WO2014164786A1 - Dosage injector with pinion system - Google Patents
Dosage injector with pinion system Download PDFInfo
- Publication number
- WO2014164786A1 WO2014164786A1 PCT/US2014/023485 US2014023485W WO2014164786A1 WO 2014164786 A1 WO2014164786 A1 WO 2014164786A1 US 2014023485 W US2014023485 W US 2014023485W WO 2014164786 A1 WO2014164786 A1 WO 2014164786A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- housing
- push button
- teeth
- ram
- medicament
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31573—Accuracy improving means
- A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31586—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
- A61M5/31595—Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking
Definitions
- the present invention relates to an injection device capable of delivering multiple doses of a liquid medicament contained therein without the need to refill the device between doses.
- a device is needed that allows for repeated administration of a dose of medicament that is easy to use correctly in self-administration,
- the present invention is a dispensing mechanism, including a housing having a proximal-distal axis; a ram within the housing and movable in a distal direction; a user-operable push button moveable along the proximal-distal axis relative to the housing, the push button including a slot at a distal portion of the push button; a crank arm having pawl tooth, a pivot point, and a crank arm protrusion slideably engageable with the slot such that movement of the push button causes the crank arm protrusion to move along the slot, causing rotation of the crank arm about the pivot point; and a ratchet gear having a first set of teeth releasably engageable with the pawl tooth and a second set of teeth releaseably engageable with the ram, wherein engagement of the pawl tooth with the first set of teeth of the ratchet gear causes the ratchet gear to rotate, causing the ram to distally advance relative to the
- the dispensing mechanism further includes an anti-reverse mechanism including at least one housing ratchet integrally formed on an internal surface of the housing on both housing parts; and a flexible column integrally formed extending from a distal portion of the push button, the flexible column having a flexible column protrusion at a proximal end thereof, wherein as the push button moves along the proximal-distal axis, the flexible column protrusion slides between the integrally formed ratchets on both housing parts and engages the housing ratchets and restricts movement of the push button to one direction during a resetting motion.
- the flexible column protrusion is almond shaped and thicker than said column.
- ratchets on both housing parts having ratchets on both housing parts, the column sliding between them, and the almond engaging said ratchets allows the ratchet and column to be supported in a double shear type fashion further strengthening and balancing applied loads on said mechanism.
- only one housing part contains an integrally formed ratchet, which makes the mechanism operate in single shear and tends to be unbalanced and weaker than other configurations.
- the ram includes at least two sets of teeth.
- a first set of ram teeth are configured to engage the second set of teeth of the ratchet gear
- a second set of ram teeth are configured to engage a housing protrusion, the housing protrusion being integrally formed within the housing and configured to facilitate movement of the ram in one direction.
- the second set of ratchet gear teeth are releasably engageable with a housing protrusion being integrally formed within the housing and configured to facilitate rotation of the gear in one direction.
- the push button slot is oriented at an oblique angle with respect to the proximal-distal axis.
- the push button slot has a portion that is oriented at an oblique angle with respect to the proximal-distal axis and a portion that has varying angles to the proximal-distal axis.
- the invention is an injector including the dispensing
- the medicament is administered at a fixed dose repetitively. In one embodiment, the medicament is administered in varying doses. In one embodiment, the medicament includes a parathyroid hormone. In another embodiment, the hormone is teriparatide. In one embodiment, the medicament includes a glucagon-like peptide- 1 agonist. In another embodiment, the glucagon-like peptide- 1 agonist is exenatide.
- Figure 1 A is a side view of an injection device according to an exemplary embodiment of the present disclosure
- Figure IB is a cross-sectional rear side view of the injection device shown in Fig. 1A;
- Figure 1C is a cross-sectional front side view of the injection device shown in Fig. 1A;
- Figure ID is a side partial view of an injection device according to an exemplary embodiment of the present disclosure.
- Figure 2A is a side view of a first portion of housing of the injection device shown in Fig. 1A;
- Figure 2B is a side view of a second portion of housing of the injection device shown in Fig. 1A;
- Figure 3A is a front side view of a dosage mechanism of the injection device shown in Fig. 1 A;
- Figure 3B is a rear side view of a dosage mechanism of the injection device shown in Fig. 1A;
- Figure 4 is a side view of a ram of the injection device shown in Fig. 1 A;
- Figure 5 is a side view of a ram and a second portion of housing of the injection device shown in Fig. 1 A;
- Figure 6 is a perspective view of a ratchet gear of the injection device shown in Fig. 1A;
- Figure 7 is a perspective view of a ratchet arm of the injection device shown in Fig. 1A;
- Figure 8 is a perspective view of a first exemplary user-manipulable push button of the injection device shown in Fig. 1 A;
- Figures 9A, 9B, and 9C are side exploded views of a second exemplary user- manipulable push button of the injection device shown in Fig. ID;
- Figures 10A, 10B, and IOC are partial side cutaway views of the injection device shown in Fig. ID during operation;
- Figures 1 1A, 1 IB, 11C, and 1 ID are a partial side cutaway views of the injection device shown in Fig. 1 D showing compression of an exemplary force limiting biasing member;
- Figures 12A, 12B, 12C, 12D, and 12E are partial side cutaway views of an anti- reverse feature of the injection device shown in Fig. ID;
- Figures 13 A, 13B, 13C, and 13D are partial side cutaway views of a lock-out feature of the injection device shown in Fig. ID;
- Figure 14A is a side view of the injection device shown in Fig. ID;
- Figure 14B is a side view of the injection device shown in Fig. ID;
- Figure 15 A is a cross-sectional rear side view of the injection device shown in Fig. ID;
- Figure 15B is a cross-sectional front side view of the injection device shown in Fig. ID;
- Figure 16A is a side view of a first portion of housing of the injection device shown in Fig. ID;
- Figure 16B is a side view of a second portion of housing of the injection device shown in Fig. ID;
- Figure 17A is a front side view of a dosage mechanism of the injection device shown in Fig. ID;
- Figure 17B is a rear side view of a dosage mechanism of the injection device shown in Fig. ID;
- Figure 18 is a side view of a ram of the injection device shown in Fig. ID;
- Figure 19 is a side view of a ram and a second portion of housing of the injection device shown in Fig. ID;
- Figure 20 is a perspective view of a ratchet gear of the injection device shown in Fig. ID;
- Figure 21 is a perspective view of a ratchet arm of the injection device shown in Fig. ID.
- FIGS. 1-21 an injection device 100, in accordance with an exemplary embodiment of the present invention. It is noted that, in the context of this disclosure, the terms “distal” and “proximal” are used in reference to the position of injection device 100 relative to a user of the injection device when merely held by a user.
- a point located distal to a second point would be further from the user (e.g., towards an injection end of injection device 100) and vice versa.
- FIGS. 1A-1C and 2-8 show one embodiment of the present invention and FIGS. ID and 9-21 show another embodiment of the present invention.
- injection device 100 is configured to administer a dose of medicament.
- injection device 100 is configured in the shape of a pen, having an elongated, substantially writing instrument-like form, although other forms are within the scope of the invention.
- injection device 100 includes a removable cap 128 attached to the distal section 122 of the injection device 100 thereto.
- injection device 100 is a disposable injection pen, in that after the quantity of medicament contained therein is exhausted by multiple operations of the injection device 100, the injection device 100 is discarded rather than being reset and re-used with a replacement container of medicament.
- injection device 100 can be reset and is reusable.
- the injection device 100 is a re-usable pen, and that after the quantity of medicament contained therein is exhausted, the injection device can be re-set and a new medicament cartridge installed.
- injection device 100 is configured to administer repeated, successive doses of a medicament.
- the medicament is delivered in successive repeated fixed doses.
- the medicament is delivered in successive repeated variable doses.
- the dosage can be controlled and adjusted.
- injection device 100 allows the injection to be administered by individuals that do not have formal training (e.g., self-administered or administered by another individual family member or other caregiver who may not be a formally trained healthcare provider, such as a parent administering a drug to a child).
- injection device 100 is triggered by one hand of a user.
- injection device 100 is held one hand of a user and triggered by the user's finger or thumb.
- injection device 100 is useful in situations where self-injections/caregiver administered injections would be beneficial, including, but not limited to, the injection of a drug to treat osteoporosis, psoriasis, and psoriatic arthritis.
- the injection device must administer a full dose prior to being able to reset. In one embodiment, the injection device must fully reset before it is able to be triggered.
- the injection device 100 can be used to inject a wide range of drugs.
- injection device 100 can be used to inject drugs, water soluble medicaments and oil soluble medicaments.
- Some medicaments that can be used with injector device 100 include parathyroid hormone ("PTH”) and various other medications such as exenatide and the like.
- PTH parathyroid hormone
- exenatide various other medications such as exenatide and the like.
- Injection device 100 can also be used to inject medicaments listed in the Physicians' Desk Reference (PDR®), 67th Edition (2013) (which is herein incorporated by reference in its entirety), and, without limitation, allergens, amebicides and trichomonacides, amino acid preparations, analeptic agents, analgesics, analgesics/antacids, anesthetics, anorexics, antacids, antihelmintics, antialcohol preparations, antiarthritics, antiasthma agents, antibacterials and antiseptics, antibiotics, antiviral antibiotics, anticancer preparations, anticholinergic drug inhibitors, anticoagulants, anticonvulsants, antidepressants, antidiabetic agents, antidiarrheals, antidiuretics, antienuresis agents, antifibrinolytic agents, antifibrotics (systemic), antiflatulents, antifungal agents, antigonadotropin, antihistamines,
- PDR® Physician
- antihyperammonia agents anti-inflammatory agents, antimalarials, antimetabolites, antimigraine preparations, antinauseants, antineoplastics, anti-obesity preparations, antiparasitics, anti-parkinsonism drugs, antipruritics, antipyretics, antispasmodics and antichloinergics, antitoxoplasmosis agents, antitussives, antivertigo agents, antiviral agents, apomorphine, atropine, biologicals, biosimilars, bismuth preparations, bone metabolism regulators, bowel evacuants, bronchial dilators, calcium preparations, cardiovascular preparations, central nervous system stimulants, cerumenolytics, chelating agents, choleretics, cholesterol reducers and anti-hyperlipemics, colonic content acidifiers, cough and cold preparations, decongestants, diazepam, dihydroergotamine, epinephrine expectorants and combinations, diuretics
- injector device 100 Some other medicaments that can be used with injector device 100 include Ergocalciferol (Calciferol), diethylstilbestrol, Diprovan
- estradiol valerate fluphenazine decanoate, fulvestrant, intralipid, liposyn, nandrolone decanoate, nebido, nutralipid, paclitaxel, progesterone, prograf, testosterone cypionate, zuclopenthixol, haloperidol dodecanoate, Enbrel, Humira, Lantus, Epogen (Procrit), Neulasta, Aranesp, Avonex, PEGasys, Rebif, Neupogen, Betaseron, Avastin, Remicade, Herceptin, Erbitux, Recombinate, Cerezyme, NovoSeven, Tysabri, Synagis, Copaxone and Kogenate FS.
- the medicament is dissolved in soybean oil, ethyl oleate, castor oil, sesame oil, safflower oil, arachis oil, polyoxyyethylated castor oil (Cremophor® EL), polyoxyl 60 hydrogenated castor oil (HCO-60), cottonseed oil, or thin oil derived from coconut oil.
- soybean oil ethyl oleate, castor oil, sesame oil, safflower oil, arachis oil, polyoxyyethylated castor oil (Cremophor® EL), polyoxyl 60 hydrogenated castor oil (HCO-60), cottonseed oil, or thin oil derived from coconut oil.
- the medicament may be a hazardous agent.
- Hazardous Agent(s) as used herein means any one or more medications that are toxic agents, cytotoxic agents and/or other dangerous agents that may cause serious effects upon contact with a subject as well as highly potent agents, agents that have profound physiological effects at low doses.
- exemplary hazardous agents include, without limitation, analgesics,
- immunomodulating agents include, but are not limited to, those disclosed in U.S. Patent Application Publication No. 2012/0157965 entitled
- cytotoxic agents include, without limitation, 6-mercaptopurine, 6-thioinosinic acid, azathioprine,
- agents that have profound physiological effects at low doses include, without limitation, antihypertensives and/or blood pressure down regulators.
- analgesics include, without limitation, fentanyl, fentanyl citrate, moiphine, meperidine, and other opioids.
- immunomodulating agents include, without limitation, adalimumab (anti -tissue necrosis factor monoclonal antibody or anti-TNF).
- IL-1 receptor antagonists include, without limitation, anakinra.
- IL- 2 alpha receptor antagonists include, without limitation, daclizumab and basiliximab.
- anti-rejection compounds include, without limitation, azathioprine,
- hormonal agents include, without limitation, testosterone, estrogen, growth hormone, insulin, thyroid hormone, follicle stimulating 3485 hormone (FSH), epinephrine/adrenaline, progesterone, parathyroid hormone, gonadotrophin releasing hormone (GHRH), leutinizing hormone releasing hormone (LHRH), other hormones such as those where contact with the hormone by members of the opposite sex can lead to side effects, and derivatives thereof.
- hormonal agents include, without limitation, testosterone, estrogen, growth hormone, insulin, thyroid hormone, follicle stimulating 3485 hormone (FSH), epinephrine/adrenaline, progesterone, parathyroid hormone, gonadotrophin releasing hormone (GHRH), leutinizing hormone releasing hormone (LHRH), other hormones such as those where contact with the hormone by members of the opposite sex can lead to side effects, and derivatives thereof.
- prostaglandins include, without limitation, gamma-linolenic acid, docosahex
- sedatives include, without limitation, barbiturates such as amobarbital, pentobarbital, secobarbital, and phenobarbitol; benzodiazepines such as clonazepam, diazepam, estazolam, flunitrazepam, lorazepam, midazolam, nitrazepam, oxazepam, triazolam, temazepam, chlordiazepoxide, and alprazolam; herbal sedatives such as ashwagandha, duboisia hopwoodii, prosanthera striatiflora, kava (piper methysticum), mandrake, valerian, and marijuana; non-benzodiazepine sedatives (a.k.a.
- Z-drugs such as eszopiclone, zaleplon, Zolpidem, zopiclone; antihistamines such as diphenhydramine, dimenhydrinate, doxylamine, and promethazine; and other sedatives such as chloral hydrate.
- anticholinergic agents include, without limitation, dicyclomine, atropine, ipratropium bromide, oxitropium bromide, and tiotropium.
- Parkinson's disease drugs include, without limitation, levodopa, dopamine, carbidopa, benserazide, co-ceraldopa, co-beneldopa, tolcapone, entacapone, bromocriptine, pergolide, pramipexole, ropinirole, piribedil, cabergoline, apomorphine, and lisuride.
- expensive agents include, without limitation, human growth hormone and erythropoietin.
- neuroleptic agents includes, without limitation, antipsychotics; butyrophenones such as haloperidol and droperidol; phenothiazines such as chlorpromazine, fluphenazine, perphenazine,
- TNF blockers includes, without limitation, etanercept.
- the hazardous agent can be selected from botulinum toxin, injectable gold, 6-mercaptopurine, 6-thioinosinic acid, azathioprine, chlorambucil, cyclophosphamide, cytophosphane, cytarabine, fluorouracil, melphalan, methotrexate, uramustine, anti-cytokine biologicals, cell receptor antagonists, cell receptor analogues, dexamethasone, progesterone, somatostatin, analogues of dexamethasone, analogues of progesterone, analogues of somatostatin, teriparatide, scopolamine, antihypertensives, blood pressure down regulators, fentanyl, fentanyl citrate, morphine, meperidine, other opioids, adalimumab (anti-tissue necrosis factor monoclonal antibody or anti-TNF), anakin
- epinephrine/adrenaline gamma-linolenic acid, docosahexanoic acid, arachidonic acid, eicosapentaenoic acid, amobarbital, pentobarbital, secobarbital, phenobarbitol, clonazepam, diazepam, estazolam, flunitrazepam, lorazepam, midazolam, nitrazepam, oxazepam, triazolam, temazepam, chlordiazepoxide, alprazolam, ashwagandha, duboisia hopwoodii, prosanthera striatiflora, kava (piper methysticum), mandrake, valerian, marijuana, eszopiclone, zaleplon, Zolpidem, zopiclone, diphenhydramine, dimenhydrinate, doxylamine,
- Repeat dosing includes repetitive injection of the same dose or variable dose.
- Medicaments that are administered intradermally, subcutaneously or intramuscularly can be used with the injector. Further, many such medicaments should be delivered in a precise amount to ensure efficacy and to reduce side-effects.
- the medicament includes a recombinant form of parathyroid hormone, e.g., teriparatide.
- teriparatide has the following structure:
- Teriparatide is typically administered by injection once a day in the thigh or abdomen.
- Teriparatide is indicated for use in postmenopausal women with osteoporosis at a high risk for fracture or with a history of osteoporotic fracture, patients with multiple risk factors for fracture, and for patients who have failed or are intolerant to other available osteoporosis therapy.
- Teriparatide is also indicated to increase bone mass in men with primary or hypogonadal osteoporosis at high risk of fracture, patients with multiple risk factors for fracture, and for patients who have failed or are intolerant to other available osteoporosis therapy.
- injection device 100 is configured to administer about 1 ⁇ g, about 2 ⁇ g, about 3 ⁇ g, about 4 ⁇ g, about 5 ⁇ g, about 6 ⁇ g, about 7 ⁇ g, about 8 ⁇ g, about 9 ⁇ g, about 10 ⁇ g, about 11 ⁇ g, about 12 ⁇ g, about 13 ⁇ g, about 14 ⁇ g, 15 ⁇ g, about 16 ⁇ g, about 17 ⁇ g, about 18 ⁇ g, about 19 ⁇ g, about 20 ⁇ g, about 21 ⁇ g, about 22 ⁇ g, about 23 ⁇ g, about 24 ⁇ g, about 25 ⁇ g, about 26 ⁇ g, about 27 ⁇ g, about 28 ⁇ g, about 29 ⁇ g, about 30 ⁇ g, about 31 ⁇ g, about 32 ⁇ g, about 33 ⁇
- injection device 100 is configured to administer about .005 mL, about .010 mL, about .015 mL, about .020 mL, about .025 mL, about .030 mL, about .035 mL, about .040 mL, about .045 mL, about .050 mL, about .055 mL, about .060 mL, about .065 mL, about .070 mL, 75 ⁇ , about .080 mL, about .085 mL, about .090 mL, about .095 mL, about .100 mL, about .105 mL, about .1 10 mL, about .115 mL, about .120 mL, about .125 mL, about .130 mL or any range determinable from the preceding dosage amounts (for example, about .025 m
- injection device 100 includes a proximal section 120 and a distal section 122.
- distal section 122 contains the medicament to be dispensed at its distal end upon operation of injection device 100.
- the proximal section 120 contains the dosage mechanism 126, as shown in FIGS. 3 A, 3B, 15A and 15B used to force the contained medicament from the distal end of distal section 122.
- injection device 100 includes housing 102. In one embodiment,
- housing 102 has a proximal-distal axis 124.
- housing 102 of injection device 100 is formed from a light weight material, e.g., an injected molded plastic.
- housing 102 is covered in an opaque or elastomeric covering to alter the color, shape or texture of housing 102.
- housing 102 is formed of at least two separate parts, e.g., first portion 1020a and second portion 1020b as shown in FIGS. 2A, 2B, 16A and 16B.
- the housing parts 1020a and 1020b are aligned via mating pins and recesses provided therein and fixedly secured together during manufacture, such as via adhesives or ultrasonic welding.
- housing parts 1020a and 1020b are fixedly secured together by a mechanical joint system where part- to-part attachment is accomplished with locating and locking features.
- housing parts 1020a and 1020b are fixedly secured using clips where said clips can be integral to one or the other or both housing parts.
- securing clips are separate from housing parts 1020a and 1020b.
- housing 102 is generally elliptical in transverse cross-section to accommodate dosage mechanism 126.
- the generally elliptical housing 102 is configured with generally flat surfaces opposing one another on said housing.
- housing 102 is configured with flat surfaces sufficient to minimize the potential for the device to roll.
- the flat surfaces found as part of elliptical housing 102 are designed to retain internal device components.
- the flat surfaces of elliptical housing 102 are designed to retain dosing mechanism 126.
- the flat surfaces for housing 102 contain rails and ribs for retaining internal device components.
- housing 102 is provided with an external thread or another suitable connections means at a distal portion of the housing 102 to releasably connect a cartridge sleeve 114 thereto.
- housing 102 is provided with suitable connection means at a distal portion of housing 102 to adjustably connect the cartridge sleeve 114 thereto.
- injection device distal section 122 includes a cartridge sleeve 114 which can be used to hold a number of differently-sized cartridges. Additionally, a number of differently-sized cartridge sleeves can be provided, as necessary for differently- sized cartridges.
