WO2015190706A1 - Diabetes measuring device and operation method thereof - Google Patents

Diabetes measuring device and operation method thereof Download PDF

Info

Publication number
WO2015190706A1
WO2015190706A1 PCT/KR2015/004627 KR2015004627W WO2015190706A1 WO 2015190706 A1 WO2015190706 A1 WO 2015190706A1 KR 2015004627 W KR2015004627 W KR 2015004627W WO 2015190706 A1 WO2015190706 A1 WO 2015190706A1
Authority
WO
WIPO (PCT)
Prior art keywords
sensor
diabetes
diabetic
insertion tube
wireless transmitter
Prior art date
Application number
PCT/KR2015/004627
Other languages
French (fr)
Korean (ko)
Inventor
최우진
Original Assignee
최우진
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 최우진 filed Critical 최우진
Publication of WO2015190706A1 publication Critical patent/WO2015190706A1/en

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • GPHYSICS
    • G08SIGNALLING
    • G08CTRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
    • G08C17/00Arrangements for transmitting signals characterised by the use of a wireless electrical link

Definitions

  • the present invention relates to a diabetic measuring apparatus and its operation method, and more particularly to a diabetic measuring apparatus and its operation method to install a diabetes sensor in the nasolacrimal duct of a diabetic patient to perform a diabetic check.
  • Diabetes mellitus is a serious disease that usually results in an increase in blood glucose due to abnormalities in the production or use of insulin and accompanying various acute and chronic complications.
  • NDFS National Diabetes Fact Sheet
  • $ 132 billion was spent on direct and indirect medical expenses related to diabetes.
  • Diabetic Retinopathy occurs in patients with diabetes more than 60% within 10 years of diabetic diagnosis and in 90% or more within 20 years.
  • Diabetic retinopathy is a micro-angiopathy of diabetes, characterized by permeability changes in retinal vessels, vascular obstruction, ischemia, neovascularization, and thus fibrovascular proliferation. to be.
  • Korean Patent Registration No. 10-1391506 (registered on April 25, 2014) describes a marker for diagnosing diabetic retinopathy and its use, and includes an agent for measuring mRNA or protein level of Alpha-1 acid glycoprotein (AGP) gene.
  • AGP Alpha-1 acid glycoprotein
  • APOC1 Polipoprotein C1
  • APOB100 Polipoprotein B100
  • APOC3 Apolipoprotein C3
  • VTN Vitronectin
  • PLG Plasminogen
  • HRP Histidine-rich protein
  • AFM Afamin
  • CP ceruloplasmin
  • CFB complement factor B
  • PEDF pigment epithelium derived factor
  • the disclosed technology by providing a marker for diagnosing diabetic retinopathy, by measuring and comparing the expression level of the gene or its protein with increased or decreased expression in diabetic retinopathy, the early diagnosis and degree of disease of diabetic retinopathy It can be significantly predicted or identified, and also enables the non-invasive diagnosis can be a simple and effective early diagnosis of diabetic retinopathy by blood, urine test, and the like.
  • Korean Patent Laid-Open Publication No. 10-2002-0066792 discloses immunochromatography that can be used to diagnose diabetes by quantitatively or semi-quantitatively confirming the sensitization in the blood of glycated hemoglobin, one of the diabetic labeling substances.
  • a quick diagnosis kit and analysis method for diabetes using graphigraphy is described.
  • the disclosed technique in an immunochromatography technique using an antigen antibody, the antibody is immobilized on the surface of the nitrocellulose membrane to be set as a signal detection region, and the buffer pad, the gold conjugate pad, the sample pad, the nitrocellulose pad, and the hygroscopic pad in that order.
  • Quantitative analysis by spectroscopy is performed in an analysis kit in which portions are overlapped, and semiquantitative analysis using color balance is performed.
  • a diagnostic marker or a diagnostic kit is used to measure diabetes, but it is highly accurate to measure diabetes by blood, and blood is collected and checked at all hospitals. Because there was no choice but to check, there was an inconvenience caused by blood collection, and the pain associated with blood collection also caused problems for diabetics and the diabetic measurement management for diabetics was not performed properly. there was.
  • the technical problem to be achieved by the present invention is to solve the inconveniences or problems as described above, and provides a diabetic measuring device and its operation method to perform a diabetic check by installing a diabetes sensor in the nasolacrimal duct of a diabetic patient.
  • the insertion tube is inserted into the nasolacrimal duct, and delivers the tears collected in the nasolacrimal duct;
  • a diabetic sensor inserted into the insertion tube to check a diabetes by receiving tears delivered through the insertion tube and measuring blood glucose;
  • a wireless transmitter for generating and transmitting a blood glucose information signal for transmitting blood glucose measured by the diabetes sensor to the outside;
  • a diabetes measuring device comprising a self-power supply for converting and supplying power to the diabetes sensor and the wireless transmitter.
  • the insertion tube is cylindrical, characterized in that the tube made of silicon material is inserted into the nasolacrimal duct.
  • the diabetes sensor has a width of 0.5 ⁇ 1.5mm and a length of 1 ⁇ 4mm, it is characterized in that it is replaced once every preset replacement period.
  • the diabetic sensor is attached along the cylindrical inner surface of the insertion tube to the inside of the insertion tube in a cylindrical shape so that tears pass through the inner surface, or ?? Put the date in the form characterized in that the tears pass on both sides.
  • the wireless transmitter is connected to the diabetic sensor in the form of a thin film, characterized in that it is fixed to the inner surface or the outer surface or the sinus of the insertion tube.
  • the self-power supply is connected to the diabetes sensor and the wireless transmitter, characterized in that the battery of the thin film form fixed to the inner surface or the outer surface or the sinus of the insertion tube.
  • the self-power supply is characterized in that the ultra-high efficiency nano power generation device for converting small micro-vibration of the nanometer level into electrical energy.
  • the diabetic measuring device characterized in that it further comprises an external display device for receiving a wireless blood glucose information signal from the wireless transmitter for displaying the measured blood glucose.
  • the external display device may include: a wireless receiver configured to receive a wireless blood sugar information signal transmitted from the wireless transmitter and convert the wireless blood sugar information signal into a measured blood sugar; A display unit which displays the measured blood sugar converted by the wireless receiver on a screen; And a power supply unit receiving external commercial power or power from a battery or a rechargeable battery, converting and supplying the power to the wireless receiver and the display.
  • the insertion tube inserted into the nasolacrimal duct to deliver the tears gathered into the nasolacrimal duct;
  • a self-power supply converts and supplies power to a diabetes sensor and a wireless transmitter;
  • a diabetic sensor inserted into the insertion tube to receive the tear and check diabetes to measure blood glucose;
  • a wireless transmitter generating and transmitting a blood glucose information signal for transmitting blood glucose measured by the diabetes sensor to the outside.
  • the operation method of the diabetic measuring device the inserting device using a probe or endoscope to insert the insertion tube which is a tube of silicon material in the nasolacrimal duct; Inserting, by the insertion apparatus, the diabetes sensor into the insertion tube using an endoscope; When the diabetic sensor is inserted and installed, the inserting device using an endoscope to securely install a wireless transmitter connected to the diabetic sensor to an inner surface, an outer surface, or a sinus of the insertion tube; And installing and inserting the self-power supply in a state connected to the diabetic sensor and the wireless transmitter to the inner surface or the outer surface or the sinus of the insertion tube by using the endoscope. It further comprises.
  • the operation method of the diabetic measuring device is installed by inserting the diabetic sensor already installed in the insertion tube, which is a tube made of silicone using a probe or endoscope directly into the nasolacrimal duct;
  • the inserting device using an endoscope to securely install a wireless transmitter connected to the diabetic sensor to an inner surface, an outer surface, or a sinus of the insertion tube;
  • the step of inserting the diabetic sensor is installed along the cylindrical inner surface of the insertion tube in a cylindrical shape so that tears pass through the inner surface, or the insertion tube Inside the ?? Put the date in the form characterized in that the tear is installed on both sides pass.
  • the step of inserting the diabetic sensor the insertion device is pulled out of the diabetic sensor inserted into the insertion tube with a forceps while looking into the endoscope once every predetermined replacement period, the insertion tube using the endoscope It further comprises the step of replacing with a new diabetes sensor.
  • the operation method of the diabetes measuring device characterized in that the external display device further comprises the step of receiving and receiving the wireless blood glucose information signal converted to the measured blood sugar to display.
  • the diabetic sensor by installing a diabetic sensor in the nasolacrimal duct of a diabetic patient to perform a diabetic check, the diabetic sensor can be installed in the nasolacrimal duct with a high density of tears through a simple non-invasive procedure, thereby easily checking blood glucose. It is very easy and convenient to manage the diabetic measurement for the diabetic patient, and it can greatly increase the accuracy of the diabetic measurement. Also, it is not necessary to collect the blood of the diabetic patient, thereby eliminating the inconvenience and pain caused by the blood collection. Non-invasive procedures for diabetics have the effect of reducing discomfort and rejection.
  • FIG. 1 is a diagram illustrating a diabetic measuring apparatus according to an embodiment of the present invention.
  • FIG. 2 is a view for explaining the installation of the insertion tube and diabetes sensor in FIG.
  • FIG. 3 is a view for explaining the installation procedure of the insertion tube in FIG.
  • FIG. 4 is a flowchart illustrating a method of operating a diabetic measuring apparatus according to an embodiment of the present invention.
  • first and second are intended to distinguish one component from another component, and the scope of rights should not be limited by these terms.
  • first component may be named a second component, and similarly, the second component may also be named a first component.
  • FIG. 1 is a view illustrating a diabetic measuring apparatus according to an embodiment of the present invention
  • Figure 2 is a view illustrating the installation of the insertion tube and the diabetes sensor in Figure 1
  • Figure 3 is an installation of the insertion tube in Figure 1 It is a figure explaining a procedure.
  • the diabetic measuring apparatus 100 includes an insertion tube 110, a diabetes sensor 120, a wireless transmitter 130, and a self-power supply 140.
  • Insertion tube 110 is inserted into the nasolacrimal duct, which is a tube leading from the eyes of the diabetic to the nostrils, and delivers the tears collected in the nasolacrimal duct to the diabetic sensor 120.
  • the insertion tube 110 is a tube made of silicon, similar to a procedure for inserting a silicon tube through a nasal tube obstruction, and as shown in FIG. 2, inserted into the nasal tube in a cylindrical shape.
  • Non-invasive procedures can reduce discomfort and rejection in diabetics.
  • the insertion tube 110 may be inserted into the nasolacrimal duct by nasal tube stenting or fistula balloon dilation through a probe (Probe) or endoscope.
  • the diabetic sensor 120 is replaced once per predetermined replacement period and inserted into the insertion tube 110 to be driven by receiving power supplied from the self-power supply 140 and transmitted through the insertion tube 110.
  • the tear is applied to check the diabetes to measure the blood sugar, and delivers the measured blood sugar to the wireless transmitter (130).
  • the diabetic sensor 120 the width of the nasolacrimal duct is more than 2mm and the length is about 1.5cm, the width of 0.5 ⁇ 1.5mm and the length of 1 ⁇ 4mm (preferably, 1.13mm in width and 2.27mm in length) It can have an internal and external), it is inserted into the insertion tube 110 is installed once per month or once every two months while performing a diabetic check can be measured easily blood sugar.
  • the nasolacrimal duct is a part where the tears are collected, and thus the density of tears is higher than that of other eyes, thereby increasing the diabetic measurement accuracy of the diabetic sensor 120 installed in the nasolacrimal tube.
  • the diabetic sensor 120 can be installed by pushing into the insertion tube 110 installed in the nasolacrimal duct using a probe or endoscope, and can be pulled out with a forceps while looking at the endoscope later to be removed.
  • the diabetic sensor 120 as shown in Figure 2, as a sensor formed of nano-porous platinum that can be used in a living environment, the elongated tip can be mounted in the nasolacrimal duct into the insertion tube 110, the electrode A wide part of the shape may be connected to the self-power supply 140 through a flip-lock connector and mounted on the sinus.
  • the diabetic sensor 120 the cylindrical through the cylindrical inner surface of the insertion tube 110 to the inside of the insertion tube 110 to pass the tears to the inner surface, or inside the insertion tube (110) On ?? You can also put a date in the form so that the tears pass on both sides.
  • the diabetic sensor 120 may be fitted into the inner surface of the insertion tube 110 in the case of a cylindrical shape.
  • the wireless transmitter 130 is a proximity wireless communication module such as an RF communication module, an NFC communication module, etc., and is driven by receiving power supplied from the self-power supply 140, and externally measures the measured blood sugar transmitted from the diabetes sensor 120.
  • the wireless glucose information signal is converted into a wireless signal (ie, a wireless blood sugar information signal) for transmission to the external display device 150 and transmitted to the outside.
  • the wireless transmitter 130 in the form of a thin film, may be connected to the diabetes sensor 120 may be fixed to the inner surface or the outer surface of the insertion tube (110).
  • the wireless transmitter 130 is connected to the diabetic sensor 120 to the sinuses through the hole to check the hole entering the sinus (Maxillary Sinus Ostium) in the nose using an endoscope placed into the nose to be installed. It may also be removed simply by an endoscope through the nose if necessary.
  • the self-power supply 140 self-generates electrical energy (that is, power) to generate power of the self-generated components of the diabetes measuring apparatus 100 (that is, the diabetes sensor 120 and the wireless transmitter 130). It converts the power required for the supply of the converted power to the diabetes sensor 120 and the wireless transmitter 130.
  • the self-power supply 140 is a thin film type battery, connected to the diabetes sensor 120 and the wireless transmitter 130 may be fixed to the inner surface or the outer surface of the insertion tube 110. .
  • the self-power supply 140 is connected to the diabetic sensor 120 and the wireless transmitter 130 to the sinuses through the hole to check the hole entering the sinus in the nose using the endoscope put into the nose It may be installed or simply removed by an endoscope through the nose if necessary.
  • the self-power supply 140 is a self-generator by vibrating using the nano-device made by coupling the micro-generator to the nanoelectronic system circuit through the nano-device manufacturing process (that is, small fine vibration of several nanometers level) Ultra-high-efficiency nano-power generation device that converts the energy into electrical energy.
  • the nanoscale polymer ribbon is laid down over a few micrometer-thick zinc oxide rod, and the nanoscale electrode is deposited thereon to deposit the electrode from the zinc oxide rod. It can be formed by electrically connecting with an external circuit formed up to this substrate.
  • the self-power supply 140 covers a 100 nanometer-thick polymer film on the substrate on which the zinc oxide microrods are placed, and then applies a strong electron beam to generate a polymer bond to localize the nanoribbon that is connected from the top of the microrods to the underlying substrate.
  • the formed nanoribbons form a strong connection between the microrods and the circuits on the substrate without being affected by the physical and chemical processes exposed during the device fabrication process, like ropes hanging from the building to the ground.
  • a few tens of nanometers of metal can be deposited over the structure to stabilize the electrical connection between the zinc oxide rods and the circuitry below the substrate.
  • Diabetic measuring device 100 having the configuration as described above, by installing the diabetic sensor 120 in the nasolacrimal duct of the diabetic patient to perform the diabetic check, denseness of the diabetic sensor 120 through a simple non-invasive procedure Because it can be installed in the high nasolacrimal duct, it is easy to check the blood sugar, and it is very easy and convenient to manage the diabetic measurement for the diabetic patient, and it is possible to increase the accuracy of the diabetic measurement very much, and also it is not necessary to collect the blood of the diabetic patient. In addition, it is possible to eliminate the discomfort and pain associated with blood collection, and to reduce the discomfort and rejection by non-invasive procedures for diabetics.
  • the diabetic measuring device 100 having the above-described configuration When the diabetic measuring device 100 having the above-described configuration is installed in the nasolacrimal duct or sinus, when the volume of the wireless transmitter 130 or the self-power supply 140 is larger than the volume of the diabetic sensor 120, Without inserting into the nasolacrimal duct to start, the nasal tube ending in the nose through the endoscope can be put into the diabetic sensor 120 installed in the insertion tube 110 toward the eye, the wireless transmitter 130 or connected to the other end The self-power supply 140 may be inserted into the sinus.
  • the diabetes measuring apparatus 100 having the above-described configuration may further include an external display device 150 including a wireless receiver 151, a display 152, and a power supply 153.
  • the external display device 150 may be a terminal capable of close wireless communication such as a smart phone, a notebook, and the like.
  • such a terminal may receive an wireless blood glucose information signal from the wireless transmitter 130 and install an app or a program for displaying the measured blood glucose.
  • the wireless receiver 151 is a proximity wireless communication module such as an RF communication module, an NFC communication module, and the like, and is driven by receiving power supplied from the power supply unit 153, and transmits a wireless blood sugar information signal transmitted from the wireless transmitter 130.
  • the received blood sugar is converted into measurement blood sugar and then transferred to the display unit 152.
  • the display unit 152 is a screen display means such as an LCD and the like, is driven by receiving power supplied from the power supply unit 153, and displays the measured blood sugar transmitted from the wireless receiver 151 on the screen.
  • the power supply unit 153 is supplied with external commercial power or a battery (or a rechargeable battery) to each component of the external display device 150 (that is, the wireless receiver 151 and the display unit 152).
  • the power is converted into necessary power and the converted power is supplied to the wireless receiver 151 and the display 152.
  • FIG. 4 is a flowchart illustrating a method of operating a diabetic measuring apparatus according to an embodiment of the present invention.
  • an insertion device such as a robot arm inserts an insertion tube 110, which is a tube made of silicon, into a nasolacrimal duct that is a tube leading from the eyes of a diabetic patient to a nostril (S401).
  • the insertion device such as a robotic arm is inserted into the insertion tube 110 into the nasolacrimal duct that is 2 mm or more in width and 1.5 cm in length by nasolacrimal stenting or fistula balloon dilation using a probe or endoscope.
  • a probe or endoscope can be.
  • an insertion device such as a robot arm can insert a cylindrical insertion tube 110 into the nasolacrimal duct, thereby providing a non-invasive procedure to a diabetic patient. It can reduce discomfort and rejection.
  • the diabetic sensor 120 is inserted into the insertion tube 110, or already in the insertion tube 110 directly in the nasolacrimal duct without performing the above-described step S401. Inserted diabetic sensor 120 is installed (S402).
  • an insertion device such as a robotic arm is 0.5 to 1.5 mm wide and 1 to 4 mm long (preferably 1.13 mm wide and into the insertion tube 110 installed in the nasolacrimal duct using a probe or endoscope). 2.27mm length) can be installed by pushing the diabetic sensor 120.
  • an insertion device such as a robot arm is attached to the inner surface of the insertion tube 110 by the cylindrical diabetic sensor 120 along the cylindrical inner surface of the insertion tube 110 so that the tears pass to the inner surface.
  • inserting device such as robot arm is inserted into the insertion tube (110) ?? By putting the diabetic sensor 120 of the date in the form of a date may be installed so that the tears pass on both sides.
  • an insertion device such as a robot arm may pull out the diabetes sensor 120 inserted into the insertion tube 110 once every predetermined replacement period and replace it with a new diabetes sensor 120.
  • an insertion device such as a robotic arm can grasp the diabetic sensor 120 inserted into the insertion tube 110 with forceps while looking at the endoscope once a month or once every two months, and then remove the endoscope.
  • the thin film-type wireless transmitter 130 having a proximity wireless communication module such as an RF communication module, an NFC communication module, and the like, such as a robotic arm also has a diabetes sensor ( 120 to be fixed to the inner surface or the outer surface of the insertion tube 110 in a connected state (S403).
  • step S403 while checking the hole to enter the sinuses in the nose using an endoscope inserted into the nose, such as a robot arm, the wireless transmitter 130 connected to the diabetes sensor 120 through the hole. It can be installed in the sinuses and can also be simply removed by endoscope through the nose when needed.
  • the self-power supply 140 which is an insertion device such as a robotic arm, is a thin film battery, and is also inserted into the diabetic sensor 120 and the wireless transmitter 130 in a state of being connected. It is to be fixed to the inner surface or the outer surface of the tube 110 (S404).
  • step S403 using an endoscope inserted into the nose by an inserting device such as a robot arm, while checking a hole entering the sinus in the nose, the state connected with the diabetes sensor 120 and the wireless transmitter 130 through the hole.
  • Self-power supply 140 can be installed in the sinuses, it can also be simply removed by the endoscope through the nose if necessary.
  • the wireless transmitter 130 or the self-power supply when installing the insertion tube 110, the diabetes sensor 120, the wireless transmitter 130, the self-power supply 140 in the above-described step S401 to S404, the wireless transmitter 130 or the self-power supply ( If the volume of the diaphragm 140 is greater than that of the diabetic sensor 120, an insertion device such as a robot arm is inserted into the insertion pipe 110 into the nasolacrimal tube ending in the nose using an endoscope, rather than being inserted into the nasolacrimal tube starting from the eye.
  • the diabetic sensor 120 installed can be pushed up toward the eye, and the wireless transmitter 130 or the self-power supply 140 connected to the other end may be inserted into the sinus.
  • the self-power supply 140 is electric energy (that is, power) By self-generating the power generated by the corresponding self-converted to each of the components of the diabetes measuring device 100 (that is, diabetes sensor 120, wireless transmitter 130) by converting the converted power to the diabetes sensor 120 ) And the radio transmitter 130 is supplied (S405).
  • the insertion tube 110 delivers the tears gathered into the nasolacrimal duct to the diabetes sensor 120, wherein the diabetes sensor 120 is supplied from the self-power supply 140. While receiving and driving the power, and receiving the tear transmitted through the insertion tube 110, check the diabetes to measure the blood sugar, and transmits the measured blood sugar to the wireless transmitter (130) (S406).
  • the wireless transmitter 130 transmits the measured blood sugar transmitted from the diabetes sensor 120 to the outside (for example, the external display device 150) while driving by receiving power supplied from the self-power supply 140. It generates (ie, converts) a wireless signal (ie, a wireless blood sugar information signal) for transmitting the converted wireless blood sugar information signal to the outside (S407).
  • a wireless signal ie, a wireless blood sugar information signal
  • the external display device 150 including the wireless receiver 151, the display unit 152, and the power supply unit 153 receives an wireless blood glucose information signal from the wireless transmitter 130 and displays the measured blood sugar as a measurement blood sugar.
  • the pre-installed app or program is driven. Accordingly, when the wireless receiver 151 having a proximity wireless communication module such as an RF communication module or an NFC communication module receives a wireless blood glucose information signal transmitted from the wireless transmitter 130 (S408), the received wireless The blood sugar information signal is converted into the measured blood sugar to transfer the converted measured blood sugar to the display unit 152 (S409).
  • the display unit 152 having screen display means such as an LCD displays the measured blood sugar transmitted from the wireless receiver 151 on the screen (S410).
  • the embodiment of the present invention is not implemented only through the above-described apparatus and / or method, but through a program for realizing a function corresponding to the configuration of the embodiment of the present invention, a recording medium on which the program is recorded, and the like.
  • Such an implementation may be easily implemented by those skilled in the art to which the present disclosure pertains based on the description of the above-described embodiments.

