 (en) * 2006-04-11 2007-10-11 Popovich Natasha D System and methods for providing corrected analyte concentration measurements
WO2010015812A1 (en) * 2008-08-04 2010-02-11 F. Hoffmann La Roche Ag Enhancement of electrochemical response
US20100219084A1 (en) * 2006-10-05 2010-09-02 Stephen Patrick Blythe Method for determining hematocrit corrected analyte concentrations
US20120234700A1 (en) * 2007-07-26 2012-09-20 Nipro Diagnostic, Inc. System and methods for determination of analyte concentration using time resolved amperometry

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110354A (en) * 1996-11-01 2000-08-29 University Of Washington Microband electrode arrays
US20070235346A1 (en) * 2006-04-11 2007-10-11 Popovich Natasha D System and methods for providing corrected analyte concentration measurements
US20100219084A1 (en) * 2006-10-05 2010-09-02 Stephen Patrick Blythe Method for determining hematocrit corrected analyte concentrations
US20120234700A1 (en) * 2007-07-26 2012-09-20 Nipro Diagnostic, Inc. System and methods for determination of analyte concentration using time resolved amperometry
WO2010015812A1 (en) * 2008-08-04 2010-02-11 F. Hoffmann La Roche Ag Enhancement of electrochemical response

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JUNG, YONGJU ET AL.: "Simultaneous Determination of Diffusion Coefficient and Concentration by Chronoamperometry at a Microdisk Electrode.", BULLETIN- KOREAN CHEMICAL SOCIETY, vol. 15, 1994, pages 209 - 213 *

Also Published As

Publication number Publication date
WO2014072820A2 (en) 2014-05-15

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