- the cartridge sleeve 114 is provided with an internal thread or another suitable connections means at a proximal portion of the cartridge sleeve 1 14 to releasably connect housing 102 thereto.
- cartridge sleeve 114 is provided with suitable connection means at its proximal end to adjustably connect the cartridge sleeve 1 14 to housing 102 thereto.
- the cartridge sleeve 114 is reversibly connected to housing 102. In one embodiment, the reversible connection of cartridge sleeve 1 14 to housing 102 allows replacement of medicament cartridge 112 and resetting of device 114.
- cartridge sleeve 114 is provided with an external thread 118 or another suitable connections means 1 18 at a distal portion of cartridge sleeve 114 to releasably connect a pen-needle assembly thereto.
- a pen-needle assembly (not shown) is of known design and includes a double-ended needle cannula or injection needle.
- the pen- needle assembly consists of an injection needle mounted in a tubular hub that is internally threaded to cooperate with the external thread 1 18 of cartridge sleeve 114 so as to be reversibly attached to the external threading of the cartridge sleeve 114.
- Other types of connection types including a snap on connection, may be provided between the needle assembly and the cartridge sleeve 114.
- the injection needle is fitted with a protective cover, e.g, a needle cap, thereover to protect those handling or who may otherwise encounter injection device 100.
- the pen-needle assembly is a single injection needle.
- Various types of other needle assemblies known in the art may be used with injection device 100, including, but not limited to, assemblies with one or more 2014/023485 shortened injection needles, including microneedle arrays, pen needle assemblies
- injection device 100 includes a cartridge 112.
- cartridge 1 12 is of the type typically used in connection with injection devices, e.g., needled injector devices, and is formed of glass or certain types of plastic that have qualities that are necessary for storage of liquid medicament. Such qualities can include low air permeation, lubricity, low leeching of chemicals and corrosion resistance.
- cartridge 1 12 is generally cylindrical in shape and can have a diameter configured to fit within cartridge sleeve 114, although other shapes can be used.
- cartridge 1 12 and cartridge sleeve 1 14 are engage at an interface.
- an adhesive is applied at the interface of cartridge 1 12 and cartridge sleeve 1 14.
- the adhesive is light cured.
- the cartridge 112 defines a medicament-filled reservoir that is closed at its proximal end by a plunger 110 that is axially slideably and sealably engaged with the cartridge interior wall to hold the medicament within the reservoir.
- the distal, outlet end of the cartridge reservoir is sealed by a septum held by a cap that is secured to a stepped-down diameter neck portion of the cartridge 112.
- the septum cap secured to the stepped- down diameter neck of the cartridge 112 is secured in the stepped down distal end of the cartridge sleeve 1 14 around which external threads 118 are present.
- cartridge 112 is configured to contain a predetermined amount of a medicament. The predetermined amount of
- medicament that the cartridge is configured to contain can vary with the medicament injected and with the recommended dose size for the particular medicament and the patient.
- distally advancing plunger 110 causes the volume of the cartridge reservoir to decrease and an amount of liquid medicament to expel from the injection needle in an amount that corresponds to the reduction in volume caused by the movement of the plunger.
- cartridge 112 is constructed to hold a predetermined number of doses. In one embodiment, the doses in cartridge 112 correspond to a predetermined period of medicament administration. In one embodiment, cartridge 1 12 is constructed to hold a predetermined volume of medicament. In one embodiment, the doses in cartridge 112 include sufficient medicament for purging air from the cartridge 112 and medicament to correspond to a predetermined period of medicament administration. In one embodiment, the medicament in the cartridge is sufficient for purging air from the cartridge, allow for practice injections, correspond to a predetermined period of medicament administration and allow for residual medicament assuring the last dose of medicament is a complete dose.
- injector device 100 is intended for use with a teriparatide solution that is to be administered once daily and sufficient drug is provided for the prescribed treatment over a pre-determined number of successive days at a dose of .08 mL administered through movement of a plunger 110 a distance of about 1.1 mm.
- injector device 100 is intended for use with a teriparatide solution that is to be administered once daily for twenty eight successive days at a dose of 0.08 mL administered through movement of a plunger 110 a distance of about 1.1 mm.
- the injector device 100 is configured to administer a dose of medicament, e.g., teriparatide, once daily for
- I day 2 successive days, 3 successive days, 4 successive days, 5 successive days, 6 successive days, 7 successive days, 8 successive days, 9 successive days, 10 successive days,
- cartridge 112 is configured to contain about 3 mL of teriparatide.
- cartridge 1 12 is configured to contain about 2.7 mL of teriaparatide.
- cartridge has a diameter of about 12 mm and a height of approximately 64 mm to contain 3 mL of medicament, although other dimensions can be used to achieve the desired accuracy.
- cartridge 1 12 has a diameter of about 12 mm and a height of approximately 64 mm to contain about 2.7 mL of medicament, although other dimensions can be used to achieve the desired accuracy. 3485
- Cartridges 1 12 containing more or less medicament can be provided and can vary in diameter, height or both.
- cartridge 1 12 is configured to hold between about 0.5 mL, 1.0 mL, about 1.5 mL, about 2.0 mL, about 2.5 mL, about 3.0 mL, about 3.5 mL, about 4.0 mL, about 4.5 mL, about 5.0 mL, about 5.5 mL, about 6.0 mL, about 6.5 mL, about 7.0 mL, about 7.5 mL, about 8.0 mL, about 8.5 mL, about 9.0 mL, about 9.5 mL, about 10.0 mL or any range determinable from the preceding amounts (for example, about 2 mL to about 5 mL or 3.0 mL to about 9.5mL) of liquid medicament.
- injection device 100 is configured to dispense different amounts of liquid medicament per dose.
- the overall volume can be increased to include a predetermined amount of additional volume that remains in cartridge 112 when the intended dosing is complete. This can reduce the likelihood of an incomplete final dose or the presence of air in an injection.
- proximal section 120 of injection device 100 contains the dosage mechanism 126 which is configured to cause movement of plunger 1 10 contained in cartridge 1 12 a predetermined dosing distance. This movement may occur in successive increments and such successive increments may correspond to the number of doses to be administered.
- dosage mechanism 126 includes a ram 108, a ratchet gear 1 16, a crank arm 106 and a user- manipulable push button 104.
- ram 108 has a foot 1084, a shaft 1086, and a support bar 1088.
- foot 1084 is at a distal end of shaft 1086 and includes a planar surface. In one embodiment, the planar surface is circular.
- foot 1084 has a larger surface area than any transverse cross-sectional area of the shaft 1086 to distribute loading on the cartridge plunger 110 that foot 1084 contacts and thereby directly engages cartridge plunger 110 during advancement.
- shaft 1086 has a distal portion 1090 having a larger transverse cross-sectional area than a transverse cross-sectional area of a proximal portion 1092 to distribute loading on the foot 1084.
- shaft 1086 is not axially aligned with the center of foot 1084.
- ram 108 includes a lock out protrusion 1094 (as shown in FIG. 4) or a lock out protrusion 1096 (as shown in FIGS. 13 A, 13B, and 18) that extends from a proximal end of shaft 1086 configured for use with a lock-out feature (described in more detail below).
- shaft 1086 has at least two sets of teeth, gear engaging teeth 1080 and pawl engaging teeth 1082 axially disposed along opposing sides of a portion of shaft 1086.
- the geometry of gear engaging teeth 1080 matches the geometry of pinion teeth 1 162 on ratchet gear 1 16 (discussed in more detail below).
- the pawl engaging teeth 1082 are spaced apart linearly according to the dose travel amount.
- pawl engaging teeth 1082 include a pressure angle.
- the pressure angle of pawl engaging teeth 1082 is axially aligned with the plunger axis.
- support bar 1088 is axially disposed along a portion of shaft 1086.
- support bar 1088 is configured to interact with second portion of housing 1020b
- support bar 1088 is on shaft 1086 to provide stiffness to the part.
- ram 108 is constrained by the internal shaping of the housing 102 to be axially translatable and rotatably fixed therein.
- second portion of housing 1020b has a support bar receiving slot 1028 which is configured to hold support bar 1088 of ram 108 to prevent rotation and allow axial translation of the ram 108.
- lateral or rotational ram movement disengages the pinion teeth 1162.
- ram 108 is movable in the distal direction and prevented from proximal movement relative to the housing 102.
- pawl engaging teeth 1082 are employed with a portion of housing 102 to provide for these one-way axial motions.
- pawl engaging teeth 1082 are provided with a one-way ramping, and are engageable with a pawl 1026, which is integrally formed within in the second portion of housing 1020b and functions within housing 102.
- ram teeth 1082 slide over pawl 1026 as the ram 108 is moved distally during injection, but pawl 1026 abuts pawl engaging teeth 1082 upon proximal movement of ram 108.
- pawl 1026 is in interference with and presses ram 108 such that gear engaging teeth 1080 are in close contact with pinion teeth 1162.
- pawl engaging teeth 1082 are equal in length, resulting in ram travel being of equal length per stroke and resulting in a single or fixed dose injection device. In a multiple dose, fixed dose
- pawl engaging teeth 1082 are of unequal in length, resulting in unequal ram travel per stroke.
- gear engaging teeth 1080 are engageable with ratchet gear 1 16.
- pinion teeth 1 162 and ratchet teeth 1 164 are in one component connected through axis 1160.
- the ratchet teeth 1164 are spaced at a predetermined angle.
- the pinion teeth 1162 have a predetermined pitch diameter and involute gear teeth geometry.
- the combination of the angular rotation of the ratchet gear 116, the pinion teeth 1162 and the 3485 gear engaging teeth 1080 on the ram 108 control the dosage amount.
- Ram 108 is shown in FIGS.
- gear engaging teeth 1080 and pawl engaging teeth 1082 such as by being made of a one-piece plastic injection molding, or a one-piece metal part.
- gear engaging teeth 1080 and pawl engaging teeth 1082 such as by being made of a one-piece plastic injection molding, or a one-piece metal part.
- Other constructions of ram 108, such as an assembly of separately formed component parts, are within the scope of the invention.
- the dosage mechanism 126 includes a ratchet gear 116.
- ratchet gear 116 is centered longitudinally within injection device 100. In one embodiment, ratchet gear 116 is not centered longitudinally within injection device 100.
- ratchet gear 1 16 includes housing engagement members 1 166a and 1 166b and two sets of gear teeth, pinion teeth 1 162 and ratchet gear teeth 1 164.
- housing engagement member 1166a defines an axis 1 160 for rolling rotation of ratchet gear 116. In one embodiment, as shown in FIG.
- ratchet gear 116 includes a recess 1168 (rather than housing engagement member 1166b), which is configured to couple with housing mating pin 1024c (as shown in FIG. 16B) disposed on the internal surface of house part 1020b to aid in preventing axial translation and allowing rotation of the ratchet gear about axis 1160.
- axis 1160 is perpendicular to axis 124.
- ratchet gear 116 is constrained by the internal shaping of the housing 102 to be rotatable about axis 1 160 and axial fixed therein.
- housing parts 1020a and 1020b have ratchet gear engagement members 1024a and 1024b which are configured to engage housing engagement members 1 166a and 1 166b of ratchet gear 116, respectively, to prevent axial translation and allow rotation of the ratchet gear about axis 1 160.
- ratchet gear 116 includes housing engagement members 1166a and 1166b configured to engage protrusions of housing parts 1020a and 1020b, such configuration preventing axial translation and allowing rotation of the ratchet gear about axis 1 160.
- pinion teeth 1162 are a continuous ring of teeth that are configured to engage gear engaging teeth 1080 of ram 108 such that as ratchet gear 116 rotates about axis 1160, ram 108 axially advances.
- the ratchet gear teeth 1164 are a continuous ring of teeth that are configured to engage a crank arm 106.
- ratchet gear teeth 1 164 have one-way ramping.
- the diameter of pinion teeth 1162 is smaller than the diameter of ratchet gear teeth 1 164.
- the number of teeth in pinion teeth 1162 is less than the number of teeth in ratchet gear teeth 1164.
- ratchet gear 116 moves forward by turning counterclockwise to dispense medicament. In another embodiment, ratchet gear 116 moves forward by turning clockwise to dispense medicament. As shown in FIG. 15B, in one embodiment, ratchet gear 116 includes a ratchet gear marker 1168.
- ratchet gear marker 1 168 alignment of ratchet gear marker 1 168 with a protrusion 1030 on either of housing parts 1020a or 1020b prior to a first use of injection device 100 ensures that dosage mechanism 126 is in a proper pre-fired orientation.
- protrusion 1030 prevents ratchet gear 116 from turning backwards by only allowing ratchet teeth 1164 to ramp over housing protrusion 1030.
- the dosage mechanism 126 includes a crank arm 106.
- crank arm 106 is generally V-shaped, having two legs, a crank arm leg 1066 and a pawl arm leg 1068.
- crank ami leg 1066 includes a crank arm pivot hole 1064 at distal end which is configured to be slideably engageable with housing engagement member 1166a of the ratchet gear 116, which allows the crank arm 106 to be rotatable about axis 1160 but be axially fixed.
- the crank arm pivot hole 1064 is generally aligned with axis 1160.
- pawl arm leg 1068 includes a pawl tooth 1062 which is shaped to mesh with ratchet teeth 1 164.
- crank arm 106 includes a push button engagement member 1060, e.g., a projection, at the apex of crank arm 106 that extends from the apex towards slot 1046b on push button 104.
- push button engagement member 1060 is configured to be slideably engageable with slot 1064b.
- axially distal movement of push button 104 relative to housing 102 causes crank ami 106 to rotate about axis 1160 and pawl tooth 1062 to engage ratchet gear teeth 1164, causing ratchet gear 1 16 to rotate pinion teeth 1 162 about axis 1160 that causes ram 108 to distally advance.
- axially proximal movement of push button 104 relative to the housing 102 causes crank arm 106 to rotate about axis 1 160 in an opposite direction and pawl tooth 1062 to disengage ratchet gear teeth 1164.
- the dosage mechanism 126 includes a user-manipulable push button 104 that allows the user to actuate the injection device 100.
- push button 104 is a unitary structure.
- push button 104 is a non-unitary structure.
- push button 104 includes a cap 1040, a connector 1042, a force limiting biasing member 1044, and a base member 1046.
- cap 1040 includes a user-contacting portion 1040a and tabs 1040b.
- user-contacting portion 1040a has a hollow portion configured to facilitate connection with connector 1042.
- tabs 1040b are configured to snap fit with corresponding features of connector 1042.
- cap 1040 is molded from plastic. In other embodiments, cap 1040a is covered with a soft touch material. In one embodiment, tabs 1040b are sized and shaped to be fixed within connector 1042.
- cap 1040 and connector 1042 are different colors. In one embodiment, when injection device 100 is in the fired state, connector 1042 is not visible. In one embodiment, when injection device 100 is not in a fired state, the connector 1042 is visible. In one embodiment, cap 1040 and connector 1042 are different colors so that a user can visually determine whether injection device 100 is in a fired state or not in a fired state.
- connector 1042 of push button 104 includes connector body 1042a having a hollow portion 1042b, tabs 1042c, and a linear travel guide 1042f.
- connector 1042 of push button 104 includes connector body 1042a having an indicating band 1042e.
- tabs 1042c proximally extend from connector body 1042a.
- tabs 1042c are sized and shaped to facilitate a fixed connection between cap 1040 and connector 1042.
- Cap 1040 and connector 1042 are shown as being fixedly connected via the use of tabs in FIG. 8.
- cap 1040 and connector 1042 are integrally formed, such as by being made of a one-piece plastic injection molding, or a one-piece metal part.
- a linear travel guide 1042f extends from a distal portion of the connector body 1042a.
- linear travel guide 1042f is configured to limit withdrawal of the push button from housing 102 and insertion of the push button into housing 102.
- linear travel guide 1042f includes a shelf 1042d configured to engage housing 102 to limit withdrawal of the push button from housing 102.
- linear travel guide 1042f includes a guide base 1042g configured to engage housing 102 to limit insertion of the push button into housing 102.
- shelf 1042d is sized and shaped to engage with lip 1032 of housing 102 to limit withdrawal of the push button 104 from housing 102.
- guide base 1042g is sized and shaped to engage a base engaging member 1034 of housing 102 to limit insertion of the push 14 023485 button 104 into the housing.
- the linear travel guide 1042f is sized and shaped to slideably fit within shelf engaging openings 1036 of housing 102 to limit both the withdrawal and insertion of push button 104 into and out of housing 102.
- linear travel guide 1042f is used to keep connector body 1042 aligned axially with the housing parts 1020a and 1020b. As shown FIG. 8, in some embodiments, the linear travel guide 1042f extends continuously along the circumference of the connector body 1042a. As shown in FIGS. 9A, 9B, and 9C, in other embodiments, linear travel guide 1042f extends discontinuously along the circumference of the connector body 1042a.
- indicating band 1042e is configured to be visible to a user when push button 104 has been properly withdrawn from the housing 102 to prepare injection device 100 for medicament delivery. As shown in FIG. 8, in one embodiment, indicating band 1042e extends continuously along the circumference of connector body 1042a. As shown in FIGS.
- indicating band 1042e extends discontinuously along the circumference of connector body 1042a.
- indicating band 1042e can incorporate a color, e.g., red, to add to the affect thereof.
- injection device 100 when indicating band 1042e is visible, injection device 100 is in the ready (or reset) state. In one embodiment, when injecting band 1042e is not visible, injection device 100 is in the fired state.
- hollow portion 1042b of connector body 1042a is sized and shaped to hold force limiting biasing member 1044.
- force limiting biasing member 1044 of push button 104 is a metal, helically-coiled compression spring. In one embodiment, force limiting biasing member 1044 is disposed within hollow portion 1042b of connector body 1042a. In one embodiment, force limiting biasing member 1044 is captured in a pre-stressed force state between the interior end of cap 1040 and a top portion of flanges 1046a of base member 1046 (described in more detail below). In one embodiment, the pre-stressing force is at minimum as large as forces users exert on the push button during proper operation of injection device 100. In one embodiment, the pre-stressing force is no larger than what the dosing mechanism 126 can withstand without damage to the interacting components.
- force limiting biasing member 1044 does not further compress, as shown in FIGS. 10A, 10B, and IOC.
- FIGS. 10A, 10B, and IOC show an exemplary force limiting biasing member 1044 during normal operation of injection device 100.
- FIGS. 10A, 10B, and IOC show an exemplary force limiting biasing member 1044 during normal operation of injection device 100.
- force limiting biasing member 1044 is designed with sufficient spacing in its coiling, and with proper elastic properties, such that the force limiting biasing member 1044, by compression, can accommodate movement of push button 104 from a ready (or reset) state to a fired stated without movement of ram 108, ratchet gear 116, or crank arm 106, whereby force limiting biasing member 1044 can absorb actuation forces that could damage components.
- FIGS. 1 1 A, 1 IB, 1 1C, and 1 ID show an exemplary force limiting biasing member 1044 compressing within connector 1042 which can occur when for example there a needle is miscoupled or occluded.
- injection device 100 has a ready (or reset) state wherein push button 104 is withdrawn from the housing 102 and indicator 1042 is visible to the user, as shown in FIG. 12C.
- injection device 100 has a fired state wherein push button 104 is actuated and the base rim of cap 1040 is flush against a top portion of the housing 102, as shown in FIGS. 12A and 12E.
- movement of push button 104 distally along axis 124 from a ready (or reset) state towards a fired state is considered firing motion, as shown in FIGS. 12C through 12E.
- movement of push button 104 proximally along axis 124 from a fired state towards a ready (or reset) state is considered resetting motion, as shown in FIGS. 12A through 12C.
- base member 1046 includes a lockout aperture 1046g configured for use with a lock-out feature (described in more detail below).
- base member 1046 of push button 104 includes flanges 1046a that are configured to be slideably connected within the hollow portion 1042b of connector 1042.
- flanges 1046a are configured to be slideably connected to tracks disposed within the hollow portion 1042b of connector 1042 to ensure axial alignment of base member 1046 and connector 1042.
- connection of flanges 1046a and the hollow portion 1042b of connector 1042 are such that base member 1046 is restricted to sliding generally axially along the interior surface of the hollow portion 1042 and such that the base member 1046 is restricted from generally rotating about the interior surface of the hollow portion 1042.
- base member 1046 and housing 1020b are integrally connected to restrict movement of push button 104 to linear movements along axis 124.
- base member 1046 is configured to engage housing 102 to restrict movement of push button 104 to linear movement along axis 124. In certain embodiments, as shown in FIGS.
- base member 1046 has housing engagement slots 1046e that engage base member engagement plates 1021 of housing 1020b to restrict 3485 movement of push button 104 to linear movement along axis 124.