Abstract

The present invention relates to: a diabetes measuring device which installs a diabetes sensor in a nasolacrimal duct of a diabetic patient, thereby checking diabetes; and an operation method thereof. An insertion tube is inserted and installed in a nasolacrimal duct to thereby transfer tears collected in the nasolacrimal duct; a diabetes sensor is inserted and installed in the insertion tube to thereby receive tears transferred through the insertion tube, check diabetes and measure the blood sugar; a wireless transmitter generates the blood sugar measured by the diabetes sensor as a wireless blood sugar information signal for transmitting to the outside, and transmits the same; and a self-supplied power supplier converts power to the power required by the diabetes sensor and the wireless transmitter and supplies the same.

Description

[규칙 제26조에 의한 보정 29.07.2015] 당뇨 측정 장치 및 그 운용방법[Revision 29.07.2015 by Rule 26] Diabetes measuring device and its operation method
본 발명은 당뇨 측정 장치 및 그 운용방법에 관한 것으로, 특히 당뇨 환자의 비루관 내에 당뇨센서를 설치하여 당뇨 체크를 수행하도록 한 당뇨 측정 장치 및 그 운용방법에 관한 것이다.The present invention relates to a diabetic measuring apparatus and its operation method, and more particularly to a diabetic measuring apparatus and its operation method to install a diabetes sensor in the nasolacrimal duct of a diabetic patient to perform a diabetic check.
당뇨병은 일반적으로 인슐린의 생성 혹은 이용 과정의 이상으로 혈당이 증가하고 그에 따른 다양한 급성, 만성 합병증을 동반하는 심각한 질환이다. 2005년 미국 NDFS(National Diabetes Fact Sheet)에 따르면, 미국의 경우에 20 세 이상 인구의 9.6%인 2000만 명 이상이 당뇨를 가지고 있고, 발병 위험이 높은 당뇨 전단계(Pre-diabetes) 환자가 5000만 명 이상으로 추정된다고 되어 있으며, 2002년 직접, 간접적인 의료비용으로 1320억 달러가 당뇨와 관련되어 지출되었다. 또한, 우리나라의 경우에도, 2005년 질병관리본부에서 시행한 국민건강영양조사에 따르면, 30세 이상 남자의 9.0%, 여자의 7.2% 가 당뇨병 환자로 나타났으며, 또한 대한 당뇨병학회가 발간한 '2007년 한국인 당뇨병 연구보고서'에 따르면, 당뇨의 유병률은 약 8%이고 매년 10%의 새로운 환자가 발생하고 있으며 당뇨 관련 의료비가 건강보험비용의 약 20%인 3조원을 차지할 것이라고 한다. 현재 400 ~ 500만 명으로 추산되는 당뇨 환자 수의 최근의 빠른 증가 속도를 고려할 때, 10 ~ 20년 후 1000만 명에 이를 수 있다.Diabetes mellitus is a serious disease that usually results in an increase in blood glucose due to abnormalities in the production or use of insulin and accompanying various acute and chronic complications. According to the 2005 National Diabetes Fact Sheet (NDFS) in the United States, more than 20 million people, or 9.6 percent of the population over 20 years of age, have diabetes and 50 million pre-diabetes patients at high risk. In 2002, $ 132 billion was spent on direct and indirect medical expenses related to diabetes. Also in Korea, according to the National Health and Nutrition Survey conducted by the Centers for Disease Control and Prevention in 2005, 9.0% of men over the age of 30 and 7.2% of women were diagnosed with diabetes, and the Korean Diabetes Association published ' According to the 2007 Korean Diabetes Research Report, the prevalence of diabetes is about 8%, 10% of new patients are generated each year, and diabetes-related medical expenses will account for about 3 trillion won, about 20% of health insurance costs. Given the recent rapid growth in the number of diabetics currently estimated at 4-5 million, it could reach 10 million in 10-20 years.
당뇨병의 이환 기간이 길어짐에 따라 전신의 다양한 합병증을 동반하게 되는데, 대표적으로 심혈관계 질환, 당뇨신증, 당뇨신경병증, 당뇨망막병증이 발생하게 된다. 당뇨망막병증(Diabetic Retinopathy, DR)은 당뇨 환자에게서 당뇨 진단 10년 내에 60% 이상에서, 20년 내에 90% 이상에서 나타난다. 당뇨망막병증은 당뇨병의 미세혈관 합병증(Micro-angiopathy)의 하나로 망막 혈관의 투과성 변화와 혈관 폐쇄, 허혈 변화(Ischemia), 신생혈관 생성(Neovascularization), 그리고 이에 따른 섬유혈관 증식(Fibrovascular Proliferation)이 특징이다.The longer the duration of diabetes is accompanied by a variety of systemic complications, including cardiovascular disease, diabetes mellitus, diabetic neuropathy, diabetic retinopathy. Diabetic Retinopathy (DR) occurs in patients with diabetes more than 60% within 10 years of diabetic diagnosis and in 90% or more within 20 years. Diabetic retinopathy is a micro-angiopathy of diabetes, characterized by permeability changes in retinal vessels, vascular obstruction, ischemia, neovascularization, and thus fibrovascular proliferation. to be.
한국등록특허 제10-1391506호(2014.04.25 등록)는 당뇨망막병증 진단용 마커 및 이의 용도에 관하여 기재되어 있는데, AGP(Alpha-1 acid glycoprotein) 유전자의 mRNA 또는 이의 단백질 수준을 측정하는 제제를 포함하는 비증식성당뇨망막병증 진단용 조성물로서, APOC1(Apolipoprotein C1), APOB100(Apolipoprotein B100), APOC3(Apolipoprotein C3), VTN(Vitronectin), PLG(Plasminogen), HRP(Histidine-rich protein), AFM(Afamin), CP(Ceruloplasmin), CFB(Complement factor B) 및 PEDF(Pigment Epithelium Derived Factor)로 이루어진 군에서 선택되는 하나 이상의 유전자의 mRNA 또는 이의 단백질 수준을 추가로 측정하는 제제를 포함하는 것을 특징으로 한다. 개시된 기술에 따르면, 당뇨망막병증을 진단할 수 있는 마커를 제공하여, 당뇨망막병증 환자에게서 발현이 증가 또는 감소한 유전자 또는 그 단백질의 발현 수준을 측정 및 비교함으로써, 당뇨망막병증의 조기진단 및 질병 정도를 유의적으로 예측 또는 파악할 수 있으며, 또한 비침습성 진단을 가능하게 하여 혈액, 뇨 검사 등으로 간단하고 유효성 있는 당뇨망막병증의 초기 진단을 할 수 있다.Korean Patent Registration No. 10-1391506 (registered on April 25, 2014) describes a marker for diagnosing diabetic retinopathy and its use, and includes an agent for measuring mRNA or protein level of Alpha-1 acid glycoprotein (AGP) gene. As a composition for diagnosing non-proliferative diabetic retinopathy, APOC1 (Apolipoprotein C1), APOB100 (Apolipoprotein B100), APOC3 (Apolipoprotein C3), VTN (Vitronectin), PLG (Plasminogen), HRP (Histidine-rich protein), AFM (Afamin) And an agent for further measuring mRNA or protein levels of at least one gene selected from the group consisting of ceruloplasmin (CP), complement factor B (CFB), and pigment epithelium derived factor (PEDF). According to the disclosed technology, by providing a marker for diagnosing diabetic retinopathy, by measuring and comparing the expression level of the gene or its protein with increased or decreased expression in diabetic retinopathy, the early diagnosis and degree of disease of diabetic retinopathy It can be significantly predicted or identified, and also enables the non-invasive diagnosis can be a simple and effective early diagnosis of diabetic retinopathy by blood, urine test, and the like.
한국공개특허 제10-2002-0066792호(2002.08.21 공개)는 당뇨 표지 물질중의 한가지인 당화혈색소의 혈액 내의 증감을 간단한 조작으로 정량 또는 반정량적으로 확인하여 당뇨병의 진단에 이용하도록 한 면역크로마토그라피법을 이용한 당뇨 신속 진단 킷트 및 분석 방법에 관하여 기재되어 있다. 개시된 기술에 따르면, 항원 항체를 이용한 면역크로마토그라피기법에 있어서, 니트로셀룰로즈 멤브레인 표면에 항체를 고정화시켜 신호 검출 지역으로 설정하고 완충용액패드, 금결합체패드, 시료패드, 니트로셀룰로즈패드, 흡습패드 순으로 일부분을 겹쳐서 위치시키는 분석 킷트에서 분광법을 통한 정량 분석을 수행하며, 색대조표를 이용한 반정량 분석을 수행하는 것을 특징으로 한다.Korean Patent Laid-Open Publication No. 10-2002-0066792 (published Aug. 21, 2002) discloses immunochromatography that can be used to diagnose diabetes by quantitatively or semi-quantitatively confirming the sensitization in the blood of glycated hemoglobin, one of the diabetic labeling substances. A quick diagnosis kit and analysis method for diabetes using graphigraphy is described. According to the disclosed technique, in an immunochromatography technique using an antigen antibody, the antibody is immobilized on the surface of the nitrocellulose membrane to be set as a signal detection region, and the buffer pad, the gold conjugate pad, the sample pad, the nitrocellulose pad, and the hygroscopic pad in that order. Quantitative analysis by spectroscopy is performed in an analysis kit in which portions are overlapped, and semiquantitative analysis using color balance is performed.
상술한 바와 같은 종래 기술에서는 당뇨 측정에 진단용 마커나 진단 킷트를 사용하고 있으나, 혈액으로 당뇨를 측정하는 것이 정확도가 높아, 모든 병원들에서 혈액을 채취하여 체크하며, 또한 당뇨환자가 직접 혈액을 채취하여 체크할 수밖에 없었으므로, 혈액 채취에 따른 불편함이 있었으며, 혈액 채취에 동반되는 통증 또한 당뇨 환자에게 고통을 주고 이에 당뇨 환자에 대한 당뇨 측정 관리가 제대로 안 이루어지지는 경우가 많이 발생되는 문제점이 있었다.In the prior art as described above, a diagnostic marker or a diagnostic kit is used to measure diabetes, but it is highly accurate to measure diabetes by blood, and blood is collected and checked at all hospitals. Because there was no choice but to check, there was an inconvenience caused by blood collection, and the pain associated with blood collection also caused problems for diabetics and the diabetic measurement management for diabetics was not performed properly. there was.
한편, 종래 기술에서 스마트 콘택트렌즈를 통해 비침습적 혈당관리제품을 개발하여 당뇨 환자 몸속에 센서를 심어 당뇨 체크를 하는 경우가 있는데, 이러한 콘택트렌즈의 경우에 착용이 길어지면 안구건조 및 이물감등의 부작용이 발생하는 문제점이 있다. 또한, 당뇨 환자의 체내에 심는 센서는 한 달마다 한 번씩 찔러야 하는 아픔을 당뇨 환자에게 주는 문제점도 있다.On the other hand, in the prior art by developing a non-invasive blood sugar management product through a smart contact lens to check the diabetes by planting a sensor in the body of the diabetic patient, side effects such as dry eye and foreign body when the wear is prolonged There is a problem that occurs. In addition, the sensor planted in the body of the diabetic patient has a problem that gives the diabetic patient the pain that must be stabbed once a month.
본 발명이 이루고자 하는 기술적 과제는, 전술한 바와 같은 불편함 내지는 문제점을 해결하기 위한 것으로, 당뇨 환자의 비루관 내에 당뇨센서를 설치하여 당뇨 체크를 수행하도록 한 당뇨 측정 장치 및 그 운용방법을 제공한다.The technical problem to be achieved by the present invention is to solve the inconveniences or problems as described above, and provides a diabetic measuring device and its operation method to perform a diabetic check by installing a diabetes sensor in the nasolacrimal duct of a diabetic patient.
이러한 과제를 해결하기 위해서는, 본 발명의 한 특징에 따르면, 비루관 내에 삽입 설치되어, 비루관으로 모이는 눈물을 전달하는 삽입튜브; 상기 삽입튜브 내에 삽입 설치되어, 상기 삽입튜브를 통해 전달되는 눈물을 인가받아 당뇨를 체크하여 혈당으로 측정하는 당뇨센서; 상기 당뇨센서에서 측정한 혈당을 외부로 전송하기 위한 무선혈당정보신호로 생성시켜 전송하는 무선송신기; 및 상기 당뇨센서 및 상기 무선송신기에 필요한 전원으로 변환시켜 공급하는 자가전원공급기를 포함하는 당뇨 측정 장치를 제공한다.In order to solve this problem, according to one feature of the present invention, the insertion tube is inserted into the nasolacrimal duct, and delivers the tears collected in the nasolacrimal duct; A diabetic sensor inserted into the insertion tube to check a diabetes by receiving tears delivered through the insertion tube and measuring blood glucose; A wireless transmitter for generating and transmitting a blood glucose information signal for transmitting blood glucose measured by the diabetes sensor to the outside; And it provides a diabetes measuring device comprising a self-power supply for converting and supplying power to the diabetes sensor and the wireless transmitter.
