What is claimed is:
1. A method for reducing an occurrence of hyperpigmentation in human skin, comprising applying a topical preparation to the skin, the preparation comprising an amount of an agent effective to reduce an occurrence of hyperpigmentation in human skin, the agent comprising idebenone or a derivative of idebenone.
2. The method as recited in claim 1 wherein the applying is performed after the hyperpigmentation has occurred.
3. The method as recited in claim 1 wherein the idebenone or derivative of idebenone has a concentration of from about 0.001% to about 30% by weight of the topical preparation.
4. The method as recited in claim 1 wherein the idebenone or derivative of idebenone has a concentration of from about 0.01% to about 10.0% by weight of the topical preparation.
5. The method as recited in claim 1 wherein the idebenone or derivative of idebenone has a concentration of from about 0.10% to about 2.0% by weight of the topical preparation.
6. The method as recited in claim 1 wherein the idebenone or derivative of idebenone has a concentration of from about 0.5% to about 1.0% by weight of the topical preparation.
7. The method as recited in claim 1 wherein the derivative of idebenone is selected from the group consisting of a salt of idebenone, an ester of idebenone, and a protein-bound form of idebenone.
8. The method as recited in claim 1 wherein the topical preparation is in the form of at least one of a lotion, a cream, a gel, a solution, a spray, a cleanser, a powder, an ointment, a wax, a lipstick, a soap, a shampoo, a hydroalcoholic solution, a suspension, a scrub, a saturated pad, and a skin or hair conditioning agent.
9. The method as recited in claim 1 wherein the applying is performed prior to an event known or suspected to cause hyperpigmentation.
10. The method as recited in claim 9 wherein the event is at least one of an exposure to ultraviolet radiation, an exposure to a chemical, an exposure to a cosmetic and an exposure to a drug.
11. The method as recited in claim 1 wherein the applying is performed at least once a day.
12. The method as recited in claim 1 wherein the applying is performed prior to engaging in outdoor activities.
13. The method as recited in claim 1 wherein the skin is at least one of facial skin, skin on the neck, skin on the arms, skin on the hands and skin on the legs.
14. The method as recited in claim 1 wherein the topical preparation is at least one of a cosmetic preparation, a dermatological preparation, an over-the-counter preparation, and a pharmaceutical preparation.
15. The method as recited in claim 0.1 wherein the topical preparation further comprises at least one antioxidant.
16. The method as recited in claim 1 wherein the topical preparation further comprises at least one antioxidant selected from the group consisting of Vitamin E, Vitamin C, Glutathione, Superoxide Dismutase, Catalase, Co-Enzyme Q10, a botanical extract, alpha lipoic acid, N-furfuryladenine and an antioxidant polyphenol.
17. The method as recited in claim 1 wherein the topical preparation further comprises at least one ultraviolet filter substance.
18. The method as recited in claim 1 wherein the topical preparation further comprises at least one ultraviolet filter substance selected from the group consisting of avenobenzene, cinoxate, dioxybenzone, homosalate, menthyl anthranilate, octocrylene, octyl methoxycinnamate, octyl salicylate, oxybenzone, padimate O, phenylbenzimidazole sulfonic acid, sulisobenzone, titanium dioxide, trolamine salicylate, and zinc oxide.
19. The method as recited in claim 1 wherein the topical preparation further comprises at least one depigmenting substance.
20. The method as recited in claim 1 wherein the topical preparation further comprises at least one depigmenting substance selected from the group consisting of kojic acid, methyl gentisate, hydroquinone, phytic acid, mulberry extract, grape seed extract, licorice extract, Vitamin A, a Vitamin A derivate, resorcinol or a derivative thereof, ellagic acid, ferulic acid, azelaic acid, an alpha hydroxyl acid and Vitamin C or derivative thereof.
21. A method for reducing an occurrence of hyperpigmentation in human skin, comprising:
- providing a person in need of a reduction of an occurrence of hyperpigmentation, the occurrence of hyperpigmentation being responsive to an application of idebenone or a derivative of idebenone; and
- applying a topical preparation to the skin, the preparation comprising an amount of an agent effective to reduce the occurrence of hyperpigmentation in human skin, the agent comprising idebenone or a derivative of idebenone.
22. The method as recited in claim 21 wherein the applying is performed after the hyperpigmentation has occurred.
23. The method as recited in claim 21 wherein the idebenone or derivative of idebenone has a concentration of from about 0.001% to about 30% by weight of the topical preparation.
24. The method as recited in claim 21 wherein the derivative of idebenone is selected from the group consisting of a salt of idebenone, an ester of idebenone, and a protein-bound form of idebenone.
25. The method as recited in claim 21 wherein the topical preparation is in the form of at least one of a lotion, a cream, a gel, a solution, a spray, a cleanser, a powder, an ointment, a wax, a lipstick, a soap, a shampoo, a hydroalcoholic solution, a suspension, a scrub, a saturated pad, and a skin or hair conditioning agent.