- base member 1046 has a housing engagement protrusion 1046f that is configured to engage base member engagement slot 1038 of housing 1020b to restrict movement of push button 104 to linear movements along axis 124.
- base member 1046 includes a slot 1046b disposed through the base member 1046.
- slot 1046b is configured to engage push button engagement member 1060 of crank arm 106.
- slot 1046b is slideably engageable with push button engagement member 1060.
- slot 1046b is generally rectangular shaped.
- slot 1046b is generally rectangular shaped with curved ends.
- slot 1046b is generally polygonal, in another embodiment, slot 1046 is curved.
- slot 1046b is oriented at an oblique angle with respect to axis 124.
- translation of push button 104 distally or proximally along axis 124 causes push button engagement member 1060 to translate along the path of slot 1046b.
- translation of push button 104 from a ready (or reset) state distally along axis 124 causes push button engagement member 1060 to translate along the path of slot 1046b, causing crank arm 106 to rotate about axis 1 160.
- the path traced by slot 1046b could be of any geometry that crank arm engagement member 1060 could travel in. While keeping the start position and end position of this slot the same, a fixed dose can be achieved while varying the button force profile exerted by the user.
- slot 1046b of base member 1046 has portion 1046i and portion 1046j.
- portion 1046i and portion 1046j of slot 1046b are at different angles with respect to axis 124.
- portion 1046i is oriented at an oblique angle with respect to axis 124.
- portion 1046j is oriented parallel to axis 124.
- slot portion 1046j allows a user to translate push button 104 from a ready (or reset) state distally along axis 124 for a distance without movement of any other components of dosing mechanism 126.
- translation of push button 104 distally along axis 124 from a ready (or reset) state translates push button engagement member 1060 (Fig. 7) along the path of slot portion 1046j, which keeps crank arm 106 from rotating about axis 1160 (Fig. 3B).
- push button engagement member 1060 when push button engagement member 1060 is positioned at the most distal portion of slot portion 1046i, further translation of push button 104 distally along axis 124 translates push button engagement member 1060 along the path of slot 1046i, causing crank arm 106 to rotate about axis 1 160.
- the orientation of slot portion 1046j allows a user to press push button 104 for a period of time without injecting any medicament.
- slot portion 1046i could have the same orientation with the same effect that push button 104 is pushed without the injection of medicament.
- the slot portion 1046j allows the user to build up momentum of push button 104 prior to injection of a medicament dose. Injection of medicament into a user can often time cause discomfort to the user, which can cause the user to withdraw the injection needle prior to full medicament dose injection.
- the momentum of push button 104 that is built up as the user presses push button without injection of medicament is sufficient to allow for injection of a medicament dose with sufficient speed as to not provide the user time to react to any discomfort from medicament injection and withdraw the injection needle prior to full medicament dose injection.
- the geometry of 1046j would have a vertical portion on the proximal end.
- slot angles with longer or shorter sections alike 1046j or curved or parabolic slot would have changing force profiles of the button.
- a straight linear slot is implemented to keep constant force and contact with crank arm engagement member.
- the angle produced by the slot is a product of two dimensions.
- the vertical dimension which stretches from the distal portion of the slot to the proximal portion of the slot and parallel to proximal- distal axis 124, is correlated to the desired button stroke.
- the horizontal dimension, perpendicular to proximal-distal axis 124 and stretching from the two furthest points on the slot directly correlate to the rotation of the crank arm 106.
- base member 1046 includes a flexible column 1046c extending proximally from a distal portion of base member 1046.
- a column tooth 1046d extends perpendicularly from a proximal portion of flexible column 1046c.
- column tooth 1046d is generally almond shaped, as shown in FIG. 9 A.
- column tooth 1046d is generally cylindrically shaped, as shown in FIG. 8.
- column tooth 1046d is generally polyhedronally shaped. Other shapes of column teeth 1046d are within the scope of this invention. In one embodiment, as shown in FIGS.
- column tooth 1046d is configured to engage the anti -retrograde ratchet side 1022b of unidirectional rack 1022.
- a unidirectional rack 1022 is integrally formed on the internal surfaces of housing parts 1020a and 1020b.
- column tooth 1046d can be found in a double shear type load, which is known to be stronger and more stable than single shear configurations.
- unidirectional rack 1022 is formed on the internal surface of only of housing parts 1020a and 1020b, placing unidirectional rack 1022 and column tooth 1046d in a single shear configuration.
- unidirectional rack 1022 has a smooth linear ratchet side 1022a and an anti-retrograde ratchet side 1022b.
- the anti-retrograde ratcheted side 1022b of unidirectional rack 1022 is configured to engage column tooth 1046d and only allow movement of push button 104 in one direction, e.g., from the fired state to the ready (or reset) state.
- the anti-retrograde ratchet side 1022b of unidirectional rack 1022 has curved surfaces at both a proximal end and a distal end.
- the proximal curved surface of anti-retrograde ratchet side 1022b is configured to bias the flexible column in a way to force column tooth 1046d to the smooth linear ratchet side 1022a of the unidirectional rack 1022.
- the distal curved surface of anti- retrograde ratchet side 1022b is configured to bias the flexible column 1046c in a way to force column tooth 1046d to the anti-retrograde ratchet side 1022b of unidirectional rack 1022.
- protrusions 1046d engage the distal curved surfaces of unidirectional rack 1022 causing flexible column 1046 to bias and forcing protrusions 1046d to the anti-retrograde ratchet side 1022b of unidirectional rack 1022, as shown in FIGS. 12A and 12B.
- protrusions 1046d would engage the ratchets of anti -retrograde ratchet side 1022b of unidirectional rack 1022, preventing distal movement.
- protrusions 1046d engage the proximal curved surfaces of anti-retrograde ratchet side 1022b of unidirectional rack 1022, causing flexible column 1046 to bias and forcing column tooth 1046d to the smooth linear ratchet side 1022a of unidirectional rack 1022, as shown in FIGS. 12C and 12D .
- the column tooth 1046d slides along the smooth linear ratchet side 1022a of unidirectional rack 1022 until the device is in the fired state.
- the full amount of medicament which is to be expelled during the firing motion is only fully expelled upon push button 104 reaching the fired state.
- the combination of the flexible column 1046c, column tooth 1046d and anti-retrograde ratchet side 1022b of unidirectional rackl022 are considered the anti-reverse feature.
- the combination of the interactions between the flexible column 1046c, column tooth 1046d and anti-retrograde ratchet side 1022b of unidirectional rack 1022, and the engagement of pawl 1026 of the housing 1020b with pawl engaging teeth 1082 are considered the anti-reverse feature.
- the dosing mechanism 126 includes a lock-out feature, e.g., prevention of push button 104 from resetting from its fired position upon completion of the allotted medicament doses.
- the lock-out feature includes a protrusion 1094, which extends from a proximal portion of ram shaft 1086 in an opposite direction of support bar 1088 (Fig. 4), and a lockout aperture 1046g disposed in the base member 1046 of push button 104 (Fig. 8).
- lockout aperture 1046g is disposed above slot 1046b.
- protrusion 1094 is sized and shaped to protrude into lockout aperture 1046g.
- lockout aperture 1046g is of a complimentary shape of protrusion 1094.
- protrusion 1094 slides into lockout aperture 1046g thereby restricting movement of push button 104, e.g., push button 104 cannot reset because it is connected to ram shaft 1086 which is prevented from moving proximally relative to the housing by pawl 1026.
- the proximal surface of protrusion 1094 is designed to promote protrusion 1094 sliding into lock out aperture 1046g.
- the distal surface of protrusion 1094 is designed to remain engaged with the proximal surface of lockout aperture 1046g.
- the lock-out feature includes a protrusion 1096 (as shown in FIG. 18), which extends from a proximal portion of ram shaft 1086, a lock-out member 2000 integrally formed within housing part 1020b, and a flange 1046h extending from base member 1046 towards housing 1020b.
- a protrusion 1096 as shown in FIG. 18
- lock-out member 2000 is only attached to the housing via a housing cross plate at a distal end of the lock-out member 2000.
- lock-out member 2000 is flexible.
- lock-out member 2000 includes a lockout deflector 2000a and a hook 2000b.
- lockout deflector 2000a of lock-out member 2000 is centrally positioned on the lock-out member 2000.
- lockout deflector 2000a of lock-out member 2000 is configured to engage protrusion 1096 of ram 108.
- lockout deflector 2000a of lockout member 2000 is configured to slidingly engage protrusion 1096 of ram 108.
- hook 2000b of lock-out member 2000 is positioned at a proximal end of lock-out member 2000. In another embodiment, hook 2000b is configured to engage flange 1046h of base member 1046. As shown in FIGS. 13A and 13B, in one embodiment, during the firing motion of push button 104 of the final medicament dose of the injection device 100, protrusion 1096 of ram 108 engages lockout deflector 2000a of lock-out member 2000. In one embodiment, engagement of protrusion 1096 and lockout deflector 2000a biases lock-out member 2000 such that hook 2000b extends into the path of flange 1046h. As shown in FIGS.
- any attempted resetting motion of push button 104 would cause engagement of hook 2000b and flange 1046h.
- engagement of hook 2000b and flange 1046h prevent any resetting motion of push button 104, thus, locking out the device from further use.
- a portion of housing part 1020b is cut out in the shape of lock-out member 2000. The cut out portion of housing part 1020b is aligned with lock-out member 2000 so as to give a visual indication that the lock-out feature has been activated.
- injection device 100 includes a cover 130 engagable with housing 102 that removably covers the cut out portion of housing part 1020b.
- the dosing mechanism described herein is shown as a part of a needled injection device for a liquid medicament, it is understood that the mechanism can be used in other dispensing devices that include a dispenser that is actuated by linear motion. This includes injection devices that use a mechanism other than a push button as well as other dispensing devices for gels or the like which may or may not contain a medicament.
- the dose size can be varied by changing the diameter of cartridge 112. In certain embodiments, a higher diameter will increase the dose size. In other embodiments, a smaller diameter will decrease the dose size. In one embodiment, varying the space between pawl engaging teeth 1082 and, correspondingly, pinion teeth 1162, can vary the dose size. In other embodiments, varying the shape of crank arm 106, the length of the crank arm leg 1066 or pawl arm leg 1068, or the angle of slot 1046b of base member 1046 can vary the dose size by varying the rotational angle of ratchet gear 1 16 caused by crank arm 106. These factors can be adjusted to derive an injector that contains a desired amount of liquid medicament and will produce the desired number of doses at a desired amount, and in certain embodiments fixed amount, and will have the desired dosing and resetting motions.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2905031A CA2905031C (en) | 2013-03-11 | 2014-03-11 | Dosage injector with pinion system |
EP19173290.8A EP3572108A1 (en) | 2013-03-11 | 2014-03-11 | Dosage injector with pinion system |
ES14778806T ES2742046T3 (en) | 2013-03-11 | 2014-03-11 | Dose injector with pinion system |
JP2016501243A JP6030803B2 (en) | 2013-03-11 | 2014-03-11 | Dose syringe with pinion system |
EP14778806.1A EP2968792B1 (en) | 2013-03-11 | 2014-03-11 | Dosage injector with pinion system |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361776269P | 2013-03-11 | 2013-03-11 | |
US61/776,269 | 2013-03-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2014164786A1 true WO2014164786A1 (en) | 2014-10-09 |
Family
ID=51488681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2014/023485 WO2014164786A1 (en) | 2013-03-11 | 2014-03-11 | Dosage injector with pinion system |
Country Status (6)
Country | Link |
---|---|
US (4) | US9707354B2 (en) |
EP (2) | EP3572108A1 (en) |
JP (1) | JP6030803B2 (en) |
CA (1) | CA2905031C (en) |
ES (1) | ES2742046T3 (en) |
WO (1) | WO2014164786A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
CA3070644C (en) | 2008-05-20 | 2022-09-13 | Avant Medical Corp. | Autoinjector system |
US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
PT2699293T (en) | 2011-04-20 | 2019-05-21 | Amgen Inc | Autoinjector apparatus |
USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
US11014696B2 (en) * | 2017-07-12 | 2021-05-25 | Vanrx Pharmasystems Inc. | Purgeable pharmaceutical fill needle |
JP6109352B2 (en) | 2013-03-14 | 2017-04-05 | ノートン・ヘルスケア・リミテッド | Dosing mechanism for medical devices |
US10314980B2 (en) | 2013-03-14 | 2019-06-11 | Norton Healthcare Limited | Dispensing mechanism for a medical device |
GB2511806A (en) * | 2013-03-14 | 2014-09-17 | Norton Healthcare Ltd | Dispensing mechanism for a medical device |
TWI580452B (en) | 2013-03-15 | 2017-05-01 | 安美基公司 | Cassette for an injector, injector, and method of using an apparatus comprising an autoinjector and a cassette |
WO2014144096A1 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
JP6720167B2 (en) * | 2014-11-12 | 2020-07-08 | ノボ・ノルデイスク・エー/エス | Method of manufacturing one of a range of auto-injectors |
EP3274026A2 (en) * | 2015-03-23 | 2018-01-31 | Sanofi-Aventis Deutschland GmbH | Injection device |
US10842941B2 (en) * | 2017-06-22 | 2020-11-24 | Wisconsin Alumni Research Foundation | Syringe attachment device and methods |
CA3101995C (en) | 2018-06-08 | 2023-10-10 | Antares Pharma, Inc. | Auto-insert injector |
US11419991B2 (en) | 2018-11-13 | 2022-08-23 | Credence Medsystems, Inc. | System and method for microdose injection |
CN113646024B (en) | 2019-03-29 | 2023-02-17 | 伊莱利利公司 | Drug delivery device with gear train dosing system |
EP3952958A4 (en) * | 2019-04-09 | 2023-03-15 | Congruence Medical Solutions, LLC | Injection device |
US11865316B2 (en) | 2020-10-23 | 2024-01-09 | Eli Lilly And Company | Medication delivery device including disposable and reusable portions |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050165363A1 (en) | 2002-03-18 | 2005-07-28 | Judson Jared A. | Medication dispensing apparatus with gear set for mechanical advantage |
US20070191784A1 (en) | 2004-03-30 | 2007-08-16 | Jacobs Alexander T | Medication dispensing apparatus with gear set having drive member accommodating opening |
US20110269750A1 (en) * | 2005-03-08 | 2011-11-03 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
US20120157965A1 (en) * | 2009-03-20 | 2012-06-21 | Antares Pharma, Inc. | Hazardous agent injection system |
US20120253287A1 (en) * | 2009-12-15 | 2012-10-04 | Shl Group Ab | Medicament delivery device |
Family Cites Families (775)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1465793A (en) | 1923-08-21 | Detachable spout fob containkbs | ||
US547370A (en) | 1895-10-01 | Detachable spout and can-opener | ||
US1687323A (en) | 1921-07-01 | 1928-10-09 | Cook Lab Inc | Medicament cartridge and hypodermic syringe embodying the same |
US1512294A (en) | 1922-05-02 | 1924-10-21 | Ernest H Marcy | Hypodermic syringe |
US2354649A (en) | 1942-03-04 | 1944-08-01 | Kimble Glass Co | Dental syringe |
GB677523A (en) | 1948-04-13 | 1952-08-20 | Becton Dickinson Co | Discharge structure for hypodermic injection device |
US2699166A (en) | 1949-07-29 | 1955-01-11 | Becton Dickinson Co | Hypodermic injection unit |
US2717601A (en) | 1949-08-10 | 1955-09-13 | Frederick M Turnbull | Syringe ampule |
US2737946A (en) | 1949-09-01 | 1956-03-13 | Jr George N Hein | Hypodermic injection apparatus |
US2648334A (en) | 1949-10-28 | 1953-08-11 | Turnbull | Hypodermic injection assembly |
US2645223A (en) | 1951-02-17 | 1953-07-14 | Becton Dickinson Co | Injection device |
US2607344A (en) | 1951-08-01 | 1952-08-19 | Frederick M Turnbull | Syringe assembly |
US2728341A (en) | 1951-11-05 | 1955-12-27 | Zbislaw M Roehr | Hypodermic syringe |
US2687730A (en) | 1951-12-04 | 1954-08-31 | Jr George N Hein | Ampoule |
US2688967A (en) | 1953-06-02 | 1954-09-14 | Huber Jennie | Metal aspirating syringe |
US2893390A (en) | 1954-04-28 | 1959-07-07 | Edgar H Wilburn | Hypodermic syringes |
GB933975A (en) | 1954-10-27 | 1963-08-14 | Astra Apotekarnes Kem Fab | Operating mechanism for automatic hypodermic syringes |
US2813528A (en) | 1956-02-13 | 1957-11-19 | Omega Prec Medical Instr Co In | Hypodermic syringe |
US2866458A (en) | 1956-05-09 | 1958-12-30 | Becton Dickinson Co | Hypodermic assembly |
US2888924A (en) | 1958-02-25 | 1959-06-02 | Russell P Dunmire | Hypodermic syringes |
US3130724A (en) | 1962-05-07 | 1964-04-28 | Roehr Products Company Inc | Syringe structure |
US3375825A (en) | 1965-09-02 | 1968-04-02 | Becton Dickinson Co | Prefilled syringe |
US3382865A (en) | 1965-10-18 | 1968-05-14 | Ashton L. Worrall Jr. | Device for taking multiple blood samples or the like |