일 실시 예에서, 상기 삽입튜브는, 원통 모양으로 상기 비루관 내에 삽입 설치되는 실리콘 재질의 관인 것을 특징으로 한다.In one embodiment, the insertion tube is cylindrical, characterized in that the tube made of silicon material is inserted into the nasolacrimal duct.
일 실시 예에서, 상기 당뇨센서는, 0.5 ~ 1.5mm의 폭과 1 ~ 4mm의 길이를 가지며, 기 설정된 교체 기간마다 한 번씩 교체되는 것을 특징으로 한다.In one embodiment, the diabetes sensor has a width of 0.5 ~ 1.5mm and a length of 1 ~ 4mm, it is characterized in that it is replaced once every preset replacement period.
일 실시 예에서, 상기 당뇨센서는, 상기 삽입튜브의 원통 모양 내부면을 따라서 원통형으로 상기 삽입튜브 내부에 붙여 내부면으로 눈물이 지나가도록 하거나, 상기 삽입튜브 내부에 ?? 형태로 일자로 넣어서 양면으로 눈물이 지나가도록 하는 것을 특징으로 한다.In one embodiment, the diabetic sensor is attached along the cylindrical inner surface of the insertion tube to the inside of the insertion tube in a cylindrical shape so that tears pass through the inner surface, or ?? Put the date in the form characterized in that the tears pass on both sides.
일 실시 예에서, 상기 무선송신기는, 박막 형태로 상기 당뇨센서와 연결되어 상기 삽입튜브의 내부면 또는 외부면이나 부비동에 고정 설치되는 것을 특징으로 한다.In one embodiment, the wireless transmitter is connected to the diabetic sensor in the form of a thin film, characterized in that it is fixed to the inner surface or the outer surface or the sinus of the insertion tube.
일 실시 예에서, 상기 자가전원공급기는, 상기 당뇨센서 및 상기 무선송신기와 연결되어 상기 삽입튜브의 내부면 또는 외부면이나 부비동에 고정 설치된 박막 형태의 전지인 것을 특징으로 한다.In one embodiment, the self-power supply is connected to the diabetes sensor and the wireless transmitter, characterized in that the battery of the thin film form fixed to the inner surface or the outer surface or the sinus of the insertion tube.
일 실시 예에서, 상기 자가전원공급기는, 나노미터 수준의 작은 미세 진동을 전기에너지로 변환하는 초고효율 나노 발전 소자인 것을 특징으로 한다.In one embodiment, the self-power supply is characterized in that the ultra-high efficiency nano power generation device for converting small micro-vibration of the nanometer level into electrical energy.
일 실시 예에서, 상기 당뇨 측정 장치는, 상기 무선송신기로부터 무선혈당정보신호를 수신받아 측정 혈당으로 표시하기 위한 외부디스플레이장치를 더 포함하는 것을 특징으로 한다.In one embodiment, the diabetic measuring device, characterized in that it further comprises an external display device for receiving a wireless blood glucose information signal from the wireless transmitter for displaying the measured blood glucose.
일 실시 예에서, 상기 외부디스플레이장치는, 상기 무선송신기로부터 전송되는 무선혈당정보신호를 수신받아 측정 혈당으로 변환시켜 주는 무선수신부; 상기 무선수신부에서 변환시킨 측정 혈당을 화면에 표시하는 디스플레이부; 및 외부의 상용전원 또는 배터리이나 충전배터리의 전원을 인가받아 상기 무선수신부 및 상기 디스플레이부에 필요한 전원으로 변환시켜 공급하는 전원공급부를 구비하는 것을 특징으로 한다.In an embodiment, the external display device may include: a wireless receiver configured to receive a wireless blood sugar information signal transmitted from the wireless transmitter and convert the wireless blood sugar information signal into a measured blood sugar; A display unit which displays the measured blood sugar converted by the wireless receiver on a screen; And a power supply unit receiving external commercial power or power from a battery or a rechargeable battery, converting and supplying the power to the wireless receiver and the display.
본 발명의 다른 한 특징에 따르면, 비루관 내에 삽입 설치된 삽입튜브가 비루관으로 모이는 눈물을 전달하는 단계; 자가전원공급기가 당뇨센서 및 무선송신기에 필요한 전원으로 변환시켜 공급하는 단계; 상기 삽입튜브 내에 삽입 설치된 당뇨센서가 상기 눈물을 인가받아 당뇨를 체크하여 혈당으로 측정하는 단계; 및 무선송신기가 상기 당뇨센서에서 측정한 혈당을 외부로 전송하기 위한 무선혈당정보신호로 생성시켜 전송하는 단계를 포함하는 당뇨 측정 장치의 운용방법을 제공한다.According to another feature of the invention, the insertion tube inserted into the nasolacrimal duct to deliver the tears gathered into the nasolacrimal duct; A self-power supply converts and supplies power to a diabetes sensor and a wireless transmitter; A diabetic sensor inserted into the insertion tube to receive the tear and check diabetes to measure blood glucose; And a wireless transmitter generating and transmitting a blood glucose information signal for transmitting blood glucose measured by the diabetes sensor to the outside.
일 실시 예에서, 상기 당뇨 측정 장치의 운용방법은, 삽입장치가 탐침 혹은 내시경을 이용하여 비루관 내에 실리콘 재질의 관인 삽입튜브를 삽입 설치하는 단계; 상기 삽입장치가 내시경을 이용해서 상기 삽입튜브 내에 상기 당뇨센서를 삽입 설치하는 단계; 상기 당뇨센서의 삽입 설치 시에, 상기 삽입장치가 내시경을 이용하여 상기 당뇨센서와 연결된 상태의 무선송신기를 상기 삽입튜브의 내부면 또는 외부면이나 부비동에 고정 설치하는 단계; 및 상기 당뇨센서의 삽입 설치 시에, 상기 삽입장치가 내시경을 이용하여 상기 당뇨센서 및 상기 무선송신기와 연결된 상태의 자가전원공급기를 상기 삽입튜브의 내부면 또는 외부면이나 부비동에 고정 설치하는 단계를 더 포함하는 것을 특징으로 한다.In one embodiment, the operation method of the diabetic measuring device, the inserting device using a probe or endoscope to insert the insertion tube which is a tube of silicon material in the nasolacrimal duct; Inserting, by the insertion apparatus, the diabetes sensor into the insertion tube using an endoscope; When the diabetic sensor is inserted and installed, the inserting device using an endoscope to securely install a wireless transmitter connected to the diabetic sensor to an inner surface, an outer surface, or a sinus of the insertion tube; And installing and inserting the self-power supply in a state connected to the diabetic sensor and the wireless transmitter to the inner surface or the outer surface or the sinus of the insertion tube by using the endoscope. It further comprises.
일 실시 예에서, 상기 당뇨 측정 장치의 운용방법은, 상기 삽입장치가 탐침 혹은 내시경을 이용해서 실리콘 재질의 관인 삽입튜브 내에 이미 설치된 당뇨센서를 비루관 내에 바로 삽입 설치하는 단계; 상기 당뇨센서의 삽입 설치 시에, 상기 삽입장치가 내시경을 이용하여 상기 당뇨센서와 연결된 상태의 무선송신기를 상기 삽입튜브의 내부면 또는 외부면이나 부비동에 고정 설치하는 단계; 및 상기 당뇨센서의 삽입 설치 시에, 상기 삽입장치가 내시경을 이용하여 상기 당뇨센서 및 상기 무선송신기와 연결된 상태의 자가전원공급기를 상기 삽입튜브의 내부면 또는 외부면이나 부비동에 고정 설치하는 단계를 더 포함하는 것을 특징으로 한다.In one embodiment, the operation method of the diabetic measuring device, the inserting device is installed by inserting the diabetic sensor already installed in the insertion tube, which is a tube made of silicone using a probe or endoscope directly into the nasolacrimal duct; When the diabetic sensor is inserted and installed, the inserting device using an endoscope to securely install a wireless transmitter connected to the diabetic sensor to an inner surface, an outer surface, or a sinus of the insertion tube; And installing and inserting the self-power supply in a state connected to the diabetic sensor and the wireless transmitter to the inner surface or the outer surface or the sinus of the insertion tube by using the endoscope. It further comprises.
일 실시 예에서, 상기 당뇨센서를 삽입 설치하는 단계는, 상기 삽입장치가 상기 삽입튜브의 원통 모양 내부면을 따라서 원통형으로 상기 삽입튜브 내부에 붙여 내부면으로 눈물이 지나가도록 설치하거나, 상기 삽입튜브 내부에 ?? 형태로 일자로 넣어서 양면으로 눈물이 지나가도록 설치하는 것을 특징으로 한다.In one embodiment, the step of inserting the diabetic sensor, the inserting device is installed along the cylindrical inner surface of the insertion tube in a cylindrical shape so that tears pass through the inner surface, or the insertion tube Inside the ?? Put the date in the form characterized in that the tear is installed on both sides pass.
일 실시 예에서, 상기 당뇨센서를 삽입 설치하는 단계는, 상기 삽입장치가 기 설정된 교체 기간마다 한 번씩 내시경으로 보면서 포셉으로 상기 삽입튜브 내에 삽입 설치된 당뇨센서를 잡아 빼내고, 내시경을 이용해서 상기 삽입튜브 내로 새로운 당뇨센서로 교체하는 단계를 더 포함하는 것을 특징으로 한다.In one embodiment, the step of inserting the diabetic sensor, the insertion device is pulled out of the diabetic sensor inserted into the insertion tube with a forceps while looking into the endoscope once every predetermined replacement period, the insertion tube using the endoscope It further comprises the step of replacing with a new diabetes sensor.
일 실시 예에서, 상기 당뇨 측정 장치의 운용방법은, 외부디스플레이장치가 상기 무선혈당정보신호를 수신받아 측정 혈당으로 변환시켜 표시하는 단계를 더 포함하는 것을 특징으로 한다.In one embodiment, the operation method of the diabetes measuring device, characterized in that the external display device further comprises the step of receiving and receiving the wireless blood glucose information signal converted to the measured blood sugar to display.
본 발명에 의하면, 당뇨 환자의 비루관 내에 당뇨센서를 설치하여 당뇨 체크를 수행하도록 함으로써, 간단한 비침습적 시술을 통해 당뇨센서를 눈물의 밀집도가 높은 비루관에 설치할 수 있어, 혈당 체크를 손쉽게 할 수 있고 이에 당뇨 환자에 대한 당뇨 측정 관리가 매우 쉽고 편리할 뿐만 아니라 당뇨 측정의 정확도를 매우 높일 수 있으며, 또한 당뇨환자의 혈액을 채취하지 않아도 되어, 혈액 채취에 따른 불편함 및 고통을 제거할 수 있을 뿐만 아니라 당뇨 환자에게 비침습적 시술로 불편함과 거부감을 감소시킬 수 있는 효과를 가진다.According to the present invention, by installing a diabetic sensor in the nasolacrimal duct of a diabetic patient to perform a diabetic check, the diabetic sensor can be installed in the nasolacrimal duct with a high density of tears through a simple non-invasive procedure, thereby easily checking blood glucose. It is very easy and convenient to manage the diabetic measurement for the diabetic patient, and it can greatly increase the accuracy of the diabetic measurement. Also, it is not necessary to collect the blood of the diabetic patient, thereby eliminating the inconvenience and pain caused by the blood collection. Non-invasive procedures for diabetics have the effect of reducing discomfort and rejection.
도 1은 본 발명의 실시 예에 따른 당뇨 측정 장치를 설명하는 도면이다.1 is a diagram illustrating a diabetic measuring apparatus according to an embodiment of the present invention.
도 2는 도 1에 있는 삽입튜브 및 당뇨센서의 설치를 설명하는 도면이다.2 is a view for explaining the installation of the insertion tube and diabetes sensor in FIG.
도 3은 도 1에 있는 삽입튜브의 설치 시술을 설명하는 도면이다.3 is a view for explaining the installation procedure of the insertion tube in FIG.
도 4는 본 발명의 실시 예에 따른 당뇨 측정 장치의 운용방법을 설명하는 순서도이다.4 is a flowchart illustrating a method of operating a diabetic measuring apparatus according to an embodiment of the present invention.
아래에서는 첨부한 도면을 참고로 하여 본 발명의 실시 예에 대하여 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 상세히 설명한다. 그러나 본 발명에 관한 설명은 구조적 내지 기능적 설명을 위한 실시 예에 불과하므로, 본 발명의 권리범위는 본문에 설명된 실시 예에 의하여 제한되는 것으로 해석되어서는 아니 된다. 즉, 실시 예는 다양한 변경이 가능하고 여러 가지 형태를 가질 수 있으므로 본 발명의 권리범위는 기술적 사상을 실현할 수 있는 균등물들을 포함하는 것으로 이해되어야 한다. 또한, 본 발명에서 제시된 목적 또는 효과는 특정 실시예가 이를 전부 포함하여야 한다거나 그러한 효과만을 포함하여야 한다는 의미는 아니므로, 본 발명의 권리범위는 이에 의하여 제한되는 것으로 이해되어서는 아니 될 것이다.Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art may easily implement the present invention. However, since the description of the present invention is only an embodiment for structural or functional description, the scope of the present invention should not be construed as being limited by the embodiments described in the text. That is, the embodiments may be variously modified and may have various forms, and thus, the scope of the present invention should be understood to include equivalents for realizing the technical idea. In addition, the objects or effects presented in the present invention does not mean that a specific embodiment should include all or only such effects, the scope of the present invention should not be understood as being limited thereby.
