WO2014179562A8 - 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof - Google Patents

1,3,5-triazinane-2,4,6-trione derivatives and uses thereof Download PDF

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Publication number
WO2014179562A8
WO2014179562A8 PCT/US2014/036355 US2014036355W WO2014179562A8 WO 2014179562 A8 WO2014179562 A8 WO 2014179562A8 US 2014036355 W US2014036355 W US 2014036355W WO 2014179562 A8 WO2014179562 A8 WO 2014179562A8
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WO
WIPO (PCT)
Prior art keywords
diseases
triazinane
compounds
subject
agent
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Application number
PCT/US2014/036355
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French (fr)
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WO2014179562A1 (en
Inventor
Yizhou Dong
Akinleye C. Alabi
Hao Yin
Joseph R. Dorkin
Delai Chen
Robert S. Langer
Daniel Griffith Anderson
Ahmed A. ELTOUKHY
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Massachusetts Institute Of Technology
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Application filed by Massachusetts Institute Of Technology filed Critical Massachusetts Institute Of Technology
Publication of WO2014179562A1 publication Critical patent/WO2014179562A1/en
Publication of WO2014179562A8 publication Critical patent/WO2014179562A8/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/30—Only oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides

Abstract

The present invention provides novel l,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, or plasmid DNA). The present invention also provides methods and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, and lung diseases.
PCT/US2014/036355 2013-05-01 2014-05-01 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof WO2014179562A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361818295P 2013-05-01 2013-05-01
US61/818,295 2013-05-01

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WO2014179562A1 WO2014179562A1 (en) 2014-11-06
WO2014179562A8 true WO2014179562A8 (en) 2015-01-08

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US (1) US9315472B2 (en)
WO (1) WO2014179562A1 (en)

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