WO2017024317A3 - Methods to induce targeted protein degradation through bifunctional molecules - Google Patents
Methods to induce targeted protein degradation through bifunctional molecules Download PDFInfo
- Publication number
- WO2017024317A3 WO2017024317A3 PCT/US2016/046087 US2016046087W WO2017024317A3 WO 2017024317 A3 WO2017024317 A3 WO 2017024317A3 US 2016046087 W US2016046087 W US 2016046087W WO 2017024317 A3 WO2017024317 A3 WO 2017024317A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- protein degradation
- targeted protein
- bifunctional molecules
- induce targeted
- Prior art date
Links
- 230000001588 bifunctional effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000017854 proteolysis Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y502/00—Cis-trans-isomerases (5.2)
- C12Y502/01—Cis-trans-Isomerases (5.2.1)
- C12Y502/01008—Peptidylprolyl isomerase (5.2.1.8), i.e. cyclophilin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
Abstract
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to nucleic acids, polypeptides, cells, and methods for highly regulated, targeted degradation of proteins through the use of the bifunctional compounds.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562202076P | 2015-08-06 | 2015-08-06 | |
US62/202,076 | 2015-08-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2017024317A2 WO2017024317A2 (en) | 2017-02-09 |
WO2017024317A3 true WO2017024317A3 (en) | 2017-04-27 |
Family
ID=56990946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2016/046087 WO2017024317A2 (en) | 2015-08-06 | 2016-08-08 | Methods to induce targeted protein degradation through bifunctional molecules |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2017024317A2 (en) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107257800B (en) | 2014-12-23 | 2020-06-30 | 达纳-法伯癌症研究所股份有限公司 | Method for inducing target protein degradation by bifunctional molecules |
US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
JP6817962B2 (en) * | 2015-01-20 | 2021-01-20 | アルビナス・オペレーションズ・インコーポレイテッドArvinas Operations, Inc. | Compounds and methods for targeted androgen receptor degradation |
US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
WO2017007612A1 (en) | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
WO2017030814A1 (en) | 2015-08-19 | 2017-02-23 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
JP6968823B2 (en) | 2016-04-22 | 2021-11-17 | ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド | Bifunctional molecule for degradation of EGFR, and how to use |
CN109641874A (en) | 2016-05-10 | 2019-04-16 | C4医药公司 | C for target protein degradation3The glutarimide degron body of carbon connection |
WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
WO2018064589A1 (en) | 2016-09-29 | 2018-04-05 | Dana-Farber Cancer Institute, Inc. | Targeted protein degradation using a mutant e3 ubiquitin ligase |
CN117510491A (en) | 2016-12-23 | 2024-02-06 | 阿尔维纳斯运营股份有限公司 | Compounds and methods for rapid accelerated targeted degradation of fibrosarcoma polypeptides |
US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
CN110769822A (en) | 2017-06-20 | 2020-02-07 | C4医药公司 | N/O-linked degron and degron bodies for protein degradation |
CN111278815B (en) | 2017-09-04 | 2024-03-08 | C4医药公司 | Glutarimide |
CN111278816B (en) | 2017-09-04 | 2024-03-15 | C4医药公司 | Dihydro quinolinones |
EP3679027A1 (en) | 2017-09-04 | 2020-07-15 | C4 Therapeutics, Inc. | Dihydrobenzimidazolones |
EP3700901A1 (en) | 2017-10-24 | 2020-09-02 | Genentech, Inc. | (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof |
WO2019099868A2 (en) | 2017-11-16 | 2019-05-23 | C4 Therapeutics, Inc. | Degraders and degrons for targeted protein degradation |
AU2019225806A1 (en) * | 2018-02-20 | 2020-07-16 | Dana-Farber Cancer Institute, Inc. | Inhibitors of EGFR and methods of use thereof |
JP2021514012A (en) * | 2018-02-20 | 2021-06-03 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Degradation inducer of EGFR and its usage |