한편, 본 발명에서 서술되는 용어의 의미는 다음과 같이 이해되어야 할 것이다.On the other hand, the meaning of the terms described in the present invention will be understood as follows.
"제1", "제2" 등의 용어는 하나의 구성요소를 다른 구성요소로부터 구별하기 위한 것으로, 이들 용어들에 의해 권리범위가 한정되어서는 아니 된다. 예를 들어, 제1 구성요소는 제2 구성요소로 명명될 수 있고, 유사하게 제2 구성요소도 제1 구성요소로 명명될 수 있다.Terms such as "first" and "second" are intended to distinguish one component from another component, and the scope of rights should not be limited by these terms. For example, the first component may be named a second component, and similarly, the second component may also be named a first component.
어떤 구성요소가 다른 구성요소에 "연결되어" 있다고 언급된 때에는, 그 다른 구성요소에 직접적으로 연결될 수도 있지만, 중간에 다른 구성요소가 존재할 수도 있다고 이해되어야 할 것이다. 반면에, 어떤 구성요소가 다른 구성요소에 "직접 연결되어" 있다고 언급된 때에는 중간에 다른 구성요소가 존재하지 않는 것으로 이해되어야 할 것이다. 한편, 구성요소들 간의 관계를 설명하는 다른 표현들, 즉 "~사이에"와 "바로 ~사이에" 또는 "~에 이웃하는"과 "~에 직접 이웃하는" 등도 마찬가지로 해석되어야 한다.When a component is referred to as being "connected" to another component, it should be understood that there may be other components in between, although it may be directly connected to the other component. On the other hand, when a component is said to be "directly connected" to another component, it should be understood that there is no other component in between. On the other hand, other expressions describing the relationship between the components, such as "between" and "immediately between" or "neighboring to" and "directly neighboring to", should be interpreted as well.
단수의 표현은 문맥상 명백하게 다르게 뜻하지 않는 한 복수의 표현을 포함하는 것으로 이해되어야 하고, "포함하다" 또는 "가지다" 등의 용어는 설시된 특징, 숫자, 단계, 동작, 구성요소, 부분품 또는 이들을 조합한 것이 존재함을 지정하려는 것이며, 하나 또는 그 이상의 다른 특징이나 숫자, 단계, 동작, 구성요소, 부분품 또는 이들을 조합한 것들의 존재 또는 부가 가능성을 미리 배제하지 않는 것으로 이해되어야 한다.Singular expressions should be understood to include plural expressions unless the context clearly indicates otherwise, and terms such as "include" or "have" refer to features, numbers, steps, operations, components, parts, or parts thereof described. It is to be understood that the combination is intended to be present and does not exclude in advance the possibility of the presence or addition of one or more other features or numbers, steps, operations, components, parts or combinations thereof.
여기서 사용되는 모든 용어들은 다르게 정의되지 않는 한, 본 발명이 속하는 분야에서 통상의 지식을 가진 자에 의해 일반적으로 이해되는 것과 동일한 의미를 가진다. 일반적으로 사용되는 사전에 정의되어 있는 용어들은 관련 기술의 문맥상 가지는 의미와 일치하는 것으로 해석되어야 하며, 본 발명에서 명백하게 정의하지 않는 한 이상적이거나 과도하게 형식적인 의미를 지니는 것으로 해석될 수 없다.All terms used herein have the same meaning as commonly understood by one of ordinary skill in the art unless otherwise defined. Generally, the terms defined in the dictionary used are to be interpreted as being consistent with the meanings in the context of the related art, and should not be interpreted as having ideal or excessively formal meanings unless clearly defined in the present invention.
이제 본 발명의 실시 예에 따른 당뇨 측정 장치 및 그 운용방법에 대하여 도면을 참고로 하여 상세하게 설명한다.Now, a diabetic measuring apparatus and its operating method according to an embodiment of the present invention will be described in detail with reference to the drawings.
도 1은 본 발명의 실시 예에 따른 당뇨 측정 장치를 설명하는 도면이며, 도 2는 도 1에 있는 삽입튜브 및 당뇨센서의 설치를 설명하는 도면이며, 도 3은 도 1에 있는 삽입튜브의 설치 시술을 설명하는 도면이다.1 is a view illustrating a diabetic measuring apparatus according to an embodiment of the present invention, Figure 2 is a view illustrating the installation of the insertion tube and the diabetes sensor in Figure 1, Figure 3 is an installation of the insertion tube in Figure 1 It is a figure explaining a procedure.
도 1 내지는 도 3을 참조하면, 당뇨 측정 장치(100)는, 삽입튜브(110), 당뇨센서(120), 무선송신기(130), 자가전원공급기(140)를 포함한다.1 to 3, the diabetic measuring apparatus 100 includes an insertion tube 110, a diabetes sensor 120, a wireless transmitter 130, and a self-power supply 140.
삽입튜브(110)는, 당뇨 환자의 눈에서 콧구멍으로 이어지는 관인 비루관 내에 삽입 설치되어, 비루관으로 모이는 눈물을 당뇨센서(120)로 전달해 준다. Insertion tube 110 is inserted into the nasolacrimal duct, which is a tube leading from the eyes of the diabetic to the nostrils, and delivers the tears collected in the nasolacrimal duct to the diabetic sensor 120.
일 실시 예에서, 삽입튜브(110)는, 실리콘 재질의 관으로서, 비루관 폐색이 있을 시에 실리콘 관을 넣어서 뚫어주는 시술과 유사하게, 도 2에 도시된 바와 같이, 원통 모양으로 비루관 내에 삽입 설치될 수 있으며, 이에 비침습적 시술로 당뇨 환자에게 불편함과 거부감을 줄일 수 있다.In one embodiment, the insertion tube 110 is a tube made of silicon, similar to a procedure for inserting a silicon tube through a nasal tube obstruction, and as shown in FIG. 2, inserted into the nasal tube in a cylindrical shape. Non-invasive procedures can reduce discomfort and rejection in diabetics.
일 실시 예에서, 삽입튜브(110)는, 도 3에 도시된 바와 같이, 탐침(Probe) 혹은 내시경을 통해서 비루관 스텐트 삽입술 혹은 누관 풍선확장술에 의해 비루관 내에 삽입 설치될 수 있다.In one embodiment, the insertion tube 110, as shown in Figure 3, may be inserted into the nasolacrimal duct by nasal tube stenting or fistula balloon dilation through a probe (Probe) or endoscope.
당뇨센서(120)는, 기 설정된 교체 기간마다 한 번씩 교체되어 삽입튜브(110) 내에 삽입 설치되어, 자가전원공급기(140)로부터 공급되는 전원을 인가받아 구동하며, 삽입튜브(110)를 통해 전달되는 눈물을 인가받아 당뇨를 체크하여 혈당으로 측정하며, 해당 측정된 혈당을 무선송신기(130)로 전달해 준다.The diabetic sensor 120 is replaced once per predetermined replacement period and inserted into the insertion tube 110 to be driven by receiving power supplied from the self-power supply 140 and transmitted through the insertion tube 110. The tear is applied to check the diabetes to measure the blood sugar, and delivers the measured blood sugar to the wireless transmitter (130).
일 실시 예에서, 당뇨센서(120)는, 비루관의 폭이 2mm 이상이고 길이가 1.5cm 가량 되므로, 0.5 ~ 1.5mm의 폭과 1 ~ 4mm의 길이(바람직하게는, 폭 1.13mm와 길이 2.27mm 내외)를 가질 수 있으며, 삽입튜브(110) 내에 삽입 설치되어 한 달에 한 번씩 혹은 두 달에 한 번씩 교체를 하면서 당뇨 체크를 수행하므로 손쉽게 혈당을 측정해 줄 수 있다. 여기서, 비루관은 눈물이 모이는 부분으로 다른 안구보다 눈물의 밀집도가 높으므로, 비루관 내 삽입튜브에 설치된 당뇨센서(120)의 당뇨 측정 정확도를 높여 줄 수 있게 된다.In one embodiment, the diabetic sensor 120, the width of the nasolacrimal duct is more than 2mm and the length is about 1.5cm, the width of 0.5 ~ 1.5mm and the length of 1 ~ 4mm (preferably, 1.13mm in width and 2.27mm in length) It can have an internal and external), it is inserted into the insertion tube 110 is installed once per month or once every two months while performing a diabetic check can be measured easily blood sugar. Here, the nasolacrimal duct is a part where the tears are collected, and thus the density of tears is higher than that of other eyes, thereby increasing the diabetic measurement accuracy of the diabetic sensor 120 installed in the nasolacrimal tube.
일 실시 예에서, 당뇨센서(120)는, 탐침이나 내시경을 이용해서 비루관 내에 설치된 삽입튜브(110) 내로 밀어 넣어 설치할 수 있으며, 추후 빼야 될 때도 내시경으로 보면서 포셉으로 잡아 빼낼 수 있다. 이때, 당뇨센서(120)는, 도 2에 도시된 바와 같이, 생체 환경에서 사용할 수 있는 나노 다공성 백금으로 형성된 센서로서, 가늘고 긴 팁이 삽입튜브(110) 내에 들어가서 비루관에 거치될 수 있으며, 전극모양의 넓은 부분이 플립-락 타입 커넥터(Flip-lock connector)를 통해 자가전원공급기(140)에 연결되어 부비동에 거치될 수 있다.In one embodiment, the diabetic sensor 120 can be installed by pushing into the insertion tube 110 installed in the nasolacrimal duct using a probe or endoscope, and can be pulled out with a forceps while looking at the endoscope later to be removed. At this time, the diabetic sensor 120, as shown in Figure 2, as a sensor formed of nano-porous platinum that can be used in a living environment, the elongated tip can be mounted in the nasolacrimal duct into the insertion tube 110, the electrode A wide part of the shape may be connected to the self-power supply 140 through a flip-lock connector and mounted on the sinus.
일 실시 예에서, 당뇨센서(120)는, 삽입튜브(110)의 원통 모양 내부면을 따라서 원통형으로 삽입튜브(110) 내부에 붙여 내부면으로 눈물이 지나가도록 하거나, 혹은 삽입튜브(110) 내부에 ?? 형태로 일자로 넣어서 양면으로 눈물이 지나가도록 할 수도 있다. 또한, 당뇨센서(120)는, 원통 모양인 경우에 삽입튜브(110)의 내부면에 딱 들어가도록 할 수 있다.In one embodiment, the diabetic sensor 120, the cylindrical through the cylindrical inner surface of the insertion tube 110 to the inside of the insertion tube 110 to pass the tears to the inner surface, or inside the insertion tube (110) On ?? You can also put a date in the form so that the tears pass on both sides. In addition, the diabetic sensor 120 may be fitted into the inner surface of the insertion tube 110 in the case of a cylindrical shape.
무선송신기(130)는, RF통신모듈, NFC통신모듈 등과 같은 근접무선통신모듈로서, 자가전원공급기(140)로부터 공급되는 전원을 인가받아 구동하며, 당뇨센서(120)로부터 전달되는 측정 혈당을 외부(예를 들어, 외부디스플레이장치(150))로 전송하기 위한 무선신호(즉 무선혈당정보신호)로 변환시켜 해당 변환시킨 무선혈당정보신호를 외부로 전송해 준다.The wireless transmitter 130 is a proximity wireless communication module such as an RF communication module, an NFC communication module, etc., and is driven by receiving power supplied from the self-power supply 140, and externally measures the measured blood sugar transmitted from the diabetes sensor 120. For example, the wireless glucose information signal is converted into a wireless signal (ie, a wireless blood sugar information signal) for transmission to the external display device 150 and transmitted to the outside.
일 실시 예에서, 무선송신기(130)는, 박막 형태로, 당뇨센서(120)와 연결되어 삽입튜브(110)의 내부면 또는 외부면에 고정 설치될 수 있다.In one embodiment, the wireless transmitter 130, in the form of a thin film, may be connected to the diabetes sensor 120 may be fixed to the inner surface or the outer surface of the insertion tube (110).
일 실시 예에서, 무선송신기(130)는, 코 안으로 넣는 내시경을 이용하여 코 안에 있는 부비동(Maxillary Sinus Ostium)으로 들어가는 구멍을 확인하여 해당 구멍을 통해 부비동에 당뇨센서(120)와 연결되어 설치될 수도 있으며, 필요시에 코를 통한 내시경으로 간단하게 제거될 수도 있다.In one embodiment, the wireless transmitter 130 is connected to the diabetic sensor 120 to the sinuses through the hole to check the hole entering the sinus (Maxillary Sinus Ostium) in the nose using an endoscope placed into the nose to be installed. It may also be removed simply by an endoscope through the nose if necessary.
