This invention provides methods of obtaining novel polynucleotides and encoded polypeptides by the use of non-stochastic methods of directed evolution (DirectEvolution). A particular advantage of end-selection-based methods is the ability to recover full-length polynucleotides from a library of progeny...http://www.google.es/patents/US6773900?utm_source=gb-gplus-sharePatente US6773900 - End selection in directed evolution
