Prothrombin time reagents are provided which comprise novel liposome compositions in which tissue factor is associated with an inserted into the phospholipid bilayer of the liposomes. Methods for their preparation are also provided. The liposome compositions may be adjusted to allow maximum coagulant...http://www.google.es/patents/US5314695?utm_source=gb-gplus-sharePatente US5314695 - Tissue factor based prothrombin time reagent