자가전원공급기(140)는, 전기에너지(즉, 전원)를 자가 발전시켜 해당 자가 발전시킨 전원을 당뇨 측정 장치(100)의 각 구성요소(즉, 당뇨센서(120), 무선송신기(130))에 필요한 전원으로 변환시켜 해당 변환시킨 전원을 당뇨센서(120) 및 무선송신기(130)에게 공급해 준다.The self-power supply 140 self-generates electrical energy (that is, power) to generate power of the self-generated components of the diabetes measuring apparatus 100 (that is, the diabetes sensor 120 and the wireless transmitter 130). It converts the power required for the supply of the converted power to the diabetes sensor 120 and the wireless transmitter 130.
일 실시 예에서, 자가전원공급기(140)는, 박막 형태의 전지로서, 당뇨센서(120) 및 무선송신기(130)와 연결되어 삽입튜브(110)의 내부면 또는 외부면에 고정 설치될 수 있다.In one embodiment, the self-power supply 140 is a thin film type battery, connected to the diabetes sensor 120 and the wireless transmitter 130 may be fixed to the inner surface or the outer surface of the insertion tube 110. .
일 실시 예에서, 자가전원공급기(140)는, 코 안으로 넣는 내시경을 이용하여 코 안에 있는 부비동으로 들어가는 구멍을 확인하여 해당 구멍을 통해 부비동에 당뇨센서(120) 및 무선송신기(130)와 연결되어 설치될 수도 있으며, 필요시에 코를 통한 내시경으로 간단하게 제거될 수도 있다.In one embodiment, the self-power supply 140 is connected to the diabetic sensor 120 and the wireless transmitter 130 to the sinuses through the hole to check the hole entering the sinus in the nose using the endoscope put into the nose It may be installed or simply removed by an endoscope through the nose if necessary.
일 실시 예에서, 자가전원공급기(140)는, 나노소자 제작 공정을 통해 마이크로 발전기를 나노 전자시스템 회로에 결합시켜 만든 나노소자를 이용한 진동에 의한 자가발전기(즉, 수 나노미터 수준의 작은 미세 진동을 전기에너지로 변환하는 초고효율 나노 발전 소자)로서, 수 마이크로미터 두께 산화아연 막대 위에 나노 스케일 고분자 리본을 덮어 아래로 늘어뜨린 후에, 그 위에 나노 스케일 전극을 증착해 전극이 산화아연 막대에서부터 산화아연이 놓여있는 기판 아래까지 형성되어 있는 외부 회로와 전기적으로 연결시켜 형성할 수 있다. 또한, 자가전원공급기(140)는, 산화아연 마이크로 막대가 놓여있는 기판 위에 100 나노미터 두께 고분자 필름을 덮어씌운 후에 강한 전자빔을 가해 중합체 결합을 일으켜 마이크로 막대 위에서부터 아래 기판까지 연결되는 나노리본을 국소적으로 형성하며, 해당 형성된 나노리본이 건물위에서 지면까지 늘어뜨려진 밧줄처럼 소자 제작 과정 중에 노출되는 물리적, 화학적 공정에 영향을 받지 않고 마이크로 막대와 기판 위 회로 사이를 튼튼하게 연결해 주게 되며, 이러한 제작 구조 위에 수십 나노미터 수준의 금속을 증착하여 산화아연 막대와 기판 아래 회로 사이의 전기적 연결을 안정화시켜 형성할 수 있다.In one embodiment, the self-power supply 140 is a self-generator by vibrating using the nano-device made by coupling the micro-generator to the nanoelectronic system circuit through the nano-device manufacturing process (that is, small fine vibration of several nanometers level) Ultra-high-efficiency nano-power generation device that converts the energy into electrical energy.The nanoscale polymer ribbon is laid down over a few micrometer-thick zinc oxide rod, and the nanoscale electrode is deposited thereon to deposit the electrode from the zinc oxide rod. It can be formed by electrically connecting with an external circuit formed up to this substrate. In addition, the self-power supply 140 covers a 100 nanometer-thick polymer film on the substrate on which the zinc oxide microrods are placed, and then applies a strong electron beam to generate a polymer bond to localize the nanoribbon that is connected from the top of the microrods to the underlying substrate. And the formed nanoribbons form a strong connection between the microrods and the circuits on the substrate without being affected by the physical and chemical processes exposed during the device fabrication process, like ropes hanging from the building to the ground. A few tens of nanometers of metal can be deposited over the structure to stabilize the electrical connection between the zinc oxide rods and the circuitry below the substrate.
상술한 바와 같은 구성을 가진 당뇨 측정 장치(100)는, 당뇨 환자의 비루관 내에 당뇨센서(120)를 설치하여 당뇨 체크를 수행하도록 함으로써, 간단한 비침습적 시술을 통해 당뇨센서(120)를 눈물의 밀집도가 높은 비루관에 설치할 수 있어, 혈당 체크를 손쉽게 할 수 있고 이에 당뇨 환자에 대한 당뇨 측정 관리가 매우 쉽고 편리할 뿐만 아니라 당뇨 측정의 정확도를 매우 높일 수 있으며, 또한 당뇨환자의 혈액을 채취하지 않아도 되어, 혈액 채취에 따른 불편함 및 고통을 제거할 수 있을 뿐만 아니라 당뇨 환자에게 비침습적 시술로 불편함과 거부감을 감소시킬 수 있다. Diabetic measuring device 100 having the configuration as described above, by installing the diabetic sensor 120 in the nasolacrimal duct of the diabetic patient to perform the diabetic check, denseness of the diabetic sensor 120 through a simple non-invasive procedure Because it can be installed in the high nasolacrimal duct, it is easy to check the blood sugar, and it is very easy and convenient to manage the diabetic measurement for the diabetic patient, and it is possible to increase the accuracy of the diabetic measurement very much, and also it is not necessary to collect the blood of the diabetic patient. In addition, it is possible to eliminate the discomfort and pain associated with blood collection, and to reduce the discomfort and rejection by non-invasive procedures for diabetics.
상술한 바와 같은 구성을 가진 당뇨 측정 장치(100)를 비루관 또는 부비동에 설치할 때에는, 무선송신기(130) 또는 자가전원공급기(140)의 부피가 당뇨센서(120)의 부피보다 큰 경우에, 눈에서 시작되는 비루관으로 삽입 설치하지 않고, 내시경을 통해서 코 안에서 끝나는 비루관으로 삽입듀브(110) 내에 설치된 당뇨센서(120)를 눈 쪽으로 밀어 올려 넣을 수 있으며, 다른 쪽 끝에 연결되어 있는 무선송신기(130) 또는 자가전원공급기(140)를 부비동 안으로 삽입 설치할 수도 있다.When the diabetic measuring device 100 having the above-described configuration is installed in the nasolacrimal duct or sinus, when the volume of the wireless transmitter 130 or the self-power supply 140 is larger than the volume of the diabetic sensor 120, Without inserting into the nasolacrimal duct to start, the nasal tube ending in the nose through the endoscope can be put into the diabetic sensor 120 installed in the insertion tube 110 toward the eye, the wireless transmitter 130 or connected to the other end The self-power supply 140 may be inserted into the sinus.
상술한 바와 같은 구성을 가진 당뇨 측정 장치(100)는, 무선수신부(151), 디스플레이부(152), 전원공급부(153)를 구비한 외부디스플레이장치(150)를 더 포함할 수도 있다. 여기서, 외부디스플레이장치(150)는, 스마트폰, 노트북 등과 같은 근접무선통신이 가능한 단말기일 수 있다. 또한, 이러한 단말기는, 무선송신기(130)로부터 무선혈당정보신호를 수신받아 측정 혈당으로 표시해 주기 위한 앱이나 프로그램 등을 설치해 둘 수 있다.The diabetes measuring apparatus 100 having the above-described configuration may further include an external display device 150 including a wireless receiver 151, a display 152, and a power supply 153. Here, the external display device 150 may be a terminal capable of close wireless communication such as a smart phone, a notebook, and the like. In addition, such a terminal may receive an wireless blood glucose information signal from the wireless transmitter 130 and install an app or a program for displaying the measured blood glucose.
무선수신부(151)는, RF통신모듈, NFC통신모듈 등과 같은 근접무선통신모듈로서, 전원공급부(153)로부터 공급되는 전원을 인가받아 구동하며, 무선송신기(130)로부터 전송되는 무선혈당정보신호를 수신받아 측정 혈당으로 변환시켜 해당 변환시킨 측정 혈당을 디스플레이부(152)로 전달해 준다.The wireless receiver 151 is a proximity wireless communication module such as an RF communication module, an NFC communication module, and the like, and is driven by receiving power supplied from the power supply unit 153, and transmits a wireless blood sugar information signal transmitted from the wireless transmitter 130. The received blood sugar is converted into measurement blood sugar and then transferred to the display unit 152.
디스플레이부(152)는, LCD 등과 같은 화면표시수단으로서, 전원공급부(153)로부터 공급되는 전원을 인가받아 구동하며, 무선수신부(151)로부터 전달되는 측정 혈당을 화면에 표시해 준다.The display unit 152 is a screen display means such as an LCD and the like, is driven by receiving power supplied from the power supply unit 153, and displays the measured blood sugar transmitted from the wireless receiver 151 on the screen.
전원공급부(153)는, 외부의 상용전원 또는 배터리(또는, 충전배터리)의 전원을 인가받아 외부디스플레이장치(150)의 각 구성요소(즉, 무선수신부(151), 디스플레이부(152))에 필요한 전원으로 변환시켜 해당 변환시킨 전원을 무선수신부(151) 및 디스플레이부(152)에게 공급해 준다.The power supply unit 153 is supplied with external commercial power or a battery (or a rechargeable battery) to each component of the external display device 150 (that is, the wireless receiver 151 and the display unit 152). The power is converted into necessary power and the converted power is supplied to the wireless receiver 151 and the display 152.
도 4는 본 발명의 실시 예에 따른 당뇨 측정 장치의 운용방법을 설명하는 순서도이다.4 is a flowchart illustrating a method of operating a diabetic measuring apparatus according to an embodiment of the present invention.
도 4를 참조하면, 우선 로봇팔 등과 같은 삽입장치가 당뇨 환자의 눈에서 콧구멍으로 이어지는 관인 비루관 내에 실리콘 재질의 관인 삽입튜브(110)를 삽입 설치하게 된다(S401).Referring to FIG. 4, first, an insertion device such as a robot arm inserts an insertion tube 110, which is a tube made of silicon, into a nasolacrimal duct that is a tube leading from the eyes of a diabetic patient to a nostril (S401).
상술한 단계 S401에 있어서, 로봇팔 등과 같은 삽입장치가 탐침 혹은 내시경을 이용하여 비루관 스텐트 삽입술 혹은 누관 풍선확장술에 의해 폭이 2mm 이상이고 길이가 1.5cm 가량인 비루관 내에 삽입튜브(110)를 삽입 설치할 수 있다. 다시 말해서, 비루관 폐색이 있을 시에 실리콘 관을 넣어서 뚫어주는 시술과 유사하게, 로봇팔 등과 같은 삽입장치가 비루관 내에 원통 모양의 삽입튜브(110)를 삽입 설치할 수 있으므로, 비침습적 시술로 당뇨 환자에게 불편함과 거부감을 줄일 수 있다.In the above-described step S401, the insertion device such as a robotic arm is inserted into the insertion tube 110 into the nasolacrimal duct that is 2 mm or more in width and 1.5 cm in length by nasolacrimal stenting or fistula balloon dilation using a probe or endoscope. Can be. In other words, similar to a procedure in which a silicone tube is inserted and drilled when there is a nasolacrimal duct obstruction, an insertion device such as a robot arm can insert a cylindrical insertion tube 110 into the nasolacrimal duct, thereby providing a non-invasive procedure to a diabetic patient. It can reduce discomfort and rejection.
상술한 단계 S401에서 삽입튜브(110)를 삽입 설치한 다음에 삽입튜브(110) 내에 당뇨센서(120)를 삽입 설치하거나, 상술한 단계 S401을 수행하지 않고 비루관 내에 바로 삽입튜브(110) 내에 이미 설치된 당뇨센서(120)를 삽입 설치하게 된다(S402).After inserting and installing the insertion tube 110 in the above-described step S401, the diabetic sensor 120 is inserted into the insertion tube 110, or already in the insertion tube 110 directly in the nasolacrimal duct without performing the above-described step S401. Inserted diabetic sensor 120 is installed (S402).
