The invention relates to an allosterically active conjugate composition comprising one or more hemoglobin tetramers and one or more adducts of a physiologically safe macromolecular agent covalently linked to one or more ligands, such that the adduct is bound to the allosteric binding site of the hemoglobin...http://www.google.es/patents/US4698387?utm_source=gb-gplus-sharePatente US4698387 - Allosteric conjugates of hemoglobin and use as blood substitutes
Allosteric conjugates of hemoglobin and use as blood substitutes
