WO2016130189A3 - Nanocomposites and methods of making same - Google Patents

Nanocomposites and methods of making same Download PDF

Info

Publication number
WO2016130189A3
WO2016130189A3 PCT/US2015/061664 US2015061664W WO2016130189A3 WO 2016130189 A3 WO2016130189 A3 WO 2016130189A3 US 2015061664 W US2015061664 W US 2015061664W WO 2016130189 A3 WO2016130189 A3 WO 2016130189A3
Authority
WO
WIPO (PCT)
Prior art keywords
layer
peg
silver
pegylated
raman reporter
Prior art date
Application number
PCT/US2015/061664
Other languages
French (fr)
Other versions
WO2016130189A2 (en
Inventor
Alexandru S. Biris
Andrew G. KUMPURIS
Zeid Nima
Original Assignee
Board Of Trustees Of The University Of Arkansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/683,929 external-priority patent/US9810687B2/en
Application filed by Board Of Trustees Of The University Of Arkansas filed Critical Board Of Trustees Of The University Of Arkansas
Publication of WO2016130189A2 publication Critical patent/WO2016130189A2/en
Publication of WO2016130189A3 publication Critical patent/WO2016130189A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles

Abstract

A nanoagent includes at least one nanocomposite. The nanocomposite includes at least one gold nanorod, a silver layer coated on an outer surface of the gold nanorod, a Raman reporter molecule layer coated on the silver layer, a pegylated layer coated on the Raman reporter molecule layer, an active layer conjugated to the pegylated layer. the active layer includes at least one of a targeting molecule configured to bind to a target of interest, and a functional molecule configured to interact with the target of interest. The silver layer has silver nanoparticles. The Raman reporter molecule layer has Raman reporter molecules that are detectable by surface enhanced Raman spectroscopy (SERS). The pegylated layer has at least one of thiolated polyethylene glycol (HS-PEG), thiolated polyethylene glycol acid (HS-PEG-COOH) and HS-PEG-NHx.
PCT/US2015/061664 2014-11-20 2015-11-19 Nanocomposites and methods of making same WO2016130189A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462082513P 2014-11-20 2014-11-20
US62/082,513 2014-11-20
US14/683,929 2015-04-10
US14/683,929 US9810687B2 (en) 2013-10-15 2015-04-10 Nanocomposites and methods of making same

Publications (2)

Publication Number Publication Date
WO2016130189A2 WO2016130189A2 (en) 2016-08-18
WO2016130189A3 true WO2016130189A3 (en) 2016-11-03

Family

ID=56615036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/061664 WO2016130189A2 (en) 2014-11-20 2015-11-19 Nanocomposites and methods of making same

Country Status (1)

Country Link
WO (1) WO2016130189A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106749518B (en) * 2016-11-10 2021-01-01 国家纳米科学中心 Polypeptide nano material containing pyrene group and preparation method and application thereof
CN113049823A (en) * 2021-03-17 2021-06-29 扬州大学 Preparation method of ultrasensitive SERS (surface enhanced Raman scattering) immunosensor and application of ultrasensitive SERS immunosensor in cervical cancer serum biomarker detection
CN114563572B (en) * 2022-04-27 2022-08-02 成都安普诺生物科技有限公司 Tobacco leaf all-in-one heavy metal rapid quantitative detection card and detection method
CN115356323A (en) * 2022-08-15 2022-11-18 滨州医学院 Method for growing gold nanorod array by evaporation-induced self-assembly and SERS (surface enhanced Raman Scattering) sensor for detecting blood sugar or glucose

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129199B2 (en) * 2004-12-13 2012-03-06 University of South Caroliina Surface enhanced Raman spectroscopy using shaped gold nanoparticles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129199B2 (en) * 2004-12-13 2012-03-06 University of South Caroliina Surface enhanced Raman spectroscopy using shaped gold nanoparticles

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KHLEBTSOV ET AL.: "Surface-enhanced raman scattering substrates based on self-assembled PEGylated gold and gold-silver core-shell nanorods", THE JOURNAL OF PHYSICAL CHEMISTRY C, vol. 117, no. 44, 2 October 2013 (2013-10-02), pages 23162 - 23171, XP055326436 *
NIMA ET AL.: "Circulating tumor cell identification by functionalized silver-gold nanorods with multicolor, super-enhanced SERS and photothermal resonances", SCIENTIFIC REPORTS, vol. 4, 9 May 2014 (2014-05-09), pages 1 - 8, XP055326426 *
NIMA ET AL.: "Single-walled carbon nanotubes as specific targeting and Raman spectroscopic agents for detection and discrimination of single human breast cancer cells", JOURNAL OF BIOMEDICAL OPTICS, vol. 18, no. 5, pages 1 - 11, XP060024150 *
ZONG ET AL.: "A SERS and fluorescence dual mode cancer cell targeting probe based on silica coated Au@Ag core-shell nanorods", TALANTA, vol. 97, pages 368 - 375, XP028450125 *

Also Published As

Publication number Publication date
WO2016130189A2 (en) 2016-08-18

Similar Documents

Publication Publication Date Title
WO2014121134A3 (en) Embodiments of a composition comprising diatom frustules and a method for making and using
WO2016094837A3 (en) Anti-c10orf54 antibodies and uses thereof
WO2016130189A3 (en) Nanocomposites and methods of making same
WO2013142440A3 (en) Mixtures, methods and compositions pertaining to conductive materials
WO2015035365A8 (en) Targeting the m2-tumor associated macrophage for cancer therapy
WO2017002115A3 (en) Hybrid nanoparticles as photoinitiators
WO2015164392A3 (en) Novel antii-rnf43 antibodies and methods of use
WO2015077635A8 (en) Macromolecular antioxidants based on dual type moiety per molecule: structures methods of making and using the same
EP3220895A4 (en) The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
WO2016055941A8 (en) Anti-tau antibody and uses thereof
WO2014130429A3 (en) Caged platinum nanoclusters for anticancer chemotherapeutics
FR3002414B1 (en) RODENTICIDE COMPOSITION IN THE FORM OF CEREALS AND / OR AGGLOMERATED SEEDS.
BR112015022975A2 (en) phenylephrine resinate particles
AU2018301442A1 (en) Targeting the HDAC2-Sp3 complex to enhance synaptic function
EP3429586A4 (en) Targeting tumor cells with chemotherapeutic agents conjugated to anti-matriptase antibodies by in vivo cleavable linking moieties
CN302165013S (en) Car driving recorder (GPS/GPRS)
Lu Showcasing research of Dr Gang Lu from the laboratory of Prof. Hiroshi Uji-i, KULeuven, Belgium and the laboratory of Prof. Hiroshi Fukumura, Tohoku University, Japan.
TH5981C3 (en) Nanoparticles and Nanoparticle Preparation Process
TH120785S (en) Mechanical pencil
CN302029913S (en) steering wheel
CN302142433S (en) Rotation angle detector
TH180425A (en) Conjugated drug antibody (ADC), which binds to the 158P1D7 protein.
TH138731S (en) Metal cross-section
TH138730S (en) Metal cross-section
TH138728S (en) Metal cross-section

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15882264

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15882264

Country of ref document: EP

Kind code of ref document: A2