상술한 단계 S402에 있어서, 로봇팔 등과 같은 삽입장치가 탐침이나 내시경을 이용해서 비루관 내에 설치된 삽입튜브(110) 내로 0.5 ~ 1.5mm의 폭과 1 ~ 4mm의 길이(바람직하게는, 폭 1.13mm와 길이 2.27mm 내외)를 가진 당뇨센서(120)를 밀어 넣어 설치할 수 있다.In the above-described step S402, an insertion device such as a robotic arm is 0.5 to 1.5 mm wide and 1 to 4 mm long (preferably 1.13 mm wide and into the insertion tube 110 installed in the nasolacrimal duct using a probe or endoscope). 2.27mm length) can be installed by pushing the diabetic sensor 120.
상술한 단계 S402에 있어서, 로봇팔 등과 같은 삽입장치가 삽입튜브(110)의 원통 모양 내부면을 따라서 원통형의 당뇨센서(120)를 삽입튜브(110) 내부에 붙여 내부면으로 눈물이 지나가도록 설치할 수 있으며, 또한 로봇팔 등과 같은 삽입장치가 삽입튜브(110) 내부에 ?? 형태로 일자 형태의 당뇨센서(120)를 일자로 넣어서 양면으로 눈물이 지나가도록 설치할 수도 있다.In the above-described step S402, an insertion device such as a robot arm is attached to the inner surface of the insertion tube 110 by the cylindrical diabetic sensor 120 along the cylindrical inner surface of the insertion tube 110 so that the tears pass to the inner surface. And also, inserting device such as robot arm is inserted into the insertion tube (110) ?? By putting the diabetic sensor 120 of the date in the form of a date may be installed so that the tears pass on both sides.
상술한 단계 S402에 있어서, 로봇팔 등과 같은 삽입장치가 기 설정된 교체 기간마다 한 번씩 삽입튜브(110) 내에 삽입 설치된 당뇨센서(120)를 잡아 빼내고 새로운 당뇨센서(120)로 교체할 수 있다. 다시 말해서, 로봇팔 등과 같은 삽입장치가 한 달에 한 번씩 혹은 두 달에 한 번씩 내시경으로 보면서 포셉으로 삽입튜브(110) 내에 삽입 설치된 당뇨센서(120)를 잡아 빼낼 수 있으며, 그런 다음에 내시경을 이용해서 비루관 내에 설치된 삽입튜브(110) 내로 새로운 당뇨센서(120)로 교체해 줌으로써, 당뇨 체크를 지속적으로 수행하여 손쉽게 혈당을 측정해 줄 수 있다.In the above-described step S402, an insertion device such as a robot arm may pull out the diabetes sensor 120 inserted into the insertion tube 110 once every predetermined replacement period and replace it with a new diabetes sensor 120. In other words, an insertion device such as a robotic arm can grasp the diabetic sensor 120 inserted into the insertion tube 110 with forceps while looking at the endoscope once a month or once every two months, and then remove the endoscope. By replacing with a new diabetes sensor 120 into the insertion tube 110 installed in the nasolacrimal duct, it is possible to measure the blood sugar easily by continuously performing the diabetic check.
상술한 단계 S402에서 당뇨센서(120)를 삽입 설치할 때, 로봇팔 등과 같은 삽입장치가 RF통신모듈, NFC통신모듈 등과 같은 근접무선통신모듈을 구비한 박막 형태의 무선송신기(130)도 당뇨센서(120)와 연결된 상태로 삽입튜브(110)의 내부면 또는 외부면에 고정 설치해 주도록 한다(S403).When the diabetic sensor 120 is inserted and installed in the above-mentioned step S402, the thin film-type wireless transmitter 130 having a proximity wireless communication module such as an RF communication module, an NFC communication module, and the like, such as a robotic arm also has a diabetes sensor ( 120 to be fixed to the inner surface or the outer surface of the insertion tube 110 in a connected state (S403).
상술한 단계 S403에 있어서, 로봇팔 등과 같은 삽입장치가 코 안으로 넣는 내시경을 이용하여 코 안에 있는 부비동으로 들어가는 구멍을 확인하면서, 해당 구멍을 통해 당뇨센서(120)와 연결된 상태의 무선송신기(130)를 부비동에 설치할 수 있으며, 또한 필요시에 코를 통한 내시경으로 간단하게 제거될 수도 있다.In the above-described step S403, while checking the hole to enter the sinuses in the nose using an endoscope inserted into the nose, such as a robot arm, the wireless transmitter 130 connected to the diabetes sensor 120 through the hole. It can be installed in the sinuses and can also be simply removed by endoscope through the nose when needed.
상술한 단계 S402에서 당뇨센서(120)를 삽입 설치할 때, 로봇팔 등과 같은 삽입장치가 박막 형태의 전지인 자가전원공급기(140)도 당뇨센서(120) 및 무선송신기(130)와 연결된 상태로 삽입튜브(110)의 내부면 또는 외부면에 고정 설치해 주도록 한다(S404).When the diabetic sensor 120 is inserted and installed in the above-described step S402, the self-power supply 140, which is an insertion device such as a robotic arm, is a thin film battery, and is also inserted into the diabetic sensor 120 and the wireless transmitter 130 in a state of being connected. It is to be fixed to the inner surface or the outer surface of the tube 110 (S404).
상술한 단계 S403에 있어서, 로봇팔 등과 같은 삽입장치가 코 안으로 넣는 내시경을 이용하여 코 안에 있는 부비동으로 들어가는 구멍을 확인하면서, 해당 구멍을 통해 당뇨센서(120) 및 무선송신기(130)와 연결된 상태의 자가전원공급기(140)를 부비동에 설치할 수 있으며, 또한 필요시에 코를 통한 내시경으로 간단하게 제거될 수도 있다.In the above-described step S403, using an endoscope inserted into the nose by an inserting device such as a robot arm, while checking a hole entering the sinus in the nose, the state connected with the diabetes sensor 120 and the wireless transmitter 130 through the hole. Self-power supply 140 can be installed in the sinuses, it can also be simply removed by the endoscope through the nose if necessary.
일 실시 예에서, 상술한 단계 S401 내지 S404에서 삽입튜브(110), 당뇨센서(120), 무선송신기(130), 자가전원공급기(140)를 설치할 때, 무선송신기(130) 또는 자가전원공급기(140)의 부피가 당뇨센서(120)의 부피보다 큰 경우에는, 로봇팔 등과 같은 삽입장치가 눈에서 시작되는 비루관으로 삽입 설치하지 않고, 내시경을 이용해서 코 안에서 끝나는 비루관으로 삽입듀브(110) 내에 설치된 당뇨센서(120)를 눈 쪽으로 밀어 올려 넣을 수 있으며, 다른 쪽 끝에 연결되어 있는 무선송신기(130) 또는 자가전원공급기(140)를 부비동 안으로 삽입 설치할 수도 있다.In one embodiment, when installing the insertion tube 110, the diabetes sensor 120, the wireless transmitter 130, the self-power supply 140 in the above-described step S401 to S404, the wireless transmitter 130 or the self-power supply ( If the volume of the diaphragm 140 is greater than that of the diabetic sensor 120, an insertion device such as a robot arm is inserted into the insertion pipe 110 into the nasolacrimal tube ending in the nose using an endoscope, rather than being inserted into the nasolacrimal tube starting from the eye. The diabetic sensor 120 installed can be pushed up toward the eye, and the wireless transmitter 130 or the self-power supply 140 connected to the other end may be inserted into the sinus.
상술한 단계 S401 내지 S404에서 삽입튜브(110), 당뇨센서(120), 무선송신기(130), 자가전원공급기(140)를 설치하게 되면, 자가전원공급기(140)는 전기에너지(즉, 전원)를 자가 발전시켜 해당 자가 발전시킨 전원을 당뇨 측정 장치(100)의 각 구성요소(즉, 당뇨센서(120), 무선송신기(130))에 필요한 전원으로 변환시켜 해당 변환시킨 전원을 당뇨센서(120) 및 무선송신기(130)에게 공급해 주게 된다(S405).When the insertion tube 110, the diabetes sensor 120, the wireless transmitter 130, the self-power supply 140 is installed in the above-described step S401 to S404, the self-power supply 140 is electric energy (that is, power) By self-generating the power generated by the corresponding self-converted to each of the components of the diabetes measuring device 100 (that is, diabetes sensor 120, wireless transmitter 130) by converting the converted power to the diabetes sensor 120 ) And the radio transmitter 130 is supplied (S405).
상술한 단계 S405에서 전원을 자가 발전 및 공급하게 되면, 삽입튜브(110)는 비루관으로 모이는 눈물을 당뇨센서(120)로 전달하게 되며, 이때 당뇨센서(120)는 자가전원공급기(140)로부터 공급되는 전원을 인가받아 구동하면서, 삽입튜브(110)를 통해 전달되는 눈물을 인가받아 당뇨를 체크하여 혈당으로 측정하며, 해당 측정된 혈당을 무선송신기(130)로 전달해 주게 된다(S406).When the power is self-generated and supplied in the above-described step S405, the insertion tube 110 delivers the tears gathered into the nasolacrimal duct to the diabetes sensor 120, wherein the diabetes sensor 120 is supplied from the self-power supply 140. While receiving and driving the power, and receiving the tear transmitted through the insertion tube 110, check the diabetes to measure the blood sugar, and transmits the measured blood sugar to the wireless transmitter (130) (S406).
무선송신기(130)는, 자가전원공급기(140)로부터 공급되는 전원을 인가받아 구동하면서, 당뇨센서(120)로부터 전달되는 측정 혈당을 외부(예를 들어, 외부디스플레이장치(150))로 전송하기 위한 무선신호(즉 무선혈당정보신호)로 생성(즉, 변환)시켜 해당 변환시킨 무선혈당정보신호를 외부로 전송해 주게 된다(S407).The wireless transmitter 130 transmits the measured blood sugar transmitted from the diabetes sensor 120 to the outside (for example, the external display device 150) while driving by receiving power supplied from the self-power supply 140. It generates (ie, converts) a wireless signal (ie, a wireless blood sugar information signal) for transmitting the converted wireless blood sugar information signal to the outside (S407).
한편, 무선수신부(151), 디스플레이부(152), 전원공급부(153)를 구비한 외부디스플레이장치(150)는, 무선송신기(130)로부터 무선혈당정보신호를 수신받아 측정 혈당으로 표시해 주기 위한 앱이나 프로그램 등을 미리 설치해 둔 후에, 해당 기 설치된 앱이나 프로그램 등을 구동시켜 주게 된다. 이에, RF통신모듈, NFC통신모듈 등과 같은 근접무선통신모듈을 구비한 무선수신부(151)는, 무선송신기(130)로부터 전송되는 무선혈당정보신호를 수신받는 경우에(S408), 해당 수신받은 무선혈당정보신호를 측정 혈당으로 변환시켜 해당 변환시킨 측정 혈당을 디스플레이부(152)로 전달해 주게 된다(S409).Meanwhile, the external display device 150 including the wireless receiver 151, the display unit 152, and the power supply unit 153 receives an wireless blood glucose information signal from the wireless transmitter 130 and displays the measured blood sugar as a measurement blood sugar. After a program or a program is installed in advance, the pre-installed app or program is driven. Accordingly, when the wireless receiver 151 having a proximity wireless communication module such as an RF communication module or an NFC communication module receives a wireless blood glucose information signal transmitted from the wireless transmitter 130 (S408), the received wireless The blood sugar information signal is converted into the measured blood sugar to transfer the converted measured blood sugar to the display unit 152 (S409).
LCD 등과 같은 화면표시수단을 구비한 디스플레이부(152)는, 무선수신부(151)로부터 전달되는 측정 혈당을 화면에 표시해 주게 된다(S410).The display unit 152 having screen display means such as an LCD displays the measured blood sugar transmitted from the wireless receiver 151 on the screen (S410).
이상, 본 발명의 실시 예는 상술한 장치 및/또는 방법을 통해서만 구현이 되는 것은 아니며, 본 발명의 실시 예의 구성에 대응하는 기능을 실현하기 위한 프로그램, 그 프로그램이 기록된 기록 매체 등을 통해 구현될 수도 있으며, 이러한 구현은 앞서 설명한 실시 예의 기재로부터 본 발명이 속하는 기술 분야의 전문가라면 쉽게 구현할 수 있는 것이다.As described above, the embodiment of the present invention is not implemented only through the above-described apparatus and / or method, but through a program for realizing a function corresponding to the configuration of the embodiment of the present invention, a recording medium on which the program is recorded, and the like. Such an implementation may be easily implemented by those skilled in the art to which the present disclosure pertains based on the description of the above-described embodiments.
이상에서 본 발명의 실시 예에 대하여 상세하게 설명하였지만 본 발명의 권리범위는 이에 한정되는 것은 아니고 다음의 청구범위에서 정의하고 있는 본 발명의 기본 개념을 이용한 당업자의 여러 변형 및 개량 형태 또한 본 발명의 권리범위에 속하는 것이다.Although the embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements of those skilled in the art using the basic concepts of the present invention defined in the following claims are also provided. It belongs to the scope of rights.