US3526225A (en) | 1967-03-31 | 1970-09-01 | Tokyo Sokuhan Kk | Jet-type hypodermic injection device |
GB1181037A (en) | 1968-05-31 | 1970-02-11 | Glover Lab Proprietary Ltd J | Disposable Hypodermic Syringe |
US3563098A (en) | 1968-06-28 | 1971-02-16 | Rex Chainbelt Inc | Automatic quick release mechanism |
DE1957833A1 (en) | 1968-11-21 | 1970-07-02 | Maurice Steiner | Injection syringe, especially injection syringe handled by the patient himself |
US3557784A (en) | 1968-12-24 | 1971-01-26 | Walter A Shields | Syringe |
GB1216813A (en) | 1969-02-21 | 1970-12-23 | Shozo Narusawa | Transcutaneous injection device |
US3605744A (en) | 1969-04-22 | 1971-09-20 | Edward M Dwyer | Injection apparatus and method of injecting |
US3831814A (en) | 1969-07-25 | 1974-08-27 | Cutter Lab | Trocar-cannula |
BE755224A (en) | 1969-08-25 | 1971-02-24 | Philips Nv | INJECTION SYRINGE |
US3688765A (en) | 1969-10-03 | 1972-09-05 | Jack S Gasaway | Hypodermic injection device |
JPS501001B1 (en) | 1969-10-14 | 1975-01-14 | ||
JPS5016490B1 (en) | 1970-02-19 | 1975-06-13 | ||
US3848593A (en) | 1970-10-09 | 1974-11-19 | Affiliated Hospital Prod | Side loading disposable carpule syringe |
JPS5033792B1 (en) | 1970-12-16 | 1975-11-04 | ||
JPS5026411B1 (en) | 1970-12-24 | 1975-09-01 | ||
US3712301A (en) | 1971-01-11 | 1973-01-23 | Survival Technology | Gun type hypodermic injector with rapid cartridge displacement within holder |
JPS5044625Y2 (en) | 1971-01-26 | 1975-12-18 | ||
US3797491A (en) | 1971-02-11 | 1974-03-19 | Ampoules Inc | Method of performing an intramuscular injection |
US3770026A (en) | 1971-09-17 | 1973-11-06 | J Isenberg | Apparatus and method for accurately loading syringes |
BE795162A (en) | 1972-02-10 | 1973-08-08 | Philips Nv | INJEKTIE-INRICHTING |
US3811441A (en) | 1972-02-10 | 1974-05-21 | Survival Technology | Cartridge syringe |
JPS5112330B2 (en) | 1972-07-24 | 1976-04-19 | ||
US3790048A (en) | 1972-07-28 | 1974-02-05 | Ortho Pharma Corp | Incremental dose dispenser |
JPS5039135B2 (en) | 1972-11-11 | 1975-12-15 | ||
FR2237643B1 (en) | 1973-07-17 | 1978-03-17 | Steiner Maurice | |
US3882863A (en) | 1973-08-01 | 1975-05-13 | Survival Technology | Hypodermic injection device having cannula covered with resilient sheath |
US3946732A (en) | 1973-08-08 | 1976-03-30 | Ampoules, Inc. | Two-chamber mixing syringe |
US3895633A (en) | 1973-09-27 | 1975-07-22 | Survival Technology | Large capacity syringe |
SE7502318L (en) | 1975-03-03 | 1976-09-06 | Af Ekenstam Thuresson Bo | PACKAGING FOR LIQUID FOR SEMI-SOLID MATERIAL, SUITABLE FOR SMALLER QUANTITIES |
AT341649B (en) | 1975-08-07 | 1978-02-27 | Immuno Ag | INJECTION SYRINGE |
US4031893A (en) | 1976-05-14 | 1977-06-28 | Survival Technology, Inc. | Hypodermic injection device having means for varying the medicament capacity thereof |
US4127118B1 (en) | 1977-03-16 | 1995-12-19 | Alvaro Latorre | Method of effecting and enhancing an erection |
US4171698A (en) | 1977-08-15 | 1979-10-23 | Abbott Laboratories | Prefilled two-compartment syringe |
US4222392A (en) | 1979-05-23 | 1980-09-16 | Alier-Screen, Inc. | Allergy testing device with vented base |
US4227528A (en) | 1978-12-26 | 1980-10-14 | Wardlaw Stephen C | Automatic disposable hypodermic syringe |
DE2929425A1 (en) | 1979-07-20 | 1981-02-12 | Lothar Kling | DEVICE FOR INJECTION SYRINGES FOR INTRAMUSCULAR AND SUBENTANE INJECTION |
US4258713A (en) | 1979-07-23 | 1981-03-31 | Wardlaw Stephen C | Automatic disposable hypodermic syringe |
US4338980A (en) | 1980-01-14 | 1982-07-13 | Schwebel Paul R | Device for filling medicament injectors |
US4316643A (en) | 1980-03-25 | 1982-02-23 | The General Tire & Rubber Co. | Vehicle suspension bushing |
US4328802A (en) | 1980-05-14 | 1982-05-11 | Survival Technology, Inc. | Wet dry syringe package |
US4411661A (en) | 1980-10-22 | 1983-10-25 | Travenol European Research And Development Centre | Spike connector |
US4316463A (en) | 1981-01-26 | 1982-02-23 | Vac-O-Cast, Inc. | Corrosive protected hypodermic module |
US4333458A (en) | 1981-02-09 | 1982-06-08 | Sterling Drug Inc. | Self-aspirating syringe with positively engaged locking collet |
US4333456A (en) | 1981-02-09 | 1982-06-08 | Sterling Drug Inc. | Self-aspirating hypodermic syringe and self-aspirating assembly therefor |
FR2506161A1 (en) | 1981-05-20 | 1982-11-26 | Alsetex Armement | Self:injection syringe with compartments for specific liquids - is spring:loaded first to penetrate patient then inject liq.(s), is automatic |
DE3278101D1 (en) | 1981-08-10 | 1988-03-17 | Duphar Int Res | Automatic injection syringe |
US4378015A (en) | 1981-12-21 | 1983-03-29 | Wardlaw Stephen C | Automatic injecting syringe |
US4558690A (en) | 1982-01-26 | 1985-12-17 | University Of Scranton | Method of administration of chemotherapy to tumors |
DE3274802D1 (en) | 1982-08-25 | 1987-02-05 | Wagner Wolfgang | Device for injection by the effect of vacuum on the skin |
ATE23802T1 (en) | 1982-10-27 | 1986-12-15 | Duphar Int Res | AUTOMATIC INJECTION DEVICE. |
FR2539302B1 (en) | 1983-01-17 | 1986-03-14 | Brunet Jean Louis | SYRINGE FOR MEDICAL USE |
US4484910A (en) | 1983-12-21 | 1984-11-27 | Survival Technology, Inc. | Dual mode automatic injector |
US4592745A (en) | 1984-02-29 | 1986-06-03 | Novo Industri A/S | Dispenser |
US5078680A (en) | 1984-08-08 | 1992-01-07 | Survival Technology, Inc. | Automatic injector for emergency treatment |
US4678461A (en) | 1984-11-01 | 1987-07-07 | Survival Technology, Inc. | Automatic injector with improved glass container protector |
EP0186916B1 (en) | 1984-11-02 | 1988-12-21 | Duphar International Research B.V | Automatic injection device |
FR2635009B2 (en) | 1984-11-20 | 1990-11-09 | Poutrait Morin | DEVICE FOR RETAINING A HYPODERMIC SYRINGE BULB IN THE CASE |
US4634027A (en) | 1985-01-04 | 1987-01-06 | Mvm Valve Co., Inc. | Liquid dispensing apparatus and an anti-drip valve cartridge therefor |
DE3673317D1 (en) | 1985-10-11 | 1990-09-13 | Duphar Int Res | AUTOMATIC SYRINGE. |
EP0245312B1 (en) | 1985-11-08 | 1990-05-02 | Disetronic Ag | Injection instrument |
US4662878A (en) | 1985-11-13 | 1987-05-05 | Patents Unlimited Ltd. | Medicine vial adaptor for needleless injector |
IE59361B1 (en) | 1986-01-24 | 1994-02-09 | Akzo Nv | Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension |
US4664653A (en) | 1986-02-24 | 1987-05-12 | Sagstetter William E | Manually operated reusable injection apparatus |
US4664655A (en) | 1986-03-20 | 1987-05-12 | Norman Orentreich | High viscosity fluid delivery system |
US4719825A (en) | 1986-03-24 | 1988-01-19 | Lahaye Peter G | Metering needle assembly |
DE3613489A1 (en) | 1986-04-22 | 1987-11-05 | Helmut Vetter | DEVICE FOR HANDLING PRE-FILLED SYRINGES |
ATE67414T1 (en) | 1986-05-15 | 1991-10-15 | Duphar Int Res | AUTOMATIC INJECTION SYRINGE. |
DE3622399A1 (en) | 1986-07-01 | 1988-02-04 | Eberhardt Schlueter | AUTOMATIC INJECTION DEVICE AND AMPOULE OR CARTRIDGE FOR AN INJECTION DEVICE |
JP2619365B2 (en) | 1986-07-25 | 1997-06-11 | 株式会社日立製作所 | Bloch line memory writing method |
DE3645245C2 (en) | 1986-11-14 | 1994-01-27 | Haselmeier Wilhelm Fa | Injection appliance |
DE3715337C2 (en) | 1986-11-14 | 1994-04-14 | Haselmeier Wilhelm Fa | Injection device |
US4722728A (en) | 1987-01-23 | 1988-02-02 | Patents Unlimited, Ltd. | Needleless hypodermic injector |
DE3715340C2 (en) | 1987-05-08 | 1995-10-19 | Haselmeier Wilhelm Fa | Injection device |
DE3715258C2 (en) | 1987-05-08 | 1996-10-31 | Haselmeier Wilhelm Fa | Injection device |
US5080648A (en) | 1987-06-08 | 1992-01-14 | Antonio Nicholas F D | Hypodermic fluid dispenser |
US5569190A (en) | 1987-06-08 | 1996-10-29 | D'antonio; Nicholas F. | Hypodermic fluid dispenser |
US6056716A (en) | 1987-06-08 | 2000-05-02 | D'antonio Consultants International Inc. | Hypodermic fluid dispenser |
GB8713810D0 (en) | 1987-06-12 | 1987-07-15 | Hypoguard Uk Ltd | Measured dose dispensing device |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
JPH02504391A (en) | 1987-07-31 | 1990-12-13 | シタス コーポレイション | Treatment of infection with tumor necrosis factor |
US4976701A (en) | 1987-09-25 | 1990-12-11 | Nordisk Gentofte A/S | Injection apparatus |
WO1989006989A1 (en) | 1988-01-29 | 1989-08-10 | The Regents Of The University Of California | Iontophoretic non-invasive sampling or delivery device |
US4973318A (en) | 1988-02-10 | 1990-11-27 | D.C.P. Af 1988 A/S | Disposable syringe |
ES2024564B3 (en) | 1988-02-16 | 1992-03-01 | Arzneimittel Gmbh Apotheker Vetter & Co Ravensburg | SYRINGE FOR MEDICINAL PURPOSES |
US4830217A (en) | 1988-02-19 | 1989-05-16 | Becton, Dickinson And Company | Body fluid sample collection tube assembly |
US4913699A (en) | 1988-03-14 | 1990-04-03 | Parsons James S | Disposable needleless injection system |
GB8809115D0 (en) | 1988-04-18 | 1988-05-18 | Turner R C | Syringes |
BR8801952A (en) | 1988-04-22 | 1989-11-14 | Sergio Landau | DISPOSABLE CAPSULE, NOT RE-USABLE, CONTAINING INDIVIDUAL DOSE OF VACCINE TO BE HYPODERMICALLY INJECTED, WITHOUT NEEDLE, WITH PRESSURE INJECTOR |
GB8819977D0 (en) | 1988-08-23 | 1988-09-21 | Medimech Ltd | Automatic injectors |
US4929238A (en) | 1988-11-23 | 1990-05-29 | Coeur Laboratories, Inc. | Multi-pressure injector device |
IT1227658B (en) | 1988-12-01 | 1991-04-23 | Vittorio Boschetti B | DISPOSABLE SYRINGE WITH RETURN AND NEEDLE LOCK AT THE END OF INJECTION FOR THE PURPOSE OF AVOID RE-USE |
GB8900763D0 (en) | 1989-01-13 | 1989-03-08 | Kabi Vitrum Peptide Hormones A | Multi-dose syringe |
US4986816A (en) | 1989-01-18 | 1991-01-22 | On-Gard Systems, Inc. | Needle unsheathing, resheathing and handling apparatus |
US4915701A (en) | 1989-02-21 | 1990-04-10 | Halkyard Douglas R | Protective device and syringe |
DE3916101A1 (en) | 1989-05-17 | 1990-11-22 | Vetter & Co Apotheker | SYRINGE FOR MEDICAL PURPOSES |
US5226895A (en) | 1989-06-05 | 1993-07-13 | Eli Lilly And Company | Multiple dose injection pen |
US5569236A (en) | 1989-06-16 | 1996-10-29 | Science Incorporated | Fluid delivery apparatus |
US5085641A (en) | 1989-07-17 | 1992-02-04 | Survival Technology, Inc. | Conveniently carried frequent use auto-injector with improved cap structure |
US5102393A (en) | 1989-07-17 | 1992-04-07 | Survival Technology, Inc. | Autoinjector converted from intramuscular to subcutaneous mode of injection |
US5085642A (en) | 1989-07-17 | 1992-02-04 | Survival Technology, Inc. | Conveniently carried frequent use autoinjector |
DE3924830A1 (en) | 1989-07-27 | 1991-02-07 | Vetter & Co Apotheker | SYRINGE CYLINDER FOR MEDICAL PURPOSES |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
GB8926825D0 (en) | 1989-11-28 | 1990-01-17 | Glaxo Group Ltd | Device |
ES2042093T3 (en) | 1990-02-07 | 1993-12-01 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | DOUBLE CHAMBER SYRINGE AND EMPLOYMENT PROCEDURE. |
US4982769A (en) | 1990-02-21 | 1991-01-08 | Survival Technology, Inc. | Package |
US5050400A (en) | 1990-02-26 | 1991-09-24 | Bohn, Inc. | Simplified hot gas defrost refrigeration system |
JP3154487B2 (en) | 1990-02-28 | 2001-04-09 | エス・アール・アイ・インターナシヨナル | A method of spectral estimation to improve noise robustness in speech recognition |
GB9007113D0 (en) | 1990-03-29 | 1990-05-30 | Sams Bernard | Dispensing device |
US5062830A (en) | 1990-04-04 | 1991-11-05 | Derata Corporation | Dry disposable nozzle assembly for medical jet injector |
DE4021836C1 (en) | 1990-07-09 | 1991-05-02 | Arzneimittel Gmbh Apotheker Vetter & Co Ravensburg, 7980 Ravensburg, De | |
US5505694A (en) | 1990-08-22 | 1996-04-09 | Tcnl Technologies, Inc. | Apparatus and method for raising a skin wheal |
DK228290D0 (en) | 1990-09-21 | 1990-09-21 | Novo Nordisk As | AND INJECTION UNIT |
US5350367A (en) | 1990-11-06 | 1994-09-27 | Sterling Winthrop Inc. | Snap together hypodermic syringe holder |
EP0511402B1 (en) | 1990-11-17 | 1997-09-10 | Santen Seiyaku Kabushiki Kaisha | Double-chamber type syringe barrel |
US5137528A (en) | 1990-11-26 | 1992-08-11 | Crose Virginia W | Ampoule for administering a liquid local anaesthetic |
GB9100819D0 (en) | 1991-01-15 | 1991-02-27 | Medimech Int Ltd | Subcutaneous injector |
US5405362A (en) | 1991-04-29 | 1995-04-11 | The Board Of Regents For The University Of Texas System | Interactive external defibrillation and drug injection system |
US5271744A (en) | 1991-04-29 | 1993-12-21 | George C. Kramer | System and method for rapid vascular drug delivery |
US5451210A (en) | 1991-04-29 | 1995-09-19 | Lifequest Medical, Inc. | System and method for rapid vascular drug delivery |
US5176643A (en) | 1991-04-29 | 1993-01-05 | George C. Kramer | System and method for rapid vascular drug delivery |
US5868711A (en) | 1991-04-29 | 1999-02-09 | Board Of Regents, The University Of Texas System | Implantable intraosseous device for rapid vascular access |
GB9111049D0 (en) | 1991-05-22 | 1991-07-17 | Parkin Adrian | Hypodermic needle |
GB9111600D0 (en) | 1991-05-30 | 1991-07-24 | Owen Mumford Ltd | Improvements relating to injection devices |
EP0518416A1 (en) | 1991-06-13 | 1992-12-16 | Duphar International Research B.V | Injection device |
US5163907A (en) | 1991-06-24 | 1992-11-17 | Szuszkiewicz Christine M | Single use retractable needle syringe |
US5102388A (en) | 1991-07-15 | 1992-04-07 | Richmond John E | Sequential delivery syringe |
ES2074771T3 (en) | 1991-07-24 | 1995-09-16 | Medico Dev Investment Co | INJECTOR. |
IT1252832B (en) | 1991-08-06 | 1995-06-28 | Sicim Spa | DISPOSABLE HEAD FOR INJECTORS FOR SUBCUTANEOUS INJECTIONS WITHOUT NEEDLE |
DE4127650C1 (en) | 1991-08-21 | 1993-02-25 | Arzneimittel Gmbh Apotheker Vetter & Co Ravensburg, 7980 Ravensburg, De | |
US5195983A (en) | 1991-08-27 | 1993-03-23 | Penta Associates | Syringe guard and disposal system |
US5544234A (en) | 1991-09-04 | 1996-08-06 | Canon Kabushiki Kaisha | Facsimile apparatus with automatic answering telephone function, and communication method in said apparatus |
US5221348A (en) | 1991-11-26 | 1993-06-22 | Masano Thomas C | High pressure glue injector |
US5263934A (en) | 1991-11-28 | 1993-11-23 | Haak Abraham Van Den | Stroke limiting syringe with retractable needle |
US5332399A (en) | 1991-12-20 | 1994-07-26 | Abbott Laboratories | Safety packaging improvements |
GB9200219D0 (en) | 1992-01-07 | 1992-02-26 | Medimech Int Ltd | Automatic injectors |
US5279585A (en) | 1992-02-04 | 1994-01-18 | Becton, Dickinson And Company | Medication delivery pen having improved dose delivery features |
EP0562671B1 (en) | 1992-03-27 | 1996-05-29 | Duphar International Research B.V | Automatic injector |
US5873857A (en) | 1992-04-17 | 1999-02-23 | Science Incorporated | Fluid dispenser with fill adapter |
SE9201246D0 (en) | 1992-04-21 | 1992-04-21 | Kabi Pharmacia Ab | INJECTION CARTRIDGE ARRANGEMENT |
NZ247392A (en) | 1992-04-30 | 1995-05-26 | Takeda Chemical Industries Ltd | Prefilled syringe containing two substances mixed before injection |
US5281198A (en) | 1992-05-04 | 1994-01-25 | Habley Medical Technology Corporation | Pharmaceutical component-mixing delivery assembly |
US5180370A (en) | 1992-05-18 | 1993-01-19 | Gillespie Elgene R | Safety hypodermic syringe with retractable needle |
US5279576A (en) | 1992-05-26 | 1994-01-18 | George Loo | Medication vial adapter |
US5304128A (en) | 1992-09-22 | 1994-04-19 | Habley Medical Technology Corporation | Gas powered self contained syringe |
US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
GB9223183D0 (en) | 1992-11-05 | 1992-12-16 | Medimech Int Ltd | Improvements related to auto injectors |
JPH08505543A (en) | 1992-11-19 | 1996-06-18 | テブロ ソシエテ アノニム | Disposable automatic injection device for prefilled syringe |
JP3172005B2 (en) | 1992-11-27 | 2001-06-04 | 株式会社大協精工 | Syringe and container |
GB9226423D0 (en) | 1992-12-18 | 1993-02-10 | Sams Bernard | Incrementing mechanisms |
WO1994017856A1 (en) | 1993-02-02 | 1994-08-18 | Vidamed, Inc. | Transurethral needle ablation device and method |
AU682670B2 (en) | 1993-02-05 | 1997-10-16 | Becton Dickinson & Company | Syringe needle isolation device |
US5330431A (en) | 1993-03-12 | 1994-07-19 | Glenn Herskowitz | Infusion pump |
EP0693946B1 (en) | 1993-03-24 | 2001-05-16 | Owen Mumford Limited | Improvements relating to injection devices |
US5358489A (en) | 1993-05-27 | 1994-10-25 | Washington Biotech Corporation | Reloadable automatic or manual emergency injection system |
US5540664A (en) | 1993-05-27 | 1996-07-30 | Washington Biotech Corporation | Reloadable automatic or manual emergency injection system |
US5415648A (en) | 1993-07-08 | 1995-05-16 | Malay; Manuel R. | Multiple purpose syringe |
US5891086A (en) | 1993-07-31 | 1999-04-06 | Weston Medical Limited | Needle-less injector |
US5425715A (en) | 1993-08-05 | 1995-06-20 | Survival Technology, Inc. | Reloadable injector |
US5308341A (en) | 1993-09-28 | 1994-05-03 | Becton, Dickinson And Company | Method of testing the dose accuracy of a medication delivery device |
US5593388A (en) | 1993-11-11 | 1997-01-14 | N.J. Phillips Pty. Limited | Injector with retractable shroud |
US5354286A (en) | 1993-12-07 | 1994-10-11 | Survival Technology, Inc. | Injection device having polyparaxylylene coated container |
US5478316A (en) | 1994-02-02 | 1995-12-26 | Becton, Dickinson And Company | Automatic self-injection device |
US5514107A (en) | 1994-02-10 | 1996-05-07 | Habley Medical Technology Corporation | Safety syringe adapter for cartridge-needle unit |
US5514097A (en) | 1994-02-14 | 1996-05-07 | Genentech, Inc. | Self administered injection pen apparatus and method |
WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
FR2718357B1 (en) | 1994-04-06 | 1997-10-03 | Defarges Alain Moreau | Improvements made to a needleless jet injection device. |
GB9408500D0 (en) | 1994-04-28 | 1994-06-22 | Pa Consulting Services | Improvements in or relating to injection devices |
FR2719224B1 (en) | 1994-04-29 | 1996-08-02 | Nycomed Lab Sa | Rapid exchange dilation catheter. |