WO2019164932A1 (en) * | 2018-02-20 | 2019-08-29 | Dana-Farber Cancer Institute, Inc. | Degraders of egfr and methods of use thereof |
EP3755325A4 (en) * | 2018-02-23 | 2022-03-02 | Dana-Farber Cancer Institute, Inc. | Small molecules for inducing selective protein degradation and uses thereof |
JP2021519337A (en) | 2018-03-26 | 2021-08-10 | シー4 セラピューティクス, インコーポレイテッド | Cereblon binder for the degradation of Ikaras |
CN112312904A (en) | 2018-04-16 | 2021-02-02 | C4医药公司 | Spiro compounds |
JP7458324B2 (en) | 2018-04-23 | 2024-03-29 | セルジーン コーポレイション | Substituted 4-aminoisoindoline-1,3-dione compounds and their use for the treatment of lymphoma |
EP3578561A1 (en) | 2018-06-04 | 2019-12-11 | F. Hoffmann-La Roche AG | Spiro compounds |
WO2019238816A1 (en) | 2018-06-13 | 2019-12-19 | University Of Dundee | Bifunctional molecules for targeting uchl5 |
WO2019238886A1 (en) | 2018-06-13 | 2019-12-19 | University Of Dundee | Bifunctional molecules for targeting usp14 |
CN112533918A (en) | 2018-06-13 | 2021-03-19 | 安菲斯塔治疗有限责任公司 | Bifunctional molecules for targeting Rpn11 |
EP3817745A4 (en) * | 2018-07-05 | 2022-04-06 | Icahn School of Medicine at Mount Sinai | Protein tyrosine kinase 6 (ptk6) degradation / disruption compounds and methods of use |
JP7297053B2 (en) | 2018-08-20 | 2023-06-23 | アルビナス・オペレーションズ・インコーポレイテッド | Alpha-Synuclein Protein-Targeted Proteolysis Targeting Chimeric (PROTAC) Compounds with E3 Ubiquitin Ligase Binding Activity to Treat Neurodegenerative Diseases |
WO2020041387A1 (en) * | 2018-08-20 | 2020-02-27 | The Brigham And Women's Hospital, Inc. | Degradation domain modifications for spatio-temporal control of rna-guided nucleases |
CN111018857B (en) * | 2018-10-09 | 2023-06-02 | 嘉兴优博生物技术有限公司 | Targeted protease degradation platform (TED) |
EP3864030A4 (en) * | 2018-10-12 | 2022-09-21 | The Scripps Research Institute | Compounds and methods for dcaf-mediated protein degradation |
CN113423701A (en) | 2018-11-13 | 2021-09-21 | 拜欧斯瑞克斯公司 | Substituted isoindolinones |
WO2020146250A1 (en) * | 2019-01-07 | 2020-07-16 | Dana-Farber Cancer Institute, Inc. | SMALL MOLECULE DEGRADERS OF FKBP12 VIA RECRUITMENT OF VON HIPPEL-LINDAU E3 UBIQUITIN LIGASE (VHL) E3 UBIQUITIN LIGASE, AND USES IN dTAG SYSTEMS |
US20220135589A1 (en) * | 2019-02-02 | 2022-05-05 | Capc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Targeted ubiquitination degradation brd4 protein compound, preparation method therefor and application thereof |
WO2020163823A2 (en) * | 2019-02-08 | 2020-08-13 | University Of Florida Research Foundation, Incorporated | Therapeutic agents and methods of treatment |
MX2021011242A (en) | 2019-03-21 | 2022-01-19 | Codiak Biosciences Inc | Extracellular vesicle conjugates and uses thereof. |
US20220387906A1 (en) | 2019-03-21 | 2022-12-08 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
US20230093099A1 (en) * | 2019-04-02 | 2023-03-23 | Cullgen (Shanghai), Inc. | Compounds and methods of treating cancers |
EP3999182A1 (en) | 2019-07-17 | 2022-05-25 | Arvinas Operations, Inc. | Tau-protein targeting compounds and associated methods of use |
MX2022007659A (en) | 2019-12-20 | 2022-07-19 | C4 Therapeutics Inc | Isoindolinone and indazole compounds for the degradation of egfr. |
KR20220151160A (en) | 2019-12-23 | 2022-11-14 | 카이메라 쎄라퓨틱스 인코포레이티드 | SMARCA disintegrant and its uses |
JP2023516073A (en) | 2020-03-05 | 2023-04-17 | シーフォー セラピューティクス, インコーポレイテッド | Compounds for targeted degradation of BRD9 |
WO2021222138A1 (en) * | 2020-04-27 | 2021-11-04 | Development Center For Biotechnology | Compounds for mutant ras protein degradation |
WO2021237100A1 (en) | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
WO2022066928A2 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
CN116323570A (en) * | 2020-09-30 | 2023-06-23 | 上海睿跃生物科技有限公司 | Compounds and methods for treating diseases |
CA3195448A1 (en) * | 2020-10-14 | 2022-04-21 | Weiwen Ying | Methods and compositions for targeted protein degradation |
TW202237095A (en) | 2020-12-03 | 2022-10-01 | 德商艾斯巴赫生物有限公司 | Alc1 inhibitors and synergy with parpi |