Claims (10)

  1. 비루관 내에 삽입 설치되어, 비루관으로 모이는 눈물을 전달하는 삽입튜브;An insertion tube installed in the nasolacrimal duct to deliver tears collected into the nasolacrimal duct;
    상기 삽입튜브 내에 삽입 설치되어, 상기 삽입튜브를 통해 전달되는 눈물을 인가받아 당뇨를 체크하여 혈당으로 측정하는 당뇨센서;A diabetic sensor inserted into the insertion tube to check a diabetes by receiving tears delivered through the insertion tube and measuring blood glucose;
    상기 당뇨센서에서 측정한 혈당을 외부로 전송하기 위한 무선혈당정보신호로 생성시켜 전송하는 무선송신기; 및A wireless transmitter for generating and transmitting a blood glucose information signal for transmitting blood glucose measured by the diabetes sensor to the outside; And
    상기 당뇨센서 및 상기 무선송신기에 필요한 전원으로 변환시켜 공급하는 자가전원공급기를 포함하는 당뇨 측정 장치.Diabetes measuring device comprising a self-power supply for converting and supplying power to the diabetes sensor and the wireless transmitter.
  2. 제1항에 있어서, 상기 당뇨센서는,The method of claim 1, wherein the diabetes sensor,
    상기 삽입튜브의 원통 모양 내부면을 따라서 원통형으로 상기 삽입튜브 내부에 붙여 내부면으로 눈물이 지나가도록 하거나, 상기 삽입튜브 내부에 ?? 형태로 일자로 넣어서 양면으로 눈물이 지나가도록 하는 것을 특징으로 하는 당뇨 측정 장치.A cylindrical shape is formed along a cylindrical inner surface of the insertion tube so that tears pass through the inner surface of the insertion tube, or inside the insertion tube. Diabetes measuring device characterized in that the tears pass on both sides by putting the date in the form.
  3. 제1항에 있어서, 상기 무선송신기는,The wireless transmitter of claim 1,
    박막 형태로 상기 당뇨센서와 연결되어 상기 삽입튜브의 내부면 또는 외부면이나 부비동에 고정 설치되는 것을 특징으로 하는 당뇨 측정 장치.Diabetic measuring device is connected to the diabetes sensor in the form of a thin film is fixed to the inner surface or the outer surface or the sinus of the insertion tube.
  4. 제1항에 있어서, 상기 자가전원공급기는,According to claim 1, wherein the self-power supply,
    상기 당뇨센서 및 상기 무선송신기와 연결되어 상기 삽입튜브의 내부면 또는 외부면이나 부비동에 고정 설치된 박막 형태의 전지인 것을 특징으로 하는 당뇨 측정 장치.Diabetic measuring device is connected to the diabetes sensor and the wireless transmitter, characterized in that the battery of the thin film form fixed to the inner surface or the outer surface or the sinus of the insertion tube.
  5. 제1항에 있어서,The method of claim 1,
    상기 무선송신기로부터 무선혈당정보신호를 수신받아 측정 혈당으로 표시하기 위한 외부디스플레이장치를 더 포함하는 것을 특징으로 하는 당뇨 측정 장치.And an external display device for receiving the wireless blood glucose information signal from the wireless transmitter and displaying the measured blood sugar.
  6. 제5항에 있어서, 상기 외부디스플레이장치는,The method of claim 5, wherein the external display device,
    상기 무선송신기로부터 전송되는 무선혈당정보신호를 수신받아 측정 혈당으로 변환시켜 주는 무선수신부;A wireless receiver which receives the wireless blood glucose information signal transmitted from the wireless transmitter and converts the measured blood glucose into measured blood glucose;
    상기 무선수신부에서 변환시킨 측정 혈당을 화면에 표시하는 디스플레이부; 및A display unit which displays the measured blood sugar converted by the wireless receiver on a screen; And
    외부의 상용전원 또는 배터리이나 충전배터리의 전원을 인가받아 상기 무선수신부 및 상기 디스플레이부에 필요한 전원으로 변환시켜 공급하는 전원공급부를 구비하는 것을 특징으로 하는 당뇨 측정 장치.Diabetes measuring device characterized in that it is provided with a power supply for converting the power supplied to the wireless receiving unit and the display unit to receive the external commercial power or the power of the battery or rechargeable battery.
  7. 비루관 내에 삽입 설치된 삽입튜브가 비루관으로 모이는 눈물을 전달하는 단계;Delivering tears collected into the nasolacrimal duct by the insertion tube inserted into the nasolacrimal duct;
    자가전원공급기가 당뇨센서 및 무선송신기에 필요한 전원으로 변환시켜 공급하는 단계;A self-power supply converts and supplies power to a diabetes sensor and a wireless transmitter;
    상기 삽입튜브 내에 삽입 설치된 당뇨센서가 상기 눈물을 인가받아 당뇨를 체크하여 혈당으로 측정하는 단계; 및A diabetic sensor inserted into the insertion tube to receive the tear and check diabetes to measure blood glucose; And
    무선송신기가 상기 당뇨센서에서 측정한 혈당을 외부로 전송하기 위한 무선혈당정보신호로 생성시켜 전송하는 단계를 포함하는 당뇨 측정 장치의 운용방법.And a wireless transmitter generating and transmitting a blood glucose information signal for transmitting blood glucose measured by the diabetes sensor to the outside.
  8. 제7항에 있어서,The method of claim 7, wherein
    삽입장치가 탐침 혹은 내시경을 이용하여 비루관 내에 실리콘 재질의 관인 삽입튜브를 삽입 설치하는 단계;Inserting and inserting an insertion tube, which is a tube made of silicon, into the nasolacrimal duct using an insertion device by using a probe or an endoscope;
    상기 삽입장치가 내시경을 이용해서 상기 삽입튜브 내에 상기 당뇨센서를 삽입 설치하는 단계;Inserting, by the insertion apparatus, the diabetes sensor into the insertion tube using an endoscope;
    상기 당뇨센서의 삽입 설치 시에, 상기 삽입장치가 내시경을 이용하여 상기 당뇨센서와 연결된 상태의 무선송신기를 상기 삽입튜브의 내부면 또는 외부면이나 부비동에 고정 설치하는 단계; 및When the diabetic sensor is inserted and installed, the inserting device using an endoscope to securely install a wireless transmitter connected to the diabetic sensor to an inner surface, an outer surface, or a sinus of the insertion tube; And
    상기 당뇨센서의 삽입 설치 시에, 상기 삽입장치가 내시경을 이용하여 상기 당뇨센서 및 상기 무선송신기와 연결된 상태의 자가전원공급기를 상기 삽입튜브의 내부면 또는 외부면이나 부비동에 고정 설치하는 단계를 더 포함하는 것을 특징으로 하는 당뇨 측정 장치의 운용방법.When the diabetic sensor is inserted and installed, the inserting device uses an endoscope to fix the self-power supply in a state connected to the diabetic sensor and the wireless transmitter to the inner surface or the outer surface or the sinus of the insertion tube. Operation method of the diabetic measuring device comprising a.
  9. 제8항에 있어서, 상기 당뇨센서를 삽입 설치하는 단계는,The method of claim 8, wherein the diabetic sensor is inserted and installed,
    상기 삽입장치가 상기 삽입튜브의 원통 모양 내부면을 따라서 원통형으로 상기 삽입튜브 내부에 붙여 내부면으로 눈물이 지나가도록 설치하거나, 상기 삽입튜브 내부에 ?? 형태로 일자로 넣어서 양면으로 눈물이 지나가도록 설치하는 것을 특징으로 하는 당뇨 측정 장치의 운용방법.The insertion device is installed along the cylindrical inner surface of the insertion tube in a cylindrical shape so that tears pass through the inner surface, or inside the insertion tube. Operating method of the diabetic measuring device, characterized in that installed in the form of a date so that tears pass on both sides.
  10. 제8항에 있어서, 상기 당뇨센서를 삽입 설치하는 단계는,The method of claim 8, wherein the diabetic sensor is inserted and installed,
    상기 삽입장치가 기 설정된 교체 기간마다 한 번씩 내시경으로 보면서 포셉으로 상기 삽입튜브 내에 삽입 설치된 당뇨센서를 잡아 빼내고, 내시경을 이용해서 상기 삽입튜브 내로 새로운 당뇨센서로 교체하는 단계를 더 포함하는 것을 특징으로 하는 당뇨 측정 장치의 운용방법.The inserting device is characterized in that it further comprises the step of pulling out the diabetic sensor inserted into the insertion tube with a forceps while looking through the endoscope every preset replacement period, and replacing the new diabetic sensor into the insertion tube using the endoscope. Operation method of diabetic measuring apparatus to say.
PCT/KR2015/004627 2014-06-10 2015-05-08 Diabetes measuring device and operation method thereof WO2015190706A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020140070025A KR20150141381A (en) 2014-06-10 2014-06-10 Diabetes measurement apparatus and operating method thereof
KR10-2014-0070025 2014-06-10

