The invention is directed to oligonucleotides and oligonucleosides functionalized to include lipophilic moieties and having improved biostability and altered biodistribution in mammals. In one embodiment, such lipophilic oligonucleotide conjugates are used in a method of targeting antisense oligonucleotides...http://www.google.es/patents/US6753423?utm_source=gb-gplus-sharePatente US6753423 - Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
Compositions and methods for enhanced biostability and altered ...
