A IFN-.beta. mutein in which phe (F), tyr (Y), trp (W) or his (H) is substituted for val (V) at position 101, when numbered in accordance with wild type IFN-.beta., DNA sequences encoding these IFN-.beta. muteins, recombinant DNA molecules containing those DNA sequences operatively linked to expression...http://www.google.es/patents/US5545723?utm_source=gb-gplus-sharePatente US5545723 - Muteins of IFN-.beta.