Publications (1)

Publication Number Publication Date
WO2015190706A1 true WO2015190706A1 (en) 2015-12-17

Family

ID=54833759

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2015/004627 WO2015190706A1 (en) 2014-06-10 2015-05-08 Diabetes measuring device and operation method thereof

Country Status (2)

Country Link
KR (1) KR20150141381A (en)
WO (1) WO2015190706A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140985A (en) * 1989-12-11 1992-08-25 Schroeder Jon M Noninvasive blood glucose measuring device
KR20110043918A (en) * 2009-10-22 2011-04-28 서강대학교산학협력단 Microminiature device for sensing glucose
US8090426B2 (en) * 2006-10-27 2012-01-03 Felder Robin A Microelectronic biosensor plug
US8385998B2 (en) * 2008-10-24 2013-02-26 Jin Zhang Contact lens integrated with a biosensor for the detection of glucose and other components in tears

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140985A (en) * 1989-12-11 1992-08-25 Schroeder Jon M Noninvasive blood glucose measuring device
US8090426B2 (en) * 2006-10-27 2012-01-03 Felder Robin A Microelectronic biosensor plug
US8385998B2 (en) * 2008-10-24 2013-02-26 Jin Zhang Contact lens integrated with a biosensor for the detection of glucose and other components in tears
KR20110043918A (en) * 2009-10-22 2011-04-28 서강대학교산학협력단 Microminiature device for sensing glucose

Also Published As

Publication number Publication date
KR20150141381A (en) 2015-12-18

Similar Documents

Publication Publication Date Title
Du et al. Multiplexed, high density electrophysiology with nanofabricated neural probes
TW552126B (en) Gateway platform for biological monitoring and delivery of therapeutic compounds
CN101646387B (en) Resposable biosensor assembly and method
CN101287407B (en) Implant transmitter
BRPI0617377A2 (en) hearing and tympanometry systems, probe and method of calibrating a tympanometry module
US20180325386A1 (en) Multiplexed implantable sensor probe
WO2013039362A2 (en) Glycated protein measurement sensor and portable glycated protein measurement apparatus including same
JPH10507652A (en) Women's urinary incontinence prevention device including electronic sensor
CN104768457A (en) Diagnostic device and method for sensing hydration state of mammalian subject
CN102781323A (en) Body parameter sensor and monitor interface
WO2013131261A1 (en) Flexible intracranial cortex microelectrode chip, preparation and packaging method therefor, and packaging structure thereof
JP3204875B2 (en) Cell potential measurement device
Ferro et al. NeuroRoots, a bio-inspired, seamless Brain Machine Interface device for long-term recording
WO2020085576A1 (en) Method for providing health care service
Niederauer et al. Development of a novel intra-abdominal pressure transducer for large scale clinical studies
WO2015190706A1 (en) Diabetes measuring device and operation method thereof
WO2021020688A1 (en) Method for stabilizing continuous glucose monitoring system
WO2020032382A1 (en) Apparatus for controlling operation of continuous blood glucose tester
JP2003235829A (en) Health check unit, health check apparatus and health check system using the same
WO2017065565A1 (en) Blood sugar measurement and sensing module having automatic calibration function and apparatus for continuous blood sugar measurement using same
WO2021025255A1 (en) Notification method of continuous glucose monitoring system
WO2019160255A1 (en) Continuous biometric information measuring device using sensor usage information stored in memory
CN205327682U (en) A voice prompt box for collecting stool and urine sample
US20210085961A1 (en) Low-invasiveness flexible neural mesh implanted through temporarily attachment to low-profile microwire
WO2021210792A1 (en) Apparatus for measuring biometric information

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15806476

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 13/04/2017)

122 Ep: pct application non-entry in european phase

Ref document number: 15806476

Country of ref document: EP

Kind code of ref document: A1