AU1994295A (en) | 1994-05-16 | 1995-12-05 | Washington Biotech Corporation | Modular automatic or manual emergency medicine injection system |
ATE252924T1 (en) | 1994-05-30 | 2003-11-15 | B D Medico S A R L | INJECTION DEVICE |
GB9412301D0 (en) | 1994-06-17 | 1994-08-10 | Safe T Ltd | Hollow-needle drugs etc applicators |
US5827232A (en) | 1994-06-22 | 1998-10-27 | Becton Dickinson And Company | Quick connect medication delivery pen |
US5725508A (en) | 1994-06-22 | 1998-03-10 | Becton Dickinson And Company | Quick connect medication delivery pen |
IE72524B1 (en) | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
US5637094A (en) | 1994-11-04 | 1997-06-10 | Pos-T-Vac, Inc. | Multiple dosage syringe |
DE4445969C1 (en) | 1994-12-22 | 1996-03-14 | Schott Glaswerke | Syringe cylinder with two compartments for two constituents |
US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
AU696439B2 (en) | 1995-03-07 | 1998-09-10 | Eli Lilly And Company | Recyclable medication dispensing device |
GB9506087D0 (en) | 1995-03-24 | 1995-05-10 | Owen Mumford Ltd | Improvements relating to medical injection devices |
US5562625A (en) | 1995-05-02 | 1996-10-08 | Stefancin, Jr.; Ronald J. | Reusasble syringe with a disposable needle sheath |
IT1275428B (en) | 1995-05-16 | 1997-08-07 | Bracco Spa | PROCESS FOR THE PRODUCTION OF PRE-FILLED SYRINGES WITHOUT RESIDUAL GAS BUBBLES |
US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
US6245347B1 (en) | 1995-07-28 | 2001-06-12 | Zars, Inc. | Methods and apparatus for improved administration of pharmaceutically active compounds |
AU1860697A (en) | 1995-09-08 | 1997-07-28 | Visionary Medical Products Corporation | Pen-type injector drive mechanism |
US5688251A (en) | 1995-09-19 | 1997-11-18 | Becton Dickinson And Company | Cartridge loading and priming mechanism for a pen injector |
US5542760A (en) | 1995-09-26 | 1996-08-06 | Becton Dickinson And Company | Syringe filler for mixing insulins |
DE19537163C1 (en) | 1995-10-06 | 1997-01-30 | Vetter & Co Apotheker | Syringe for medical purposes |
US6080130A (en) | 1998-11-14 | 2000-06-27 | Castellano; Thomas P. | Gas power source for a needle-less injector |
US5776103A (en) | 1995-10-11 | 1998-07-07 | Science Incorporated | Fluid delivery device with bolus injection site |
US5658259A (en) | 1995-10-19 | 1997-08-19 | Meridian Medical Technologies, Inc. | Dental cartridge assembly auto-injector with protective needle cover |
US5567160A (en) | 1995-10-26 | 1996-10-22 | Survival Technology, Inc. | Autoinjector training device |
ZA9610374B (en) | 1995-12-11 | 1997-06-23 | Elan Med Tech | Cartridge-based drug delivery device |
US5836911A (en) | 1996-02-01 | 1998-11-17 | Medi-Ject Corporation | Injection device having positioning means |
US5865795A (en) | 1996-02-29 | 1999-02-02 | Medi-Ject Corporation | Safety mechanism for injection devices |
US5860456A (en) | 1996-03-22 | 1999-01-19 | Eli Lilly And Company | Syringe alignment device |
US5801057A (en) | 1996-03-22 | 1998-09-01 | Smart; Wilson H. | Microsampling device and method of construction |
US5769138A (en) | 1996-04-01 | 1998-06-23 | Medi-Ject Corporation | Nozzle and adapter for loading medicament into an injector |
IT1284642B1 (en) | 1996-05-02 | 1998-05-21 | Ermanno Greco | REFINEMENTS FOR AUTOMATIC SYRINGES FOR INJECTION |
GB9612724D0 (en) | 1996-06-18 | 1996-08-21 | Owen Mumford Ltd | Improvements relating to injection devices |
US5843036A (en) | 1996-08-23 | 1998-12-01 | Becton Dickinson And Company | Non-dosing cartridge for an injection device |
US5875976A (en) | 1996-12-24 | 1999-03-02 | Medi-Ject Corporation | Locking mechanism for nozzle assembly |
WO1998031369A1 (en) | 1997-01-16 | 1998-07-23 | Sekisui Chemical Co., Ltd. | External preparations for percutaneous absorption |
GB9701413D0 (en) | 1997-01-24 | 1997-03-12 | Smithkline Beecham Biolog | Novel device |
KR20000070460A (en) | 1997-01-24 | 2000-11-25 | 왈리스 조 앤 | Treatment of autoimmune disease using tolerization in combination with methotrexate |
US6607509B2 (en) | 1997-12-31 | 2003-08-19 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
US5851197A (en) | 1997-02-05 | 1998-12-22 | Minimed Inc. | Injector for a subcutaneous infusion set |
BR9700930A (en) | 1997-02-07 | 1998-12-08 | Rhone Poulenc Rorer Gmbh | Unit for sale intended for parenteral application a device for the execution of parenteral application as well as a refill unit for the above mentioned unit for sale |
JP2003514587A (en) | 1997-07-14 | 2003-04-22 | ノボ ノルディスク アクティーゼルスカブ | Injection parts |
GB9714948D0 (en) | 1997-07-16 | 1997-09-17 | Owen Mumford Ltd | Improvements relating to injection devices |
US6171276B1 (en) | 1997-08-06 | 2001-01-09 | Pharmacia & Upjohn Ab | Automated delivery device and method for its operation |
US5921966A (en) | 1997-08-11 | 1999-07-13 | Becton Dickinson And Company | Medication delivery pen having an improved clutch assembly |
US6656163B1 (en) | 1997-08-21 | 2003-12-02 | Ares-Trading S.A. | Injection devices |
IE970782A1 (en) | 1997-10-22 | 1999-05-05 | Elan Corp | An improved automatic syringe |
US6045534A (en) | 1997-10-27 | 2000-04-04 | Sarcos, Inc. | Disposable fluid injection module |
FR2770404B1 (en) | 1997-11-05 | 2000-01-28 | Sedat | AUTOMATIC INJECTOR WITH NEEDLE RETRACTION AT THE END OF INJECTION |
DE19751219A1 (en) | 1997-11-19 | 1999-05-27 | Vetter & Co Apotheker | Syringe, especially prefilled syringe, or carpule |
DE59811344D1 (en) | 1997-11-19 | 2004-06-09 | B D Medico S A R L | NEEDLE ARRANGEMENT |
US6706000B2 (en) | 1997-11-21 | 2004-03-16 | Amira Medical | Methods and apparatus for expressing body fluid from an incision |
AU738058B2 (en) | 1997-12-16 | 2001-09-06 | Meridian Medical Technologies, Inc. | Automatic injector |
DE29801168U1 (en) | 1998-01-24 | 1999-08-12 | Medico Dev Investment Co | Injection device |
DE69900026T2 (en) | 1998-01-30 | 2001-05-10 | Novo Nordisk As | AN INJECTION SYRINGE |
GB9803084D0 (en) | 1998-02-14 | 1998-04-08 | Owen Mumford Ltd | Improvements relating to medical injection devices |
US6221053B1 (en) | 1998-02-20 | 2001-04-24 | Becton, Dickinson And Company | Multi-featured medication delivery pen |
US5935949A (en) | 1998-03-20 | 1999-08-10 | Trustees Of Dartmouth College | Use of androgen therapy in fibromyalgia and chronic fatigue syndrome |
GB9808408D0 (en) | 1998-04-18 | 1998-06-17 | Owen Mumford Ltd | Improvements relating to injection devices |
DE19822031C2 (en) | 1998-05-15 | 2000-03-23 | Disetronic Licensing Ag | Auto injection device |
JP2002516867A (en) | 1998-06-05 | 2002-06-11 | スーパージェン インコーポレイテッド | Composition comprising methotrexate and pentostatin for treating rheumatoid arthritis |
WO2000006227A1 (en) | 1998-07-27 | 2000-02-10 | Medi-Ject Corporation | Loading mechanism for medical injector assembly |
WO2000006228A1 (en) | 1998-07-27 | 2000-02-10 | Medi-Ject Corporation | Injection-assisting probe for medical injector assembly |
US6428528B2 (en) | 1998-08-11 | 2002-08-06 | Antares Pharma, Inc. | Needle assisted jet injector |
SE9803662D0 (en) | 1998-10-26 | 1998-10-26 | Pharmacia & Upjohn Ab | autoinjector |
US6264629B1 (en) | 1998-11-18 | 2001-07-24 | Bioject, Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
US6383168B1 (en) | 1998-12-08 | 2002-05-07 | Bioject Medical Technologies Inc. | Needleless syringe with prefilled cartridge |
US6132395A (en) | 1998-12-08 | 2000-10-17 | Bioject, Inc. | Needleless syringe with prefilled cartridge |
US6083201A (en) | 1999-01-07 | 2000-07-04 | Mckinley Medical, Llp | Multi-dose infusion pump |
DE29900482U1 (en) | 1999-01-14 | 2000-08-31 | Medico Dev Investment Co | Injection device |
US6695830B2 (en) | 1999-01-15 | 2004-02-24 | Scimed Life Systems, Inc. | Method for delivering medication into an arterial wall for prevention of restenosis |
GB9903475D0 (en) | 1999-02-17 | 1999-04-07 | Owen Mumford Ltd | Improvements relating to injection devices |
EP1033143B1 (en) | 1999-02-26 | 2007-01-10 | F. Hoffmann-La Roche Ag | Device for administering a medication |
SE9901366D0 (en) | 1999-04-16 | 1999-04-16 | Pharmacia & Upjohn Ab | Injector device and method for its operation |
KR100335050B1 (en) | 1999-07-06 | 2002-05-02 | 구자홍 | multiple micro wave oven |
DE19935681A1 (en) | 1999-07-29 | 2001-02-15 | Vetter & Co Apotheker | Device for filling a syringe barrel and / or for placing a stopper in the syringe barrel |
ES2258469T3 (en) | 1999-08-05 | 2006-09-01 | Becton Dickinson And Company | MEDICATION ADMINISTRATION PENCIL. |
US6319224B1 (en) | 1999-08-20 | 2001-11-20 | Bioject Medical Technologies Inc. | Intradermal injection system for injecting DNA-based injectables into humans |
US8465468B1 (en) | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
US6569143B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Method of intradermally injecting substances |
US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
US6569123B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Prefillable intradermal injector |
US6673035B1 (en) | 1999-10-22 | 2004-01-06 | Antares Pharma, Inc. | Medical injector and medicament loading system for use therewith |
US6391003B1 (en) | 1999-10-25 | 2002-05-21 | Antares Pharma, Inc. | Locking mechanism for a jet injector |
EP1253958B1 (en) | 2000-01-27 | 2004-11-10 | Afra Design PTY. Limited | A single-use syringe |
ATE275914T1 (en) | 2000-02-16 | 2004-10-15 | Haselmeier S A R L | METHOD FOR RECONSTITUTING AN INJECTION FLUID AND INJECTION DEVICE FOR CARRYING OUT SUCH PROCESS |
GB0003790D0 (en) | 2000-02-18 | 2000-04-05 | Astrazeneca Uk Ltd | Medical device |
US6689092B2 (en) | 2000-03-03 | 2004-02-10 | Boehringer International Gmbh | Needle-less injector of miniature type |
AU2001247721A1 (en) | 2000-03-23 | 2001-10-03 | Antares Pharma, Inc. | Single use disposable jet injector |
GB0007071D0 (en) | 2000-03-24 | 2000-05-17 | Sams Bernard | One-way clutch mechanisms and injector devices |
US6607508B2 (en) | 2000-04-27 | 2003-08-19 | Invivotech, Inc. | Vial injector device |
US6613025B1 (en) | 2000-05-25 | 2003-09-02 | Scimed Life Systems, Inc. | Method and apparatus for diagnostic and therapeutic agent delivery |
US6547764B2 (en) | 2000-05-31 | 2003-04-15 | Novo Nordisk A/S | Double pointed injection needle |
US6517517B1 (en) | 2000-06-08 | 2003-02-11 | Mayo Foundation For Medical Education And Research | Automated injection device for administration of liquid medicament |
US6406456B1 (en) | 2000-06-08 | 2002-06-18 | Avant Drug Delivery Systems, Inc. | Jet injector |
WO2001095960A1 (en) | 2000-06-15 | 2001-12-20 | Hambley Limited | Hypodermic syringe with passive aspiration feature |
US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
US6530904B1 (en) | 2000-08-15 | 2003-03-11 | Evan T. Edwards | Medical injector |
ES2267820T3 (en) | 2000-10-09 | 2007-03-16 | Eli Lilly And Company | PEN TYPE DEVICE FOR THE ADMINISTRATION OF PARTIROID HORMONE. |
US6656150B2 (en) | 2000-10-10 | 2003-12-02 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
US7621887B2 (en) | 2000-10-10 | 2009-11-24 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
US6641561B1 (en) | 2000-10-10 | 2003-11-04 | Meridian Medical Technologies, Inc. | Drug delivery device |
FR2815543B1 (en) | 2000-10-19 | 2003-10-24 | Sedat | SELF-INJECTION SYRINGE OF AN EXTEMPORANEOUS MIXTURE |
SE518981C2 (en) | 2000-12-14 | 2002-12-17 | Shl Medical Ab | autoinjector |
US6387078B1 (en) | 2000-12-21 | 2002-05-14 | Gillespie, Iii Richard D. | Automatic mixing and injecting apparatus |
IL156245A0 (en) | 2000-12-22 | 2004-01-04 | Dca Design Int Ltd | Drive mechanism for an injection device |
DE10106367B4 (en) | 2001-02-12 | 2009-11-19 | Tecpharma Licensing Ag | A reading aid for a device for administering an adjustable dose of an injectable product |
US6645170B2 (en) | 2001-03-05 | 2003-11-11 | Bioject Medical Technologies, Inc. | Simplified disposable needle-free injection apparatus and method |
US6471669B2 (en) | 2001-03-05 | 2002-10-29 | Bioject Medical Technologies Inc. | Disposable needle-free injection apparatus and method |
JP2002264621A (en) | 2001-03-12 | 2002-09-18 | Pacific Ind Co Ltd | Transmitter of tire condition monitoring device |
GB0107604D0 (en) | 2001-03-27 | 2001-05-16 | Dca Design Int Ltd | Improvements in and relating to injection device |
GB0107608D0 (en) | 2001-03-27 | 2001-05-16 | Dca Design Int Ltd | Improvements in and relating to an injection device |
CA2444377C (en) | 2001-04-13 | 2014-09-02 | Paul G. Alchas | Method of intradermally injecting substances |
GB0110053D0 (en) | 2001-04-24 | 2001-06-13 | Axis Shield Asa | Assay |
US6903100B2 (en) | 2001-05-03 | 2005-06-07 | Midamerica Neuroscience Research Foundation | Use of regularly scheduled high dose intravenous methotrexate therapy, with interim administration of immunomodulatory agents, to treat multiple sclerosis and other diseases of the central nervous system |
EP1776975B1 (en) | 2001-05-16 | 2011-06-22 | Eli Lilly & Company | Medication injector apparatus with drive assembly that facilitates reset |
US6585685B2 (en) | 2001-06-08 | 2003-07-01 | Bioject Inc. | Jet injector apparatus and method |
US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
DE10129585A1 (en) | 2001-06-20 | 2003-01-09 | Disetronic Licensing Ag | Device for the dosed administration of an injectable product |
DE60203118T2 (en) | 2001-07-16 | 2006-04-13 | Eli Lilly And Co., Indianapolis | MEDICAMENT ADMINISTRATION DEVICE WITH ROTATION PRIMING AND BY PULL / MOVE EXECUTABLE INJECTION |
US7544188B2 (en) | 2001-07-19 | 2009-06-09 | Intelliject, Inc. | Medical injector |
GB0118419D0 (en) | 2001-07-28 | 2001-09-19 | Owen Mumford Ltd | Improvements relating to injection devices |
BR0211894A (en) | 2001-08-17 | 2005-06-28 | Antares Pharma Inc | Method of minimizing and reducing mean glucose levels, treating a medical condition caused by high blood glucose levels and reducing hba1c value in an insulin dependent patient |
JP4224702B2 (en) | 2001-08-27 | 2009-02-18 | ノボ・ノルデイスク・エー/エス | Cartridge and drug administration system containing the cartridge |
GB2391480B (en) | 2002-08-05 | 2007-02-28 | Caretek Medical Ltd | Drug delivery system |
EP1307012A3 (en) | 2001-10-26 | 2009-12-30 | Tenovis GmbH & Co. KG | Telecommunication system and method of control of circuit and packet switching |
US6872193B2 (en) | 2001-10-26 | 2005-03-29 | Retractable Technologies, Inc. | IV catheter introducer with retractable needle |
EP1455864A2 (en) | 2001-11-02 | 2004-09-15 | Meridian Medical Technologies, Inc. | A medicament container, a medicament dispensing kit for administering medication and a method for packaging the same |
US7569035B1 (en) | 2001-11-02 | 2009-08-04 | Meridian Medical Technologies, Inc. | Automatic injector with anti-coring needle |
IL161301A0 (en) | 2001-11-09 | 2004-09-27 | Alza Corp | Pneumatic powered autoinjector |
ES2278992T3 (en) | 2001-11-09 | 2007-08-16 | Alza Corporation | COLLATABLE SYRINGE CARTRIDGE. |
US7488313B2 (en) | 2001-11-29 | 2009-02-10 | Boston Scientific Scimed, Inc. | Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment |
US20030105430A1 (en) | 2001-11-30 | 2003-06-05 | Elan Pharma International Limited Wil House | Automatic injector |
GB0129171D0 (en) | 2001-12-06 | 2002-01-23 | Dca Design Int Ltd | Improvements in and relating to a medicament cartridge |
EP2319564B1 (en) * | 2001-12-13 | 2013-07-17 | Panasonic Corporation | Administration instrument for medical use |
GB0130139D0 (en) | 2001-12-18 | 2002-02-06 | Dca Design Int Ltd | Improvements in and relating to a medicament injection apparatus |
US7247149B2 (en) | 2001-12-20 | 2007-07-24 | Advanced Cardiovascular Systems, Inc. | Contact and penetration depth sensor for a needle assembly |
GB0200637D0 (en) | 2002-01-12 | 2002-02-27 | Dca Design Int Ltd | Improvements in and relating to medicament injection apparatus |
CA2475573C (en) | 2002-02-11 | 2013-03-26 | Antares Pharma, Inc. | Intradermal injector |
GB0203276D0 (en) | 2002-02-12 | 2002-03-27 | Novartis Ag | Organic compounds |
WO2003070296A2 (en) | 2002-02-15 | 2003-08-28 | Antares Pharma, Inc. | Injector with bypass channel |
GB0205066D0 (en) | 2002-03-05 | 2002-04-17 | Owen Mumford Ltd | Improvements relating to injection devices |
GB0205485D0 (en) | 2002-03-08 | 2002-04-24 | Dca Design Int Ltd | Improvements in and relating to a medicament delivery service |
US7218962B2 (en) | 2002-03-29 | 2007-05-15 | Boston Scientific Scimed, Inc. | Magnetically enhanced injection catheter |
US6584910B1 (en) | 2002-04-19 | 2003-07-01 | David J. Plass | Animal syringe system |
US7519418B2 (en) | 2002-04-30 | 2009-04-14 | Boston Scientific Scimed, Inc. | Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment |
CA2484265C (en) | 2002-05-06 | 2012-08-07 | Becton, Dickinson And Company | Method and device for controlling drug pharmacokinetics |
GB0210631D0 (en) | 2002-05-09 | 2002-06-19 | Glaxo Group Ltd | Novel device |
WO2003097137A2 (en) | 2002-05-16 | 2003-11-27 | Scott Laboratories, Inc. | Drug container entry mechanisms and method |
GB0211294D0 (en) | 2002-05-17 | 2002-06-26 | Owen Mumford Ltd | Improvements relating to injection devices |
US6979316B1 (en) | 2002-05-23 | 2005-12-27 | Seedlings Life Science Ventures Llc | Apparatus and method for rapid auto-injection of medication |
WO2004004809A1 (en) | 2002-07-02 | 2004-01-15 | Matsushita Electric Industrial Co., Ltd. | Medical automatic medicator |
US20040039337A1 (en) | 2002-08-21 | 2004-02-26 | Letzing Michael Alexander | Portable safety auto-injector |
US7637891B2 (en) | 2002-09-12 | 2009-12-29 | Children's Hospital Medical Center | Method and device for painless injection of medication |
WO2004028598A1 (en) | 2002-09-24 | 2004-04-08 | Shl Medical Ab | Injecting device |
WO2004030730A2 (en) | 2002-10-01 | 2004-04-15 | Becton, Dickinson And Company | Medication delivery pen |
EP1554000A2 (en) * | 2002-10-15 | 2005-07-20 | Eli Lilly And Company | Medication dispensing apparatus with squeezable actuator |
KR20050075373A (en) | 2002-11-01 | 2005-07-20 | 앤태어스 파머, 인코퍼레이티드 | Administration of insulin by jet injection |