WO2022125804A1 (en) * | 2020-12-09 | 2022-06-16 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
JP2024504932A (en) | 2021-01-13 | 2024-02-02 | モンテ ローザ セラピューティクス, インコーポレイテッド | isoindolinone compound |
WO2023283130A1 (en) | 2021-07-04 | 2023-01-12 | Newave Pharmaceutical Inc. | Isoquinoline derivatives as mutant egfr modulators and uses thereof |
AU2022317019A1 (en) * | 2021-07-30 | 2024-02-29 | Hinova Pharmaceuticals Inc. | Bifunctional chimeric heterocyclic compound and use thereof as androgen receptor degrader |
WO2023172889A1 (en) * | 2022-03-07 | 2023-09-14 | The University Of North Carolina At Chapel Hill | Use of chemical epigenetic modifiers to modulate gene expression |
WO2023213833A1 (en) | 2022-05-02 | 2023-11-09 | Eisbach Bio Gmbh | Use of alc1 inhibitors and synergy with parpi |
WO2023242176A1 (en) * | 2022-06-13 | 2023-12-21 | Julius-Maximilians-Universität Würzburg | Transposase fusion proteins for use in cell and gene therapy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003029827A2 (en) * | 2001-10-01 | 2003-04-10 | Bioimage A/S | A method of detecting intracellular protein-protein interactions using three heterologous conjugates |
WO2014159312A2 (en) * | 2013-03-14 | 2014-10-02 | University Of Florida Research Foundation, Incorporated | A novel single chain antibody reduced mutant alpha-1 antitrypsin aggregation and toxicity |
US20140335539A1 (en) * | 2011-12-05 | 2014-11-13 | Medical & Biological Laboratories Co., Ltd. | Method for detecting protein-protein interaction |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
DE3751873T2 (en) | 1986-04-09 | 1997-02-13 | Genzyme Corp | Genetically transformed animals that secrete a desired protein in milk |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
AU7979491A (en) | 1990-05-03 | 1991-11-27 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
US6231600B1 (en) | 1995-02-22 | 2001-05-15 | Scimed Life Systems, Inc. | Stents with hybrid coating for medical devices |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
ZA9710342B (en) | 1996-11-25 | 1998-06-10 | Alza Corp | Directional drug delivery stent and method of use. |
US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
US5891507A (en) | 1997-07-28 | 1999-04-06 | Iowa-India Investments Company Limited | Process for coating a surface of a metallic stent |
US6153252A (en) | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
US6248127B1 (en) | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US6258121B1 (en) | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
US6203551B1 (en) | 1999-10-04 | 2001-03-20 | Advanced Cardiovascular Systems, Inc. | Chamber for applying therapeutic substances to an implant device |
US6251136B1 (en) | 1999-12-08 | 2001-06-26 | Advanced Cardiovascular Systems, Inc. | Method of layering a three-coated stent using pharmacological and polymeric agents |
US6517889B1 (en) | 2001-11-26 | 2003-02-11 | Swaminathan Jayaraman | Process for coating a surface of a stent |
US9405700B2 (en) | 2010-11-04 | 2016-08-02 | Sonics, Inc. | Methods and apparatus for virtualization in an integrated circuit |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
-
2016
- 2016-08-08 WO PCT/US2016/046087 patent/WO2017024317A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003029827A2 (en) * | 2001-10-01 | 2003-04-10 | Bioimage A/S | A method of detecting intracellular protein-protein interactions using three heterologous conjugates |
US20140335539A1 (en) * | 2011-12-05 | 2014-11-13 | Medical & Biological Laboratories Co., Ltd. | Method for detecting protein-protein interaction |
WO2014159312A2 (en) * | 2013-03-14 | 2014-10-02 | University Of Florida Research Foundation, Incorporated | A novel single chain antibody reduced mutant alpha-1 antitrypsin aggregation and toxicity |
Non-Patent Citations (7)
Title |
---|
G. E. WINTER ET AL: "Phthalimide conjugation as a strategy for in vivo target protein degradation", SCIENCE, vol. 348, no. 6241, 19 June 2015 (2015-06-19), pages 1376 - 1381, XP055328122, ISSN: 0036-8075, DOI: 10.1126/science.aab1433 * |