26. The method as recited in claim 21 wherein the topical preparation further comprises at least one ultraviolet filter substance.
27. The method as recited in claim 21 wherein the topical preparation further comprises at least one ultraviolet filter substance selected from the group consisting of avenobenzene, cinoxate, dioxybenzone, homosalate, menthyl anthranilate, octocrylene, octyl methoxycinnamate, octyl salicylate, oxybenzone, padimate O, phenylbenzimidazole sulfonic acid, sulisobenzone, titanium dioxide, trolamine salicylate, and zinc oxide.
28. The method as recited in claim 21 wherein the topical preparation further comprises at least one of an antioxidant and a depigmenting substance.
29. A method for reducing occurrence of hyperpigmentation in human skin, the method comprising:
- making available a topical preparation directed to reducing an occurrence of hyperpigmentation in human skin, the topical preparation comprising an amount of an agent effective to reduce the occurrence of hyperpigmentation in human skin, the agent comprising idebenone or a derivative of idebenone; and
- providing an information on applying the topical preparation to the skin.
30. The method as recited in claim 29 wherein the information includes an indication that the applying is performed for the purpose of reducing the occurrence of hyperpigmentation in human skin.
31. The method as recited in claim 29 wherein the making available includes engaging in marketing, advertising or indicating that the topical preparation is for reducing an occurrence of hyperpigmentation in human skin.
32. The method as recited in claim 29 wherein the applying is performed after the hyperpigmentation has occurred.
33. The method as topical preparation recited in claim 29 wherein the idebenone or derivative of idebenone has a concentration of from about 0.001% to about 30% by weight of the topical preparation.
34. The method as recited in claim 29 wherein the derivative of idebenone is selected from the group consisting of a salt of idebenone, an ester of idebenone, and a protein-bound form of idebenone.
35. The method as recited in claim 29 wherein the topical preparation is in the form of at least one of a lotion, a cream, a gel, a solution, a spray, a cleanser, a powder, an ointment, a wax, a lipstick, a soap, a shampoo, a hydroalcoholic solution, a suspension, a scrub, a saturated pad, and a skin or hair conditioning agent.
36. The method as recited in claim 29 wherein the topical preparation further comprises at least one ultraviolet filter substance.
37. The method as recited in claim 29 wherein the topical preparation further comprises at least one ultraviolet filter substance selected from the group consisting of avenobenzene, cinoxate, dioxybenzone, homosalate, menthyl anthranilate, octocrylene, octyl methoxycinnamate, octyl salicylate, oxybenzone, padimate O, phenylbenzimidazole sulfonic acid, sulisobenzone, titanium dioxide, trolamine salicylate, and zinc oxide.
38. A topical preparation for reducing an occurrence of hyperpigmentation in human skin, comprising:
- at least one of an ultraviolet filter substance, a depigmentation substance and an antioxidant; and
- an amount of idebenone or a derivative of idebenone effective to reduce an occurrence of hyperpigmentation in human skin.
39. The preparation as recited in claim 38 wherein the ultraviolet filter substance is selected from the group consisting of avenobenzene, cinoxate, dioxybenzone, homosalate, menthyl anthranilate, octocrylene, octyl methoxycinnamate, octyl salicylate, oxybenzone, padimate O, phenylbenzimidazole sulfonic acid, sulisobenzone, titanium dioxide, trolamine salicylate, and zinc oxide.
40. The preparation as recited in claim 38 wherein the antioxidant is selected from the group consisting of Vitamin E, Vitamin C, Glutathione, Superoxide Dismutase, Catalase, Co-Enzyme Q10, a botanical extract, alpha lipoic acid, N-furfuryladenine and an antioxidant polyphenol.
41. The preparation as recited in claim 38 wherein the depigmenting substance is selected from the group consisting of kojic acid, methyl gentisate, hydroquinone, phytic acid, mulberry extract, grape seed extract, licorice extract, Vitamin A, a Vitamin A derivate, resorcinol or a derivative thereof, ellagic acid, ferulic acid, azelaic acid, an alpha hydroxyl acid and Vitamin C or derivative thereof.
42. The preparation as recited in claim 38 wherein the hyperpigmentation occurs upon an exposure of the skin to at least one of ultraviolet radiation, a chemical, a cosmetic and a drug.
43. The preparation as recited in claim 38 wherein the idebenone or derivative of idebenone has a concentration of from about 0.001% to about 30% by weight of the preparation.
44. The preparation as recited in claim 38 wherein the derivative of idebenone is selected from the group consisting of a salt of idebenone, an ester of idebenone, and a protein-bound form of idebenone.
45. The preparation as recited in claim 38 wherein the preparation is in the form of at least one of a lotion, a cream, a gel, a solution, a spray, a cleanser, a powder, an ointment, a wax, a lipstick, a soap, a shampoo, and a hydroalcoholic solution.