WO2004043534A1 (en) | 2002-11-12 | 2004-05-27 | Collegium Pharmaceutical, Inc. | Inertial drug delivery system |
AU2002952691A0 (en) | 2002-11-15 | 2002-11-28 | Sunshine Heart Company Pty Ltd | Heart assist device utilising aortic deformation |
AU2003280270B2 (en) | 2002-11-25 | 2008-01-24 | Tecpharma Licensing Ag | Injection apparatus comprising a needle-protecting device |
EP1572271A1 (en) | 2002-11-25 | 2005-09-14 | Tecpharma Licensing AG | Auto-injector comprising a resettable releasing safety device |
EP3597262B1 (en) | 2002-12-20 | 2023-12-27 | Xeris Pharmaceuticals, Inc. | Formulation for intracutaneous injection |
US7252651B2 (en) | 2003-01-07 | 2007-08-07 | Becton, Dickinson And Company | Disposable injection device |
US6969372B1 (en) | 2003-01-07 | 2005-11-29 | Halseth Thor R | Automatic retraction Huber needle safety enclosure |
US6767336B1 (en) | 2003-01-09 | 2004-07-27 | Sheldon Kaplan | Automatic injector |
GB0304823D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
US9205197B2 (en) | 2003-03-03 | 2015-12-08 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device dose setting mechanism |
US7390314B2 (en) | 2003-03-05 | 2008-06-24 | Medtronic Minimed, Inc. | Lead screw driven reservoir with integral plunger nut and method of using the same |
GB0306642D0 (en) | 2003-03-22 | 2003-04-30 | Dca Design Int Ltd | Improvements in and relating to an injector for a medical product |
US6932794B2 (en) | 2003-04-03 | 2005-08-23 | Becton, Dickinson And Company | Medication delivery pen |
GB0308267D0 (en) | 2003-04-10 | 2003-05-14 | Dca Design Int Ltd | Improvements in and relating to a pen-type injector |
US7517342B2 (en) | 2003-04-29 | 2009-04-14 | Boston Scientific Scimed, Inc. | Polymer coated device for electrically medicated drug delivery |
US6805686B1 (en) | 2003-05-06 | 2004-10-19 | Abbott Laboratories | Autoinjector with extendable needle protector shroud |
GB0312852D0 (en) | 2003-06-05 | 2003-07-09 | Owen Mumford Ltd | Improvements relating to syringe firing mechanisms |
WO2005000384A1 (en) | 2003-06-05 | 2005-01-06 | University Of Florida | Auto-injection devices and methods for intramuscular administration of medications |
US8308232B2 (en) | 2003-06-10 | 2012-11-13 | Antonio Zamperla S.P.A. | Seat for amusement apparatus |
GB0315600D0 (en) | 2003-07-04 | 2003-08-13 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
DE10330986B4 (en) | 2003-07-09 | 2010-01-07 | Tecpharma Licensing Ag | Non-contact scanning with magnetoresistive sensor |
US7500963B2 (en) | 2003-07-22 | 2009-03-10 | Safety Syringes, Inc. | Systems and methods for automatic medical injection with safeguard |
US20050027255A1 (en) | 2003-07-31 | 2005-02-03 | Sid Technologies, Llc | Automatic injector |
DE20311996U1 (en) | 2003-08-01 | 2003-10-16 | Hoelzle Dieter Tech Projekte | injection device |
AU2004266131C1 (en) | 2003-08-12 | 2010-12-16 | Eli Lilly And Company | Medication dispensing apparatus with triple screw threads for mechanical advantage |
AT7347U1 (en) | 2003-08-29 | 2005-02-25 | Pharma Consult Ges M B H & Co | DEVICE FOR THE AUTOMATIC INJECTION OF INJECTION LIQUIDS |
DE10342058B4 (en) | 2003-09-11 | 2007-10-25 | Tecpharma Licensing Ag | Administration device for an injectable product with a trigger safety device |
DE10342059B4 (en) | 2003-09-11 | 2007-03-01 | Tecpharma Licensing Ag | Delivery device with piercing and Ausschutinrichtung |
IL157981A (en) | 2003-09-17 | 2014-01-30 | Elcam Medical Agricultural Cooperative Ass Ltd | Auto-injector |
US8777889B2 (en) | 2004-06-15 | 2014-07-15 | Ceramatec, Inc. | Apparatus and method for administering a therapeutic agent into tissue |
US7615030B2 (en) | 2003-10-06 | 2009-11-10 | Active O, Llc | Apparatus and method for administering a therapeutic agent into tissue |
US8066659B2 (en) | 2004-06-15 | 2011-11-29 | Ceramatec, Inc. | Apparatus and method for treating and dispensing a material into tissue |
UA86778C2 (en) | 2003-10-16 | 2009-05-25 | Елі Ліллі Енд Компані | Fixed dose medication dispensing device |
US8360114B2 (en) | 2003-10-23 | 2013-01-29 | Niles Clark | Apparatus and method for filing a syringe |
DE20317377U1 (en) | 2003-11-03 | 2005-03-17 | B D Medico S A R L | injection device |
US7635348B2 (en) | 2003-11-04 | 2009-12-22 | Meridian Medical Technologies, Inc. | Container for medicament automatic injector and automatic injector adapted therefor |
US20050101919A1 (en) | 2003-11-07 | 2005-05-12 | Lennart Brunnberg | Device for an injector |
EP1541185A1 (en) | 2003-12-08 | 2005-06-15 | Novo Nordisk A/S | Automatic syringe with priming mechanism |
CH696421A5 (en) | 2003-12-18 | 2007-06-15 | Tecpharma Licensing Ag | Autoinjector with arresting the drug container. |
WO2005058396A1 (en) | 2003-12-18 | 2005-06-30 | Tecpharma Licensing Ag | Releasable injection device |
JP4721902B2 (en) | 2003-12-26 | 2011-07-13 | 久光製薬株式会社 | Activated iontophoresis device |
AU2005206872B2 (en) | 2004-01-12 | 2011-05-26 | Iscience Surgical Corporation | Injector for viscous materials |
GB2410188B (en) | 2004-01-23 | 2006-01-25 | Medical House Plc | Injection device |
US7670314B2 (en) | 2004-02-17 | 2010-03-02 | Children's Hospital Medical Center | Injection device for administering a vaccine |
WO2005091922A2 (en) | 2004-03-03 | 2005-10-06 | Becton, Dickinson And Company | Methods and devices for improving delivery of a substance to skin |
ES2728788T3 (en) | 2004-03-30 | 2019-10-28 | Lilly Co Eli | Medication dispensing device with spring-activated locking activated by the administration of the final dose |
DE202004006611U1 (en) | 2004-04-23 | 2005-08-25 | Tecpharma Licensing Ag | Injection device for administering an injectable product with secured dosing device |
GB2414404B (en) | 2004-05-28 | 2009-06-03 | Cilag Ag Int | Injection device |
US20050273054A1 (en) | 2004-06-03 | 2005-12-08 | Florida Atlantic University | Epinephrine auto-injector |
GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
US7572613B2 (en) | 2004-06-25 | 2009-08-11 | Klein Jeffrey A | Drug delivery system for accelerated subcutaneous absorption |
US7615041B2 (en) | 2004-07-29 | 2009-11-10 | Boston Scientific Scimed, Inc. | Vial adaptor |
US8048035B2 (en) | 2004-08-06 | 2011-11-01 | Meridian Medical Technologies, Inc. | Automatic injector with needle cover |
US7449012B2 (en) | 2004-08-06 | 2008-11-11 | Meridian Medical Technologies, Inc. | Automatic injector |
WO2006029192A1 (en) | 2004-09-08 | 2006-03-16 | Dermatrends, Inc. | Transdermal delivery of hydrophobic bioactive agents |
UA92707C2 (en) | 2004-09-24 | 2010-11-25 | Санофи-Авентис Дойчланд Гмбх | Cap for drug delivery device, drug delivery device and method of attaching/detaching a needle cover from the needle of a drug delivery device using the cap |
EP1642607A1 (en) | 2004-10-04 | 2006-04-05 | Sanofi-Aventis Deutschland GmbH | Dose display mechanism for a drug delivery device |
US8313763B2 (en) | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
AU2005291585B2 (en) | 2004-10-04 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for a drug delivery device |
EP2484399B1 (en) | 2004-10-14 | 2013-08-07 | Midland Medical Devices Holdings, LLC | Safety medical syringe with retractable needle |
DE602005017171D1 (en) | 2004-10-21 | 2009-11-26 | Novo Nordisk As | INJECTION DEVICE WITH INTERNAL DOSE DISPLAY |
WO2006045528A1 (en) | 2004-10-21 | 2006-05-04 | Novo Nordisk A/S | Injection device with torsion spring and rotatable display |
US7648482B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
US7947017B2 (en) | 2004-11-22 | 2011-05-24 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
GB2453069B (en) | 2004-11-22 | 2009-12-09 | Intelliject Llc | Devices,systems and methods for medicament delivery |
AU2005310060B2 (en) | 2004-11-24 | 2010-01-14 | Shl Medical Ag | Injection device |
US20060129122A1 (en) | 2004-12-06 | 2006-06-15 | Wyrick Ronald E | Method and apparatus for delivering epinephrine |
WO2007008257A2 (en) | 2005-07-06 | 2007-01-18 | Washington Biotech Corp. | Method and apparatus for delivering epinephrine |
US7297136B2 (en) | 2004-12-06 | 2007-11-20 | Wyrick Ronald E | Medicine injection devices and methods |
US7905352B2 (en) | 2004-12-06 | 2011-03-15 | Washington Biotech Corporation | Kits containing medicine injection devices and containers |
US7621891B2 (en) | 2004-12-06 | 2009-11-24 | Washington Biotech Corporation | Method and apparatus for delivering epinephrine |
US7403261B2 (en) | 2004-12-15 | 2008-07-22 | Asml Netherlands B.V. | Lithographic apparatus and device manufacturing method |
DE102004063648A1 (en) | 2004-12-31 | 2006-07-20 | Tecpharma Licensing Ag | Injection or infusion device with life-determining device |
CA2594764C (en) | 2005-01-21 | 2014-01-14 | Novo Nordisk A/S | An automatic injection device with a top release mechanism |
BRPI0614025A2 (en) | 2005-01-24 | 2012-12-25 | Antares Pharma Inc | jet injectors |
US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US7731686B2 (en) | 2005-02-01 | 2010-06-08 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
EP1843812A4 (en) | 2005-02-01 | 2008-12-03 | Intelliject Llc | Devices, systems, and methods for medicament delivery |
US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
ATE418351T1 (en) | 2005-02-11 | 2009-01-15 | Novo Nordisk As | INJECTION DEVICE |
DE102005017477A1 (en) | 2005-02-18 | 2006-08-31 | Tecpharma Licensing Ag | Spring in or for an injection device |
DE102005063311A1 (en) | 2005-02-23 | 2006-08-24 | Tecpharma Licensing Ag | Dispensing device for medical, diagnosic/cosmetic product, comprises indicator cylinder, housing, promoters for promoting the product relative to the housing, dosing equipment for adjusting product dose, and coupling elements |
JP4353113B2 (en) | 2005-03-14 | 2009-10-28 | ヤマハ株式会社 | Audio mixer parameter setting device |
US7390319B2 (en) | 2005-04-13 | 2008-06-24 | Steven Friedman | Automatic needle injector having safety triggering mechanism |
US20090043264A1 (en) | 2005-04-24 | 2009-02-12 | Novo Nordisk A/S | Injection Device |
CH699723B1 (en) | 2005-04-25 | 2010-04-30 | Tecpharma Licensing Ag | A device for administering a fluid product. |
EP1881859B1 (en) | 2005-05-10 | 2011-01-19 | Novo Nordisk A/S | Injection device comprising an optical sensor |
DE102005023824A1 (en) | 2005-05-24 | 2006-12-07 | Tecpharma Licensing Ag | Dosing device for an injection device |
DE102005023823B4 (en) | 2005-05-24 | 2022-11-17 | Tecpharma Licensing Ag | Dosing device for an injection device and injection device with such a dosing device |
EP1907031A2 (en) | 2005-05-31 | 2008-04-09 | Novo Nordisk A/S | Injection device with visual end-of-content indication |
DK1885415T3 (en) | 2005-06-01 | 2013-08-05 | Shl Group Ab | DEVICE FOR THE DELIVERY OF A MEDICINE |
JP5026411B2 (en) | 2005-06-01 | 2012-09-12 | エスエイチエル グループ エービー | Drug delivery device |
JP4994370B2 (en) | 2005-07-08 | 2012-08-08 | ノボ・ノルデイスク・エー/エス | Injection device |
US7955304B2 (en) | 2005-07-15 | 2011-06-07 | Shl Group Ab | Injector |
EP1904125B1 (en) | 2005-07-18 | 2018-10-17 | West Pharmaceutical Services, Inc. | Auto-injection syringe having vent device |
US8998881B2 (en) | 2005-08-10 | 2015-04-07 | Alza Corporation | Method for delivering drugs to tissue under microjet propulsion |
GB0517699D0 (en) | 2005-09-01 | 2005-10-05 | Owen Mumford Ltd | Needle shroud assembly |
US20070185432A1 (en) | 2005-09-19 | 2007-08-09 | Transport Pharmaceuticals, Inc. | Electrokinetic system and method for delivering methotrexate |
US20110098656A1 (en) | 2005-09-27 | 2011-04-28 | Burnell Rosie L | Auto-injection device with needle protecting cap having outer and inner sleeves |
JP2009511177A (en) | 2005-10-11 | 2009-03-19 | イーライ リリー アンド カンパニー | Medicine injection device |
US7611502B2 (en) | 2005-10-20 | 2009-11-03 | Covidien Ag | Connector for enteral fluid delivery set |
DE102005052502A1 (en) | 2005-11-03 | 2007-05-16 | Tecpharma Licensing Ag | Auto-injector activation trigger element |
GB0524604D0 (en) | 2005-12-02 | 2006-01-11 | Owen Mumford Ltd | Injection method and apparatus |
GB0524962D0 (en) | 2005-12-07 | 2006-01-18 | Pharmakodex Ltd | Topical pharmaceutical compositions |
GB2433032A (en) | 2005-12-08 | 2007-06-13 | Owen Mumford Ltd | Syringe with dose adjustment means |
US7988675B2 (en) | 2005-12-08 | 2011-08-02 | West Pharmaceutical Services Of Delaware, Inc. | Automatic injection and retraction devices for use with pre-filled syringe cartridges |
WO2007075677A2 (en) | 2005-12-20 | 2007-07-05 | Antares Pharma, Inc. | Needle-free injection device |
TW200744697A (en) | 2006-02-28 | 2007-12-16 | Verus Pharmaceuticals Inc | Shock absorber for an automatic injector |
EP1996260B1 (en) | 2006-03-10 | 2015-09-23 | Novo Nordisk A/S | An injection device having a gearing arrangement |
US8298194B2 (en) | 2006-03-10 | 2012-10-30 | Novo Nordisk A/S | Injection device and a method of changing a cartridge in the device |
JP5225974B2 (en) | 2006-03-20 | 2013-07-03 | ノボ・ノルデイスク・エー/エス | Measurement of cartridge contents by capacitive means |
RU2459247C2 (en) | 2006-03-20 | 2012-08-20 | Ново Нордиск А/С | Electronic module for mechanical device for administering medical drugs |
FR2899482A1 (en) | 2006-04-11 | 2007-10-12 | Becton Dickinson France Soc Pa | Automatic medicament/product injection device for patient, has safety shield coupled to housing, and provided in active state at end of needle insertion step before which product/medicament injection step is not started |
DE102006017209A1 (en) | 2006-04-12 | 2007-10-18 | Tecpharma Licensing Ag | Injection device with tension spring and tensioning element |
CN101420997B (en) | 2006-04-19 | 2013-03-27 | 诺沃-诺迪斯克有限公司 | A fluid infusion system, a method of assembling such system and drug reservoir for use in the system |
WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
WO2007131025A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injector with adjustable dosing |
GB2437922B (en) | 2006-05-10 | 2010-12-08 | Owen Mumford Ltd | Injection device comprising a window and a shutter element |
GB2437924B (en) | 2006-05-11 | 2010-12-22 | Owen Mumford Ltd | Injection device |
ATE458517T1 (en) | 2006-05-16 | 2010-03-15 | Novo Nordisk As | TRANSMISSION MECHANISM FOR AN INJECTION DEVICE |
BRPI0712028A2 (en) | 2006-05-18 | 2011-12-20 | Novo Nordisk As | injector with a locking means so |
AU2007267259A1 (en) | 2006-05-29 | 2007-12-06 | Novo Nordisk A/S | Mechanism for injection device |
EP2029198B1 (en) | 2006-05-30 | 2010-06-23 | Eli Lilly And Company | Module for a medication injection device |
US20070293582A1 (en) | 2006-06-05 | 2007-12-20 | Malcolm Hill | Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms |
WO2007147741A1 (en) | 2006-06-21 | 2007-12-27 | Novo Nordisk A/S | A one-hand operated drug mixing and expelling device |
CN103316403B (en) | 2006-06-30 | 2017-05-24 | 艾伯维生物技术有限公司 | Automatic injection device |
US8574199B2 (en) | 2006-07-03 | 2013-11-05 | Novo Nordisk A/S | Coupling for injection devices |
ITMO20060222A1 (en) | 2006-07-10 | 2008-01-11 | Alfio Bertolini | ANTIEMORRAGIC MEDICATION PACKAGE |
DE102006033837A1 (en) | 2006-07-21 | 2008-01-31 | Medac Gesellschaft für klinische Spezialpräparate m.b.H | Concentrated methotrexate solutions |
DE102006038101A1 (en) | 2006-08-14 | 2008-02-21 | Tecpharma Licensing Ag | Injection device with jaw safety |
DE102007001432A1 (en) | 2006-08-14 | 2008-02-21 | Tecpharma Licensing Ag | Blocking unit for dosing mechanism of injection device, has retaining unit acting together with dosing mechanism or dosing unit such that adjusting movement of mechanism or dosing unit in starting position of blocking unit is prevented |
WO2008025772A1 (en) | 2006-08-28 | 2008-03-06 | Novo Nordisk A/S | A medical delivery system adapted to be locked axially and unlocked rotationally |
DE102006042236A1 (en) | 2006-09-06 | 2008-03-27 | Tecpharma Licensing Ag | Needle guard with blocked guard position |
DE102006041809B4 (en) | 2006-09-06 | 2012-11-15 | Tecpharma Licensing Ag | Needle protection device with blocking device |
FR2905273B1 (en) | 2006-09-06 | 2009-04-03 | Becton Dickinson France Soc Pa | AUTOMATIC INJECTION DEVICE WITH TIMING MEANS. |
DE102006042233B3 (en) | 2006-09-06 | 2008-03-06 | Tecpharma Licensing Ag | Needle guard with distal and proximal needle guard |
EP3738626B1 (en) | 2006-09-15 | 2022-08-10 | Ypsomed AG | Injection device comprising an improved delivery element |
BRPI0717260A2 (en) | 2006-09-29 | 2013-10-15 | Novo Nordisk As | INJECTION DEVICES WITH ELECTRONIC DETECTION |
US7547293B2 (en) | 2006-10-06 | 2009-06-16 | Bioject, Inc. | Triggering mechanism for needle-free injector |
US7811254B2 (en) | 2006-10-18 | 2010-10-12 | Meridian Medical Technologies, Inc. | Autoinjector with needle depth adapter |
US9345831B2 (en) | 2006-10-19 | 2016-05-24 | E3D Agricultural Cooperative Association Ltd | Automatic injection device |
EP1923083A1 (en) | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Drive mechanisms for use in drug delivery devices |
EP1923084A1 (en) | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Dosing and drive mechanism for drug delivery device |
WO2008065646A1 (en) | 2006-11-28 | 2008-06-05 | Medingo Ltd. | An insertion device and method for inserting a subcutaneously insertable element into a body |
JP2010512817A (en) | 2006-12-15 | 2010-04-30 | ノボ・ノルデイスク・エー/エス | Medical delivery system comprising a container and a dosing assembly having a radially moving fastening means |
JP5213875B2 (en) | 2006-12-21 | 2013-06-19 | ノボ・ノルデイスク・エー/エス | Injection device |
ES2345694T3 (en) | 2007-01-17 | 2010-09-29 | Shl Group Ab | DEVICE FOR MANAGING MEDICANTS. |
DE102007004211A1 (en) | 2007-01-27 | 2008-07-31 | Lts Lohmann Therapie-Systeme Ag | Disposable injector with at least one towing hook |
DE602008002896D1 (en) | 2007-02-05 | 2010-11-18 | Novo Nordisk As | INJECTION BUTTON |
EP2125073A1 (en) | 2007-03-02 | 2009-12-02 | TecPharma Licensing AG | Modular administration system |