JAN KRÖNKE ET AL: "Lenalidomide induces ubiquitination and degradation of CK1[alpha] in del(5q) MDS", NATURE, vol. 523, no. 7559, 9 July 2015 (2015-07-09), United Kingdom, pages 183 - 188, XP055336278, ISSN: 0028-0836, DOI: 10.1038/nature14610 * |
M. SEKIGUCHI ET AL: "An evaluation tool for FKBP12-dependent and -independent mTOR inhibitors using a combination of FKBP-mTOR fusion protein, DSC and NMR", PROTEIN ENGINEERING, DESIGN AND SELECTION, vol. 24, no. 11, 6 September 2011 (2011-09-06), GB, pages 811 - 817, XP055336205, ISSN: 1741-0126, DOI: 10.1093/protein/gzr045 * |
PHILIP P CHAMBERLAIN ET AL: "Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs", NATURE STRUCTURAL AND MOLECULAR BIOLOGY, vol. 21, no. 9, 10 August 2014 (2014-08-10), US, pages 803 - 809, XP055336279, ISSN: 1545-9993, DOI: 10.1038/nsmb.2874 * |
ROBERS MATT ET AL.: "Fluorescent labeling of proteins in living cells using the FKBP12 (F36V) tag", CYTOMETRY. PART A : THE JOURNAL OF THE INTERNATIONAL SOCIETY FOR ANALYTICAL CYTOLOGY, vol. 75, no. 3, March 2009 (2009-03-01), pages 207 - 224, XP002762671, ISSN: 1552-4930 * |
WANG T ET AL: "Specific Interaction of Type I Receptors of the TGF-beta Family with the Immunophilin FKBP-12", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, vol. 265, 29 July 1994 (1994-07-29), pages 674 - 676, XP002173914, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.7518616 * |
WANG XIAO-SONG ET AL: "Characterization of KRAS rearrangements in metastatic prostate cancer", CANCER DISCOVERY,, vol. 1, no. 1, 1 June 2011 (2011-06-01), pages 35 - 43, XP009167682, ISSN: 2159-8290, DOI: 10.1158/2159-8274.CD-10-0022 * |
Also Published As
Publication number | Publication date |
---|---|
WO2017024317A2 (en) | 2017-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2017024317A3 (en) | Methods to induce targeted protein degradation through bifunctional molecules | |
SA518400424B1 (en) | Antibody molecules for cancer treatment | |
PH12018502361A1 (en) | Gdf15 fusion proteins and uses thereof | |
TWI799368B (en) | Anti-tl1a antigen binding proteins and related nucleic acids, expression vectors, host cells, pharmaceutical composition, methods and uses | |
WO2015109124A3 (en) | Immunomodulatory agents | |
MX2019006045A (en) | Psma targeting trispecific proteins and methods of use. | |
EP3741848A3 (en) | Protease variants and polynucleotides encoding same | |
WO2015196128A3 (en) | Alternative nucleic acid molecules and uses thereof | |
WO2016107818A8 (en) | Compositions and methods for protein glycosylation | |
WO2015196130A3 (en) | Alternative nucleic acid molecules and uses thereof | |
MX2017014908A (en) | Trispecific binding proteins and methods of use. | |
EP3773727A4 (en) | Bifunctional small molecules to target the selective degradation of circulating proteins | |
EP4219744A3 (en) | Methods of preparing nucleic acids for sequencing | |
WO2018081592A3 (en) | Compositions and methods for the production of compounds | |
WO2016066756A3 (en) | Protease variants and polynucleotides encoding same | |
WO2016066757A3 (en) | Protease variants and polynucleotides encoding same | |
EP3234200A4 (en) | Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using crispr/cas system proteins | |
WO2015112886A3 (en) | Binding proteins and methods of use thereof | |
MX2021010668A (en) | Cytokine fusion proteins. | |
WO2015089511A3 (en) | Modified nucleic acid molecules and uses thereof | |
WO2016065349A8 (en) | Short non-coding protein regulatory rnas (sprrnas) and methods of use | |
BR112017016897A2 (en) | fungal strains and methods of use | |
EA201790505A1 (en) | CONNECTION, AIMED ON IL-23A AND TNF-ALPHA, AND ITS APPLICATION | |
EP3543335A3 (en) | Soluble intein fusion proteins and methods for purifying biomolecules | |
EP3964575A3 (en) | Alpha-amylase variants and polynucleotides encoding same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 16770585 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 16770585 Country of ref document: EP Kind code of ref document: A2 |