WO2016165838A3 - Optical monitoring system & sensor therefor - Google Patents

Optical monitoring system & sensor therefor Download PDF

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Publication number
WO2016165838A3
WO2016165838A3 PCT/EP2016/025038 EP2016025038W WO2016165838A3 WO 2016165838 A3 WO2016165838 A3 WO 2016165838A3 EP 2016025038 W EP2016025038 W EP 2016025038W WO 2016165838 A3 WO2016165838 A3 WO 2016165838A3
Authority
WO
WIPO (PCT)
Prior art keywords
sensor
monitoring system
optical monitoring
sensor therefor
fluorescence
Prior art date
Application number
PCT/EP2016/025038
Other languages
French (fr)
Other versions
WO2016165838A2 (en
Inventor
John Julian DAVENPORT
Panayiotis Anastasios Kyriacou
Justin Phillips
Michelle Hickey
Original Assignee
The City University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The City University filed Critical The City University
Publication of WO2016165838A2 publication Critical patent/WO2016165838A2/en
Publication of WO2016165838A3 publication Critical patent/WO2016165838A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004—Gaseous mixtures, e.g. polluted air
    • G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
    • G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
    • G01N33/0036—Specially adapted to detect a particular component
    • G01N33/004—Specially adapted to detect a particular component for CO, CO2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6434—Optrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7793—Sensor comprising plural indicators

Abstract

An optical sensor comprising first and second photoresponsive components that are each configured to fluoresce, responsive to excitation by light of a first wavelength, and emit light including a second and a third wavelength respectively; wherein the fluorescence of said first component varies with oxygen concentration of a medium with which the sensor is in contact, and the fluorescence of said second component varies with carbon dioxide concentration of a medium with which the sensor is in contact.
PCT/EP2016/025038 2015-04-14 2016-04-14 Optical monitoring system & sensor therefor WO2016165838A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1506332.4 2015-04-14
GBGB1506332.4A GB201506332D0 (en) 2015-04-14 2015-04-14 Optical sensing system & sensor therefor

Publications (2)

Publication Number Publication Date
WO2016165838A2 WO2016165838A2 (en) 2016-10-20
WO2016165838A3 true WO2016165838A3 (en) 2016-11-24

Family

ID=53333772

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2016/025038 WO2016165838A2 (en) 2015-04-14 2016-04-14 Optical monitoring system & sensor therefor

Country Status (2)

Country Link
GB (2) GB201506332D0 (en)
WO (1) WO2016165838A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107084967A (en) * 2017-06-15 2017-08-22 福州普贝斯智能科技有限公司 A kind of oxygen in water measuring instrument

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5152287A (en) * 1990-08-15 1992-10-06 Cordis Corporation Cross-linked fluorinated polymers for use in gas sensors
US20010034479A1 (en) * 2000-04-19 2001-10-25 Ring Lawrence S. Optically based transcutaneous blood gas sensor
US20110105869A1 (en) * 2006-01-04 2011-05-05 The Trustees Of The University Of Pennsylvania Sensor for Internal Monitoring of Tissue O2 and/or pH/CO2 In Vivo

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5330718A (en) * 1989-08-16 1994-07-19 Puritan-Bennett Corporation Sensor element and method for making the same
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
WO2008133551A1 (en) * 2007-04-27 2008-11-06 St. Jude Medical Ab Implantable concentration sensor and device
US8223325B2 (en) * 2008-09-19 2012-07-17 Sensors For Medicine & Science, Inc. Optical sensor assembly
CN202005754U (en) * 2011-03-25 2011-10-12 复旦大学附属中山医院 Fluorescent optical fiber sensor capable of monitoring dissolved oxygen partial pressure and carbon dioxide partial pressure in blood

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5152287A (en) * 1990-08-15 1992-10-06 Cordis Corporation Cross-linked fluorinated polymers for use in gas sensors
US20010034479A1 (en) * 2000-04-19 2001-10-25 Ring Lawrence S. Optically based transcutaneous blood gas sensor
US20110105869A1 (en) * 2006-01-04 2011-05-05 The Trustees Of The University Of Pennsylvania Sensor for Internal Monitoring of Tissue O2 and/or pH/CO2 In Vivo

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SERGEY M. BORISOV ET AL: "Modified Dual Lifetime Referencing Method for Simultaneous Optical Determination and Sensing of Two Analytes", APPLIED SPECTROSCOPY, vol. 60, no. 10, 1 October 2006 (2006-10-01), pages 1167 - 1173, XP055152735, ISSN: 0003-7028, DOI: 10.1366/000370206778664590 *

Also Published As

Publication number Publication date
WO2016165838A2 (en) 2016-10-20
GB201506332D0 (en) 2015-05-27
GB2537504A (en) 2016-10-19

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