WO2008107199A1 (en) | 2007-03-07 | 2008-09-12 | Novo Nordisk A/S | Back needle |
JP2010519993A (en) | 2007-03-07 | 2010-06-10 | ノボ・ノルデイスク・エー/エス | Drug delivery device with multiple reservoirs |
EP2134391B1 (en) | 2007-03-09 | 2017-12-13 | Eli Lilly and Company | Delay mechanism for automatic injection device |
KR100820523B1 (en) | 2007-03-14 | 2008-04-08 | 홍관호 | Blood lancet device |
EP2129419A2 (en) | 2007-03-21 | 2009-12-09 | Midland Medical Devices Holdings, LLC | Safety medical syringe with retractable needle and including a plunger that is received within a barrel |
EP2129416A1 (en) | 2007-03-22 | 2009-12-09 | Tecpharma Licensing AG | Spring assembly in an injection device |
JP5307038B2 (en) | 2007-03-23 | 2013-10-02 | エス・ホー・エル・グループ・アクチボラゲット | Automatic syringe |
AU2008231897B2 (en) | 2007-03-23 | 2012-11-29 | Novo Nordisk A/S | An injection device comprising a locking nut |
GB0705782D0 (en) | 2007-03-26 | 2007-05-02 | Novartis Ag | Vial assemblies |
EP2144649B1 (en) | 2007-04-05 | 2011-07-20 | Tecpharma Licensing AG | Administering apparatus with functional drive element |
DE102007016811A1 (en) | 2007-04-05 | 2008-10-09 | Tecpharma Licensing Ag | Device for administering a fluid substance from a multi-chamber ampoule |
DE102007018868A1 (en) | 2007-04-19 | 2008-10-23 | Lts Lohmann Therapie-Systeme Ag | Disposable injector with at least one towing hook and a sliding wedge gear for unlocking releasing a locking element |
US8057427B2 (en) | 2007-05-09 | 2011-11-15 | Meridian Medical Technologies, Inc. | Drug delivery system with a small amount of a therapeutic agent |
CN101715371B (en) | 2007-05-14 | 2012-09-05 | Shl集团有限责任公司 | Delivery device |
DE102007026083A1 (en) | 2007-05-25 | 2008-11-27 | Haselmeier S.A.R.L. | injection device |
ES2612032T3 (en) | 2007-06-04 | 2017-05-11 | Shear/Kershman Laboratories, Inc. | Oral pharmaceutical forms based on inviolable lipids for opioid agonists |
WO2008157610A1 (en) | 2007-06-19 | 2008-12-24 | Stat Medical Devices, Inc. | Lancet device with depth adjustment and lancet removal system and method |
EP2192939B1 (en) | 2007-06-19 | 2011-03-16 | SHL Group AB | Device for delivering medicament |
DE102007030327A1 (en) | 2007-06-29 | 2009-01-02 | Tecpharma Licensing Ag | Injection device with a spring for a needle protection sleeve |
ATE501749T1 (en) | 2007-07-06 | 2011-04-15 | Shl Group Ab | MONOINJECTOR WITH DOUBLE SPRINGS |
WO2009007305A1 (en) | 2007-07-06 | 2009-01-15 | Novo Nordisk A/S | Automatic injection device |
GB2452030A (en) | 2007-08-10 | 2009-02-25 | Owen Mumford Ltd | Injection devices |
ES2710175T3 (en) | 2007-09-25 | 2019-04-23 | Becton Dickinson France | Auto-injector with deactivation means that can be moved by a safety guard |
CN101854966B (en) | 2007-09-25 | 2012-10-10 | 贝克顿迪金森法国公司 | Autoinjector received in external socket |
ES2641881T3 (en) | 2007-09-25 | 2017-11-14 | Becton Dickinson France | Automatic injector with activator positionable in active position by the movement of a safety guard and indication of the active position |
WO2009040602A1 (en) | 2007-09-25 | 2009-04-02 | Becton Dickinson France | Autoinject0r with deactivating means moveable by a safety shield |
CN101903058B (en) | 2007-10-10 | 2013-03-20 | Shl集团有限责任公司 | Medical delivery device |
DE202008014334U1 (en) | 2007-10-17 | 2009-02-26 | Haselmeier S.A.R.L. | injection device |
CN101918730B (en) | 2007-10-22 | 2015-04-01 | Gkn烧结金属股份有限公司 | Reduced stress pawl and ratchet tooth for a one-way clutch |
DE102007053743A1 (en) | 2007-11-12 | 2009-06-10 | Tecpharma Licensing Ag | Rotatable guide sleeve with over-tensioned spring |
DE602008006458D1 (en) | 2007-11-12 | 2011-06-01 | Bang & Olufsen Medicom As | AUTOMATIC INJECTOR WITH AUTOMATIC NEEDLE FEED |
EP2237817B1 (en) | 2007-11-14 | 2019-02-13 | SHL Group AB | Automatic injection device with actively triggered syringe withdrawal |
EP2229201B1 (en) | 2007-12-31 | 2012-05-02 | Novo Nordisk A/S | Electronically monitored injection device |
GB0800103D0 (en) | 2008-01-04 | 2008-02-13 | Owen Mumford Ltd | Sheath removver device |
BRPI0923666A2 (en) | 2008-01-23 | 2012-12-25 | Novo Nordisk As | injection device for delivering distributed doses of liquid drug |
WO2009100550A1 (en) | 2008-02-11 | 2009-08-20 | Tecpharma Licensing Ag | Administering apparatus comprising a blockable actuation element |
ES2507518T3 (en) | 2008-02-12 | 2014-10-15 | Shl Group Ab | Autoinjector |
DE102008011881A1 (en) | 2008-02-29 | 2009-09-10 | Tecpharma Licensing Ag | Empty shooting speed limit brake |
CA2718053C (en) | 2008-03-10 | 2016-09-27 | Antares Pharma, Inc. | Injector safety device |
US8177758B2 (en) | 2008-04-08 | 2012-05-15 | Rochester Area Consulting Engineers (RACE) | Pneumatic injector |
US8187233B2 (en) | 2008-05-02 | 2012-05-29 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device |
US8647309B2 (en) | 2008-05-02 | 2014-02-11 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device |
GB2460398A (en) | 2008-05-20 | 2009-12-02 | Owen Mumford Ltd | Auto-injector having a magnetic injection indicator and a needle sheath retainer |
EP2288400B1 (en) | 2008-05-20 | 2012-09-19 | Tecpharma Licensing AG | Device for administering an injectable product comprising a residual amount display |
WO2009147026A1 (en) | 2008-06-02 | 2009-12-10 | Shl Group Ab | Medicament delivery device |
AT506690B1 (en) | 2008-06-16 | 2009-11-15 | Pharma Consult Ges M B H & Co | INJECTION DEVICE |
GB2461088B (en) | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Injection device |
CN102065938B (en) | 2008-06-20 | 2014-09-03 | 西部制药服务公司 | Automatic injection mechanism with frontal buttress |
NZ590352A (en) | 2008-07-09 | 2012-10-26 | Sanofi Aventis Deutschland | Medication delivery device with optical magnification of indicated dosage and method of assembly |
PT2307079E (en) | 2008-07-15 | 2015-10-14 | Shl Group Ab | Medicament delivery device |
US8632493B2 (en) | 2008-07-17 | 2014-01-21 | Medigard Limited | Retractable syringe |
JP5611208B2 (en) | 2008-08-05 | 2014-10-22 | アンタレス・ファーマ・インコーポレーテッド | Multiple dose injection device |
GB2462811B (en) | 2008-08-18 | 2012-08-15 | Medical House Ltd | Improved autoinjector |
DE202008011175U1 (en) | 2008-08-18 | 2010-01-07 | Haselmeier Gmbh | injection device |
GB2463034B (en) | 2008-08-28 | 2012-11-07 | Owen Mumford Ltd | Autoinjection devices |
RU2508922C2 (en) | 2008-08-29 | 2014-03-10 | Ново Нордиск А/С | Medical injection device with time delay indicator |
AU2009299888B2 (en) | 2008-10-01 | 2012-07-05 | Shl Group Ab | Medicament delivery device powered by volute spring |
BRPI0920191B8 (en) | 2008-10-13 | 2021-06-22 | Sanofi Aventis Deutschland | drug delivery device |
US8568434B2 (en) | 2008-10-14 | 2013-10-29 | Bionime Corporation | Lancing device |
CA2738877A1 (en) | 2008-10-24 | 2010-04-29 | Claus Schmidt Moller | Dial-down mechanism for wind-up pen |
EP2355864B1 (en) | 2008-11-14 | 2016-11-09 | The Board of Regents of The University of Texas System | Nanochanneled device and related methods |
US8777907B2 (en) | 2008-12-12 | 2014-07-15 | Shl Group Ab | Medicament delivery device |
ES2572362T3 (en) | 2008-12-12 | 2016-05-31 | Shl Group Ab | Medication delivery device |
WO2010066706A1 (en) | 2008-12-12 | 2010-06-17 | Shl Group Ab | Medicament delivery device |
DK2355867T3 (en) | 2008-12-12 | 2014-09-08 | Shl Group Ab | DEVICE FOR MEDICINE DELIVERY |
CN102245234B (en) | 2008-12-12 | 2014-06-04 | Shl集团有限责任公司 | Medicament delivery device |
US8876785B2 (en) | 2008-12-12 | 2014-11-04 | Shl Group Ab | Delivery member attachment device |
US8366680B2 (en) | 2008-12-12 | 2013-02-05 | Sanofi-Aventis Deutschland Gmbh | Resettable drive mechanism for a medication delivery device and medication delivery device |
GB0823693D0 (en) | 2008-12-31 | 2009-02-04 | Owen Mumford Ltd | Autoinjector |
EP2208503A1 (en) | 2009-01-20 | 2010-07-21 | Sanofi-Aventis Deutschland GmbH | Drive assembly and medication delivery device |
WO2010084084A1 (en) | 2009-01-23 | 2010-07-29 | Sanofi-Aventis Deutschland Gmbh | Medicament identification system for multi-dose injection devices |
US8693773B2 (en) | 2009-01-29 | 2014-04-08 | Nec Corporation | Color image processing method, color image processing device, and recording medium |
WO2010086273A1 (en) | 2009-01-30 | 2010-08-05 | Sanofi-Aventis Deutschland Gmbh | Cartridge and medication delivery device |
AU2010210158B2 (en) | 2009-02-05 | 2014-09-25 | Sanofi-Aventis Deutschland Gmbh | Medicament delivery devices |
TWI519331B (en) | 2009-02-05 | 2016-02-01 | 賽諾菲阿凡提斯德意志有限公司 | Medicament delivery devices |
GB0901801D0 (en) | 2009-02-05 | 2009-03-11 | Medical House Plc The | Improved autoinjector |
WO2010093834A2 (en) | 2009-02-12 | 2010-08-19 | Incube Labs, Llc | Skin penetrating device and method for subcutaneous solid drug delivery |
EP2401009B1 (en) | 2009-02-26 | 2012-11-28 | Tecpharma Licensing AG | Product container holder for an injection device and for receiving a product container |
TR201807257T4 (en) | 2009-02-26 | 2018-06-21 | Shl Group Ab | Dose adjustment mechanisms. |
US8366682B2 (en) | 2009-03-04 | 2013-02-05 | Washington Biotech Corporation | Medicine injection apparatuses |
DK2403567T3 (en) | 2009-03-05 | 2015-03-09 | Sanofi Aventis Deutschland | Needle devices |
EP2403569B1 (en) | 2009-03-05 | 2014-04-23 | Sanofi-Aventis Deutschland GmbH | Drug delivery device with retractable needle |
EP2403568B1 (en) | 2009-03-05 | 2014-12-17 | Sanofi-Aventis Deutschland GmbH | Needle unit |
WO2010100246A1 (en) | 2009-03-06 | 2010-09-10 | Sanofi-Aventis Deutschland Gmbh | Syringe, auto-injector device and set of auto-injector devices and syringes |
EP2405961A4 (en) | 2009-03-09 | 2012-08-08 | Purdue Research Foundation | Compact device for rapidly mixing and delivering substances to a patient |
BRPI1009100A2 (en) | 2009-03-13 | 2016-03-08 | Lilly Co Eli | apparatus for injecting a pharmaceutical with automatic retraction of syringe followed by injection |
DK3643347T3 (en) | 2009-03-30 | 2021-04-26 | Sanofi Aventis Deutschland | MEDICINE DELIVERY DEVICE WITH AN IMPROVED STAMP |
EP2413993B1 (en) | 2009-03-31 | 2020-07-15 | Sanofi-Aventis Deutschland GmbH | Drug delivery device body |
EP2414002B1 (en) | 2009-03-31 | 2019-10-30 | Sanofi-Aventis Deutschland GmbH | Mounting arrangement and coupling assembly for a drug delivery device |
AU2010230176B2 (en) | 2009-03-31 | 2015-01-15 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
CA2756587A1 (en) | 2009-03-31 | 2010-10-07 | Sanofi-Aventis Deutschland Gmbh | Medical device having a mechanism with a spring and use of a wave spring or wave washer within a medical device |
CN102448522B (en) | 2009-03-31 | 2014-06-04 | 赛诺菲-安万特德国有限公司 | Drug delivery device |
WO2010115818A1 (en) | 2009-03-31 | 2010-10-14 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
CA2756972A1 (en) | 2009-03-31 | 2010-10-07 | Sanofi-Aventis Deutschland Gmbh | Medical device having a mechanism and use of a low-friction synthetic material within a medical device |
EP2415041B1 (en) | 2009-03-31 | 2018-11-21 | Sanofi-Aventis Deutschland GmbH | Method for manufacturing a drug delivery device body using an adhesive and drug delivery device body |
CN102438680B (en) | 2009-04-01 | 2013-11-27 | Shl集团有限责任公司 | Medicament delivery device |
EP2414005B1 (en) | 2009-04-03 | 2017-07-26 | SHL Group AB | Medicament delivery device |
US8424768B2 (en) | 2009-04-09 | 2013-04-23 | Metrologic Instruments, Inc. | Trigger mechanism for hand held devices |
GB0906640D0 (en) | 2009-04-17 | 2009-06-03 | Owen Mumford Ltd | A needle cap assembly |
GB2469672B (en) | 2009-04-23 | 2013-09-25 | Medical House Ltd | Improved autoinjector |
EP2421587B1 (en) | 2009-04-24 | 2019-05-22 | SHL Medical AG | Medicament delivery device |
JP5433075B2 (en) | 2009-04-27 | 2014-03-05 | エス・ホー・エル・グループ・アクチボラゲット | Safety pen needle device |
KR101721906B1 (en) | 2009-04-29 | 2017-03-31 | 애브비 바이오테크놀로지 리미티드 | Automatic injection device |
JP5666560B2 (en) | 2009-04-30 | 2015-02-12 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Pen syringe with ergonomic button arrangement |
BRPI1016143A2 (en) | 2009-04-30 | 2016-04-19 | Sanofi Aventis Deutschland | axially adjustable piston rod connection for triggering mechanism of a drug delivery device |
GB0907534D0 (en) | 2009-05-01 | 2009-06-10 | Owen Mumford Ltd | Injection devices |
CN104383625B (en) | 2009-05-07 | 2017-09-29 | 药物注射器械公司 | Drugs distribution apparatus |
EP3421067B1 (en) | 2009-05-29 | 2021-12-15 | Ypsomed AG | Injection device, especially auto-injector, comprising an anti-pricking mechanism and/or overload protection for a product container |
US9108007B2 (en) | 2009-06-01 | 2015-08-18 | Sanofi-Aventis Deutschland Gmbh | Spindle and bearing combination and drug delivery device |
US9345840B2 (en) | 2009-06-01 | 2016-05-24 | Sanofi-Aventis Deutschland Gmbh | Drug delivery dose setting mechanism with variable maximum dose |
US9463283B2 (en) | 2009-06-01 | 2016-10-11 | Sanofi-Aventis Deutschland Gmbh | Dosing mechanism for a drug deliver device |
US9623187B2 (en) | 2009-06-01 | 2017-04-18 | Sanofi-Aventis Deutschland Gmbh | Resettable drug delivery device |
US10034982B2 (en) | 2009-06-01 | 2018-07-31 | Sanofi-Aventis Deutschland Gmbh | Spindle for a drug delivery device |
US9950116B2 (en) | 2009-06-01 | 2018-04-24 | Sanofi-Aventis Deutschland Gmbh | Dose setting mechanism for priming a drug delivery device |
US9125994B2 (en) | 2009-06-01 | 2015-09-08 | Sanofi—Aventis Deutschland GmbH | Drug delivery device with dose dial sleeve rotational stop |
US8672896B2 (en) | 2009-06-01 | 2014-03-18 | Sanofi-Aventis Deutschland Gmbh | Inner housing for a drug delivery device |
US9199040B2 (en) | 2009-06-01 | 2015-12-01 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device last dose lock-out mechanism |
US9457150B2 (en) | 2009-06-01 | 2016-10-04 | Sanofi-Aventis Deutschland Gmbh | Biasing mechanism for a drug delivery device |
US9238106B2 (en) | 2009-06-01 | 2016-01-19 | Sanofi-Aventis Deutschland Gmbh | Dose setting mechanism for priming a drug delivery device |
US8257319B2 (en) | 2009-06-01 | 2012-09-04 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device inner housing having helical spline |
US8728043B2 (en) | 2009-06-01 | 2014-05-20 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for a drug delivery device |
US20110015576A1 (en) | 2009-06-01 | 2011-01-20 | Sanofi-Aventis Deutschland Gmbh | Medicament identification system for multi-dose injection devices |
US8585656B2 (en) | 2009-06-01 | 2013-11-19 | Sanofi-Aventis Deutschland Gmbh | Dose setting mechanism for priming a drug delivery device |
US8974423B2 (en) | 2009-06-01 | 2015-03-10 | Sanofi-Aventis Deutschland Gmbh | Resettable drug delivery device |
TW201109060A (en) | 2009-06-02 | 2011-03-16 | Sanofi Aventis Deutschland | Delivery of two or more medicaments through a single dose selection and dispense interface |
TW201109058A (en) | 2009-06-02 | 2011-03-16 | Sanofi Aventis Deutschland | Medicated module with needle guard |
TW201103592A (en) | 2009-06-02 | 2011-02-01 | Sanofi Aventis Deutschland | Medicated module for a drug delivery device |
AR076718A1 (en) | 2009-06-02 | 2011-06-29 | Sanofi Aventis Deutschland | MEDICINAL MODULE WITH USER SELECTION |
AR076716A1 (en) | 2009-06-02 | 2011-06-29 | Sanofi Aventis Deutschland | MEDICATED MODULE WITH PREMIX MEDICATION |
AR076624A1 (en) | 2009-06-02 | 2011-06-22 | Sanofi Aventis Deutschland | SUPPLY OF TWO OR MORE MEDICINES THROUGH A SINGLE DOSE SELECTION AND A SINGLE DISPENSATION INTERFACE |
AU2010254627B2 (en) | 2009-06-05 | 2012-08-02 | Shl Group Ab | Medicament delivery device |
US20100324480A1 (en) | 2009-06-17 | 2010-12-23 | Thomas Chun | Automatic injection syringe assembly |
DK2442856T3 (en) | 2009-06-17 | 2024-03-04 | Shl Medical Ag | MEDICATION CONTAINER HOLDER DEVICE |
US8876781B2 (en) | 2009-06-18 | 2014-11-04 | Shl Group Ab | Safety pen needle device |
WO2010149209A1 (en) | 2009-06-23 | 2010-12-29 | Tecpharma Licensing Ag | Injection device having a dosing mechanism for limiting a dose setting |
DK2445552T3 (en) | 2009-06-24 | 2016-01-25 | Tecpharma Licensing Ag | Administering the init function |
GB2471304B (en) | 2009-06-24 | 2013-12-11 | Oval Medical Technologies Ltd | A pre-filled syringe or autoinjector |
EP2266647A1 (en) | 2009-06-25 | 2010-12-29 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for drug delivery device |
GB2471473A (en) | 2009-06-30 | 2011-01-05 | Owen Mumford Ltd | Syringe sheath remover |
US9458536B2 (en) * | 2009-07-02 | 2016-10-04 | Sio2 Medical Products, Inc. | PECVD coating methods for capped syringes, cartridges and other articles |
US8263581B2 (en) | 2009-07-03 | 2012-09-11 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
TWI393578B (en) | 2009-07-07 | 2013-04-21 | Shl Group Ab | Injection device |
PL2451508T3 (en) | 2009-07-08 | 2014-04-30 | Novo Nordisk As | Frost protected injection device |
CN102548599B (en) | 2009-07-08 | 2014-07-23 | 诺沃-诺迪斯克有限公司 | Auto-priming injection device |
GB2471726B (en) | 2009-07-10 | 2013-09-11 | Oval Medical Technologies Ltd | A pre-filled syringe including an oxygen absorber |
JP5727473B2 (en) | 2009-07-14 | 2015-06-03 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Injection device |
CA2765899A1 (en) | 2009-07-15 | 2011-01-20 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for an injection device and an injection device with such a drive mechanism |
US20120209200A1 (en) | 2009-07-15 | 2012-08-16 | Sanofi-Aventis Deutschland Gmbh | Drive Assembly for a Pen-Type Injector and Pen-Type Injector with a Drive Assembly |
AU2010272599A1 (en) | 2009-07-15 | 2012-02-02 | Sanofi-Aventis Deutschland Gmbh | Thrust bearing assembly, drive train, and medicament delivery device |
GB0913385D0 (en) | 2009-07-31 | 2009-09-16 | Medical House The Plc | Improved autoinjector |
GB2472578A (en) | 2009-08-10 | 2011-02-16 | Owen Mumford Ltd | Sheath removal device and needle protector |
CN102573963B (en) | 2009-08-24 | 2014-09-24 | Shl集团有限责任公司 | Dose reset mechanism and medicine delivery device including dose reset mechanism |
FR2949284B1 (en) | 2009-08-24 | 2011-09-09 | Alcatel Lucent | REPRESENTATION OF PHYSICAL DEGRADATION IN AN OPTICAL COMMUNICATION NETWORK |
CA2771273A1 (en) | 2009-08-27 | 2011-03-03 | Sanofi-Aventis Deutschland Gmbh | Housing component for a drug delivery device |
EP2470150A2 (en) | 2009-08-27 | 2012-07-04 | Sanofi-Aventis Deutschland GmbH | Reminder device for drug delivery devices |
WO2011026931A1 (en) | 2009-09-07 | 2011-03-10 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for drug delivery device |
EP2475408B1 (en) | 2009-09-10 | 2015-02-18 | Sanofi-Aventis Deutschland GmbH | Medicament container |
US8512285B2 (en) | 2009-09-18 | 2013-08-20 | Sanofi-Aventis Deutschland Gmbh | Latching and control unit for integration in a medical device |
DK2480268T3 (en) | 2009-09-23 | 2016-12-12 | Sanofi Aventis Deutschland | Interior and indicator for pharmaceutical feed device |
US9402959B2 (en) | 2009-09-23 | 2016-08-02 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
DE102009048497A1 (en) | 2009-09-26 | 2011-03-31 | Haselmeier Gmbh | injection device |
AR079286A1 (en) | 2009-09-29 | 2012-01-18 | Sanofi Aventis Deutschland | ASSEMBLY FOR A FARMACO ADMINISTRATION DEVICE |
TW201127435A (en) | 2009-09-30 | 2011-08-16 | Sanofi Aventis Deutschland | Drive mechanism for a drug delivery device |
CA2774565A1 (en) | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Assembly and piston rod for a drug delivery device |
EP2482886B1 (en) | 2009-09-30 | 2014-08-06 | Sanofi-Aventis Deutschland GmbH | An assembly for use in a drug delivery device |
AR078458A1 (en) | 2009-09-30 | 2011-11-09 | Sanofi Aventis Deutschland | DRIVE ASSEMBLY, PISTON VASTAGO, DRUG DELIVERY DEVICE, AND USE OF A SPRING |
WO2011039236A1 (en) | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Resettable drive assembly and drug delivery device |
EP2482890B1 (en) | 2009-09-30 | 2014-12-03 | Sanofi-Aventis Deutschland GmbH | Button member for operating a drive assembly |
CA2772984A1 (en) | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device, assembly for a drug delivery device and method for setting up a drug delivery device |
TW201121602A (en) | 2009-09-30 | 2011-07-01 | Sanofi Aventis Deutschland | Drive assembly, piston rod, drug delivery device, and use of a spring |
WO2011039208A2 (en) | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for a drug delivery device |
AU2010302987B2 (en) * | 2009-09-30 | 2015-01-29 | Sanofi-Aventis Deutschland Gmbh | A resettable drive mechanism for a drug delivery device |
US8911402B2 (en) | 2009-09-30 | 2014-12-16 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
WO2011039228A1 (en) | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Method and assembly for a drug delivery device |
JP5752692B2 (en) | 2009-09-30 | 2015-07-22 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Use of drive mechanism for drug delivery device and reset member for drive mechanism |
WO2011039233A1 (en) | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Injection device |
WO2011039232A1 (en) | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for a drug delivery device |
EP2482882A2 (en) | 2009-09-30 | 2012-08-08 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a drug delivery device and resilient element for a drive mechanism |
CN102639170B (en) | 2009-09-30 | 2014-10-15 | Shl集团有限责任公司 | Medicament delivery device |
EP2485787A1 (en) | 2009-10-08 | 2012-08-15 | Sanofi-Aventis Deutschland GmbH | Medicament injection device with lockout feature |
AU2010303987B2 (en) | 2009-10-08 | 2012-10-18 | Shl Medical Ag | Medicament delivery device |
WO2011042537A1 (en) | 2009-10-08 | 2011-04-14 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with biodegradable plastic components |
US8882748B2 (en) | 2009-10-08 | 2014-11-11 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including chemical permeation enhancers |
US8948863B2 (en) | 2009-10-09 | 2015-02-03 | Board Of Regents, The University Of Texas System | Photokinetic ocular drug delivery methods and apparatus |
KR101762327B1 (en) | 2009-10-15 | 2017-07-27 | 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 | Electrostatic dissipative tpu and compositions thereof |
JP5706902B2 (en) | 2009-10-16 | 2015-04-22 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Drug delivery device |
EP2311513A1 (en) | 2009-10-16 | 2011-04-20 | Sanofi-Aventis Deutschland GmbH | Cartridge holder assembly for a drug delivery device |
GB0918145D0 (en) | 2009-10-16 | 2009-12-02 | Owen Mumford Ltd | Injector apparatus |
CA2777146A1 (en) | 2009-10-16 | 2011-04-21 | Sanofi-Aventis Deutschland Gmbh | Arrangement for use in a drug delivery device |
CN104689426B (en) | 2009-10-21 | 2018-10-02 | 欧文蒙福德有限公司 | Automatic injector |
US8864718B2 (en) | 2009-10-23 | 2014-10-21 | Bang & Olufsen Medicom A/S | Auto injector with automatic needle shielding |
WO2011050359A1 (en) | 2009-10-23 | 2011-04-28 | Massachusetts Institute Of Technology | Biotemplated inorganic materials |
DK2493529T3 (en) | 2009-10-26 | 2016-05-17 | Shl Group Ab | Drug delivery device |
EP3170526B1 (en) | 2009-10-30 | 2021-07-14 | Sanofi-Aventis Deutschland GmbH | Cartridge for a drug delivery device |
EP2496290B1 (en) | 2009-11-03 | 2017-01-04 | Sanofi-Aventis Deutschland GmbH | Assembly for a drug delivery device and drug delivery device |
DK2496292T3 (en) | 2009-11-06 | 2014-10-06 | Shl Group Ab | DEVICE FOR MEDICINE DELIVERY |
WO2011060087A1 (en) | 2009-11-11 | 2011-05-19 | Alphatec Spine, Inc. | Methods and devices for portal fixation to the spine |
EP2335755A1 (en) | 2009-12-17 | 2011-06-22 | Sanofi-Aventis Deutschland GmbH | Device and method for delivery of two or more drug agents |
EP2506898B1 (en) | 2009-12-02 | 2013-09-04 | Sanofi-Aventis Deutschland GmbH | Drug delivery device and associated packaging |
EP2329857A1 (en) | 2009-12-03 | 2011-06-08 | Sanofi-Aventis Deutschland GmbH | A drug delivery device |
JP5684982B2 (en) | 2009-12-04 | 2015-03-18 | 東レ・ダウコーニング株式会社 | Silicone oil emulsion, method for producing the same, and silicone oil composition |
GB0921295D0 (en) | 2009-12-04 | 2010-01-20 | Owen Mumford Ltd | Injection appaeratus |
BR112012013767A2 (en) | 2009-12-07 | 2016-04-26 | Sanofi Aventis Deutschland | drive assembly for a drug delivery device and drug delivery device |
US8856501B2 (en) | 2009-12-14 | 2014-10-07 | Sandisk Technologies Inc. | Method and system for controlling operation of interconnected devices by circulating host capability without a centralized manager |
PL3020427T3 (en) | 2009-12-17 | 2019-03-29 | Sanofi-Aventis Deutschland Gmbh | Medical device and method of assembly |
EP2512562B1 (en) | 2009-12-18 | 2018-09-12 | Sanofi-Aventis Deutschland GmbH | A drug delivery device |
US9320854B2 (en) | 2009-12-18 | 2016-04-26 | Sanofi-Aventis Deutschland Gmbh | Dose setting mechanism with maximum dose limited element |
WO2011076280A1 (en) | 2009-12-23 | 2011-06-30 | Tecpharma Licensing Ag | Injection device comprising a needle protection sleeve |
EP3421028A3 (en) | 2010-01-22 | 2019-04-10 | Sanofi-Aventis Deutschland GmbH | Coded collapsible drug reservoir |
US9835279B2 (en) | 2010-01-22 | 2017-12-05 | Sanofi-Aventis Deutschland Gmbh | Coded cartridge holder and fastener enabled by cartridge size |
EP2351591A1 (en) | 2010-02-02 | 2011-08-03 | Sanofi-Aventis Deutschland GmbH | Assembly for a drug delivery device and drug delivery device |
AU2011212564B2 (en) | 2010-02-05 | 2015-02-05 | Sanofi-Aventis Deutschland Gmbh | Medicated module with lockable needle guard |
JP5805106B2 (en) | 2010-02-05 | 2015-11-04 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Medicinal module with double safety guard |
WO2011095483A1 (en) | 2010-02-05 | 2011-08-11 | Sanofi-Aventis Deutschland Gmbh | Medicated module with time lock |
CN102821802B (en) | 2010-02-05 | 2015-04-01 | 赛诺菲-安万特德国有限公司 | Medicated module having a double needle guard |
US9358342B2 (en) | 2010-02-05 | 2016-06-07 | Sanofi-Aventis Deutschland Gmbh | Flexible reservoir for a medicated module |
US9352103B2 (en) | 2010-02-05 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Push rod activated medicated module |
DK2533834T3 (en) | 2010-02-09 | 2018-01-15 | Shl Group Ab | DRUG DELIVERY DEVICES |
US9227015B2 (en) | 2010-02-17 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Spring driven injection device with twin cartridges |
CA2790190A1 (en) | 2010-02-17 | 2011-08-25 | Sanofi-Aventis Deutschland Gmbh | Automatic injection device with torsional spring |
EP2536453B1 (en) | 2010-02-18 | 2014-08-20 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
WO2011101375A1 (en) | 2010-02-18 | 2011-08-25 | Sanofi-Aventis Deutschland Gmbh | Auto-injector with a torsion spring |
WO2011101378A1 (en) | 2010-02-18 | 2011-08-25 | Sanofi-Aventis Deutschland Gmbh | Finger guard for an injection device |
EP2536452B1 (en) | 2010-02-18 | 2018-08-29 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
WO2011101380A1 (en) | 2010-02-18 | 2011-08-25 | Sanofi-Aventis Deutschland Gmbh | Auto-injector |
EP2536458B1 (en) | 2010-02-18 | 2017-10-25 | Sanofi-Aventis Deutschland GmbH | Clutch mechanism |
DK2538997T3 (en) | 2010-02-22 | 2019-07-22 | Sanofi Aventis Deutschland | Auto-Injector Power Transmission Mechanism |
US9358351B2 (en) | 2010-02-22 | 2016-06-07 | Sanofi-Aventis Deutschland Gmbh | Gearbox |
JP5820401B2 (en) | 2010-02-22 | 2015-11-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Automatic syringe with needle shield and needle protection cap |
RS53618B1 (en) | 2010-03-01 | 2015-04-30 | Eli Lilly And Company | Automatic injection device with delay mechanism including dual functioning biasing member |
GB2478349A (en) | 2010-03-05 | 2011-09-07 | Owen Mumford Ltd | Injection device having projections reducing the diameter of the syringe passage |
EP2364741A1 (en) | 2010-03-09 | 2011-09-14 | Sanofi-Aventis Deutschland GmbH | Interlock mechanism for defining an operation sequence of an auto-injector |
CN102869399B (en) | 2010-03-09 | 2015-06-24 | Shl集团有限责任公司 | Medicament delivery device |
EP2364739A1 (en) | 2010-03-09 | 2011-09-14 | Sanofi-Aventis Deutschland GmbH | Re-usable autoinjector |
EP2364740A1 (en) | 2010-03-09 | 2011-09-14 | Sanofi-Aventis Deutschland GmbH | Arrangement for transferring a translation of a drive means to a plunger |
IT1398501B1 (en) | 2010-03-10 | 2013-03-01 | Menarini Int Operations Lu Sa | AUTOINECTOR DEVICE FOR TWO DRUG DOSES |
WO2011114430A1 (en) | 2010-03-15 | 2011-09-22 | 富士通株式会社 | Radio base station and radio parameter adjusting method |
US8834413B2 (en) | 2010-03-16 | 2014-09-16 | Sanofi-Aventis Deutschland Gmbh | Controlling a motor of an injection device |
TWI633902B (en) | 2010-03-22 | 2018-09-01 | 賽諾菲阿凡提斯德意志有限公司 | Device, method, system and computer program for determining information related to a medical device |
CN102905743B (en) | 2010-03-25 | 2015-04-22 | 赛诺菲-安万特德国有限公司 | Medicated module with user selection |
CN102905744B (en) | 2010-03-25 | 2016-03-30 | 赛诺菲-安万特德国有限公司 | There is the medicated module that automatic liquid reservoir engages |
TW201200190A (en) | 2010-03-26 | 2012-01-01 | Sanofi Aventis Deutschland | Electro-mechanical drug delivery device |
US8986259B2 (en) | 2010-03-31 | 2015-03-24 | Sanofi-Aventis Deutschland Gmbh | Piston rod assembly for a drug delivery device |
CA2794816A1 (en) | 2010-03-31 | 2011-10-06 | Sanofi-Aventis Deutschland Gmbh | Set of drug delivery devices with tactile or visual enhancements |
CN103143082B (en) | 2010-03-31 | 2015-03-25 | Shl集团有限责任公司 | Medicament delivery device |
US9327083B2 (en) | 2010-04-07 | 2016-05-03 | Shl Group Ab | Medicament delivery device |
EP2555818A2 (en) | 2010-04-09 | 2013-02-13 | Sanofi-Aventis Deutschland GmbH | Coded cap for use with a drug delivery device |
MX2012012325A (en) | 2010-04-23 | 2013-01-29 | Sanofi Aventis Deutschland | Coded cartridge assembly. |
CN102946928B (en) | 2010-04-23 | 2015-08-26 | 赛诺菲-安万特德国有限公司 | Coding fastener assembly |
US9381304B2 (en) | 2010-04-23 | 2016-07-05 | Sanofi-Aventis Deutschland Gmbh | Cartridge holder and alignment interface |
WO2011152772A1 (en) | 2010-06-03 | 2011-12-08 | Shl Group Ab | Medicament delivery device |
EP2579922B1 (en) * | 2010-06-11 | 2016-11-16 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a drug delivery device and drug delivery device |
CA2801161A1 (en) | 2010-06-11 | 2011-12-15 | Sanofi-Aventis Deutschland Gmbh | A drive assembly for a medication delivery device and medication delivery device |
EP3639775A1 (en) | 2010-06-23 | 2020-04-22 | Zimmer, Inc. | Flexible plate fixation of bone fractures |
US8790379B2 (en) | 2010-06-23 | 2014-07-29 | Zimmer, Inc. | Flexible plate fixation of bone fractures |
US8728040B2 (en) | 2010-06-23 | 2014-05-20 | Tcb Medical Devices, Llc | Injector for auto-injection of medication and associated method of use |
EP2588166B1 (en) | 2010-07-02 | 2018-09-05 | Sanofi-Aventis Deutschland GmbH | Safety device for a pre-filled syringe and injection device |
RU2578360C2 (en) | 2010-07-02 | 2016-03-27 | Санофи-Авентис Дойчланд Гмбх | Injection device |
DK2588165T3 (en) | 2010-07-02 | 2020-09-14 | Sanofi Aventis Deutschland | SAFETY DEVICE FOR A FILLED SYRINGE Syringe, INJECTION DEVICE AND INJECTION KIT |
SG186321A1 (en) | 2010-07-02 | 2013-02-28 | Sanofi Aventis Deutschland | Needle shield for a safety device, safety device and injection device |
RU2573039C2 (en) | 2010-07-02 | 2016-01-20 | Санофи-Авентис Дойчланд Гмбх | Safety device for pre-filled syringe and injector |
SG186317A1 (en) | 2010-07-02 | 2013-01-30 | Sanofi Aventis Deutschland | Safety device for a pre-filled syringe and injection device |
CA2803486A1 (en) | 2010-07-02 | 2012-01-05 | Sanofi-Aventis Deutschland Gmbh | Safety device for a pre-filled syringe and injection device |
JP5901627B2 (en) | 2010-07-02 | 2016-04-13 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Safety devices for drug-filled syringes and injection devices |
EP2603261A2 (en) | 2010-08-13 | 2013-06-19 | Sanofi-Aventis Deutschland GmbH | Connector for a drug delivery device reservoir |
CA2808469A1 (en) | 2010-08-19 | 2012-02-23 | Sanofi-Aventis Deutschland Gmbh | Method and system for determining information related to a drug reservoir using an electronic sensor |
US20120101475A1 (en) | 2010-10-21 | 2012-04-26 | Meridian Medical Technologies, Inc. | High Efficiency Auto-Injector |
US20130281934A1 (en) | 2010-12-30 | 2013-10-24 | Meridian Medical Technologies, Inc. | Slip-Resistant Autoinjectors |
US9283020B2 (en) | 2011-01-03 | 2016-03-15 | Warsaw Orthopedic, Inc. | Surgical tack delivery system, method and kit |
WO2012122643A1 (en) | 2011-03-11 | 2012-09-20 | University Of Saskatchewan | Injection assist device and method |
US20120253314A1 (en) | 2011-03-30 | 2012-10-04 | Ziv Harish | Palm-controlled injectors |
KR20120119280A (en) | 2011-04-21 | 2012-10-31 | 한국전자통신연구원 | Capacitor |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
CN103747824B (en) | 2011-08-24 | 2016-08-17 | 尤尼特拉克特注射器控股有限公司 | Automatic injector for concertina type precharging type syringe |
GB2576384B (en) | 2018-10-30 | 2022-09-21 | Grey Orange Pte Ltd | Method for operating a pallet pick put system for transporting objects |
-
2014
- 2014-03-11 WO PCT/US2014/023485 patent/WO2014164786A1/en active Application Filing
- 2014-03-11 CA CA2905031A patent/CA2905031C/en active Active
- 2014-03-11 JP JP2016501243A patent/JP6030803B2/en active Active
- 2014-03-11 ES ES14778806T patent/ES2742046T3/en active Active
- 2014-03-11 US US14/204,641 patent/US9707354B2/en active Active
- 2014-03-11 EP EP19173290.8A patent/EP3572108A1/en not_active Withdrawn
- 2014-03-11 EP EP14778806.1A patent/EP2968792B1/en active Active
-
2017
- 2017-07-14 US US15/650,332 patent/US10610649B2/en active Active
-
2020
- 2020-02-21 US US16/797,447 patent/US11628260B2/en active Active
-
2023
- 2023-03-14 US US18/183,372 patent/US20230211089A1/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050165363A1 (en) | 2002-03-18 | 2005-07-28 | Judson Jared A. | Medication dispensing apparatus with gear set for mechanical advantage |
US20070191784A1 (en) | 2004-03-30 | 2007-08-16 | Jacobs Alexander T | Medication dispensing apparatus with gear set having drive member accommodating opening |
US20110269750A1 (en) * | 2005-03-08 | 2011-11-03 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
US20120157965A1 (en) * | 2009-03-20 | 2012-06-21 | Antares Pharma, Inc. | Hazardous agent injection system |
US20120253287A1 (en) * | 2009-12-15 | 2012-10-04 | Shl Group Ab | Medicament delivery device |
Non-Patent Citations (1)
Title |
---|
See also references of EP2968792A4 |
Also Published As
Publication number | Publication date |
---|---|
JP2016512461A (en) | 2016-04-28 |
US20140257197A1 (en) | 2014-09-11 |
CA2905031C (en) | 2018-01-23 |
ES2742046T3 (en) | 2020-02-12 |
US11628260B2 (en) | 2023-04-18 |
EP3572108A1 (en) | 2019-11-27 |
EP2968792A1 (en) | 2016-01-20 |
EP2968792B1 (en) | 2019-05-15 |
US20170312448A1 (en) | 2017-11-02 |
US9707354B2 (en) | 2017-07-18 |
JP6030803B2 (en) | 2016-11-24 |
US20230211089A1 (en) | 2023-07-06 |
EP2968792A4 (en) | 2016-03-23 |
US20200188603A1 (en) | 2020-06-18 |
US10610649B2 (en) | 2020-04-07 |
CA2905031A1 (en) | 2014-10-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11628260B2 (en) | Multiple dosage injector with rack and pinion dosage system | |
US11446440B2 (en) | Needle assisted injection device having reduced trigger force | |
US11291773B2 (en) | Multiple dosage injector with rotating screw dosage system | |
US20210113768A1 (en) | Needle Assisted Injection Device Having Reduced Trigger Force | |
US20220062564A1 (en) | Syringe shock absorber for use in an injection device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 14778806 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2905031 Country of ref document: CA Ref document number: 2016501243 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2014778806 Country of ref document: EP |